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Personlig profil

CV

Academic qualifications
1974: B.Sc., McGill University, Montreal, Canada
1977:M.Sc., McGill University, Montreal, Canada
1981:PhD, University of Ottawa, Canada

Postdoctoral training: University College London 1981-1984 (NA Mitchison); Walter and Eliza Hall Institute, Melbourne 1984-1987 (JFAP Miller).

Relevant Professional Positions and Employment
1987 - Appointed to faculty, McGill University, Montreal
2001 - 2006 Professor, McGill University
2004 - Professor, Univ. of Southern Denmark (SDU), Odense, Denmark.
2006 - Adjunct Professor, McGill University
2010 - Head of Research, Neurobiology Dept, Inst of Molecular Medicine, SDU

Research Funding
Danish Agency for Research and Innovation, Scleroseforeningen, Lundbeckfonden, NovoNordiskfonden, Carlsbergfondet.

Lab members: Reza Khorooshi, Nasrin Asgari, Agnieszka Wlodarczyk, Joanna Marczynska, Ruthe Storgaard Dieu, Marlene Mørch, Anouk Benmamar.Badel, Mads Olesen, Bhavya Ojha, Magdalena Dubik, Sofie Forsberg Sørensen, Marco Anzalone, Darius Musteika, Dina Arengoth, Pia Nyborg Nielsen

PUBLICATIONS: 172 total, 120 peer-reviewed.

Research areas
Neuroimmunology, central nervous system inflammation and glial response, with reference to Mutliple sclerosis (see Owens group here)

Positions
We do not have funded PhD or postdoc positions but we always welcome bright and interested candidates who will apply for funds to join one of our projects

Selected activities
•Head of Research, Neurobiology Dept, Inst of Molecular Medicine, SDU - 2010
•President, Scandinavian Society for Immunology – 2015 - present
•Editorial Board for: J Neuropathol Exp Neurol - 2005-2017; Glia - 2010-present; Scand J Immunol - 2016-present

Selected recent papers (from 172 total)

• Khorooshi, R., J. Marczynska, R.S. Dieu, V. Wais, C.R. Hansen, S. Kavan, M. Thomassen, M. Burton, T. Kruse, G.A. Webster, and T. Owens. 2020. Innate signaling within the central nervous system recruits protective neutrophils. Acta Neuropathologica Communications (in press)

• Khorooshi R, Tofte-Hansen EU, Tygesen C, Montañana-Rosell R, Limburg HL, Marczynska, J, Asgari N, Steckelings UM, and Owens T. 2019. Angiotensin AT2-receptor induced interleukin-10 attenuates neuromyelitis optica spectrum disorder-like pathology. MS Journal (in press) doi: 10.1177/1352458519860327.

•Wlodarczyk A, Benmamar-Badel A, Cédile O, Jensen KN, Kramer I, Elsborg NB, and Owens T. 2018. CSF1R stimulation promotes increased neuroprotection by CD11c+ microglia in EAE. Frontiers Cell. Neurosci. 12: doi: 10.3389/fncel.2018.00523.

•Mørch, M, Forsberg Sørensen, S, Khorooshi, R, Asgari, N, Owens, T. 2018. Selective localization of IgG from cerebrospinal fluid to brain parenchyma. J Neuroinflammation 15:110. doi:10.1186/s12974-018-1159-8

•Wlodarczyk A, Holtman IR, Krueger M, Yogev N, Bruttger J, Khorooshi, R, Benmamar-Badel, A, de Boer-Bergsma JJ, Martin,NA, Karram K, Kramer, I, Boddeke EWGM, Waisman A, Eggen BJL and Owens T. (2017). A novel microglial subset plays a key role in myelinogenesis in developing brain. EMBO J. doi: 10.15252/embj.201696056

•Berg, CT, Khorooshi, R, Asgari, N. and Owens, T. (2017). Influence of Type I IFN signaling on anti-MOG antibody-mediated demyelination. J. Neuroinflammation 14:127

