Poul Nielsen

ph.d.

  • Campusvej 55

    5230 Odense M

    Danmark

1994 …2021
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Publikationer 1994 2019

  • 106 Tidsskriftartikel
  • 5 Konferenceabstrakt til konference
  • 1 Bidrag til bog/antologi
  • 1 Konferenceabstrakt i tidsskrift
1994
spleen exonuclease
Oligodeoxyribonucleotides
Oligomers
Thymidine
Degradation
1995

Evaluation of Oligonucleotides with Novel Modifications

Larsen, E., Danel, K., Abdel-Aleem, A-A. H., Nielsen, P., Wengel, J. & Pedersen, E. B., 1995, I : Nucleosides, Nucleotides and Nucleic Acids. 14, 3-5, s. 1097-1100

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Oligodeoxyribonucleotides
Nucleosides
Oligonucleotides
DNA

Synthesis and Evaluation of Oligodeoxynucleotides Containing Acyclic Nucleosides: Introduction of Three Novel Analogues and a Summary

Nielsen, P., Dreiøe, L. H. & Wengel, J., 1995, I : Bioorganic & Medicinal Chemistry. 3, 1, s. 19-28

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Oligodeoxyribonucleotides
Nucleosides
Degradation
Thymine
Oligomers
1996

Stereoselective Preparation of 3'-C-Allyluridines and 3'-Spiro-gamma-Lactone Uridine Analogues

Nielsen, P., Larsen, K. & Wengel, J., 1996, I : Acta Chemica Scandinavica. 50, 11, s. 1030-1035

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

1997

A novel class of conformationally restricted oligonucleotide analogues: synthesis of 2',3'-bridged monomers and RNA-selective hybridisation

Nielsen, P., Pfundheller, H. M. & Wengel, J., 1997, I : Chemical Communications. 1997, 9, s. 825-826

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Oligonucleotides
RNA
Nucleosides
Monomers

Synthesis and Evaluation of Novel Oligodeoxynucleotides Containing 3′-C-(3-Benzoyloxypropyl)thymidine and Bicyclo Nucleoside Derivatives

Pfundheller, H. M., Nielsen, P. & Wengel, J., 1997, I : Nucleosides, Nucleotides and Nucleic Acids. 16, 7-9, s. 1439-1442

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Oligodeoxyribonucleotides
Nucleosides
Thymidine
Derivatives
Monomers

Synthesis of 2'-O,3'-C-linked bicyclic nucleosides and bicyclic oligonucleotides

Nielsen, P., Pfundheller, H. M., Olsen, C. E. & Wengel, J., 1997, I : Royal Chemical Society. Journal. Perkin Transactions 1. 1997, 22, s. 3423-3434

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Nucleosides
Oligonucleotides
Complementary RNA
Thymine
Oligodeoxyribonucleotides
1998

An Efficient Protocol for the Stereoselective Dihydroxylation of Ene-Ester Systems

Hermitage, S. A., Murphy, A., Nielsen, P. & Roberts, S. M., 1998, I : Tetrahedron. 54, s. 13185-13202

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

A Novel Class of Oligonucleotide Analogues Containing 2'-O,3'-C-Linked [3.2.0]Bicyclo-arabinonucleoside Monomers: Synthesis, Thermal Affinity Studies and Molecular Modelling

Christensen, N. K., Petersen, M., Nielsen, P., Jacobsen, J. P., Olsen, C. E. & Wengel, J., 1998, I : Journal of the American Chemical Society. 120, 22, s. 5458-5463

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

LNA (Locked Nucleic Acids): An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes

Koshkin, A. A., Nielsen, P., Meldgaard, M., Rajwanshi, V. K., Singh, S. K. & Wengel, J., 1998, I : Journal of the American Chemical Society. 120, 50, s. 13252-13253

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

Singh, S. K., Nielsen, P., Koshkin, A. A. & Wengel, J., 1998, I : Chemical Communications. 1998, 4, s. 455-456

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Nucleic acids
Nucleic Acids
Complementary RNA
Thermodynamic stability
Complementary DNA

