Foto af Kim Ravnskjær
  • Campusvej 55

    5230 Odense M

    Danmark

20032023
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Personlig profil

Forskningsområde

FUNCTIONAL GENOMICS AND METABOLIC SIGNALING IN THE LIVER

Metabolic disease is one of the biggest health problems in modern society and a tremendous burden on healthcare systems worldwide. Obesity, high blood pressure, heart disease, insulin resistance, and diabetes are aspects of a systemic state of metabolic dysfunction referred to as the metabolic syndrome.

The metabolic syndrome is commonly linked to a sedentary lifestyle with excess calorie intake but it is well documented that also genetic traits contribute. Hallmarks at the cellular level include chronic, systemic inflammation and a profound metabolic inflexibility.

We are interested in the hepatic manifestations of the metabolic syndrome: Hepatic insulin resistance, steatosis, fibrosis, and cirrhosis. Insufficiently treated liver cirrhosis may result in liver failure or progress into hepatocellular carcinoma.

Through in vivo studies of cell-signaling pathways, transcriptional networks, and physiology we pursue a deeper understanding of disease mechanisms. This knowledge will help us identify and explore novel molecular targets for therapeutic intervention.

Areas of particular interest to us:

- Cross talk between hepatic cell types in the pathogenesis of hepatic fibrosis.
- Mechanisms controlling hepatic stellate cell trans-differentiation in the fibrotic liver.
- Nutritional and hormonal signaling in metabolic disease.

Our core techniques include:

- Transgenic animals and animal models of metabolic disease
- In vivo gene manipulation by adeno-associated virus
- Isolation and culture of primary hepatic cell populations
- Cre-TRAP Ribosomal profiling
- RNA-seq and RT-qPCR
- ChIP-qPCR and ChIP-seq
- Confocal fluorescence microscopy
- Protein analyses by western blotting, immunofluorescence, and mass spectrometry*
- Bioinformatic data analysis*

(* collaborative projects possible)

We are currently looking for highly motivated and committed students at the bachelor-, ITEK-, and master-level.

For inquiries about our research and student projects please contact me at ravnskjaer@bmb.sdu.dk or swing by my office at BMB on Campusvej.

Fingeraftryk Fingeraftryk er baseret på at anvende teksten fra personernes videnskabelige dokumenter til at skabe et indeks med vægtede emneordskoncepter, som definerer de vigtigste emner for hver enkelt forsker.

  • 15 Lignende profiler
Glucagon Medicin og biovidenskab
Insulin-Secreting Cells Medicin og biovidenskab
Liver Medicin og biovidenskab
Gluconeogenesis Medicin og biovidenskab
Fasting Medicin og biovidenskab
Fatty Acids Medicin og biovidenskab
PPAR alpha Medicin og biovidenskab
Insulin Medicin og biovidenskab

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Publikationer 2003 2019

  • 14 Tidsskriftartikel
  • 1 Bidrag til bog/antologi
  • 1 Poster
162 Downloads (Pure)

Transcriptional regulation of Hepatic Stellate Cell activation in NASH

Marcher, A-B., Bendixen, S. M., Terkelsen, M. K., Hohmann, S. S., Hansen, M. H., Larsen, B. D., Mandrup, S., Dimke, H., Detlefsen, S. & Ravnskjaer, K., 20. feb. 2019, I : Scientific Reports. 9, 1, 55 s., 2324.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Hepatic Stellate Cells
Fatty Liver
Liver
Liver Diseases
Extracellular Matrix Proteins

Role of the cAMP Pathway in Glucose and Lipid Metabolism

Ravnskjær, K., Madiraju, A. & Montminy, M., 1. jan. 2016, Handbook of Experimental Pharmacology. Springer, s. 29-49 21 s. (Handbook of Experimental Pharmacology).

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskning

Lipid Metabolism
Glycogenolysis
Metabolic Networks and Pathways
Glucagon
Homeostasis
79 Downloads (Pure)

Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2

Hogan, M. F., Ravnskjaer, K., Matsumura, S., Huising, M. O., Hull, R. L., Kahn, S. E. & Montminy, M., 4. sep. 2015, I : Journal of Biological Chemistry. 290, 43, s. 25997-26006

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Phosphorylation
Insulin Resistance
Chemical activation
Gene expression
Insulin

Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects

Ravnskjær, K., Hogan, M. F., Lackey, D., Tora, L., Dent, S. Y. R., Olefsky, J. & Montminy, M., okt. 2013, I : Journal of Clinical Investigation. 123, 10, s. 4318-28 11 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Cyclic AMP Response Element-Binding Protein
Gluconeogenesis
Glucagon
Epigenomics
Fasting

Keystone Symposia on Epigenomics and Chromatin Dynamics: Keystone resort, CO, January 17-22, 2012

Ravnskjær, K., 2012, I : Epigenetics. 7, 5, s. 522-523

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Epigenomics

Aktiviteter 2015 2019

  • 3 Foredrag og præsentationer i privat eller offentlig virksomhed
  • 2 Organisering af eller deltagelse i workshop, kursus, seminar eller lignende
  • 1 Organisering af eller deltagelse i konference
  • 1 Peer reviewer/fagfællebedømmer af manuskripter

ATLAS Symposium 2019 - Tissue Plasticity of Obesity

Susanne Mandrup (Arrangør), Lars Grøntved (Chairman), Kim Ravnskjær (Chairman), Blagoy Blagoev (Chairman), Jesper Grud Skat Madsen (Chairman), Aleksander Krag (Chairman), Søren Kragh Moestrup (Chairman), Jonas Heilskov Graversen (Chairman)
30. jun. 20191. jul. 2019

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i workshop, kursus, seminar eller lignende

Hepatic deconstruction - listening in on the cellular symphony of disease

Kim Ravnskjær (Foredragsholder)
30. nov. 2016

Aktivitet: Foredrag og mundtlige bidragForedrag og præsentationer i privat eller offentlig virksomhed

Hepatic deconstruction: Behind the scenes of hepatic fibrosis

Kim Ravnskjær (Foredragsholder)
29. jun. 2016

Aktivitet: Foredrag og mundtlige bidragForedrag og præsentationer i privat eller offentlig virksomhed

2nd International Symposium on Mesenchymal Stem Cell Differentiation

Kim Ravnskjær (Arrangør)
27. jun. 2016

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

First year projects - Poster session

Kim Ravnskjær (Arrangør)
10. jun. 2016

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i workshop, kursus, seminar eller lignende

Projekter 2015 2023