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Publikationer 1992 2019

2019
Adipogenesis
Stem Cell Factor
Osteogenesis
Color
10 Downloads (Pure)

ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

Søndergaard, E., Rauch, A., Michaut, M., Rapin, N., Rehn, M., Wilhelmson, A. S., Camponeschi, A., Hasemann, M. S., Bagger, F. O., Jendholm, J., Knudsen, K. J., Mandrup, S., Mårtensson, I. L. & Porse, B. T., 26. nov. 2019, I : Cell Reports. 29, 9, s. 2756-2769.e6 21 s.

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Genes
Cells
Transcription Factors
Immunoglobulin Heavy Chains
Transcription
58 Downloads (Pure)

Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism

Pearson, S., Loft, A., Rahbhandari, P., Simcox, J., Lee, S., Tontonoz, P., Mandrup, S. & Villanueva, C. J., 1. jul. 2019, I : Genes & Development. 33, 13-14, s. 747-762 17 s.

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Transducin
Mitochondrial Genes
White Adipose Tissue
Chromatin Immunoprecipitation
Oxidative Phosphorylation

Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

Rauch, A., Haakonsson, A. K., Madsen, J. G. S., Larsen, M., Forss, I., Madsen, M. R., Van Hauwaert, E. L., Wiwie, C., Jespersen, N. Z., Tencerova, M., Nielsen, R., Larsen, B. D., Röttger, R., Baumbach, J., Scheele, C., Kassem, M. & Mandrup, S., apr. 2019, I : Nature Genetics. 51, 4, s. 716-727

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Adipogenesis
Stem Cell Factor
Mesenchymal Stromal Cells
Osteogenesis
Chromatin Assembly and Disassembly
53 Downloads (Pure)

Time-Resolved Systems Medicine Reveals Viral Infection-Modulating Host Targets

Wiwie, C., Kuznetsova, I., Mostafa, A., Rauch, A., Haakonsson, A., Barrio-Hernandez, I., Blagoev, B., Mandrup, S., Schmidt, H. H. H. W., Pleschka, S., Röttger, R. & Baumbach, J., 2019, I : Systems medicine (New Rochelle, N.Y.). 2, 1, 9 s.

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Virus Diseases
Influenza A virus
Pharmaceutical Preparations
Orthomyxoviridae
Proteins
182 Downloads (Pure)

Transcriptional regulation of Hepatic Stellate Cell activation in NASH

Marcher, A-B., Bendixen, S. M., Terkelsen, M. K., Hohmann, S. S., Hansen, M. H., Larsen, B. D., Mandrup, S., Dimke, H., Detlefsen, S. & Ravnskjaer, K., 20. feb. 2019, I : Scientific Reports. 9, 1, 55 s., 2324.

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Hepatic Stellate Cells
Fatty Liver
Liver
Liver Diseases
Extracellular Matrix Proteins
2018
149 Downloads (Pure)

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Sustarsic, E. G., Ma, T., Lynes, M. D., Larsen, M., Karavaeva, I., Havelund, J. F., Nielsen, C. H., Jedrychowski, M. P., Moreno-Torres, M., Lundh, M., Plucinska, K., Jespersen, N. Z., Grevengoed, T. J., Kramar, B., Peics, J., Hansen, J. B., Shamsi, F., Forss, I., Neess, D., Keipert, S. & 24 flere, Wang, J., Stohlmann, K., Brandslund, I., Christensen, C., Jørgensen, M. E., Linneberg, A., Pedersen, O., Kiebish, M. A., Qvortrup, K., Han, X., Pedersen, B. K., Jastroch, M., Mandrup, S., Kjær, A., Gygi, S. P., Hansen, T., Gillum, M. P., Grarup, N., Emanuelli, B., Nielsen, S., Scheele, C., Tseng, Y. H., Færgeman, N. J. & Gerhart-Hines, Z., 3. jul. 2018, I : Cell Metabolism. 28, 1, s. 159-174.e11

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Homeostasis
Fats
Energy Metabolism
Insulin Resistance
Adipocytes

Chromatin Immunoprecipitation for Identification of Protein-DNA Interactions in Human Cells

Larsen, B. D., Madsen, M. R., Nielsen, R. & Mandrup, S., 2018, Two-Hybrid Systems: Methods and Protocols. Oñate-Sánchez, L. (red.). Humana Press, s. 335-352 (Methods in Molecular Biology, Bind 1794).

