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2011

High Expression of Carcinoembryonic Antigen-Related Cell Adhesion Molecule (CEACAM) 6 in Primary Myelofibrosis

Hasselbalch, H. C., Skov, V., Larsen, T. S., Thomassen, M., Riley, C., Jensen, M. K., Bjerrum, O. W. & Kruse, T. A., 2011, I : Blood. 116, 4116

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

2012

Clinical utility gene card for: Alport syndrome

Hertz, J. M., Thomassen, M., Storey, H. & Flinter, F., 2012, I : European Journal of Human Genetics. 20, 6

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

2013

Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk

Couch, F. J., Wang, X., McGuffog, L., Lee, A. R., Olswold, C., Kuchenbaecker, K. B., Soucy, P., Fredericksen, Z., Barrowdale, D., Dennis, J., Gaudet, M. M., Dicks, E., Kosel, M., Healey, S., Sinilnikova, O. M., Lee, A., Bacot, F., Vincent, D., Hogervorst, F. B. L., Peock, S. & 31 flere, Stoppa-Lyonnet, D., Jakubowska, A., Radice, P., Schmutzler, R. K., Domchek, S. M., Piedmonte, M., Singer, C. F., Friedman, E., Thomassen, M., Hansen, T. V. O., Neuhausen, S. L., Szabo, C. I., Blanco, I., Greene, M. H., Karlan, B. Y., Garber, J., Phelan, C. M., Weitzel, J. N., Montagna, M., Olah, E., Andrulis, I. L., Godwin, A. K., Yannoukakos, D., Goldgar, D. E., Caldes, T., Nevanlinna, H., Skytte, A-B., Gerdes, A-M., Moeller, S. T., Kruse, T. A. & kConFab Investigators, 2013, I : P L o S Genetics. 9, 3, s. e1003212

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

ovarian neoplasms
Genome-Wide Association Study
breast neoplasms
Ovarian Neoplasms
mutation
2012

Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study

Jakubowska, A., Rozkrut, D., Antoniou, A., Hamann, U., Scott, R. J., McGuffog, L., Healy, S., Sinilnikova, O. M., Rennert, G., Lejbkowicz, F., Flugelman, A., Andrulis, I. L., Glendon, G., Ozcelik, H., Thomassen, M., Paligo, M., Aretini, P., Kantala, J., Aroer, B., von Wachenfeldt, A. & 31 flere, Liljegren, A., Loman, N., Herbst, K., Kristoffersson, U., Rosenquist, R., Karlsson, P., Stenmark-Askmalm, M., Melin, B., Nathanson, K. L., Domchek, S. M., Byrski, T., Huzarski, T., Gronwald, J., Menkiszak, J., Cybulski, C., Serrano, P., Osorio, A., Cajal, T. R., Tsitlaidou, M., Benítez, J., Gilbert, M., Rookus, M., Aalfs, C. M., Kluijt, I., Boessenkool-Pape, J. L., Meijers-Heijboer, H. E. J., Oosterwijk, J. C., van Asperen, C. J., Blok, M. J., Nelen, M. R. & OCGN, 2012, I : B J C. 106, 12, s. 2016-24 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Ovarian Neoplasms
Multicenter Studies
Mutation
Penetrance
prohibitin
2011

Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers

Antoniou, A. C., Kartsonaki, C., Sinilnikova, O. M., Soucy, P., McGuffog, L., Healey, S., Lee, A., Peterlongo, P., Manoukian, S., Peissel, B., Zaffaroni, D., Cattaneo, E., Barile, M., Pensotti, V., Pasini, B., Dolcetti, R., Giannini, G., Putignano, A. L., Varesco, L., Radice, P. & 31 flere, Mai, P. L., Greene, M. H., Andrulis, I. L., Glendon, G., Ozcelik, H., Thomassen, M., Gerdes, A-M., Kruse, T. A., Jensen, U. B., Crüger, D. G., Caligo, M. A., Laitman, Y., Milgrom, R., Kaufman, B., Paluch-Shimon, S., Friedman, E., Loman, N., Harbst, K., Lindblom, A., Arver, B., Ehrencrona, H., Melin, B., Nathanson, K. L., Domchek, S. M., Rebbeck, T., Jakubowska, A., Lubinski, J., Gronwald, J., Huzarski, T., Byrski, T. & SWE-BRCA, 2011, I : Human Molecular Genetics. 20, 16, s. 3304-21 18 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Alleles
Single Nucleotide Polymorphism
Mutation
Confidence Intervals
Genome-Wide Association Study
2012

Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

Couch, F. J., Gaudet, M. M., Antoniou, A. C., Ramus, S. J., Kuchenbaecker, K. B., Soucy, P., Beesley, J., Chen, X., Wang, X., Kirchhoff, T., McGuffog, L., Barrowdale, D., Lee, A., Healey, S., Sinilnikova, O. M., Andrulis, I. L., Ozcelik, H., Mulligan, A. M., Thomassen, M., Gerdes, A-M. & 31 flere, Jensen, U. B., Skytte, A-B., Kruse, T. A., Caligo, M. A., von Wachenfeldt, A., Barbany-Bustinza, G., Loman, N., Soller, M., Ehrencrona, H., Karlsson, P., Nathanson, K. L., Rebbeck, T. R., Domchek, S. M., Jakubowska, A., Lubinski, J., Jaworska, K., Durda, K., Zlowocka, E., Huzarski, T., Byrski, T., Gronwald, J., Cybulski, C., Górski, B., Osorio, A., Durán, M., Tejada, M. I., Benitez, J., Hamann, U., Hogervorst, F. B. L., van Os, T. A. & OCGN, 2012, I : Cancer Epidemiology, Biomarkers & Prevention. 21, 4, s. 645-57 13 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Ovarian Neoplasms
Mutation
Genome-Wide Association Study
Research Personnel
2019

Genomisk medicin og kunstig intelligens

Kruse, T. A., Larsen, M. J., Tan, Q., Andersen, L. & Thomassen, M., 1. apr. 2019, I : Ugeskrift for Laeger. 181, 7A, V02190085.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Medicine
Datasets
Clinical Decision-Making
2015
145 Downloads (Pure)

Clonal expansion and linear genome evolution through breast cancer progression from pre-invasive stages to asynchronous metastasis

Krøigård, A. B., Larsen, M. J., Lænkholm, A. V., Knoop, A., Jensen, J. D., Bak, M., Mollenhauer, J., Kruse, T. A. & Thomassen, M., 2015, I : OncoTarget. 6, 8, s. 5634-5649

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Neoplasms
Exome
Point Mutation
Mutation
2014

RNA profiling reveals familial aggregation of molecular subtypes in non-BRCA1/2 breast cancer families

Larsen, M. J., Thomassen, M., Tan, Q., Lænkholm, A. V., Bak, M., Sørensen, K. P., Andersen, M. K., Kruse, T. A. & Gerdes, A-M., 2014, I : B M C Medical Genomics. 7, s. 9 9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
RNA
Neoplasms
Mutation
Penetrance
Germ-Line Mutation
2013
Long Noncoding RNA
Antisense RNA
Neoplasms
Liver Neoplasms
Survival Analysis
2012

Membrane-Tethered Delta-Like 1 Homolog (DLK1) Restricts Adipose Tissue Size By Inhibiting Preadipocyte Proliferation

Mortensen, S. B., Jensen, C. H., Schneider, M., Thomassen, M., Kruse, T. A., Laborda, J., Sheikh, S. P. & Andersen, D. C., 2012, I : Diabetes. 61, 11, s. 2814-22 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Adipose Tissue
Protein Isoforms
Adipogenesis
Membranes
Adipocytes
2011

Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers

Cox, D. G., Simard, J., Sinnett, D., Hamdi, Y., Soucy, P., Ouimet, M., Barjhoux, L., Verny-Pierre, C., McGuffog, L., Healey, S., Szabo, C., Greene, M. H., Mai, P. L., Andrulis, I. L., Thomassen, M., Gerdes, A-M., Caligo, M. A., Friedman, E., Laitman, Y., Kaufman, B. & 31 flere, Paluch, S. S., Borg, A., Karlsson, P., Stenmark Askmalm, M., Barbany Bustinza, G., Nathanson, K. L., Domchek, S. M., Rebbeck, T. R., Benítez, J., Hamann, U., Rookus, M. A., van den Ouweland, A. M. W., Ausems, M. G. E. M., Aalfs, C. M., van Asperen, C. J., Devilee, P., Gille, H. J. J. P., Peock, S., Frost, D., Evans, D. G., Eeles, R., Izatt, L., Adlard, J., Paterson, J., Eason, J., Godwin, A. K., Remon, M-A., Moncoutier, V., Gauthier-Villars, M., Lasset, C. & Ontario Cancer Genetics Network, 2011, I : Human Molecular Genetics. 20, 23, s. 4732-4747

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Alleles
Mutation
BRCA1 Gene
Haplotypes
BRCA1 Protein

A growth curve model with fractional polynomials for analysing incomplete time-course data in microarray gene expression studies

Tan, Q., Thomassen, M., Hjelmborg, J. V. B., Clemmensen, A., Andersen, K. E., Petersen, T. K., McGue, M., Christensen, K. & Kruse, T. A., 27. sep. 2011, I : Advances in Bioinformatics. 2011, Article ID 261514, 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Microarrays
Gene expression
Genes
Polynomials
Growth
2015

Repeated monthly epicutaneous challenges with diphencyprone result in a 'response plateau' in healthy volunteers

Mose, K. F., Andersen, K. E., Andersen, F., Thomassen, M., Kruse, T. A., Kristensen, B. W., Clemmensen, O., Tan, Q., Burton, M., Skov, L., Litman, T., Almose Røpke, M. & S. Friedmann, P., 19. mar. 2015.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

2011

Genetic Variation at 9p22.2 and Ovarian Cancer Risk for BRCA1 and BRCA2 Mutation Carriers

