Uddannelses- og Forskningsministeriet – METABOLISM-NET EUopSTART

Projekter: ProjektForskning



The main scientific objective of METABOLISM-NET is to study the role of nuclear
receptor signaling pathways in the regulation of metabolic homeostasis in
physiological and pathological settings. Focus will be on the understanding of
disease-specific cellular and structural changes affecting NR function and on NRdependent regulation of gene expression programs associated with metabolic
disease, e.g. obesity and type-2-diabetes (T2D). We propose a multifaceted
approach organized under 3 major overlapping activities with the following
Specific Aims: 1. Studies on the role of NR and NR-coregulator function in the epigenetic regulation of metabolism and linked inflammatory processes in physiological and various pathological contexts. 2. Studies on the mechanism of NR and NR-coregulator mediated regulation of gene networks implicated in obesity, type 2 diabetes and fatty liver disease. 3. Studies on the role of NRs in the control of metabolism flexibility capacity and the regulation of circadian rhythm. The above broad thematic areas offer a rich interface for scientific training, with opportunities for students to become exposed to fields as diverse as medical therapeutics, epigenetics, network biology, genomics, metabolism, proteomics, and endocrinology.
Effektiv start/slut dato08/10/201815/01/2019