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskning

Chromatin Immunoprecipitation
DNA
Proteins
Guidelines
141 Downloads (Pure)

Elucidation of time-dependent systems biology cell response patterns with time course network enrichment

Wiwie, C., Rauch, A., Haakonsson, A., Barrio-Hernandez, I., Blagoev, B., Mandrup, S., Röttger, R. & Baumbach, J., 2018, I : arxiv.org.

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Systems Biology
Orthomyxoviridae
Cluster Analysis
RNA
Lung
78 Downloads (Pure)

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver

Kalvisa, A., Siersbæk, M. S., Præstholm, S. M., Christensen, L. J. L., Nielsen, R., Stohr, O., Vettorazzi, S., Tuckermann, J., White, M., Mandrup, S. & Grøntved, L., 10. dec. 2018, I : PLOS Biology. 16, 12, s. 1-32 e2006249.

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Glucocorticoid Receptors
Gene expression
Liver
insulin
Genes

Insulin signaling in combination with reduced glucocorticoid activity attenuate post-prandial gene expression in liver

Bidragets oversatte titel: Insulin signalering i kombination med nedsat glukokortikoid aktivitet hæmmer post-prandial genudtryk i leverenSiersbæk, M., Kalvisa, A., Præstholm, S. M., Christensen, L. J. L., Nielsen, R., Stohr, O., Vettorazzi, S., Tuckermann, J., White, M., Mandrup, S. & Grøntved, L., 11. sep. 2018.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

100 Downloads (Pure)

Integrated analysis of motif activity and gene expression changes of transcription factors

Madsen, J. G. S., Rauch, A., Van Hauwaert, E. L., Schmidt, S. F., Winnefeld, M. & Mandrup, S., 2018, I : Genome Research. 28, 2, s. 243-255

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Position-Specific Scoring Matrices
Adipocytes
Databases
Gene Expression Profiling
Mesenchymal Stromal Cells

Neuroprotective effects of the gliopeptide ODN in an in vivo model of Parkinson's disease

Bahdoudi, S., Ghouili, I., Hmiden, M., do Rego, J-L., Lefranc, B., Leprince, J., Chuquet, J., do Rego, J-C., Marcher, A-B., Mandrup, S., Vaudry, H., Tonon, M-C., Amri, M., Masmoudi-Kouki, O. & Vaudry, D., jun. 2018, I : Cellular and Molecular Life Sciences. 75, 11, s. 2075-2091

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diazepam binding inhibitor (33-50)
Neuroprotective Agents
Parkinson Disease
Dopaminergic Neurons
Diazepam Binding Inhibitor

Plasticity of Thermogenic Adipocytes

Markussen, L. K., Andersen, M. W. & Mandrup, S., 2018, I : Biozoom. 3, s. 10-15

Publikation: Bidrag til tidsskriftReviewForskning

54 Downloads (Pure)

SnapShot: Niche Determines Adipocyte Character I

Bagchi, D. P., Forss, I., Mandrup, S. & MacDougald, O. A., 9. jan. 2018, I : Cell Metabolism. 27, 1, s. 264-264.e1

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Adipocytes
Adipose Tissue
Rodentia
Homeostasis
70 Downloads (Pure)

SnapShot: Niche Determines Adipocyte Character II

Bagchi, D. P., Forss, I., Mandrup, S. & MacDougald, O. A., 9. jan. 2018, I : Cell Metabolism. 27, 1, s. 266-266.e1

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Adipocytes
Rodentia
2017

Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation

Siersbæk, R., Madsen, J. G. S., Javierre, B. M., Nielsen, R., Bagge, E. K., Cairns, J., Wingett, S. W., Traynor, S., Spivakov, M., Fraser, P. & Mandrup, S., 2017, I : Molecular Cell. 66, 3, s. 420-435.e5

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Adipocytes
Histones
Lysine
Acetylation
Transcriptional Activation

Genome-Wide Insights into the Development and Function of Thermogenic Adipocytes

Loft, A., Forss, I. & Mandrup, S., 2017, I : Trends in Endocrinology and Metabolism. 28, 2, s. 104–120

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Adipocytes
White Adipocytes
Brown Adipocytes

Hierarchical role for transcription factors and chromatin structure in genome organization along adipogenesis

Sarusi Portuguez, A., Schwartz, M., Siersbaek, R., Nielsen, R., Sung, M-H., Mandrup, S., Kaplan, T. & Hakim, O., 2017, I : F E B S Journal. 284, 19, s. 3230-3244

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Adipogenesis
3T3-L1 Cells
Genome-Wide Association Study
Adipocytes
Cluster Analysis
168 Downloads (Pure)

High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss

Siersbæk, M., Varticovski, L., Yang, S., Baek, S., Nielsen, R., Mandrup, S., Hager, G., H. Chung, J. & Grøntved, L., 10. jan. 2017, I : Scientific Reports. 7, 13 s., 40220.