Ramus, S. J., Kartsonaki, C., Gayther, S. A., Pharoah, P. D. P., Sinilnikova, O. M., Beesley, J., Chen, X., McGuffog, L., Healey, S., Couch, F. J., Wang, X., Fredericksen, Z., Peterlongo, P., Manoukian, S., Peissel, B., Zaffaroni, D., Roversi, G., Barile, M., Viel, A., Allavena, A. & 31 flere, Ottini, L., Papi, L., Gismondi, V., Capra, F., Radice, P., Greene, M. H., Mai, P. L., Andrulis, I. L., Glendon, G., Ozcelik, H., Thomassen, M., Gerdes, A-M., Kruse, T. A., Cruger, D., Jensen, U. B., Caligo, M. A., Olsson, H., Kristoffersson, U., Lindblom, A., Arver, B., Karlsson, P., Stenmark Askmalm, M., Borg, A., Neuhausen, S. L., Ding, Y. C., Nathanson, K. L., Domchek, S. M., Jakubowska, A., Lubinski, J., Huzarski, T. & OCGN, 2011, I : National Cancer Institute. Journal (Print). 103, 2, s. 105-116

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Ovarian Neoplasms
Mutation
Single Nucleotide Polymorphism
Alleles
BRCA2 Gene
2014
Microarrays
Gene expression
RNA
Genes
Essential Genes

Comparison of mRNA Splicing Assay Protocols across Multiple Laboratories: Recommendations for Best Practice in Standardized Clinical Testing

Whiley, P., de la Hoya, M., Thomassen, M., Becker, A., Brandão, R., Pedersen, I. S., Montagna, M., Menéndez, M., Quiles, F., Enríquez, S. G., De Leeneer, K., Tenés, A., Montalban, G., Tserpelis, D., Yoshimatsu, T., Tirapo, C., Raponi, M., Caldes, T., Blanco, A., Santamariña, M. & 31 flere, Guidugli, L., de Garibay, G. R., Wong, M., Tancredi, M., Fachal, L., Ding, Y., Kruse, T., Lattimore, V., Kwong, A., Chan, T., Colombo, M., De Vecchi, G., Caligo, M., Baralle, D., Lázaro, C., Couch, F., Radice, P., Southey, M., Neuhausen, S., Houdayer, C., Fackenthal, J., Hansen, T., Vega, A., Diez, O., Blok, R., Claes, K., Wappenschmidt, B., Walker, L., Spurdle, A., Brown, M. & on behalf of the ENIGMA consortium, 2014, I : Clinical Chemistry (Chicago). 60, 2, s. 341–352 12 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Practice Guidelines
Messenger RNA
Polymerase Chain Reaction
Computational Biology
Protein Isoforms
2016

Evidence of non-canonical NOTCH signaling: Delta-like 1 homolog (DLK1) directly interacts with the NOTCH1 receptor in mammals

Traustadóttir, G. Á., Jensen, C. H., Thomassen, M., Beck, H. C., Mortensen, S. B., Laborda, J., Baladrón, V., Sheikh, S. P. & Andersen, D. C., 11. jan. 2016, I : Cellular Signalling. 28, 4, s. 246–254

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Mammals
Epidermal Growth Factor
Ligands
Small Interfering RNA
Proteins
2015

Clonal expansion and linear genome evolution through breast cancer progression from pre-invasive stages to asynchronous metastasis

Krøigård, A. B., Larsen, M. J., Lænkholm, A. V., Knoop, A., Jensen, J. D., Bak, M., Mollenhauer, J., Kruse, T. A. & Thomassen, M., 2015, I : European Journal of Human Genetics. 23, 1 Supplement, PM12.032.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

2014
Large Granular Lymphocytic Leukemia
Mutation
Pentostatin
2012

A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers

Ding, Y. C., McGuffog, L., Healey, S., Friedman, E., Laitman, Y., Paluch-Shimon, S., Kaufman, B., Liljegren, A., Lindblom, A., Olsson, H., Kristoffersson, U., Stenmark-Askmalm, M., Melin, B., Domchek, S. M., Nathanson, K. L., Rebbeck, T. R., Jakubowska, A., Lubinski, J., Jaworska, K., Durda, K. & 31 flere, Gronwald, J., Huzarski, T., Cybulski, C., Byrski, T., Osorio, A., Cajal, T. R., Stavropoulou, A. V., Benítez, J., Hamann, U., Rookus, M., Aalfs, C. M., de Lange, J. L., Meijers-Heijboer, H. E. J., Oosterwijk, J. C., van Asperen, C. J., Gómez García, E. B., Hoogerbrugge, N., Jager, A., van der Luijt, R. B., Easton, D. F., Peock, S., Frost, D., Ellis, S. D., Platte, R., Fineberg, E., Evans, D. G., Lalloo, F., Gerdes, A-M., Thomassen, M., Skytte, A-B. & SWE-BRCA, 2012, I : Cancer Epidemiology, Biomarkers & Prevention. 21, 8, s. 1362-70 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Ovarian Neoplasms
Mutation
2017
150 Downloads (Pure)
Åben adgang
Fil
Cluster Analysis
Health
2016
186 Downloads (Pure)

Aquaporin-4 IgG autoimmune syndrome and immunoreactivity associated with thyroid cancer

