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2018
108 Downloads (Pure)

Multiple intracellular signaling pathways orchestrate adipocytic differentiation of human bone marrow stromal stem cells

Ayesh Hafez Ali, D., Abuelreich, S., Alkeraishan, N., Shwish, N. B., Hamam, R., Kassem, M., Alfayez, M., Aldahmash, A. & Alajez, N. M., 30. jan. 2018, I : Bioscience Reports. 38, 1, 10 s., BSR20171252.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Stem cells
Mesenchymal Stromal Cells
Adipocytes
Bone
Metabolism
2019
108 Downloads (Pure)

Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation

El-Safadi, M., Shinwari, T., Al-Malki, S., Manikandan, M., Mahmood, A., Aldahmash, A., Alfayez, M., Kassem, M. & Alajez, N. M., 21. mar. 2019, I : Scientific Reports. 9, 13 s., 4977.

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Mesenchymal Stromal Cells
Cell Differentiation
Up-Regulation
Regenerative Medicine
Gene Expression Profiling

Absence of an osteopetrosis phenotype in IKBKG (NEMO) mutation-positive women: A case-control study

Frost, M., Tencerova, M., Andreasen, C. M., Levin Andersen, T., Ejersted, C. A., Svaneby, D., Kassem, M., Whyte, M. P. & Frederiksen, A. L., apr. 2019, I : Bone. 121, s. 243-254

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Osteopetrosis
Case-Control Studies
Mutation
Incontinentia Pigmenti
X Chromosome Inactivation
2018

International Harmonization and Standardization between Denmark and Germany: The German-Danish Interreg project BONEBANK

Maushagen, R., Gemoll, T., Oberlaender, M., Faccinetti, G., Figge, L., Kock-Schoppenhauer, A-K., Duhm-Harbeck, P., Niessen, L., Unger, A., Wendlandt, R., Kowal, J. M., Haakonsson, A. K., Bober, C., Diercks, K., Nassutt, R., Buescher, R., Reimers, N., Schmal, H., Frahm, T., Eckers, A. & 5 flere, Brilling, J., Barington, T., Kassem, M., Schulz, A-P. & Habermann, J. K., 31. jul. 2018.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

2015
83 Downloads (Pure)

Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells

Andersen, R. K., Zaher, W., Larsen, K. H., Ditzel, N., Drews, K., wruck, W., Adjaye, J., Abdallah, B. & Kassem, M., 8. okt. 2015, I : Stem Cell Research & Therapy. 6, s. 196

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Mesenchymal Stromal Cells
Osteogenesis
Bone
Clone Cells
Platelet-Derived Growth Factor Receptors
2019

Strontium functionalized scaffold for bone tissue engineering

Prabha, R. D., Nair, B. P., Ditzel, N., Kjems, J., Nair, P. D. & Kassem, M., 1. jan. 2019, I : Materials Science and Engineering C: Biomimetic Materials, Sensors and Systems. 94, s. 509-515

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

strontium ranelate
Tissue Engineering
Stromal Cells
Growth
Dentistry
2015
230 Downloads (Pure)

Inhibiting actin depolymerization enhances osteoblast differentiation and bone formation in human stromal stem cells

Chen, L., Shi, K., Frary, C., Ditzel, N., Hu, H., Qiu, W. & Kassem, M., 2015, I : Stem Cell Research. 15, 2, s. 281-289

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Stromal Cells
Osteoblasts
Osteogenesis
Actins
Cell Differentiation
2016

Neonatal High Bone Mass With First Mutation Of The NF-κB Complex: Heterozygous De Novo Missense (p.Asp512Ser) RELA (Rela/p65)

Frederiksen, A. L., Larsen, M. J., Brusgaard, K., Norvack, D. V., Knudsen, P. J. T., Schrøder, H. D., Qiu, W., Eckhardt, C., McAlister, W. H., Kassem, M., Mumm, S., Nielsen, M. F. M. & Whyte, M. P., 2016, I : Journal of Bone and Mineral Research. 31, 1, s. 163–172

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Osteopetrosis
Osteoclasts
Mutation
Osteoblasts
Fibroblasts
2015

