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2018
102 Downloads (Pure)

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Mahajan, A., Taliun, D., Thurner, M., Robertson, N. R., Torres, J. M., Rayner, N. W., Payne, A. J., Steinthorsdottir, V., Scott, R. A., Grarup, N., Cook, J. P., Schmidt, E. M., Wuttke, M., Sarnowski, C., Mägi, R., Nano, J., Gieger, C., Trompet, S., Lecoeur, C., Preuss, M. H. & 95 flere, Prins, B. P., Guo, X., Bielak, L. F., Below, J. E., Bowden, D. W., Chambers, J. C., Kim, Y. J., Ng, M. C. Y., Petty, L. E., Sim, X., Zhang, W., Bennett, A. J., Bork-Jensen, J., Brummett, C. M., Canouil, M., Ec Kardt, K-U., Fischer, K., Kardia, S. L. R., Kronenberg, F., Läll, K., Liu, C-T., Locke, A. E., Luan, J., Ntalla, I., Nylander, V., Schönherr, S., Schurmann, C., Yengo, L., Bottinger, E. P., Brandslund, I., Christensen, C., Dedoussis, G., Florez, J. C., Ford, I., Franco, O. H., Frayling, T. M., Giedraitis, V., Hackinger, S., Hattersley, A. T., Herder, C., Ikram, M. A., Ingelsson, M., Jørgensen, M. E., Jørgensen, T., Kriebel, J., Kuusisto, J., Ligthart, S., Lindgren, C. M., Linneberg, A., Lyssenko, V., Mamakou, V., Meitinger, T., Mohlke, K. L., Morris, A. D., Nadkarni, G., Pankow, J. S., Peters, A., Sattar, N., Stančáková, A., Strauch, K., Taylor, K. D., Thorand, B., Thorleifsson, G., Thorsteinsdottir, U., Tuomilehto, J., Witte, D. R., Dupuis, J., Peyser, P. A., Zeggini, E., Loos, R. J. F., Froguel, P., Ingelsson, E., Lind, L., Groop, L., Laakso, M., Collins, F. S., Jukema, J. W., Palmer, C. N. A., Grallert, H., Metspalu, A., Dehghan, A., Köttgen, A., Abecasis, G. R., Meigs, J. B., Rotter, J. I., Marchini, J., Pedersen, O., Hansen, T., Langenberg, C., Wareham, N. J., Stefansson, K., Gloyn, A. L., Morris, A. P., Boehnke, M. & McCarthy, M. I., nov. 2018, I : Nature Genetics. 50, 11, s. 1505–1513

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Type 2 Diabetes Mellitus
Genome-Wide Association Study
Epigenomics
Equipment and Supplies
2017
120 Downloads (Pure)

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Willems, S. M., Wright, D. J., Day, F. R., Trajanoska, K., Joshi, P. K., Morris, J. A., Matteini, A. M., Garton, F. C., Grarup, N., Oskolkov, N., Thalamuthu, A., Mangino, M., Liu, J., Demirkan, A., Lek, M., Xu, L., Wang, G., Oldmeadow, C., Gaulton, K. J., Lotta, L. A. & 31 flere, Miyamoto-Mikami, E., Rivas, M. A., White, T., Loh, P. R., Aadahl, M., Amin, N., Attia, J. R., Austin, K., Benyamin, B., Brage, S., Cheng, Y. C., Ciȩszczyk, P., Derave, W., Eriksson, K. F., Eynon, N., Linneberg, A., Lucia, A., Massidda, M., Mitchell, B. D., Miyachi, M., Murakami, H., Padmanabhan, S., Pandey, A., Papadimitriou, I., Rajpal, D. K., Sale, C., Schnurr, T. M., Sessa, F., Shrine, N., Hansen, T. & GEFOS Anytype of Fracture Consortium, 12. jul. 2017, I : Nature Communications. 8, 12 s., 16015.