Soelberg, K., Larsen, S. R., Mørch, M., Thomassen, M., Brusgaard, K., Paul, F., Smith, T. J., Godballe, C., Grauslund, J., Lillevang, S. T. & Asgari, N., aug. 2016, I : Neurology: Neuroimmunology & Neuroinflammation. 3, 4, 4 s., e252.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
2015

Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer

Rebbeck, T. R., Mitra, N., Wan, F., Sinilnikova, O. M., Healey, S., McGuffog, L., Mazoyer, S., Chenevix-Trench, G., Easton, D. F., Antoniou, A. C., Nathanson, K. L., Laitman, Y., Kushnir, A., Paluch-Shimon, S., Berger, R., Zidan, J., Friedman, E., Ehrencrona, H., Stenmark-Askmalm, M., Einbeigi, Z. & 31 flere, Loman, N., Harbst, K., Rantala, J., Melin, B., Huo, D., Olopade, O. I., Seldon, J., Ganz, P. A., Nussbaum, R. L., Chan, S. B., Odunsi, K., Gayther, S. A., Domchek, S. M., Arun, B. K., Lu, K. H., Mitchell, G., Karlan, B. Y., Walsh, C., Lester, J., Godwin, A. K., Pathak, H., Ross, E., Gerdes, A-M., Hansen, T. V. O., Bojesen, A., Thomassen, M., Moeller, S. T., Kruse, T. A., Pedersen, I. S., Skytte, A-B. & CIMBA Consortium, 7. apr. 2015, I : J A M A: The Journal of the American Medical Association. 313, 13, s. 1347-1361

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Ovarian Neoplasms
Mutation
Neoplasms
Second Primary Neoplasms
Nonsense Codon

Acute hypoxia induces upregulation of microRNA-210 expression in glioblastoma spheroids

Rosenberg, T. A., Thomassen, M., Jensen, S. S., Larsen, M. J., Sørensen, K. P., Hermansen, S. K., Kruse, T. A. & Kristensen, B. W., 2015, I : C N S Oncology. 4, 1, s. 25-35 11 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Glioblastoma
MicroRNAs
Up-Regulation
Oxygen
2016

Ultra-deep sequencing reveals the subclonal structure and genomic evolution of oral squamous cell carcinoma

Tabatabaeifar, S., Thomassen, M., Larsen, M. J., Larsen, S. R., Kruse, T. A. & Sørensen, J. A., 9. jul. 2016. 1 s.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterFormidling

Neoplasms
Lymph Nodes
Mutation
Exome
Squamous Cell Neoplasms
2018

SAFETY AND EFFICACY OF COMBINATION THERAPY OF INTERFERON ΑLPHA-2 AND RUXOLITINIB IN POLYCYTHEMIA VERA AND LOW-/INTERMEDIATE-1-RISK MYELOFIBROSIS – A ONE YEAR FOLLOW-UP UPDATE OF A PHASE II STUDY

Mikkelsen, S. U., Kjær, L., Bjørn, M. E., Knudsen, T. A., Sørensen, A. L., Skov, V., Andersen, C. B. L., Weiss Bjerrum, O., Brochmann Mortensen, N., El Fassi, D., Kruse, T. A., Larsen, T. S., Mourits-Andersen, H. T., Nielsen, C. H., Pallisgaard, N., Thomassen, M. & Hasselbalch, H. C., jun. 2018, I : EHA Learning Center. 2018, PF620.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

2014

Transcriptional profiling of whole blood identifies a unique 5-gene signature for myelofibrosis and imminent myelofibrosis transformation

Hasselbalch, H. C., Skov, V., Stauffer Larsen, T., Thomassen, M., Hasselbalch Riley, C., Jensen, M. K., Bjerrum, O. W. & Kruse, T. A., 2014, I : PLOS ONE. 9, 1, e85567.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Blood
Genes
blood
genes
thrombocythemia
2016

BRCA1/BRCA2 founder mutations and cancer risks: impact in the western Danish population

Nielsen, H. R., Nilbert, M., Petersen, J., Ladelund, S., Thomassen, M., Pedersen, I. S., Hansen, T. V. O., Skytte, A-B., Borg, Å. & Therkildsen, C., 2016, I : Familial Cancer. 15, 4, s. 507-512

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Mutation
Population
Neoplasms
Ovarian Neoplasms
BRCA2 Gene
2018

NEW POTENTIAL CANDIDATE GENES IN MANTLE CELL LYMPHOMA

Cédile, O., Hansen, M. C., Ebbesen, L. H., Nørgaard Bentzen, H. H., Thomassen, M., Kruse, T. A., Kavan, S., Møller, M. B., Kielsgaard Kristensen, T., Christensen, J. H., Abildgaard, N. & Nyvold, C. G., 14. jun. 2018.