Anabolic compounds for treating and preventing bone loss diseases

Jafari, A., Chen, L., Kassem, M. & Abdallah, B., 7. maj 2015, Patentnr. WO2013167475 (A1), 7. maj 2015, Prioritetsdato 3. maj 2013, Prioritetsnr. US201314399726

Publikation: Patent

181 Downloads (Pure)

CD34 defines an osteoprogenitor cell population in mouse bone marrow stromal cells

Abdallah, B. M., Al-Shammary, A., Skagen, P., Abu Dawud, R., Adjaye, J., Aldahmash, A. & Kassem, M., 21. sep. 2015, I : Stem Cell Research. 15, 3, s. 449-458 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Mesenchymal Stromal Cells
Osteoblasts
Population
Stromal Cells
Computational Biology
2019

Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells

Nehlin, J. O., Jafari, A., Tencerova, M. & Kassem, M., 1. jun. 2019, I : Bone. 123, s. 265-273

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Stromal Cells
Adipocytes
Physiological Phenomena
Adiposity
Osteoblasts
2015

Pharmacological Inhibition of Protein Kinase G1 Enhances Bone Formation by Human Skeletal Stem Cells Through Activation of RhoA-Akt Signaling.

Jafari, A., Siersbæk, M., Chen, L., Qanie, D. W. M., Zaher, W., Abdallah, B. & Kassem, M., 2015, I : Stem Cells. 33, 7, s. 2219–2231

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Osteogenesis
Mesenchymal Stromal Cells
Osteoblasts
Adipogenesis

Human stromal stem cell therapy using gene-modified cells

Zaher, W. & Kassem, M., 2015, Somatic Genome Manipulation: Advances, Methods, and Applications. Li, X-Q., Donnelly, D. J. & Jensen, T. G. (red.). Springer, s. 105-121

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

2019

Insulin Signaling in Bone Marrow Adipocytes

Tencerova, M., Okla, M. & Kassem, M., dec. 2019, I : Current Osteoporosis Reports. 17, 6, s. 446-454

Publikation: Bidrag til tidsskriftReviewForskningpeer review

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Adipocytes
Insulin
Fats
Cell Aging
Adiposity
2017

CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling

Abdallah, B. M., Figeac, F., Larsen, K. H., Ditzel, N., Keshari, P., Isa, A., Jafari, A., Andersen, T. L., Delaisse, J. M., Goshima, Y., Ohshima, T. & Kassem, M., maj 2017, I : Journal of Bone and Mineral Research. 32, 5, s. 913-926

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Osteoblasts
Osteogenesis
Proteins
Mesenchymal Stromal Cells
Cyclin D1
2015

MicroRNAs as Regulators of Adipogenic Differentiation of Mesenchymal Stem Cells

Hamam, D., Ali, D., Kassem, M., Aldahmash, A. & Alajez, N. M., 2015, I : Stem Cells and Development. 24, 4, s. 417-425

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

MicroRNAs
Mesenchymal Stromal Cells
Fats
Physiological Phenomena
Adipogenesis
2016

Study On Impact of Obesity On Cellular And Molecular Characteristics Of Bone Marrow Stromal Stem Cells In Healthy Men.

Tencerova, M., Frost, M., Nielsen, T. K. L. & Kassem, M., 2016.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

113 Downloads (Pure)

Egypt: Its Artists, Intellectuals, and Neglected Tropical Diseases

Hotez, P. J. & Kassem, M., 2016, I : P L o S Neglected Tropical Diseases (Online). 10, 12, 4 s., e0005072.

Publikation: Bidrag til tidsskriftLederForskning

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566 Downloads (Pure)

Characterization of Cellular and Molecular Heterogeneity of Bone Marrow Stromal Cells

Elsafadi, M., Manikandan, M., Atteya, M., Hashmi, J. A., Iqbal, Z., Aldahmash, A., Alfayez, M., Kassem, M. & Mahmood, A., 2016, I : Stem Cells International. 2016, 18 s., 9378081.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Mesenchymal Stromal Cells
Alkaline Phosphatase
Stromal Cells
Osteoblasts
Homeobox Genes
114 Downloads (Pure)

Epigenetic Library Screen Identifies Abexinostat as Novel Regulator of Adipocytic and Osteoblastic Differentiation of Human Skeletal (Mesenchymal) Stem Cells

Ali, D., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Alajez, N. M., 2016, I : Stem Cells Translational Medicine. 5, 8, s. 1036-1047

