Danmarks Grundforskningsfond – Centers of Excellence - ATLAS - DG Center for Functional Genomics and Tissue Plasticity

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Projektdetaljer

Beskrivelse

Tissue plasticity, i.e. the ability of tissues to adapt to changes in the physiological environment, is essential in health and disease. However, our understanding of responses within discrete cell types and cross-talk between these in the complex tissue setting is limited. The overarching aim of ATLAS is to gain detailed in situ insight into how metabolic stress such as high or low-caloric intake, alcohol and drugs affects the programming of specific cell types in metabolically very responsive tissues such as the liver and adipose tissues. The genome and its associated layers of epigenomic information represent a unique source of information not only for recording changes in programming but also for understanding how these occur. We will therefore take a genome-centric approach combining novel strategies for tagging specific cell types in vivo with advanced genomic tools. This will allow us to record dynamic changes in the epigenome and transcriptome of individual cell types in their natural organ context in mouse models. Moreover, by combining this approach with technologies used to target specific cell types in liver and fat tissues in vivo, we will determine the significance of the recorded changes in tissue plasticity and disease development. Finally, we will apply the knowledge obtained from mouse model systems for translational analyses of human liver and fat biopsies to improve our understanding of how changes in cell programming contributes to human physiology.
StatusIgangværende
Effektiv start/slut dato01/10/201730/09/2023

Emneord

  • Obesity
  • NASH
  • NAFLD
  • Genomics
  • Science
  • Metabolic disease
  • DNRF

Relaterede publikationer

  • 9 Tidsskriftartikel
  • 1 Kommentar/debat

Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis

Ægidius, H. M., Veidal, S. S., Feigh, M., Hallenborg, P., Puglia, M., Pers, T. H., Vrang, N., Jelsing, J., Kornum, B. R., Blagoev, B. & Rigbolt, K. T. G., 2020, I : Scientific Reports. 10, 1, 12 s., 1148.

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    Phosphoproteomic profiling reveals a defined genetic program for osteoblastic lineage commitment of human bone marrow-derived stromal stem cells

    Barrio-Hernandez, I., Jafari, A., Rigbolt, K. T. G., Hallenborg, P., Sanchez-Quiles, V., Skovrind, I., Akimov, V., Kratchmarova, I., Dengjel, J., Kassem, M. & Blagoev, B., jan. 2020, I : Genome Research. 30, 1, s. 127-137 11 s.

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    Relaterede aktiviteter

    • 3 Organisering af eller deltagelse i workshop, kursus, seminar eller lignende

    ATLAS Annual meeting 2019

    Susanne Mandrup (Arrangør)

    2. jul. 2019

    Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i workshop, kursus, seminar eller lignende

    ATLAS Symposium 2019 - Tissue Plasticity of Obesity

    Susanne Mandrup (Arrangør), Lars Grøntved (Chairman), Kim Ravnskjær (Chairman), Blagoy Blagoev (Chairman), Jesper Grud Skat Madsen (Chairman), Aleksander Krag (Chairman), Søren Kragh Moestrup (Chairman) & Jonas Heilskov Graversen (Chairman)

    30. jun. 20191. jul. 2019

    Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i workshop, kursus, seminar eller lignende

    Opening Symposium for Center of Excellence ATLAS - Center for Functional Genomics and Tissue Plasticity

    Susanne Mandrup (Arrangør)

    6. nov. 2017

    Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i workshop, kursus, seminar eller lignende