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskningpeer review

2015

Chemotherapy effects on intestinal gene expression profiles in piglets

Rathe, M., Thomassen, M., Shen, R. L., Husby, S., Müller, K., Kruse, T. A. & Sangild, P. T., 6. maj 2015.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

2017
137 Downloads (Pure)

Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3

Hamdi, Y., Soucy, P., Kuchenbaeker, K. B., Pastinen, T., Droit, A., Lemaçon, A., Adlard, J., Aittomäki, K., Andrulis, I. L., Arason, A., Arnold, N., Arun, B. K., Azzollini, J., Bane, A., Barjhoux, L., Barrowdale, D., Benítez, J., Berthet, P., Blok, M. J., Bobolis, K. A. & 31 flere, Bonadona, V., Bonanni, B., Bradbury, A. R., Brewer, C., Buecher, B., Buys, S., Caligo, M. A., Chiquette, J., Chung, W. K., Claes, K. B. M., Daly, M. B., Damiola, F., Davidson, R., de la Hoya, M., De Leeneer, K., Díez, O., Ding, Y. C., Dolcetti, R., Domchek, S. M., Dorfling, C. M., Eccles, D., Eeles, R., Einbeigi, Z., Ejlertsen, B., Engel, C., Gareth Evans, D., Feliubadaló, L., Foretova, L., Gerdes, A-M., Thomassen, M. & EMBRACE, 2017, I : Breast Cancer Research and Treatment. 161, 1, s. 117-134

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Heterozygote
Single Nucleotide Polymorphism
Mutation
Quantitative Trait Loci
Progesterone Receptors
2018

A Danish national effort of BRCA1/2 variant classification

Pedersen, I. S., Schmidt, A. Y., Bertelsen, B., Ernst, A., Andersen, C. L. T., Kruse, T., Rossing, M. & Thomassen, M., 2. jan. 2018, I : Acta Oncologica. 57, 1, s. 159-162

Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

2016

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170

Dunning, A. M., Michailidou, K., Kuchenbaecker, K. B., Thompson, D. J., French, J. D., Beesley, J., Healey, C. S., Kar, S., Pooley, K. A., Lopez-Knowles, E., Dicks, E., Barrowdale, D., Sinnott-Armstrong, N. A., Sallari, R. C., Hillman, K. M., Kaufmann, S., Sivakumaran, H., Moradi Marjaneh, M., Lee, J. S., Hills, M. & 31 flere, Jarosz, M., Drury, S., Canisius, S., Bolla, M. K., Dennis, J., Wang, Q., Hopper, J. L., Southey, M. C., Broeks, A., Schmidt, M. K., Lophatananon, A., Muir, K., Beckmann, M. W., Fasching, P. A., Dos Santos Silva, I., Peto, J., Sawyer, E. J., Tomlinson, I., Burwinkel, B., Marme, F., Guénel, P., Truong, T., Bojesen, S. E., Flyger, H., González-Neira, A., Perez, J. I. A., Shen, C-Y., Hansen, T. V. O., Bojesen, A., Thomassen, M. & EMBRACE, 2016, I : Nature Genetics. 48, 4, s. 374-386

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Alleles
Neoplasms
2019
8 Downloads (Pure)

Epigenetic association analysis of clinical sub-phenotypes in patients with polycystic ovary syndrome (PCOS)

Jacobsen, V. M., Li, S., Wang, A., Zhu, D., Liu, M., Thomassen, M., Kruse, T. A. & Tan, Q., 3. aug. 2019, I : Gynecological Endocrinology. 35, 8, s. 691-694

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Polycystic Ovary Syndrome
Epigenomics
DNA Methylation
HLA-G Antigens
Chromosomes, Human, Pair 19
2017
126 Downloads (Pure)

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Milne, R. L., Kuchenbaecker, K. B., Michailidou, K., Beesley, J., Kar, S., Lindström, S., Hui, S., Lemaçon, A., Soucy, P., Dennis, J., Jiang, X., Rostamianfar, A., Finucane, H., Bolla, M. K., McGuffog, L., Wang, Q., Aalfs, C. M., Adams, M., Adlard, J., Agata, S. & 31 flere, Ahmed, S., Ahsan, H., Aittomäki, K., Al-Ejeh, F., Allen, J., Ambrosone, C. B., Amos, C. I., Andrulis, I. L., Anton-Culver, H., Antonenkova, N. N., Arndt, V., Arnold, N., Aronson, K. J., Auber, B., Auer, P. L., Ausems, M. G. E. M., Azzollini, J., Bacot, F., Balmaña, J., Barile, M., Barjhoux, L., Barkardottir, R. B., Barrdahl, M., Barnes, D., Barrowdale, D., Bojesen, A., Gerdes, A-M., Kruse, T. A., Lænkholm, A-V., Thomassen, M. & ABCTB Investigators, 1. dec. 2017, I : Nature Genetics. 49, 12, s. 1767–1778

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Genome-Wide Association Study
Mutation
2018
63 Downloads (Pure)

Publisher Correction: Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations (Scientific Reports, (2017), 7, 1, (6774), 10.1038/s41598-017-07057-3)

Nielsen, H. M., Andersen, C. L., Westman, M., Kristensen, L. S., Asmar, F., Kruse, T. A., Thomassen, M., Larsen, T. S., Skov, V., Hansen, L. L., Bjerrum, O. W., Hasselbalch, H. C., Punj, V. & Grønbæk, K., 20. nov. 2018, I : Scientific Reports. 8, 1 s., 17311.