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High Fat Diet
Liver
Fasting
Insulin
Transcriptome

Hypoxia-Inducible Lipid Droplet-Associated Is Not a Direct Physiological Regulator of Lipolysis in Adipose Tissue

Dijk, W., Mattijssen, F., de la Rosa Rodriguez, M., Loza Valdes, A., Loft, A., Mandrup, S., Kalkhoven, E., Qi, L., Borst, J. W. & Kersten, S., 2017, I : Endocrinology. 158, 5, s. 1231-1251

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Adipose Tissue
Adipocytes
Adrenergic Agents
Nonesterified Fatty Acids
Hepatocytes
97 Downloads (Pure)

Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegans

Harvald, E. B., Sprenger, R. R., Dall, K. B., Ejsing, C. S., Nielsen, R., Mandrup, S., Murillo, A. B., Larance, M., Gartner, A., Lamond, A. I. & Færgeman, N. J., 2017, I : Cell Systems. 5, 1, s. 38-52.e4

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Lipoproteins
RNA Sequence Analysis
Premature Mortality
Caenorhabditis elegans
Metabolic Networks and Pathways

Nuclear phosphoproteome analysis of 3T3-L1 preadipocyte differentiation reveals system-wide phosphorylation of transcriptional regulators

Rabiee, A., Schwämmle, V., Sidoli, S., Dai, J., Rogowska-Wrzesinska, A., Mandrup, S. & Jensen, O. N., 2017, I : Proteomics. 17, 6, 5 s., 1600248.

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Phosphorylation
Adipogenesis
Adipocytes
Gene expression
Nuclear Proteins
95 Downloads (Pure)

RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs

Wang, J., Rajbhandari, P., Damianov, A., Han, A., Sallam, T., Waki, H., Villanueva, C. J., Lee, S. D., Nielsen, R., Mandrup, S., Reue, K., Young, S. G., Whitelegge, J., Saez, E., Black, D. L. & Tontonoz, P., 2017, I : Journal of Clinical Investigation. 127, 3, s. 987-1004

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Cell Nucleus Active Transport
Adipocytes
RNA
RNA Sequence Analysis
Adipogenesis
119 Downloads (Pure)

The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation

Brier, A-S. B., Loft, A., Madsen, J. G. S., Nielsen, T. R., Nielsen, R., Schmidt, S. F., Liu, Z., Yan, Q., Gronemeyer, H. & Mandrup, S., 2017, I : Nucleic Acids Research. 45, 4, s. 1743-1759

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cdc Genes
Adipocytes
Histone Demethylases
3T3-L1 Cells
Cell Cycle
2016

Cofactor squelching: Artifact or fact?

Schmidt, S. F., Larsen, B. D., Loft, A. & Mandrup, S., jul. 2016, I : BioEssays. 38, 7, s. 618-626

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Artifacts
Transcription Factors
Assays
Genes

DBI/ACBP loss-of-function does not affect anxiety-like behaviour but reduces anxiolytic responses to diazepam in mice

Budry, L., Bouyakdan, K., Tobin, S., Rodaros, D., Marcher, A-B., Mandrup, S., Fulton, S. & Alquier, T., 15. okt. 2016, I : Behavioural Brain Research. 313, s. 201-207

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Diazepam Binding Inhibitor
GABA-A Receptors
85 Downloads (Pure)

Effects of selected bioactive food compounds on human white adipocyte function

Björk, C., Wilhelm, U., Mandrup, S., Larsen, B. D., Bordoni, A., Hedén, P., Rydén, M., Arner, P. & Laurencikiene, J., 2016, I : Nutrition & Metabolism. 13, 10 s., 4.

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White Adipocytes
Docosahexaenoic Acids
Adipocytes
Food
Lipogenesis

HIGH FAT DIET-INDUCED CHANGES OF MOUSE HEPATIC TRANSCRIPTION AND ENHANCER ACTIVITY ARE REVERSED BY SUBSEQUENT WEIGHT LOSS.

