18F-FDG-PET/CT in measuring volume and global metabolic activity of thigh muscles: a novel CT-based tissue segmentation methodology

Esha Kothekar, Dani Yellanki, Austin J Borja, Abdullah Al-Zaghal, Thomas J Werner, Mona-Elisabeth Revheim, Oke Gerke, Babak Saboury, Ali Gholamrezanezad, Poul F Høilund-Carlsen, Abass Alavi

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

PURPOSE: We present a novel computed tomography-based tissue segmentation methodology for determining volume and global uptake of FDG of the thigh muscles and correlate these parameters with age.

MATERIALS AND METHODS: A total of 71 subjects from a prospective clinical trial (NCT01724749) were included. PET/CT scans were acquired 180 minutes after intravenous injection of FDG. A 3D growing region algorithm with neighborhood Hounsfield unit threshold between one and 150 was used to highlight the muscle. FDG uptake was expressed as the average mean standardized uptake value normalized for lean body mass (average SULmean). Femur volume was used to normalize thigh muscle volume to calculate normalized volume and correlate with age.

RESULTS: We found a significant negative correlation between normalized volume and age (left side r = -0.262, P = 0.02; right side r = -0.286, P = 0.01). No statistically significant difference was found between SUL and age or between SUL and BMI. There was no statistically significant difference in muscle volume on the two sides. Statistically significant difference was noted in the global metabolic activity (SUL) between the two sides (left 0.39 ± 0.06, right 0.42 ± 0.08, P < 0.001), with 56/71 (78.8%) subjects having higher uptake on the right side.

CONCLUSION: FDG-PET/CT using CT-based segmentation is a novel imaging modality assessing the volume and global metabolic activity of the thigh muscles. It could be possible to utilize this methodology for the research and understanding of lower limb muscle pathophysiology.

OriginalsprogEngelsk
TidsskriftNuclear Medicine Communications
Vol/bind41
Udgave nummer2
Sider (fra-til)162-168
ISSN0143-3636
DOI
StatusUdgivet - feb. 2020

Fingeraftryk

Fluorodeoxyglucose F18
Muscles
Intravenous Injections
Clinical Trials
Research

Citer dette

Kothekar, Esha ; Yellanki, Dani ; Borja, Austin J ; Al-Zaghal, Abdullah ; Werner, Thomas J ; Revheim, Mona-Elisabeth ; Gerke, Oke ; Saboury, Babak ; Gholamrezanezad, Ali ; Høilund-Carlsen, Poul F ; Alavi, Abass. / 18F-FDG-PET/CT in measuring volume and global metabolic activity of thigh muscles : a novel CT-based tissue segmentation methodology. I: Nuclear Medicine Communications. 2020 ; Bind 41, Nr. 2. s. 162-168.
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title = "18F-FDG-PET/CT in measuring volume and global metabolic activity of thigh muscles: a novel CT-based tissue segmentation methodology",
abstract = "PURPOSE: We present a novel computed tomography-based tissue segmentation methodology for determining volume and global uptake of FDG of the thigh muscles and correlate these parameters with age.MATERIALS AND METHODS: A total of 71 subjects from a prospective clinical trial (NCT01724749) were included. PET/CT scans were acquired 180 minutes after intravenous injection of FDG. A 3D growing region algorithm with neighborhood Hounsfield unit threshold between one and 150 was used to highlight the muscle. FDG uptake was expressed as the average mean standardized uptake value normalized for lean body mass (average SULmean). Femur volume was used to normalize thigh muscle volume to calculate normalized volume and correlate with age.RESULTS: We found a significant negative correlation between normalized volume and age (left side r = -0.262, P = 0.02; right side r = -0.286, P = 0.01). No statistically significant difference was found between SUL and age or between SUL and BMI. There was no statistically significant difference in muscle volume on the two sides. Statistically significant difference was noted in the global metabolic activity (SUL) between the two sides (left 0.39 ± 0.06, right 0.42 ± 0.08, P < 0.001), with 56/71 (78.8{\%}) subjects having higher uptake on the right side.CONCLUSION: FDG-PET/CT using CT-based segmentation is a novel imaging modality assessing the volume and global metabolic activity of the thigh muscles. It could be possible to utilize this methodology for the research and understanding of lower limb muscle pathophysiology.",
author = "Esha Kothekar and Dani Yellanki and Borja, {Austin J} and Abdullah Al-Zaghal and Werner, {Thomas J} and Mona-Elisabeth Revheim and Oke Gerke and Babak Saboury and Ali Gholamrezanezad and H{\o}ilund-Carlsen, {Poul F} and Abass Alavi",
year = "2020",
month = "2",
doi = "10.1097/MNM.0000000000001127",
language = "English",
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pages = "162--168",
journal = "Nuclear Medicine Communications",
issn = "0143-3636",
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Kothekar, E, Yellanki, D, Borja, AJ, Al-Zaghal, A, Werner, TJ, Revheim, M-E, Gerke, O, Saboury, B, Gholamrezanezad, A, Høilund-Carlsen, PF & Alavi, A 2020, '18F-FDG-PET/CT in measuring volume and global metabolic activity of thigh muscles: a novel CT-based tissue segmentation methodology', Nuclear Medicine Communications, bind 41, nr. 2, s. 162-168. https://doi.org/10.1097/MNM.0000000000001127