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Epigenomics
Mutation
2016

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, and Consortium of Modifiers of BRCA1 and BRCA2, Australian Ovarian Cancer Study Group, Breast Cancer Family Register, EMBRACE, GEMO Study Collaborators, GENICA Network, HEBON, kConFab Investigators & SWE-BRCA, 2016, I : Gynecologic Oncology. 141, 2, s. 386-401

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Ovarian Neoplasms
Mutation
MicroRNAs
Neoplasms
152 Downloads (Pure)

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Couch, F. J., Kuchenbaecker, K. B., Michailidou, K., Mendoza-Fandino, G. A., Nord, S., Lilyquist, J., Olswold, C., Hallberg, E., Agata, S., Ahsan, H., Aittomäki, K., Ambrosone, C., Andrulis, I. L., Anton-Culver, H., Arndt, V., Arun, B. K., Arver, B., Barile, M., Barkardottir, R. B., Barrowdale, D. & 229 flere, Beckmann, L., Beckmann, M. W., Benítez, J., Blank, S. V., Blomqvist, C., Bogdanova, N. V., Bojesen, S. E., Bolla, M. K., Bonanni, B., Brauch, H., Brenner, H., Burwinkel, B., Buys, S., Caldes, T., Caligo, M. A., Canzian, F., Carpenter, J., Chang-Claude, J., Chanock, S. J., Chung, W. K., Claes, K. B. M., Cox, A., Cross, S. S., Cunningham, J. M., Czene, K., Daly, M. B., Damiola, F., Darabi, H., de la Hoya, M., Devilee, P., Díez, O., Ding, Y. C., Dolcetti, R., Domchek, S. M., Dorfling, C. M., Dos Santos Silva, I., Dumont, M., Dunning, A. M., Eccles, D. M., Ehrencrona, H., Ekici, A. B., Eliassen, H., Ellis, S., Fasching, P. A., Figueroa, J., Flesch-Janys, D., Försti, A., Fostira, F., Foulkes, W. D., Friebel, T. M., Friedman, E., Frost, D., Gabrielson, M., Gammon, M. D., Ganz, P. A., Gapstur, S. M., Garber, J., Gaudet, M., Gayther, S. A., Gerdes, A-M., Ghoussaini, M., Giles, G., Glendon, G., Godwin, A. K., Goldberg, M. S., Goldgar, D. E., González-Neira, A., Greene, M. H., Gronwald, J., Guénel, P., Gunter, M. J., Haeberle, L., Haiman, C. A., Hamann, U., Hansen, T. V. O., Hart, S., Healey, S., Heikkinen, T., Henderson, B. E., Herzog, J., Hogervorst, F. B. L., Hollestelle, A., Hooning, M. J., Hoover, R. N., Hopper, J. L., Humphreys, K., Hunter, D. J., Huzarski, T., Imyanitov, E. N., Isaacs, C., Jakubowska, A., James, P. A., Janavicius, R., Jensen, U. B., John, E. M., Jones, M., Kabisch, M., Kar, S., Karlan, B. Y., Khan, S., Khaw, K-T., Kibriya, M. G., Knight, J. A., Ko, Y-D., Konstantopoulou, I., Kosma, V-M., Kristensen, V., Kwong, A., Laitman, Y., Lambrechts, D., Lázaro, C., Lee, E., Le Marchand, L., Lester, J., Lindblom, A., Lindor, N., Lindstrom, S., Liu, J., Long, J., Lubinski, J., Mai, P. L., Makalic, E., Malone, K. E., Mannermaa, A., Manoukian, S., Margolin, S., Marme, F., Martens, J. W. M., McGuffog, L., Meindl, A., Miller, A., Milne, R. L., Miron, P., Montagna, M., Mazoyer, S., Mulligan, A. M., Muranen, T. A., Nathanson, K. L., Neuhausen, S. L., Nevanlinna, H., Nordestgaard, B. G., Nussbaum, R. L., Offit, K., Olah, E., Olopade, O. I., Olson, J. E., Osorio, A., Park, S. K., Peeters, P. H. M., Peissel, B., Peterlongo, P., Peto, J., Phelan, C. M., Pilarski, R., Poppe, B., Pylkäs, K., Radice, P., Rahman, N., Rantala, J., Rappaport, C., Rennert, G., Richardson, A., Robson, M., Romieu, I., Rudolph, A., Rutgers, E. J., Sánchez, M-J., Santella, R. M., Sawyer, E. J., Schmidt, D. F., Schmidt, M. K., Schmutzler, R. K., Schumacher, F., Scott, R. J., Senter, L., Sharma, P., Simard, J., Singer, C. F., Sinilnikova, O. M., Soucy, P., Southey, M., Steinemann, D., Stenmark Askmalm, M., Stoppa-Lyonnet, D., Swerdlow, A., Szabo, C. I., Tamimi, R., Tapper, W., Teixeira, M. R., Teo, S-H., Terry, M. B., Thomassen, M., Thompson, D. J., Tihomirova, L., Toland, A. E., Tollenaar, R. A. E. M., Tomlinson, I., Truong, T., Tsimiklis, H., Teulé, A., Tumino, R., Tung, N., Turnbull, C., Ursin, G., van Deurzen, C. H. M., van Rensburg, E. J., Varon-Mateeva, R., Wang, Z., Wang-Gohrke, S., Weiderpass, E., Weitzel, J. N., Whittemore, A. S., Wildiers, H., Winqvist, R., Yang, X. R., Yannoukakos, D., Yao, S., Zamora, M. P., Zheng, W., Hall, P., Kraft, P., Vachon, C., Slager, S., Chenevix-Trench, G., Pharoah, P. D. P., Monteiro, A. N. A., Garcia-Closas, M., Easton, D. F. & Antoniou, A. C., 2016, I : Nature Communications. 7, 13 s., 11375.

