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Personlig profil

Forskningsområde

FUNCTIONAL GENOMICS AND METABOLIC SIGNALING IN THE LIVER

Metabolic disease is one of the biggest health problems in modern society and a tremendous burden on healthcare systems worldwide. Obesity, high blood pressure, heart disease, insulin resistance, and diabetes are aspects of a systemic state of metabolic dysfunction referred to as the metabolic syndrome.

The metabolic syndrome is commonly linked to a sedentary lifestyle with excess calorie intake but it is well documented that also genetic traits contribute. Hallmarks at the cellular level include chronic, systemic inflammation and a profound metabolic inflexibility.

We are interested in the hepatic manifestations of the metabolic syndrome: Hepatic insulin resistance, steatosis, fibrosis, and cirrhosis. Insufficiently treated liver cirrhosis may result in liver failure or progress into hepatocellular carcinoma.

Through in vivo studies of cell-signaling pathways, transcriptional networks, and physiology we pursue a deeper understanding of disease mechanisms. This knowledge will help us identify and explore novel molecular targets for therapeutic intervention.

Areas of particular interest to us:

- Cross talk between hepatic cell types in the pathogenesis of hepatic fibrosis.
- Mechanisms controlling hepatic stellate cell trans-differentiation in the fibrotic liver.
- Nutritional and hormonal signaling in metabolic disease.

Our core techniques include:

- Transgenic animals and animal models of metabolic disease
- In vivo gene manipulation by adeno-associated virus
- Isolation and culture of primary hepatic cell populations
- Cre-TRAP Ribosomal profiling
- RNA-seq and RT-qPCR
- ChIP-qPCR and ChIP-seq
- Confocal fluorescence microscopy
- Protein analyses by western blotting, immunofluorescence, and mass spectrometry*
- Bioinformatic data analysis*

(* collaborative projects possible)

We are currently looking for highly motivated and committed students at the bachelor-, ITEK-, and master-level.

For inquiries about our research and student projects please contact me at ravnskjaer@bmb.sdu.dk or swing by my office at BMB on Campusvej.

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  • 15 Lignende profiler

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Publikationer

Osteoprotegerin is more than a possible serum marker in liver fibrosis: A study into its function in human and murine liver

Adhyatmika, A., Beljaars, L., Putri, K. S. S., Habibie, H., Boorsma, C. E., Reker‐smit, C., Luangmonkong, T., Guney, B., Haak, A., Mangnus, K. A., Post, E., Poelstra, K., Ravnskjaer, K., Olinga, P. & Melgert, B. N., 2020, I : Pharmaceutics. 12, 5, 21 s., 471.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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    Transcriptional regulation of Hepatic Stellate Cell activation in NASH

    Marcher, A-B., Bendixen, S. M., Terkelsen, M. K., Hohmann, S. S., Hansen, M. H., Larsen, B. D., Mandrup, S., Dimke, H., Detlefsen, S. & Ravnskjaer, K., 20. feb. 2019, I : Scientific Reports. 9, 1, 55 s., 2324.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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    Identification of NASH-associated signaling networks in murine hepatic stellate cells

    Ravnskjær, K., 15. okt. 2017.

    Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

  • Role of the cAMP Pathway in Glucose and Lipid Metabolism

    Ravnskjær, K., Madiraju, A. & Montminy, M., 1. jan. 2016, Handbook of Experimental Pharmacology. Springer, s. 29-49 21 s. (Handbook of Experimental Pharmacology).

    Publikation: Kapitel i bog/rapport/konference-proceedingKapitel i bogForskning

  • Aktiviteter

    • 5 Organisering af eller deltagelse i konference
    • 3 Foredrag og præsentationer i privat eller offentlig virksomhed
    • 2 Organisering af eller deltagelse i workshop, kursus, seminar eller lignende
    • 1 Peer reviewer/fagfællebedømmer af manuskripter

    Metabolism in Action

    Kim Ravnskjær (Deltager), & Jonas T Treebak (Arrangør)

    27. okt. 201931. okt. 2019

    Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

    Danish Single Cell symposium 2019

    Kim Ravnskjær (Deltager)

    3. okt. 2019

    Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

    Single cell Genomics 2019

    Kim Ravnskjær (Deltager)

    24. sep. 201927. sep. 2019

    Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

    ATLAS Symposium 2019 - Tissue Plasticity of Obesity

    Susanne Mandrup (Arrangør), , Lars Grøntved (Chairman), , Kim Ravnskjær (Chairman), , Blagoy Blagoev (Chairman), , Jesper Grud Skat Madsen (Chairman), , Aleksander Krag (Chairman), , Søren Kragh Moestrup (Chairman), & Jonas Heilskov Graversen (Chairman)

    30. jun. 20191. jul. 2019

    Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i workshop, kursus, seminar eller lignende

    Gordon Research Conference - Tissue Repair and Regeneration

    Kim Ravnskjær (Deltager), & William Wood (Chairman)

    9. jun. 201914. jun. 2019

    Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

    Projekter