18F-FDG-PET/CT in measuring volume and global metabolic activity of thigh muscles : a novel CT-based tissue segmentation methodology. / Kothekar, Esha; Yellanki, Dani; Borja, Austin J; Al-Zaghal, Abdullah; Werner, Thomas J; Revheim, Mona-Elisabeth; Gerke, Oke; Saboury, Babak; Gholamrezanezad, Ali; Høilund-Carlsen, Poul F; Alavi, Abass.

I: Nuclear Medicine Communications, Bind 41, Nr. 2, 02.2020, s. 162-168.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - 18F-FDG-PET/CT in measuring volume and global metabolic activity of thigh muscles

T2 - a novel CT-based tissue segmentation methodology

AU - Kothekar, Esha

AU - Yellanki, Dani

AU - Borja, Austin J

AU - Al-Zaghal, Abdullah

AU - Werner, Thomas J

AU - Revheim, Mona-Elisabeth

AU - Gerke, Oke

AU - Saboury, Babak

AU - Gholamrezanezad, Ali

AU - Høilund-Carlsen, Poul F

AU - Alavi, Abass

PY - 2020/2

Y1 - 2020/2

N2 - PURPOSE: We present a novel computed tomography-based tissue segmentation methodology for determining volume and global uptake of FDG of the thigh muscles and correlate these parameters with age.MATERIALS AND METHODS: A total of 71 subjects from a prospective clinical trial (NCT01724749) were included. PET/CT scans were acquired 180 minutes after intravenous injection of FDG. A 3D growing region algorithm with neighborhood Hounsfield unit threshold between one and 150 was used to highlight the muscle. FDG uptake was expressed as the average mean standardized uptake value normalized for lean body mass (average SULmean). Femur volume was used to normalize thigh muscle volume to calculate normalized volume and correlate with age.RESULTS: We found a significant negative correlation between normalized volume and age (left side r = -0.262, P = 0.02; right side r = -0.286, P = 0.01). No statistically significant difference was found between SUL and age or between SUL and BMI. There was no statistically significant difference in muscle volume on the two sides. Statistically significant difference was noted in the global metabolic activity (SUL) between the two sides (left 0.39 ± 0.06, right 0.42 ± 0.08, P < 0.001), with 56/71 (78.8%) subjects having higher uptake on the right side.CONCLUSION: FDG-PET/CT using CT-based segmentation is a novel imaging modality assessing the volume and global metabolic activity of the thigh muscles. It could be possible to utilize this methodology for the research and understanding of lower limb muscle pathophysiology.

AB - PURPOSE: We present a novel computed tomography-based tissue segmentation methodology for determining volume and global uptake of FDG of the thigh muscles and correlate these parameters with age.MATERIALS AND METHODS: A total of 71 subjects from a prospective clinical trial (NCT01724749) were included. PET/CT scans were acquired 180 minutes after intravenous injection of FDG. A 3D growing region algorithm with neighborhood Hounsfield unit threshold between one and 150 was used to highlight the muscle. FDG uptake was expressed as the average mean standardized uptake value normalized for lean body mass (average SULmean). Femur volume was used to normalize thigh muscle volume to calculate normalized volume and correlate with age.RESULTS: We found a significant negative correlation between normalized volume and age (left side r = -0.262, P = 0.02; right side r = -0.286, P = 0.01). No statistically significant difference was found between SUL and age or between SUL and BMI. There was no statistically significant difference in muscle volume on the two sides. Statistically significant difference was noted in the global metabolic activity (SUL) between the two sides (left 0.39 ± 0.06, right 0.42 ± 0.08, P < 0.001), with 56/71 (78.8%) subjects having higher uptake on the right side.CONCLUSION: FDG-PET/CT using CT-based segmentation is a novel imaging modality assessing the volume and global metabolic activity of the thigh muscles. It could be possible to utilize this methodology for the research and understanding of lower limb muscle pathophysiology.

U2 - 10.1097/MNM.0000000000001127

DO - 10.1097/MNM.0000000000001127

M3 - Journal article

C2 - 31860525

VL - 41

SP - 162

EP - 168

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

SN - 0143-3636

IS - 2

ER -