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Signal transduction
fitness
Genome-Wide Association Study
loci
Muscle
2018
91 Downloads (Pure)

Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood: A family-based study

Hollensted, M., Ekstrøm, C. T., Pedersen, O., Eiberg, H., Hansen, T. & Gjesing, A. P., 4. dec. 2018, I : BMC Medical Genetics. 19, 9 s., 207.

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Adiposity
Weights and Measures
Insulin Resistance
Insulin
Glucose Tolerance Test
2019

Correlation between tumor-specific mutated and methylated DNA in colorectal cancer

Thomsen, C. B., Andersen, R. F., Lindebjerg, J., Hansen, T. F., Jensen, L. H. & Jakobsen, A., 2019, I : JCO Precision Oncology. 3, s. 1-8

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Colorectal Neoplasms
DNA
Neoplasms
Neuropeptide Y
Precision Medicine

Polygenic predisposition to breast cancer and the risk of coronary artery disease

D'Souza, M., Schou, M., Skals, R., Weeke, P. E., Lee, C., Smedegaard, L., Madelaire, C., Gerds, T. A., Poulsen, H. E., Hansen, T., Grarup, N., Pedersen, O., Stender, S., Engstrøm, T., Fosbøl, E., Nielsen, D., Gislason, G., Køber, L., Torp-Pedersen, C. & Andersson, C., 15. sep. 2019, I : International Journal of Cardiology. 291, s. 145-151

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Coronary Artery Disease
Confidence Intervals
Odds Ratio
Logistic Models
Coronary Angiography
2018
118 Downloads (Pure)

The effect of drinking water pH on the human gut microbiota and glucose regulation: results of a randomized controlled cross-over intervention

Hansen, T. H., Thomassen, M. T., Madsen, M. L., Kern, T., Bak, E. G., Kashani, A., Allin, K. H., Hansen, T. & Pedersen, O., 9. nov. 2018, I : Scientific Reports. 8, 12 s., 16626.

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Rodentia
Microbiota
Glucose Tolerance Test
rRNA Genes
Cross-Over Studies
2016

Human gut microbes impact host serum metabolome and insulin sensitivity

Pedersen, H. K., Gudmundsdottir, V., Bjørn Nielsen, H., Hyotylainen, T., Nielsen, T., Jensen, B. A. H., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., Le Chatelier, E., Levenez, F., Dore, J., Mattila, I., Plichta, D. R., Pöhö, P., Hellgren, L. I., Arumugam, M., Sunagawa, S., Vieira-Silva, S. & 13 flere, Jørgensen, T., Holm, J. B., Trošt, K., Kristiansen, K., Brix, S., Raes, J., Wang, J., Hansen, T., Bork, P., Brunak, S., Oresic, M., Dusko Ehrlich, S. & Pedersen, O., 2016, I : Nature. 535, 7612, s. 376-381

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2019

Glucose metabolism in children and adolescents: Population-based reference values and comparisons to children and adolescents enrolled in obesity treatment

Frithioff-Bøjsøe, C., Lund, M. A. V., Kloppenborg, J. T., Nielsen, T. T. H., Fonvig, C. E., Lausten-Thomsen, U., Hedley, P. L., Hansen, T., Pedersen, O. B., Christiansen, M., Baker, J. L., Hansen, T. & Holm, J. C., 1. aug. 2019, I : Pediatric Diabetes. 20, 5, s. 538-548

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Reference Values
Insulin Resistance
Homeostasis
Insulin
Population
2018
115 Downloads (Pure)

An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese

Graae, A. S., Hollensted, M., Kloppenborg, J. T., Mahendran, Y., Schnurr, T. M., Appel, E. V. R., Rask, J., Nielsen, T. R. H., Johansen, M., Linneberg, A., Jørgensen, M. E., Grarup, N., Kadarmideen, H. N., Holst, B., Pedersen, O., Holm, J. C. & Hansen, T., aug. 2018, I : Diabetologia. 61, 8, s. 1769–1779

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Insulin Resistance
Fats
Fasting
HDL Cholesterol
Population
122 Downloads (Pure)