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Mesenchymal Stromal Cells
Epigenomics
Stromal Cells
Libraries
Osteoblasts
140 Downloads (Pure)

MicroRNA-320 suppresses colorectal cancer by targeting SOX4, FOXM1, and FOXQ1

Vishnubalaji, R., Hamam, R., Shijun, Y., AI-Obeed, O., Kassem, M., Liu, F-F., Aldahmash, A. & Alajez, N. M., 2016, I : Oncotarget. 7, 24, s. 35789–35802

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MicroRNAs
Colorectal Neoplasms
Neoplasms
SCID Mice
Fluorouracil
2019
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Mesenchymal Stromal Cells
Osteoblasts
Translational Medical Research
Adipocytes
Osteogenesis
2016
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Osteoblasts
Homeostasis
Luciferases
Osteogenesis
Osteoclasts

Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial

Fuleihan G, EI-H., Baddoura, R., Habib, R. H., Halaby, G., Arabi, A., Rahme, M., Singh, R. J., Kassem, M., Mahfoud, Z., Hoteit, M., Daher, R. T. & Kassir, M-F., 2016, I : The American Journal of Clinical Nutrition. 104, 2, s. 315-323

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Insulin Resistance
Randomized Controlled Trials
Homeostasis
Calcium Citrate
Prediabetic State
2017

Impact of Calcium and Two Doses of Vitamin D on Bone Metabolism in the Elderly: A Randomized Controlled Trial

Rahme, M., Sharara, S. L., Baddoura, R., Habib, R. H., Halaby, G., Arabi, A., Singh, R. J., Kassem, M., Mahfoud, Z., Hoteit, M., Daher, R. T., Bassil, D., El Ferkh, K. & El-Hajj Fuleihan, G., 2017, I : Journal of Bone and Mineral Research. 32, 7, s. 1486-1495

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
Randomized Controlled Trials
Calcium Citrate
Hip
Body Mass Index

Effects of GIP, GLP-1 and GLP-1RAs on bone cell metabolism

Hansen, M. S., Tencerova, M., Frølich, J. S., Kassem, M. & Frost, M., 2017, I : Basic & Clinical Pharmacology & Toxicology.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

2019
Adipogenesis
Stem Cell Factor
Osteogenesis
Color
2016
100 Downloads (Pure)

Aarhus Regenerative Orthopaedics Symposium (AROS): Regeneration in the ageing population

Foldager, C. B., Bendtsen, M., Berg, L. C., Brinchmann, J. E., Brittberg, M., Bunger, C., Canseco, J., Chen, L., Christensen, B., Colombier, P., Deleuran, B. W., Edwards, J., Elmengaard, B., Farr, J., Gatenholm, B., Gomoll, A. H., Hui, J. H., Jakobsen, R. B., Jørgensen, N. L., Kassem, M. & 18 flere, Koch, T., Kold, S., Krogsgaard, M. R., Lauridsen, H., Le, D., Le Visage, C., Lind, M., Nygaard, J. V., Olesen, M. L., Pedersen, M., Rathcke, M. W., Richardson, J. B., Roberts, S., Rölfing, J. D., Sakai, D., Seong Toh, W., Urban, J. & Spector, M., 2016, I : Acta Orthopaedica (Print Edition). 87, s. 1-5

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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2018
130 Downloads (Pure)

Antibody-based inhibition of circulating DLK1 protects from estrogen deficiency-induced bone loss in mice

Figeac, F., Andersen, D. C., Nipper Nielsen, C. A., Ditzel, N., Sheikh, S. P., Skjødt, K., Kassem, M., Jensen, C. H. & Abdallah, B. M., maj 2018, I : Bone. 110, s. 312-320

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Estrogens
Osteogenesis
Serum
X-Ray Microtomography
Adipogenesis
2016
131 Downloads (Pure)

Transgelin is a TGFβ-inducible gene that regulates osteoblastic and adipogenic differentiation of human skeletal stem cells through actin cytoskeleston organization

Elsafadi, E., Manikandan, M., Dawud, R. A., Alajez, N. M., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Mahmood, A., 2016, I : Cell Death & Disease. 7, s. e2321 14 s.

