Intet foto af Sanne Skov Jensen

Sanne Skov Jensen

Cand. Scient. Biology-Biotechnology

20122018
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Personlig profil

Forskningsområde

HIV Immunology and Virology

CV

Education and relevant employments:
2013         Maternity leave.
2011-        Ph.d. at the Department Infectious Diseases, Odense University Hospital (OUH), Clinical Institute, University of Southern          Denmark and Department of Virology, Statens Serum Institut.
2010-2011Master thesis at Department of Virology, Statens Serum Institut.
2009-2010Deployed in Guinea-Bissau, West Africa for Statens Serum Institut as cohort responsible for therapeutic HIV-1 vaccine trial.
2008-2011Master: Biology – Biotechnology, KU-LIFE.
2005-2008 Assistant in Department of Clinical Research: GlaxoSmithKline DK-Brøndby.
2004-2008 Bachelor: Biology – Biotechnology, University of Copenhagen -LIFE.

Publications:
Assessment of HIV-1 patient recruitability in the Republic of Guinea-Bissau using African versus North American hematology and biochemistry reference intervals.
SS Jensen, Gómez Román VR, Leo-Hansen C, Jensen KJ, Janitzek CM, Rodrigues CM, Jespersen S, Katzenstein TL, Té Dda S, Fomsgaard A.
Clin Vaccine Immunol. 2012 Aug;19(8):1322-5. doi: 10.1128/CVI.00170-12. Epub 2012 Jun 6.

Clade A HIV-1 Gag-specific T cell responses are frequent but do not correlate with viral loads in a cohort of treatment-naive HIV-infected individuals living in Guinea-Bissau.
Jensen KJ, Gómez Román VR, Jensen SS, Leo-Hansen C, Karlsson I, Katzenstein TL, Rodrigues CM, Jespersen S, Janitzek CM, Té Dda S, Hayes P, Fomsgaard A.
Clin Vaccine Immunol. 2012 Dec;19(12):1999-2001. doi: 10.1128/CVI.00399-12. Epub 2012 Oct 17. No abstract available.

Therapeutic vaccination using cationic liposome-adjuvanted HIV type 1 peptides representing HLA-supertype-restricted subdominant T cell epitopes: safety, immunogenicity, and feasibility in Guinea-Bissau.
Román VR, Jensen KJ, Jensen SS, Leo-Hansen C, Jespersen S, da Silva Té D, Rodrigues CM, Janitzek CM, Vinner L, Katzenstein TL, Andersen P, Kromann I, Andreasen LV, Karlsson I, Fomsgaard A.
AIDS Res Hum Retroviruses. 2013 Nov;29(11):1504-12. doi: 10.1089/AID.2013.0076. Epub 2013 Jun 21.

Oral presentations:

•Danish Infectious Diseases Society (DSI): Workshop for active scientists, Korsør, Denmark: November 10th-11th 2011.
•Keystone Symposia Conference X5 on HIV vaccines, Keystone, Colorado, USA: March 21th-26th 2012.
•The 8th Smögen Summer Symposium on Virology, Smögen, Sweden: August 23th-25th 2012.

Posters:

Restoration of the NK cells ability to Mediate ADCC in HIV-1 Positives after Six Months of HAART can be explained by Normalization of their Phenotype Sanne Skov JENSEN1,2, Hans Jakob HARTLING3, Jeanette Linnea TINGSTEDT1, Tine Kochendorf LARSEN1, Susanne Dam NIELSEN3, Court PEDERSEN2, Anders FOMSGAARD1,2 AND Ingrid KARLSSON1
1Virus Research & Development Laboratory, Department of Microbial Diagnostic and Virology, Statens Serum Institut, 2300 Copenhagen S, Denmark; 2 Department of Infectious Diseases, Odense University Hospital, 5000 Odense C, Denmark; 3Viro-immunology Research Unit, Department of Infectious Diseases, Copenhagen University Hospital, 2100 Copenhagen Ø, Denmark.

ADCC measurements in rabbits immunized with clade B HIV-1 vaccine candidates
Jensen SS1, Borggren M1, Scarlatti G2, Heyndrickx L3, Fomsgaard A1 and Karlsson I1 for the NGIN consortium
1 Department of Microbiology Diagnostics and Virology, Statens Serum Institut, Denmark, 2San Raffaele Scientific Institute, Italy, 3Biomedical Department, Virology Unit, Institute of Tropical Medicine, Antwerp, Belgium.