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

Finnish Diabetic Nephropathy Study (FinnDiane), 1. jul. 2018, I : Diabetes. 67, 7, s. 1414-1427

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Genome-Wide Association Study
Diabetic Nephropathies
Type 2 Diabetes Mellitus
Glomerular Filtration Rate
Sample Size
2017
150 Downloads (Pure)

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Scott, R. A., Scott, L. J., Mägi, R., Marullo, L., Gaulton, K. J., Kaakinen, M., Pervjakova, N., Pers, T. H., Johnson, A. D., Eicher, J. D., Jackson, A. U., Ferreira, T., Lee, Y., Ma, C., Steinthorsdottir, V., Thorleifsson, G., Qi, L., Van Zuydam, N. R., Mahajan, A., Chen, H. & 31 flere, Almgren, P., Voight, B. F., Grallert, H., Müller-Nurasyid, M., Ried, J. S., Rayner, N. W., Robertson, N., Karssen, L. C., van Leeuwen, E. M., Willems, S. M., Fuchsberger, C., Kwan, P., Teslovich, T. M., Chanda, P., Li, M., Lu, Y., Dina, C., Thuillier, D., Yengo, L., Jiang, L., Sparso, T., Kestler, H. A., Chheda, H., Eisele, L., Gustafsson, S., Frånberg, M., Strawbridge, R. J., Benediktsson, R., Jørgensen, M. E., Hansen, T. & DIAGRAM Consortium, 1. nov. 2017, I : Diabetes. 66, 11, s. 2888-2902

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Genome-Wide Association Study
Type 2 Diabetes Mellitus
Insulin
Biodiversity
Islets of Langerhans

FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans

Søberg, S., Sandholt, C. H., Jespersen, N. Z., Toft, U., Madsen, A. L., von Holstein-Rathlou, S., Grevengoed, T. J., Christensen, K. B., Bredie, W. L. P., Potthoff, M. J., Solomon, T. P. J., Scheele, C., Linneberg, A., Jørgensen, T., Pedersen, O., Hansen, T., Gillum, M. P. & Grarup, N., 2017, I : Cell Metabolism. 25, 5, s. 1045-1053.e6

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Hormones
Primates
Rodentia
Smoking
Alcohols
2019
1 Downloads (Pure)

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

EGG Consortium, 1. maj 2019, I : Nature Genetics. 51, 5, s. 804-814

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Mothers
Alleles
Genome-Wide Association Study
Proxy
Random Allocation
105 Downloads (Pure)

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

Ahluwalia, T. S., Schulz, C-A., Waage, J., Skaaby, T., Sandholm, N., van Zuydam, N., Charmet, R., Bork-Jensen, J., Almgren, P., Thuesen, B. H., Bedin, M., Brandslund, I., Christensen, C. K., Linneberg, A., Ahlqvist, E., Groop, P-H., Hadjadj, S., Tregouet, D-A., Jørgensen, M. E., Grarup, N. & 9 flere, Pedersen, O., Simons, M., Groop, L., Orho-Melander, M., McCarthy, M. I., Melander, O., Rossing, P., Kilpeläinen, T. O. & Hansen, T., feb. 2019, I : Diabetologia. 62, 2, s. 292-305

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Exome
Albuminuria
Meta-Analysis
Kidney Diseases
Type 2 Diabetes Mellitus
2018

Recovery of gut microbiota of healthy adults following antibiotic exposure

Palleja, A., Mikkelsen, K. H., Forslund, S. K., Kashani, A., Allin, K. H., Nielsen, T., Hansen, T. H., Liang, S., Feng, Q., Zhang, C., Pyl, P. T., Coelho, L. P., Yang, H., Wang, J., Typas, A., Nielsen, M. F., Nielsen, H. B., Bork, P., Wang, J., Vilsbøll, T. & 4 flere, Hansen, T., Knop, F. K., Arumugam, M. & Pedersen, O., nov. 2018, I : Nature Microbiology. 3, 11, s. 1255-1265

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Microbial Drug Resistance
Fusobacterium nucleatum
Metagenomics
Lactams
Firearms