3',4'-trans-Linked bicyclic nucleosides locked in S-type conformations

H. Thomasen, M. Meldgaard, M. Freitag, M. Petersen, J. Wengel, P. Nielsen

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Abstrakt

A novel class of 3′,4′-trans-linked bicyclic nucleosides with locked S-type furanose conformations is introduced by synthesis of two model derivatives; one was obtained by cyclic ether formation and the other by ring-closing metathesis methodology.

OriginalsprogEngelsk
TidsskriftChemical Communications
Vol/bind2002
Udgave nummer17
Sider (fra-til)1888-1889
ISSN1359-7345
DOI
StatusUdgivet - 2002

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