Fuhrmann Fonden - APPLICATIONS OF LIVE CELL IMAGING TO STUDY THE BARRIER AND MECHANICAL PROPERTIES OF SKIN

Projekter: ProjektForskning

Beskrivelse

Bevilling givet til Katharina Kaiser med Jonathan R. Brewer som vejleder.
The aim of this project is to study the dynamics of the intercellular molecular structures responsible for the barrier and mechanical properties of skin. This will be done by means of live
cell imaging of live 3D artificial skin models. The skin has a major role in providing a barrier against the hostile external environment. It prevents excessive water loss from the aqueous interior, the ingress of foreign chemicals and micro-organisms and provides strength and stiffness to resist mechanical loading [1, 2]. Other functions include insulation, temperature regulation and sensation. To fulfill these functions, mechanical stability is as important as mechanical flexibility. However, the mechanical balance of skin can be threatened by diseases, trauma, medical or cosmetic treatments. To understand the skin behavior following the onset of these conditions, knowledge of the mechanical
behavior of healthy skin in is essential. However, there is a paucity of information regarding the role of tissue mechanics in disease progression, skin-device interaction, tissue repair, and remodeling mechanisms associated with those treatments.
StatusIgangværende
Effektiv start/slut dato01/12/201801/11/2019