LNA (Locked Nucleic Acids): Synthesis of Adenin, Cytosine, Guanine, 5-Methylcytosine, Thymine and Uracil Bicyclonucleoside Monomers, Oligomerisation, and Unprecedented Nucleic Acid Recognition

Koshkin, A. A., Singh, S. K., Nielsen, P., Rajwanshi, V. K., Kumar, R., Meldgaard, M., Olsen, C. E. & Wengel, J., 1998, I : Tetrahedron. 54, 14, s. 3607-3630

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

5-Methylcytosine
Oligomerization
Thymine
Uracil
Cytosine

Synthesis and chemoselective activation of phenyl 3,5-di-O-benzyl-2-O,4-C-methylene-1-thio-b-D-ribofuranoside: a key synthon towards a-LNA

Nielsen, P. & Wengel, J., 1998, I : Chemical Communications. 1998, 23, s. 2645-2646

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Chemical activation
Acids
2'-O-4'-C-methylene-ribofuranosyl nucleotide
Nucleosides

Synthesis of novel 3'-C-branched 2'-deoxynucleosides. Incorporation of 3'-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides

Pfundheller, H. M., Jørgensen, P. N., Sørensen, U. S., Sharma, S. K., Grimstrup, M., Ströch, C., Nielsen, P., Viswanadham, G., Olsen, C. E. & Wengel, J., 1998, I : Royal Chemical Society. Journal. Perkin Transactions 1. 1998, 8, s. 1409-1422

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Oligodeoxyribonucleotides
Thymidine
Glycosides
Monomers
Derivatives
1999

A new synthetic approach towards ?- and ?-LNA (locked nucleic acids)

Nielsen, P. & Wengel, J., 1999, I : Nucleosides, Nucleotides and Nucleic Acids. 18, 5-5, s. 701-702

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Thioglycosides
Isomers
Acids
2'-O-4'-C-methylene-ribofuranosyl nucleotide
locked nucleic acid

LNA (locked nucleic acids)

Wengel, J., Koshkin, A., Singh, S. K., Nielsen, P., Meldgaard, M., Rajwanshi, V. K., Kumar, R., Skouv, J., Nielsen, C. B. & Jacobsen, J. P., 1999, I : Nucleosides, Nucleotides and Nucleic Acids. 18, 6-7, s. 1365-1370

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

RNA
Complementary RNA
locked nucleic acid
DNA
Conformations
2000

Alfa-LNA; Locked Nucleic Acid with alfa-D-configuration

Nielsen, P. & Dalskov, J. K., 2000, I : Chemical Communications. s. 1179-8

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Structural basis of cleavage by RNase H of hybrids of arabinonucleic acids and RNA

Minasov, G., Teplova, M., Nielsen, P., Wengel, J. & Egli, M., 2000, I : Biochemistry. 39, 13, s. 3525–3532

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Synthesis of conformationally restricted dinucleotides by ring closing metathesis

Sørensen, A. M. & Nielsen, P., 2000, I : Organic Letters. 2, s. 4217-1

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The eight stereoisomers of LNA (Locked Nucleic Acid): A remarkable family of strong RNA binding molecules

Rajwanshi, V. K., Håkansson, A. E., Sørensen, M. D., Pitsch, S., Singh, S. K., Kumar, R., Nielsen, P. & Wengel, J., 2000, I : Angewandte Chemie - International Edition. 39, 9, s. 1656-1659

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Stereoisomerism
Nucleic acids
RNA
Molecules
Complementary RNA

The solution structure of a DNA duplex containing a single 1-(2-O,3-C-ethylene-?-D-arabinofuranosyl)thymidine nucleoside

Jørgensen, L. B., Nielsen, P., Wengel, J. & Jacobsen, J. P., 2000, I : Journal of Biomolecular Structure & Dynamics. 18, 1, s. 45-57

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DNA
Molecular Dynamics Simulation
Protons
Proton Magnetic Resonance Spectroscopy

Tricyclic nucleosides derived from D-glucose: Synthesis and conformational behaviour

Nielsen, P., Petersen, M. & Jacobsen, J. P., 2000, I : Royal Chemical Society. Journal. Perkin Transactions 1. s. 3706-1

