Impact of knee joint loading exercise on articular cartilage: Systematic reviews and meta-analyses

Projekter: ProjektPh.d-projekt



Exercise does not harm knee cartilage nor trigger inflammation in people at risk of, or with, knee osteoarthritis.


Osteoarthritis (OA) is the most common joint disease. By 2050, 130 million people world-wide are expected to suffer from OA, and the knee is responsible for over 80% of the disease burden. OA affects the whole person, causing pain, disability and a decline in quality of life. Inactivity and being overweight, together with other biomechanical and pro-inflammatory factors, are thought to be the major causes of increased articular cartilage breakdown, the hallmark of OA. To date, no cure exists for OA. Weight management together with knee joint loading exercise, in the forms of physical activity and exercise therapy, are cornerstones in the management of healthy and osteoarthritic joints. It is well established that exercise therapy reduces pain, improves function and increases quality of life. However, less is known about the impact of knee joint loading exercise on joint structures such as articular cartilage. Since many patients express a concern that exercise may affect their joint cartilage negatively, there was a need to summarize the available evidence. Therefore, the overall aim of this thesis was to investigate the impact of knee joint loading exercise on knee joint articular cartilage.
Effektiv start/slut dato01/04/201531/05/2018