Pernille B. Lærkegaard Hansen

cand.scient.,ph.d.

  • J.B. Winsløws Vej 21, 3.

    5000 Odense C

    Danmark

19982019
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Personlig profil

CV

Academic qualifications and professional experience:
2013- Professor with special responsibilities. Cardiovascular and Renal Research, Institute for Molecular Medicine. University of Southern Denmark
2011-2012 Research Management Master Class, Copenhagen Business School
2011 Maternity Leave, 6 month
2010-2011 University of Southern Denmark, Management course
2010- Vice Head of Research, Cardiovascular and Renal Research, Institute for Molecular Medicine
2009-2010 Research Management Course, Copenhagen Business School.
2007-2013 Associate Professor, Physiology and Pharmacology, University of Southern Denmark
2006 Maternity Leave, 6 month
2004-2007 Assistant Professor, Physiology and Pharmacology, University of Southern Denmark
2001-2004 Post. Doc, National Institutes of Health, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, USA
2001 Research assistant, Dept. of Physiology and Pharmacology, University of Southern Denmark
2001 Ph.D., Physiology. Contraction mechanisms in renal resistance vessels illustrated by in vitro techniques. University of Southern Denmark
1998-2001 Ph.D. Student, Dept. of Physiology and Pharmacology, University of Southern Denmark
1998 Research assistant. Dept. of Physiology and Pharmacology, Odense University
1998 M.Sc. (Master of Science) Biology and Chemistry, Odense University
 
Honors and awards:
2010 Danish Hypertension Society and Novartis Research Award
2005 The renal paper of the year: Castrop et al. 2005 American Journal of Physiology, Renal.
2005 LeoPharma´s Hypertension award, Danish Hypertension Society
2005 Renal Research Recognition Award, American Physiological Society
2003 Fellows Award for Research Excellence (FARE 2004), National Institutes of Health (NIH), Bethesda, USA
2003 First Place Awardee, Aventis Pharma Awards for Excellence in Renal Research, American Physiological Society, Renal section

Research focus:
My main research interests are vascular function both in normal physiological settings and in cardiovascular and renal diseases. My research group uses techniques from the molecular level, to in vitro techniques to the integrated in vivo level. I focus on resistance vessels and their involvement in regulation of blood flow and blood pressure. The major aim of my research activities has fallen into three main areas; 1) calcium channels, 2) adenosine and 3) aldosterone and their involvement in cardiovascular and renal physiology and patophysiology. I have collaborations to Odense University Hospital and we can as something exceptional perform functional studies on freshly isolated human blood vessels. I verify our data from animal models in humans which gives new insights in the mechanisms relevant for the understanding of regulation of blood pressure and vascular function in humans.
 
Supervision and referee service:
Supervisor for bachelor students, graduate students and Ph.D students. Opponent at 8 ph.d thesis in Copenhagen and Aarhus. On the review committee for seven associate professor positions at Aarhus University and Copenhagen University.
Associate Editor, Acta Physiologica, symposium issue (2010)
Member of the editorial board Am. J. Physiol. Renal 2013-.
Member of reviewing committee for Faculty of 1000 medicine.
Reviewer on a book on respiratory physiology by Søren Lyager “Respirations Fysiology, FADL” (2010).

Scientific presentations:
Local Chair” on international Acta symposium, SDU, “12th International symposium on vascular neuroeffector mechanisms”. 31 oral presentations at national and international meetings. Invited speaker at 7 international and 8 national meetings.

Memberships:
Danish representative in the Management Committee of the EU network COST ADMIRE. Board
member of the Scandinavian Physiological Society and member of the
American Physiological Society. Member of the Danish Pharmacology Society, the Danish Heart
Foundation and Danish Hypertension Society.