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

2001

A conformationally locked tricyclic nucleoside: Synthesis, crystal structure and incorporation into oligonucleotides

Ravn, J., Thorup, N. & Nielsen, P., 2001, I : Royal Chemical Society. Journal. Perkin Transactions 1. s. 1855-61

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

ChemInform Abstract: Tricyclic Nucleosides Derived from D‐Glucose. Synthesis and Conformational Behavior

Nielsen, P., Petersen, M. & Jacobsen, J. P., 2001, I : ChemInform. 32, 12, 1 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskning

Incorporation of (alfa)- and (beta)-LNA (locked nucleic acid) monomers in oligodeoxynucleotides with polarity reversals YYYY No org found YYY

Christensen, N. K., Dahl, B. M. & Nielsen, P., 2001, I : Bioorganic & Medicinal Chemistry Letters. 11, s. 1765-68

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Synthesis and Evaluation of a-LNA

Christensen, N. K., Dalskov, J. K. & Nielsen, P., 2001, I : Nucleosides, Nucleotides and Nucleic Acids. 20, s. 825-829

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Synthesis and NMR-analysis of Tricyclic Nucleosides

Nielsen, P., Petersen, M. & Jacobsen, J. P., 2001, I : Nucleosides, Nucleotides and Nucleic Acids. 20, s. 1309-1312

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Synthesis and NMR-studies of dinucleotides with conformationally restricted cyclic phosphotriester linkages

Sørensen, A. M., Nielsen, K. E., Vogg, B., Jacobsen, J. P. & Nielsen, P., 2001, I : Tetrahedron. 57, s. 10191-201

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Synthesis of a bicyclic analogue of AZT restricted in an unusual O4'-endo conformation

Sørensen, M. H., Nielsen, C. & Nielsen, P., 2001, I : Journal of Organic Chemistry. 66, s. 4878-86

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Synthesis of bicyclic nucleosides by ring-closing metathesis

Ravn, J. & Nielsen, P., 2001, I : Royal Chemical Society. Journal. Perkin Transactions 1. s. 985-93

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

2002

(-LNA (Locked Nucleic Acid with (-D-Configuration): Synthesis and Selective Parallel Recognition of RNA

Nielsen, P., Christensen, N. K. & Dalskov, J. K., 2002, I : Chemistry: A European Journal. 8, s. 712-22

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

3',4'-trans-Linked bicyclic nucleosides locked in S-type conformations

Thomasen, H., Meldgaard, M., Freitag, M., Petersen, M., Wengel, J. & Nielsen, P., 2002, I : Chemical Communications. 2002, 17, s. 1888-1889

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Cyclic Ethers
Nucleosides
Conformations
Ethers
Derivatives

A Ring-Closing Metathesis Strategy Towards Conforma-tionally Restricted Di-and Trinucleotides

Børsting, P., Sørensen, A. M. & Nielsen, P., 2002, I : Synthesis. 6, s. 797-801

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Synthesis and antiviral evaluation of novel conformationally locked nucleosides and masked 5'-phosphate derivatives thereof

Bryld, T., Sørensen, M. H., Nielsen, P., Koch, T., Nielsen, C. & Wengel, J., 2002, I : Royal Chemical Society. Journal. Perkin Transactions 1. 2002, 14, s. 1655-1662

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Nucleosides
Antiviral Agents
Phosphates
Derivatives
Conformations

Tandem ring-closing metathesis and hydrogenation towards cyclic dinucleotides

Børsting, P., Sørensen, A. M. & Nielsen, P., 2002, I : Chemical Communications. s. 2140-1

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

2003

a-LNA (a-D-Configured Locked Nucleic Acid)

Christensen, N. K., Petersen, M., Vester, B. & Nielsen, P., 2003, I : Nucleosides, Nucleotides and Nucleic Acids. 22, s. 1143-1145

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Bi- and Tricyclic Nucleoside Derivatives Restricted in S-Type Conformations and Obtained by RCM-Reactions

Albæk, N., Ravn, J., Freitag, M., Thomasen, H., Christensen, N. K., Petersen, M. & Nielsen, P., 2003, I : Nucleosides, Nucleotides and Nucleic Acids. 22, s. 723-725