Bidragets oversatte titel: Ændringer i leverens transkriptionelle respons og enhancer aktivitet forårsaget at indtagelse af fedtholdig kost kan reverseres ved vægttab.Siersbæk, M., Varticovski, L., Yang, S., Baek, S., Nielsen, R., Mandrup, S., Hager, G., H. Chung, J. & Grøntved, L., 25. aug. 2016.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

132 Downloads (Pure)

Integrative genomics outlines a biphasic glucose response and a ChREBP-RORγ axis regulating proliferation in β cells

Schmidt, S. F., Madsen, J. G. S., Østerli, K., Poulsen, L. L. C., Salö, S., Boergesen, M., Loft, A., Larsen, B. D., Madsen, M. S., Holst, J. J., Maechler, P., Dalgaard, L. T. & Mandrup, S., 30. aug. 2016, I : Cell Reports. 16, 9, s. 2359-2372

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Cell Proliferation
Glucose
Genes
cdc Genes
Transcription Factors
99 Downloads (Pure)

MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3

Hallenborg, P., Siersbæk, M., Barrio-Hernandez, I., Nielsen, R., Kristiansen, K., Mandrup, S., Grøntved, L. & Blagoev, B., 1. jul. 2016, I : Cell Death & Disease. 7, 6, s. e2289

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Adipocytes
Adipogenesis
Ligases
Ubiquitin
Neoplasms
2015
Tumor Necrosis Factor-alpha
Avian Reticuloendotheliosis
Adipocytes
Transcriptional Activation
Insulin Resistance

A Genome-Wide Perspective on Metabolism

Rauch, A. & Mandrup, S., 23. apr. 2015, -. Springer, s. 1-28 (Handbook of Experimental Pharmacology).

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskning

Metabolic Networks and Pathways
Transcriptional Activation
Mammals
Hormones
Food

A novel role for central ACBP/DBI as a regulator of long-chain fatty acid metabolism in astrocytes

Bouyakdan, K., Taïb, B., Budry, L., Zhao, S., Rodaros, D., Neess, D., Mandrup, S., Faergeman, N. J. & Alquier, T., apr. 2015, I : Journal of Neurochemistry. 133, 2, s. 253-65 13 s.

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Diazepam Binding Inhibitor
Metabolism
Fatty Acids
Protein Deficiency
5-methoxy-methylindoleacetic acid
248 Downloads (Pure)

Browning of human adipocytes requires KLF11 and reprogramming of PPARgamma superenhancers

Loft, A., Forss, I., Siersbæk, M. S., Schmidt, S. F., Larsen, A-S. B., Madsen, J. G. S., Pisani, D. F., Nielsen, R., Aagaard, M. M., Mathison, A., Neville, M. J., Urrutia, R., Karpe, F., Amri, E-Z. & Mandrup, S., 2015, I : Genes & Development. 29, 1, s. 7-22

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rosiglitazone
PPAR gamma
Adipocytes
White Adipocytes
Rodentia
109 Downloads (Pure)

Compromised epidermal barrier stimulates Harderian gland activity and hypertrophy in ACBP-/- mice

Sørensen, S. B., Neess, D., Dixen, K., Bloksgaard, M., Marcher, A-B., Chemnitz, J., Færgeman, N. J. & Mandrup, S., sep. 2015, I : Journal of Lipid Research. 56, 9, s. 1738-46 9 s.

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Diazepam Binding Inhibitor
Harderian Gland
Genes
Lipids
Lubrication
130 Downloads (Pure)
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RNA
RNA Polymerase II
Introns

Lessons Learned from Systems Approaches to Metabolism

Mandrup, S., 2015, I : Trends in Endocrinology and Metabolism. 26, 12, s. 669-670

Publikation: Bidrag til tidsskriftLederForskning

89 Downloads (Pure)

Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity

Bindesbøll, C., Fan, Q., Nørgaard, R. C., MacPherson, L., Ruan, H-B., Wu, J., Pedersen, T. Å., Steffensen, K. R., Yang, X., Matthews, J., Mandrup, S., Nebb, H. I. & Grønning-Wang, L. M., apr. 2015, I : Journal of Lipid Research. 56, 4, s. 771-85 15 s.