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Actins
Cell Movement
Regenerative Medicine
Cell Proliferation
Focal Adhesions
127 Downloads (Pure)

Dasatinib and Doxorubicin Treatment of Sarcoma Initiating Cells: A Possible New Treatment Strategy

Aggerholm-Pedersen, N., Demouth, C., Safwat, A., Meldgaard, P., Kassem, M. & Sorensen, B. S., 2016, I : Stem Cells International. 2016, 8 s., 9601493.

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Sarcoma
Epidermal Growth Factor Receptor
Cell Survival
Cell Line
Transformed Cell Line
2015
106 Downloads (Pure)

Molecular characterisation of stromal populations derived from human embryonic stem cells: Similarities to immortalised bone marrow derived stromal stem cells

Harkness, L., Twine, N. A., Abu Dawud, R., Jafari, A., Aldahmash, A., Wilkins, M. R., Adjaye, J. & Kassem, M., 2015, I : Bone Reports. 3, s. 32-39

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2019

Efficacy of Injection of Freshly Collected Autologous Adipose Tissue Into Perianal Fistulas in Patients With Crohn's Disease

Dige, A., Hougaard, H. T., Agnholt, J., Pedersen, B. G., Tencerova, M., Kassem, M., Krogh, K. & Lundby, L., 1. jun. 2019, I : Gastroenterology. 156, 8, s. 2208-2216.e1

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Crohn Disease
Adipose Tissue
Cutaneous Fistula
Lipectomy
Perineum

Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

Rauch, A., Haakonsson, A. K., Madsen, J. G. S., Larsen, M., Forss, I., Madsen, M. R., Van Hauwaert, E. L., Wiwie, C., Jespersen, N. Z., Tencerova, M., Nielsen, R., Larsen, B. D., Röttger, R., Baumbach, J., Scheele, C., Kassem, M. & Mandrup, S., apr. 2019, I : Nature Genetics. 51, 4, s. 716-727

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Adipogenesis
Stem Cell Factor
Mesenchymal Stromal Cells
Osteogenesis
Chromatin Assembly and Disassembly
2017

Bone and Skeletal Stem Cells are Affected in High Fat Diet Mice

Figeac, F., Tencerova, M., Ditzel, N., Nielsen, T. K. L., Jørgensen, B. & Kassem, M., 2017. 1 s.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

2018
115 Downloads (Pure)

TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin Cytoskeleton

Elsafadi, M., Manikandan, M., Almalki, S., Mobarak, M., Atteya, M., Iqbal, Z., Hashmi, J. A., Shaheen, S., Alajez, N., Alfayez, M., Kassem, M., Dawud, R. A. & Mahmood, A., 2018, I : Stem Cells International. 2018, 14 s., 6913594.

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Cytochalasin D
Adipogenesis
Gene Expression Profiling
Computational Biology
Transcriptome
109 Downloads (Pure)

Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions

Schmal, H., Kowal, J. M., Kassem, M., Seidenstuecker, M., Bernstein, A., Böttiger, K., Xiong, T., Südkamp, N. P. & Kubosch, E. J., 1. jan. 2018, I : Stem Cells International. 2018, 12 s., 4142031.

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Chondrocytes
Rabbits
Collagen Type X
Collagen Type II
Collagen Type I
15 Downloads (Pure)
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Gastric Inhibitory Polypeptide
Glucagon-Like Peptide 1
Metabolism
Bone
Incretins
2019

Mesenchymal stem cells isolated from both distal femurs of patients with unilateral trauma or osteoarthritis of the knee exhibit similar in-vitro ability of bone formation

Falster, C., Poulsen, S. S., Storaas, A. M., Schroeder, H. M., Vinther, J. H., Kassem, M. & Joergensen, U., 1. sep. 2019, I : Journal of Orthopaedic Science. 24, 5, s. 918-924

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Knee Osteoarthritis
Mesenchymal Stromal Cells
Osteogenesis
Wounds and Injuries
Knee
2016

Normal hematopoiesis and lack of β-catenin activation in osteoblasts of patients and mice harboring Lrp5 gain of function mutations

Galan-Diez, M., Isa, A., Ponzetti, M., Nielsen, M. F. M., Kassem, M. & Kousteni, S., 2016, I : BBA General Subjects. 1863, 3, s. 490-8

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2017
89 Downloads (Pure)