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Bicyclic nucleosides; stereoselective dihydroxylation and 2'-deoxygenation

Ravn, J., Freitag, M. & Nielsen, P., 2003, I : Organic & Biomolecular Chemistry. 1, s. 811-16

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Conformationally Restricted Dinucleotides: Tandem Ring-Closing Metathesis and Hydrogenation Approach

Børsting, P. & Nielsen, P., 2003, I : Nucleosides, Nucleotides and Nucleic Acids. 22, s. 1139-41

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Dinucleotides of 4'-C-vinyl- and 5'-C-allylthymidine as substrates for ring-closing metathesis reactions

Kirchhoff, C. & Nielsen, P., 2003, I : Tetra Lett. 44, s. 6475-78

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

NMR solution structure of dsDNA containing a bicyclic D-arabino-configured nucleotide fixed in an O4'-endo sugar conformation

Tømmerholt, H. V., Christensen, N. K., Nielsen, P., Wengel, J., Stein, P. C., Jacobsen, J. P. & Petersen, M., 2003, I : Organic & Biomolecular Chemistry. 2003, 10, s. 1790-1797

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Sugars
Conformations
Nucleotides
Nuclear magnetic resonance
Deoxyribose

Synthesis of hydroxymethyl branched [3.2.0]bicyclic nucleosides using a regioselective oxetane ring-formation

Christensen, N. K., Andersen, A. K. L., Schultz, T. R. & Nielsen, P., 2003, I : Organic & Biomolecular Chemistry. 1, s. 3738-48

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

2004

(1R,2R)-1,3-bis(tert-butyidimethylsilyloxy)-2-(4-hydroxybutanamido)-1-(4-nitrophenyl)-propane

Johansson, D., Larsen, F. B., Bond, A. D. & Nielsen, P., 2004, I : Acta Crystallographica. Section E: Structure Reports Online. E60, s. o907-o908

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

A ring-closing metathesis based synthesis of bicyclic nucleosides locked in S-type conformations by hydroxyl functionalised 3',4'-trans linkages

Freitag, M., Thomasen, H., Christensen, N. K., Petersen, M. & Nielsen, P., 2004, I : Tetrahedron. 60, s. 3775-3786

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Dinucleotides containing two allyl groups by combinations of allyl phosphortriesters, 5-allyl-, 2´-O-allyl- and 2´-arabino-O-allyl uridine derivatives as substrates for ring-closing metathesis

Børsting, P., Freitag, M. & Nielsen, P., 2004, I : Tetrahedron. 60, s. 10955-10966

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

New Ruthenium-Based Protocol for Cleavage of Terminal Olefins to Primary Alcohols: Improved Synthesis of a Bicyclic Nucleoside.

Sharma, P. K. & Nielsen, P., 2004, I : Journal of Organic Chemistry. 69, s. 5742-5745

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Parallel nucleic acid recognition by the LNA (Locked Nucleic Acid) stereoisomers ß-L-LNA and a-D-LNA; studies in the mirror image world.

Christensen, N. K., Bryld, T., Sørensen, M. D., Arar, K., Wengel, J. & Nielsen, P., 2004, I : Chemical Communications. s. 282-283

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

2005

An alfa-D-Configured Bicyclic Nucleoside Restricted in an Etype Conformation: Synthesis and Parallel RNA Recognition

Sharma, P. K., Petersen, M. & Nielsen, P., 2005, I : Journal of Organic Chemistry. 70, s. 4918-4928

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Design, synthesis and ribosome binding of chloramphenicol nucleotide and intercalator conjugates

Johansson, D., Jessen, C. H., Pøhlsgaard, J., Jensen, K. B., Vester, B., Pedersen, E. B. & Nielsen, P., 2005, I : Bioorganic & Medicinal Chemistry Letters. 15, 8, s. 2079-2083

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Ring-closing metathesis reactions in nucleic acid chemistry: - cyclic dinucleotides for targeting secondary nucleic acid structures

Nielsen, P. & Børsting, P., 2005, I : Nucleosides, Nucleotides and Nucleic Acids. 24, s. 349-352

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review