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estrogens
loci
breast
Estrogen Receptors
Genes
2015
163 Downloads (Pure)

Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers

Blanco, I., Kuchenbaecker, K., Cuadras, D., Wang, X., Barrowdale, D., de Garibay, G. R., Librado, P., Sánchez-Gracia, A., Rozas, J., Bonifaci, N., McGuffog, L., Pankratz, V. S., Islam, A., Mateo, F., Berenguer, A., Petit, A., Català, I., Brunet, J., Feliubadaló, L., Tornero, E. & 31 flere, Benítez, J., Osorio, A., Cajal, T. R. Y., Nevanlinna, H., Aittomäki, K., Arun, B. K., Toland, A. E., Karlan, B. Y., Walsh, C., Lester, J., Greene, M. H., Mai, P. L., Nussbaum, R. L., Andrulis, I. L., Domchek, S. M., Nathanson, K. L., Rebbeck, T. R., Barkardottir, R. B., Jakubowska, A., Lubinski, J., Durda, K., Jaworska-Bieniek, K., Claes, K., Van Maerken, T., Díez, O., Hansen, T. V., Gerdes, A-M., Bojesen, A., Thomassen, M., Kruse, T. A. & Teixeira, 1. apr. 2015, I : PLOS ONE. 10, 4, 18 s., e0120020.

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Aurora Kinase A
breast neoplasms
mutation
Mutation
Hazards
2018
59 Downloads (Pure)

A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk

Lu, Y., Beeghly-Fadiel, A., Wu, L., Guo, X., Li, B., Schildkraut, J. M., Im, H. K., Chen, Y. A., Permuth, J. B., Reid, B. M., Teer, J. K., Moysich, K. B., Andrulis, I. L., Anton-Culver, H., Arun, B. K., Bandera, E. V., Barkardottir, R. B., Barnes, D. R., Benitez, J., Bjorge, L. & 124 flere, Brenton, J., Butzow, R., Caldes, T., Caligo, M. A., Campbell, I., Chang-Claude, J., Claes, K. B. M., Couch, F. J., Cramer, D. W., Daly, M. B., deFazio, A., Dennis, J., Diez, O., Domchek, S. M., Dörk, T., Easton, D. F., Eccles, D. M., Fasching, P. A., Fortner, R. T., Fountzilas, G., Friedman, E., Ganz, P. A., Garber, J., Giles, G. G., Godwin, A. K., Goldgar, D. E., Goodman, M. T., Greene, M. H., Gronwald, J., Hamann, U., Heitz, F., Hildebrandt, M. A. T., Høgdall, C. K., Hollestelle, A., Hulick, P. J., Huntsman, D. G., Imyanitov, E. N., Isaacs, C., Jakubowska, A., James, P., Karlan, B. Y., Kelemen, L. E., Kiemeney, L. A., Kjaer, S. K., Kwong, A., Le, N. D., Leslie, G., Lesueur, F., Levine, D. A., Mattiello, A., May, T., McGuffog, L., McNeish, I. A., Merritt, M. A., Modugno, F., Montagna, M., Neuhausen, S. L., Nevanlinna, H., Nielsen, F. C., Nikitina-Zake, L., Nussbaum, R. L., Offit, K., Olah, E., Olopade, O. I., Olson, S. H., Olsson, H., Osorio, A., Park, S. K., Parsons, M. T., Peeters, P. H. M., Pejovic, T., Peterlongo, P., Phelan, C. M., Pujana, M. A., Ramus, S. J., Rennert, G., Risch, H., Rodriguez, G. C., Rodríguez-Antona, C., Romieu, I., Rookus, M. A., Rossing, M. A., Rzepecka, I. K., Sandler, D. P., Schmutzler, R. K., Setiawan, V. W., Sharma, P., Sieh, W., Simard, J., Singer, C. F., Song, H., Southey, M. C., Spurdle, A. B., Sutphen, R., Swerdlow, A. J., Teixeira, M. R., Teo, S. H., Thomassen, M., Tischkowitz, M., Toland, A. E., Trichopoulou, A., Tung, N., Tworoger, S. S., van Rensburg, E. J., Vanderstichele, A., Vega, A., Edwards, D. V., Webb, P. M., Weitzel, J. N., Wentzensen, N., White, E., Wolk, A., Wu, A. H., Yannoukakos, D., Zorn, K. K., Gayther, S. A., Antoniou, A. C., Berchuck, A., Goode, E. L., Chenevix-Trench, G., Sellers, T. A., Pharoah, P. D. P., Zheng, W. & Long, J., 15. sep. 2018, I : Cancer Research. 78, 18, s. 5419-5430