Sensitive method for amplification of full-length HIV-1 env, applied to construct pseudo-type virus; CRF02_AG/A3 hybrid and CRF02_AG from plasma collected in Guinea-Bissau, West Africa
Jensen S. S.1,2, Rosenstierne M. W.2, Erlandsson L.2, Da Silva Té D.3, C. M. Rodrigues3, Katzenstein T. L.4, Da Silva Z.5, Camara C.5, Aaby P.6, Leo-Hansen C.2, Jensen K. J.2, Gómez Román V. R. 2, Fomsgaard A2, Vinner L.2
1Clinical Institute, University of Southern Denmark, Odense, Denmark; 2Department of Virology, Statens Serum Institut, Copenhagen, Denmark; 3National HIV Programme, Ministry of Health, Bissau, Guinea-Bissau; 4Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark; 5National Public Health Laboratory, Bissau, Guinea-Bissau; 6Bandim Health Project, Bissau, Guinea-Bissau

Research grants:
Title: Characterization of HIV-1 envelope sequence from Guinea-Bissau and creation of panel envelopes for selection AIDS foundation: 60,000 DKK.

Title: Rationale for immunotherapy against HIV-1 infection combining induction of protective antibodies and cell-mediated immunity.
•Region of Southern Denmark Ph.d. grant: 500,000 DKK.
•University of Southern Denmark Ph.d. grant: 500,000 DKK.

Collaborator in research grant:
Title: A joint initiative to sustain HIV vaccine trials and research capacity in the Republic of Guinea-Bissau, West Africa.
EDCTP: Capacity building work package, component coordinator located in Bissau.
EDCTP: Project manager work package, collaborator located in Bissau.
•European and Developing Countries Clinical Trials Partnership (EDCTP): amount (€301,859)

Forskningsområder

  • HIV og andre retrovira

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  • 2 Lignende profiler
HIV-1 Medicin og biovidenskab
Guinea-Bissau Medicin og biovidenskab
HIV Antibodies Medicin og biovidenskab
env Gene Products Medicin og biovidenskab
T-cells Kemiske forbindelser
Human immunodeficiency virus 1 Landbrug og biologi
therapeutics Landbrug og biologi
T-Lymphocyte Epitopes Medicin og biovidenskab

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Publikationer 2012 2018

  • 8 Tidsskriftartikel
  • 1 Ph.d.-afhandling

Immunization with Clinical HIV-1 Env Proteins Induces Broad Antibody Dependent Cellular Cytotoxicity-Mediating Antibodies in a Rabbit Vaccination Model

on behalf of the NGIN Consortium, feb. 2018, I : AIDS Research and Human Retroviruses. 34, 2, s. 206-217

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

env Gene Products
HIV-1
Rabbits
AIDS Vaccines
DNA

HIV-specific ADCC improves after antiretroviral therapy and correlates with normalization of the NK cell phenotype

Jensen, S. S., Hartling, H. J., Tingstedt, J. L., Larsen, T., Nielsen, S. D., Pedersen, C., Fomsgaard, A. & Karlsson, I., 2015, I : J A I D S. 68, 2, s. 103-111

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

HIV Antibodies
HIV-1

HIV-Specific Antibody-Dependent Cellular Cytotoxicity (ADCC) -Mediating Antibodies Decline while NK Cell Function Increases during Antiretroviral Therapy (ART)

Skov Jensen, S., Fomsgaard, A., Borggren, M., Tingstedt, J. L., Gerstoft, J., Kronborg, G., Rasmussen, L. D., Pedersen, C. & Karlsson, I., 2015, I : PLOS ONE. 10, 12, e0145249.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

HIV Antibodies
natural killer cells
Cytotoxicity
cytotoxicity
therapeutics

Initiation of Antiretroviral Therapy (ART) at Different Stages of HIV-1 Disease Is Not Associated with the Proportion of Exhausted CD8+ T Cells

Jensen, S. S., Fomsgaard, A., Larsen, T. K., Tingstedt, J. L., Gerstoft, J., Kronborg, G., Pedersen, C. & Karlsson, I., 2015, I : PLOS ONE. 10, 10, 14 s., e0139573.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

T-cells
Human immunodeficiency virus 1
HIV-1
T-lymphocytes
therapeutics