 

Forskningsområde

Research focus:
 
My main research interests are vascular function both in normal physiological settings and in cardiovascular and renal diseases. My research group uses techniques from the molecular level, to in vitro techniques to the integrated in vivo level. I focus on resistance vessels and their involvement in regulation of blood flow and blood pressure. The major aim of my research activities has fallen into three main areas; 1) calcium channels, 2) adenosine and 3) aldosterone and their involvement in cardiovascular and renal physiology and patophysiology. I have collaborations to Odense University Hospital and we can as something exceptional perform functional studies on freshly isolated human blood vessels. I verify our data from animal models in humans which gives new insights in the mechanisms relevant for the understanding of regulation of blood pressure and vascular function in humans.

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  • 21 Lignende profiler
Kidney Medicin og biovidenskab
T-Type Calcium Channels Medicin og biovidenskab
Aldosterone Medicin og biovidenskab
Renin Medicin og biovidenskab
Arterial Pressure Medicin og biovidenskab
Vasoconstriction Medicin og biovidenskab
Vascular Smooth Muscle Medicin og biovidenskab
Vasodilation Medicin og biovidenskab

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Publikationer 1998 2019

19 Downloads (Pure)
Åben adgang
Fil
Aldosterone
Arterial Pressure
Mineralocorticoid Receptors
Messenger RNA
Indwelling Catheters

Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor

Bach, A., Clausen, B. H., Kristensen, L. K., Andersen, M. G., Ellman, D. G., Hansen, P. B. L., Hasseldam, H., Heitz, M., Özcelik, D., Tuck, E. J., Kopanitsa, M. V., Grant, S. G. N., Lykke-Hartmann, K., Johansen, F. F., Lambertsen, K. L. & Strømgaard, K., 15. maj 2019, I : Neuropharmacology. 150, s. 100-111

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

N-Methyl-D-Aspartate Receptors
Arterial Pressure
Fluorescence Polarization
Middle Cerebral Artery Infarction
Rodentia
11 Downloads (Pure)

The acute blood pressure-lowering effect of amiloride is independent of endothelial ENaC and eNOS in humans and mice

Ydegaard, R., Andersen, H., Oxlund, C. S., Jacobsen, I. A., Hansen, P. B. L., Jürgensen, J. F., Peluso, A. A., Vanhoutte, P. M., Staehr, M., Svenningsen, P. & Jensen, B. L., 1. jan. 2019, I : Acta Physiologica (Print). 225, 1, 12 s., e13189.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Amiloride
NG-Nitroarginine Methyl Ester
Urine
Arterial Pressure
Indwelling Catheters
T-Type Calcium Channels
Nitric Oxide
Aging of materials
Acetylcholine
Dilatation
82 Downloads (Pure)

Endothelial mineralocorticoid receptor ablation does not alter blood pressure, kidney function or renal vessel contractility

Laursen, S. B., Finsen, S., Marcussen, N., Quaggin, S. E., Hansen, P. B. L. & Dimke, H., 1. feb. 2018, I : PLOS ONE. 13, 2, 20 s., e0193032.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Mineralocorticoid Receptors
Endothelial cells
Blood pressure
renal function
Ablation

Aktiviteter 2008 2017

Physiologi seminar

Pernille B. Lærkegaard Hansen (Deltager)
18 maj 2017

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

cost admire

Pernille B. Lærkegaard Hansen (Arrangør)
1 dec. 20162 dec. 2016

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

Welcome Trust Foundation (Tidsskrift)

Pernille B. Lærkegaard Hansen (Peer reviewer)
10 nov. 2016

Aktivitet: Redaktionelt arbejde og fagfællebedømmelseRedaktør af tidsskriftForskning

britisk farmakologisk selskab

Pernille B. Lærkegaard Hansen (Arrangør)
10 okt. 2016

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

FASEB Renal Hæmodynamik møde

Pernille B. Lærkegaard Hansen (Arrangør)
6 jun. 201610 jun. 2016

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

Presse/medie

Støtte til forskningsprojekt

Pernille B. Lærkegaard Hansen

24/12/2014

1 element af Mediedækning

Presse/medie

Medlem af EU-styregruppe

Pernille B. Lærkegaard Hansen

23/12/2013

1 element af Mediedækning

Presse/medie

APROPOS

Uffe Holmskov & Pernille B. Lærkegaard Hansen

25/07/2013

1 element af Mediedækning

Presse/medie