•Wlodarczyk, A, Cédile, O, Jensen, KN, Jasson, A, Mony, JT, Khorooshi, R, and Owens, T. 2015. Pathologic and protective roles for microglial subsets and bone marrow- and blood-derived myeloid cells in central nervous system inflammation. Frontiers in Immunology 6:463 doi: 10.3389/fimmu.2015.00463•Asgari N, Berg CT, Mørch MT, Khorooshi R, and Owens T. 2015. Cerebrospinal Fluid Aquaporin-4-IgG induces blood brain barrier breakdown. Ann Clin Trans Neurol, 2: 857-863 DOI: 101002/acn3221:n/a-n/a
•Khorooshi, R., Mørch, M, Berg, CT, Holm, TH, Dieu, RT, Dræby, D, Issazadeh-Navikas, S, Weiss, S, Lienenklaus, S and Owens, T. 2015. Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis. Acta Neuropathologica, 130:107-118.
•Cédile, O, Løbner, M, Toft-Hansen, H, Frank, I, Wlodarczyk, A, Irla, M, & Owens, T. 2014 Thymic CCL2 influences induction of T-cell tolerance. J Autoimmun 55:73-85.
•Mony, JT, Khorooshi R, & Owens, T. 2014. Chemokine receptor expression by inflammatory T cells in EAE. Front. Cell. Neurosci. 8:187. doi: 10.3389/fncel.2014.00187.
•Wlodarczyk, A., Løbner, M., Cédile, O., and Owens, T. 2014. Comparison of microglia and infiltrating CD11c+ cells as antigen presenting cells for T cell proliferation and cytokine response. J Neuroinflammation 11:57-65.
•Khorooshi R, Wlodarczyk A, Asgari N, Owens T. 2013. Neuromyelitis optica-like pathology is dependent on type I interferon response. Exp Neurol, 247:744-747.
•Owens, T., Khorooshi, R., Wlodarczyk, A. and Asgari, N. (2013), Interferons in the central nervous system: A few instruments play many tunes. Glia. doi: 10.1002/glia.22608
•Khorooshi, R., Wlodarczyk, A., Asgari, N., Owens, T., 2013. Neuromyelitis optica-like pathology is dependent on type I interferon response. Exp Neurol. doi: 10.1016/j.expneurol.2013.02.005.
•Asgari, N., R. Khorooshi, S. Lillevang, and T. Owens. 2013. Complement-dependent pathogenicity of brain-specific antibodies in cerebrospinal fluid. J. Neuroimmunol. 254:76-82. Epub 2012/10/04.
•Maiorino, C., R Khorooshi, F Ruffini, M Løbner, A Bergami, L Garzetti, G Martino, T Owens, and R Furlan. 2012. Lentiviral-mediated administration of IL-25 in the CNS induces alternative activation of microglia. Gene Therapy Epub 2012/08/03.
•Holm, TH., D, Draeby, and T. Owens. 2012. Microglia are required for astroglial Toll-like receptor 4 response, and for optimal Toll-like receptor 2 and 3 response. Glia 60:630-638
•Finsen, B. and Owens, T. 2011. Innate immune responses in central nervous system inflammation. FEBS Letts 585:3806-3812.
•Toft-Hansen, H., Füchtbauer, LM, and Owens, T. 2011. Inhibition of reactive astrocytosis in established experimental autoimmune encephalomyelitis favors infiltration by myeloid cells over T cells and enhances severity of disease. Glia 59:166-176.
•Millward, J. M., M. Løbner, R. D. Wheeler, and T. Owens. 2010. Inflammation in the central nervous system and Th17 responses are inhibited by interferon-gamma-induced interleukin-18 binding protein. J. Immunol. 185:2458-2466
•Khorooshi, R., and T. Owens. 2010. Injury-induced type I interferon signaling regulates inflammatory responses in the CNS. J Immunol. 185:1258-1264
•Khorooshi, R., Babcock, A.A., and Owens, T. 2008. NFkappaB-driven STAT2 and CCL2 expression in astrocytes in response to brain injury. J. Immunol. 181: 7284-7291
•Babcock AA, Wirenfeldt M, Holm, T, Nielsen, HH, Dissing-Olesen, L, Toft-Hansen H, Millward JM, Landmann R, Rivest S, Finsen B, and Owens T. 2006. Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation. J Neurosci 26:12826-12837.