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Liver
Carrier Proteins
Carbohydrates
Sterol Regulatory Element Binding Protein 1
Glucokinase

Modulating the Genomic Programming of Adipocytes

Loft, A., Schmidt, S. F. & Mandrup, S., 2015, I : Cold Spring Harbor Laboratory. Symposia on Quantitative Biology. 80, s. 239-248

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Peroxisome Proliferator-Activated Receptors
Adipocytes
rosiglitazone
Genes
Transcription Factors
126 Downloads (Pure)

RNA-Seq and Mass-Spectrometry-Based Lipidomics Reveal Extensive Changes of Glycerolipid Pathways in Brown Adipose Tissue in Response to Cold

Marcher, A-B., Loft, A., Nielsen, R., Vihervaara, T., Madsen, J. G. S., Sysi-Aho, M., Ekroos, K. & Mandrup, S., 1. dec. 2015, I : Cell Reports. 13, 9, s. 2000-2013

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Glycerophospholipids
Mass spectrometry
RNA
Tissue
Triglycerides
159 Downloads (Pure)

Selection of LNA-containing DNA aptamers against recombinant human CD73

Elle, I. C., Karlsen, K. K., Terp, M. G., Larsen, N., Nielsen, R., Derbyshire, N., Mandrup, S., Ditzel, H. J. & Wengel, J., 21. apr. 2015, I : Molecular BioSystems. 11, 5, s. 1260-1270

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Nucleotide Aptamers
Surface Plasmon Resonance
Computational Biology
Libraries
Cluster Analysis
2014

Acyl-CoA binding protein and epidermal barrier function

Bloksgaard, M., Neess, D., Færgeman, N. J. & Mandrup, S., 2014, I : BBA General Subjects. 1841, 3, s. 369-76 8 s.

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Diazepam Binding Inhibitor
Epidermis
Skin
Esters
Lipids

CD1d-mediated presentation of endogenous lipid antigens by adipocytes requires microsomal triglyceride transfer protein (MTP)

Rakhshandehroo, M., Gijzel, S. M. W., Siersbæk, R., Broekema, M. F., de Haar, C., Schipper, H. S., Boes, M., Mandrup, S. & Kalkhoven, E., 25. jun. 2014, I : Journal of Biological Chemistry. 289, s. 22128-22139

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Adipocytes
Lipids
Antigens
CCAAT-Enhancer-Binding Proteins
Adipose Tissue

Genome-wide profiling of transcription factor binding and epigenetic marks in adipocytes by ChIP-seq

Nielsen, R. & Mandrup, S., 2014, I : Methods in Enzymology. 537, s. 261-79 19 s.

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Chromatin Immunoprecipitation
Adipocytes
Epigenomics
Chromatin
Transcription Factors

In memoriam: M. Daniel Lane, 1930-2014

Mandrup, S., MacDougald, O. A., Moss, J., Ntambi, J., Pekala, P., Tang, Q-Q., Wolfgang, M. & Bernlohr, D. A., 2014, I : Trends in Endocrinology and Metabolism. 25, 9, s. 437-439

Publikation: Bidrag til tidsskriftKommentar/debatForskning

Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

Christensen, D. P., Gysemans, C., Lundh, M., Dahllöf, M. S., Noesgaard, D., Schmidt, S. F., Mandrup, S., Birkbak, N., Workman, C., Piemonti, L., Blaabjerg, L., Monzani, V., Fossati, G., Mascagni, P., Paraskevas, S., Aikin, R. A., Billestrup, N., Grunnet, L. G., Dinarello, C. A., Mathieu, C. & 1 flere, Mandrup-Poulsen, T., 21. jan. 2014, I : Proceedings of the National Academy of Sciences of the United States of America. 111, 3, s. 1055-9 5 s.

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Cytoprotection
Inbred NOD Mouse
Lysine
Sirtuin 1
Insulin

Molecular architecture of transcription factor hotspots in early adipogenesis

Siersbæk, R., Baek, S., Rabiee, A., Nielsen, R., Traynor, S., Clark, N., Sandelin, A., Jensen, O. N., Sung, M-H., Hager, G. L. & Mandrup, S., 12. jun. 2014, I : Cell Reports. 7, 5, s. 1434-42 9 s.

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Adipogenesis
Transcription Factors
Chromatin
Genes
Adipocytes
Adipocytes
RNA Sequence Analysis
Adipogenesis
Chromatin Assembly and Disassembly
Chromatin Immunoprecipitation

PPAR gamma and the global map of adipogenesis and beyond

Lefterova, M. I., Haakonsson, A. K., Lazar, M. A. & Mandrup, S., 2014, I : Trends in Endocrinology and Metabolism. 25, 6, s. 293-302

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Adipogenesis
PPAR gamma
Adipocytes
Cytoplasmic and Nuclear Receptors