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Transcriptome
Genome-Wide Association Study
RNA Sequence Analysis
2019

Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study

Thomassen, M. & GEMO Study Collaborators, 1. apr. 2019, I : National Cancer Institute. Journal (Print). 111, 4, s. 350-364

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Random Allocation
Body Mass Index
Mutation
Confidence Intervals
Proportional Hazards Models
2012

BRCA1 R1699Q variant displaying ambiguous functional abrogation confers intermediate breast and ovarian cancer risk

Spurdle, A. B., Whiley, P. J., Thompson, B., Feng, B., Healey, S., Brown, M. A., Pettigrew, C., Van Asperen, C. J., Ausems, M. G. E. M., Kattentidt-Mouravieva, A. A., van den Ouweland, A. M. W., Lindblom, A., Pigg, M. H., Schmutzler, R. K., Engel, C., Meindl, A., Caputo, S., Sinilnikova, O. M., Lidereau, R., Couch, F. J. & 14 flere, Guidugli, L., Hansen, T. V. O., Thomassen, M., Eccles, D. M., Tucker, K., Benitez, J., Domchek, S. M., Toland, A. E., Van Rensburg, E. J., Wappenschmidt, B., Borg, Å., Vreeswijk, M. P. G., Goldgar, D. E. & kConFab Investigators, 2012, I : Journal of Medical Genetics. 49, 8, s. 525-32 8 s.

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Genetic Counseling
Ovarian Neoplasms
Transcriptional Activation
Neoplasms
2017
105 Downloads (Pure)

Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development

Andersen, M., Sajid, Z., Pedersen, R. K., Gudmand-Hoeyer, J., Ellervik, C., Skov, V., Kjær, L., Pallisgaard, N., Kruse, T. A., Thomassen, M., Troelsen, J., Hasselbalch, H. C. & Ottesen, J. T., 2017, I : PLOS ONE. 12, 8, 18 s., e0183620.

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Stem cells
mathematical models
inflammation
neoplasms
Feedback
2012

Prediction of breast cancer metastasis by gene expression profiles: A comparison of metagenes and single genes

Burton, M., Thomassen, M., Tan, Q. & Kruse, T. A., 2012, I : Cancer Informatics. 11, s. 193-217 25 s.

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2018

Myeloproliferative Neoplasms in Danish Twins

Andersen, M. A., Bjerrum, O. W., Ranjan, A., Skov, V., Kruse, T. A., Thomassen, M., Skytthe, A., Hasselbalch, H. C. & Christensen, K., 3. maj 2018, I : Acta Haematologica. 139, 3, s. 195-198

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Neoplasms
Monozygotic Twins
Registries
Dizygotic Twins
Cell Lineage
2013

Genomsekventering - klinisk anvendelse

Hertz, J. M., Gerdes, A-M., Grønskov, K., Thomassen, M. & Vogel, I., 2013, I : Ugeskrift for Laeger. 175, 12, s. 818

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2019
Monozygotic Twins
Immune System Diseases
Transcriptome
Individuality
Cognition
40 Downloads (Pure)

A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence

Brückmann, N. H., Bennedsen, S. N., Duijf, P. H. G., Terp, M. G., Thomassen, M., Larsen, M., Pedersen, C. B., Kruse, T., Alcaraz, N., Ditzel, H. J. & Gjerstorff, M. F., 6. nov. 2019, I : Cell Death & Disease. 10, 11, 12 s., 841.

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Neoplasms
Epirubicin
Proteins
Cell Aging
Nevus
2012

Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers

Antoniou, A., Kuchenbaecker, K., Soucy, P., Beesley, J., Chen, X., McGuffog, L., Lee, A., Barrowdale, D., Healey, S., Sinilnikova, O., Caligo, M., Loman, N., Harbst, K., Lindblom, A., Arver, B., Rosenquist, R., Karlsson, P., Nathanson, K., Domchek, S., Rebbeck, T. & 31 flere, Jakubowska, A., Lubinski, J., Jaworska, K., Durda, K., Złowowcka-Perłowska, E., Osorio, A., Durán, M., Andrés, R., Benítez, J., Hamann, U., Hogervorst, F., van Os, T., Verhoef, S., Meijers-Heijboer, H., Wijnen, J., Gómez Garcia, E., Ligtenberg, M., Kriege, M., Collée, J. M., Ausems, M., Oosterwijk, J., Peock, S., Frost, D., Ellis, S., Platte, R., Fineberg, E., Thomassen, M., Gerdes, A-M., Skytte, A-B., Kruse, T. A. & CIMBA, SWE-BRCA, 2012, I : Breast Cancer Research (Online Edition). 14, 1, s. R33

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Mutation
Genome-Wide Association Study
Ovarian Neoplasms
Alleles