Forskningsinformation

 

 

We study inflammation in the central nervous system, using animal models to dissect cellular and molecular interactions that underlie pathogenesis of diseases such as Multiple sclerosis (MS) and Neuromyelitis optica (NMO). MS is considered to be primarily a T-cell-mediated autoimmune inflammatory disease, with associated neurodegeneration, whereas NMO is considered to be an antibody-mediated inflammatory disease with demyelination. Both diseases show activation of microglia, and astrocytes are the main target of antibody in NMO. The interactions of these cells with T cells macrophages and antibodies are the major focus of our research.

For more information see www.sdu.dk/immed/nb-ow

Also follow this link to COPING-AD, a collaborative project

http://www.sdu.dk/en/Om_SDU/Institutter_centre/IMM_Molekylaer_Medicin/Forskning/Forskningsenheder/Neurobiologisk/COPING+AD

 

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Publikationer

Absence of miRNA-146a Differentially Alters Microglia Function and Proteome

Martin, N. A., Hyrlov, K. H., Elkjaer, M. L., Thygesen, E. K., Wlodarczyk, A., Elbaek, K. J., Aboo, C., Okarmus, J., Benedikz, E., Reynolds, R., Hegedus, Z., Stensballe, A., Svenningsen, Å. F., Owens, T. & Illes, Z., 5. jun. 2020, I : Frontiers in Immunology. 11, 21 s., 1110.

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    Diffusion Kurtosis Imaging maps neural damage in the EAE model of multiple sclerosis

    Chuhutin, A., Hansen, B., Wlodarczyk, A., Owens, T., Shemesh, N. & Jespersen, S. N., mar. 2020, I : NeuroImage. 208, 14 s., 116406.

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    Innate signaling within the central nervous system recruits protective neutrophils

    Khorooshi, R., Marczynska, J., Dieu, R. S., Wais, V., Hansen, C. R., Kavan, S., Thomassen, M., Burton, M., Kruse, T., Webster, G. A. & Owens, T., 8. jan. 2020, I : Acta Neuropathologica Communications. 8, 13 s., 2.

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    Protective Microglial Subset in Development, Aging, and Disease: Lessons From Transcriptomic Studies

    Benmamar-Badel, A., Owens, T. & Wlodarczyk, A., 3. apr. 2020, I : Frontiers in Immunology. 11, 19 s., 430.

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    Absence of miR-146a alters the function and proteome of microglia

    Hyrlov, K. H., Martin, N. A., Elkjaer, M. L., Thygesen, E. K., Wlodarczyk, A., Elbaek, K. J., Okarmus, J., Benedikz, E., Stensballe, A., Svenningsen, A. F., Owens, T. & Illes, Z., 1. sep. 2019, I : Multiple Sclerosis Journal. 25, 2 Suppl. 1, s. 651-652 P1203.

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    Aktiviteter

    Microglia and myeloid cells as regulators of neuroinflammation

    Trevor Owens (Underviser)

    22. okt. 2019

    Aktivitet: Foredrag og mundtlige bidragKonferenceoplæg

    PhD defense Jay Roodselaar Somerville College University of Oxford (Begivenhed)

    Trevor Owens (Medlem)

    8. okt. 2019

    Aktivitet: MedlemskabMedlemskab af bedømmelsesudvalg

    European School of Neuroimmunology

    Trevor Owens (Underviser)

    16. jul. 201919. jul. 2019

    Aktivitet: Foredrag og mundtlige bidragGæsteforelæsning, undervisning og kursusvirksomhed ved andre universiteter

    XIV European Meeting Glial cells in Health and Disease

    Trevor Owens (Deltager)

    10. jul. 201913. jul. 2019

    Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

    PhD defense (Begivenhed)

    Trevor Owens (Medlem)

    26. apr. 2019

    Aktivitet: MedlemskabMedlemskab af bedømmelsesudvalg