Chromosome copy number variation in telomerized human bone marrow stromal cells; insights for monitoring safe ex-vivo expansion of adult stem cells

Burns, J. S., Harkness, L., Aldahmash, A., Gautier, L. & Kassem, M., 2017, I : Stem Cell Research. 25, s. 6-17

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Mesenchymal Stromal Cells
Diploidy
Comparative Genomic Hybridization
Cell Cycle Checkpoints
Computational Biology
2019
54 Downloads (Pure)

TAFA2 Induces Skeletal (Stromal) Stem Cell Migration Through Activation of Rac1-p38 Signaling

Jafari, A., Isa, A., Chen, L., Ditzel, N., Zaher, W., Harkness, L., Johnsen, H. E., Abdallah, B. M., Clausen, C. & Kassem, M., 1. mar. 2019, I : Stem Cells. 37, 3, s. 407-416

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Stromal Cells
Mesenchymal Stromal Cells
Cell Movement
Closed Fractures
Pseudopodia
2018
97 Downloads (Pure)

Stem cell library screen identified ruxolitinib as regulator of osteoblastic differentiation of human skeletal stem cells

AlMuraikhi, N., Ali, D., Alshanwani, A., Vishnubalaji, R., Manikandan, M., Atteya, M., Siyal, A., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 21. nov. 2018, I : Stem Cell Research & Therapy. 9, 10 s., 319.

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Osteoblasts
Stem cells
Bone
Osteogenesis
Bioinformatics
2015
309 Downloads (Pure)

CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells

Al-toub, M., Vishnubalaji, R., Hamam, R., Kassem, M., Abdallah, B. & Alajez, N. M., 2015, I : Stem Cell Research & Therapy. 24, 6, s. 135

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Mitogen-Activated Protein Kinase Kinases
Stem cells
Mesenchymal Stromal Cells
Cells
Neoplasms
2018
109 Downloads (Pure)

Secreted Clusterin protein inhibits osteoblast differentiation of bone marrow mesenchymal stem cells by suppressing ERK1/2 signaling pathway

Abdallah, B., Alzahrani, A. M. & Kassem, M., maj 2018, I : Bone. 110, s. 221-229

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Clusterin
MAP Kinase Signaling System
Osteoblasts
Mesenchymal Stromal Cells
Adipocytes
2017

Bone morphology in IKBKG (NEMO) mutation positive women: A case-control study

Frost, M., Tencerova, M., Ejersted, C. A., Svaneby, D., Levin Andersen, T., Kassem, M., McAlister, W. H., Novack, D. V., Whyte, M. P. & Frederiksen, A. L., dec. 2017, I : Journal of Bone and Mineral Research. 32, S1, s. S395 1 s., MO0710.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Bone morphology in IKBKG (NEMO) mutation positive women: A case-control study

Frost, M., Tencerova, M., Ejersted, C. A., Svaneby, D., Levin Andersen, T., Kassem, M., McAlister, W. H., Novack, D., Whyte, M. P. & Frederiksen, A. L., 2017.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

2016
142 Downloads (Pure)

Transcription factor ZNF25 is associated with osteoblast differentiation of human skeletal stem cells

Twine, N. A., Harkness, L., Kassem, M. & Wilkins, M. R., 2016, I : BMC Genomics. 17, 15 s., 872.

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Osteoblasts
Small Interfering RNA
Up-Regulation
Nuclear Proteins
G-Protein-Coupled Receptors
273 Downloads (Pure)

Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells

Vishnubalaji, R., Yue, S., Alfayez, M., Kassem, M., Liu, FF., Aldahmash, A. & Alajez, N. M., 2016, I : Cancer Cell International. 16, 12 s., 77.

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Colonic Neoplasms
Colorectal Neoplasms
Growth
SCID Mice
Computational Biology
149 Downloads (Pure)

microRNA expression profiling on individual breast cancer patients identifies novel panel of circulating microRNA for early detection

Hamam, R., Ali, A. M., Alsaleh, K. A., Kassem, M., Alfayez, M., Aldahmash, A. & Alajez, N. M., 2016, I : Scientific Reports. 2016, 8 s., 25997.

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MicroRNAs
Second Primary Neoplasms
Disease Management
Vacuum
Polymerase Chain Reaction