Forskningsinteresser

Design, analysis, and reporting of diagnostic and prognostic trials in molecular imaging.

DMSc thesis: https://portal.findresearcher.sdu.dk/en/publications/variability-of-quantitative-health-measurements-on-method-compari

----- Sequential and adaptive trial designs in diagnostic research -----

** Sample size recalculation based on the overall success rate in a randomized test- treatment trial with restricting randomization to discordant pairs. BMC Med Res Methodol. In press.

** A unified framework for diagnostic test development and evaluation during outbreaks of emerging infections. Commun Med (Lond). 2024; 4(1): 263. https://www.nature.com/articles/s43856-024-00691-9  

** Sample size recalculation based on the prevalence in a randomized test-treatment study. BMC Med Res Methodol. 2022; 22(1): 205. https://doi.org/10.1186/s12874-022-01678-7

** Randomized test-treatment studies with an outlook on adaptive designs. BMC Med Res Methodol. 2021; 21(1): 110. https://doi.org/10.1186/s12874-021-01293-y

** The potential for seamless designs in diagnostic research. J Clin Epidemiol. 2021; 129: 51-59. https://doi.org/10.1016/j.jclinepi.2020.09.019

** Adaptive trial designs in diagnostic accuracy research. Stat Med. 2020; 39(5): 591-601. https://doi.org/10.1002/sim.8430

---- Other topics -----

** Modeling Bland–Altman Limits of Agreement with Fractional Polynomials – An Example with the Agatston Score for Coronary Calcification. Axioms. 2023; 12(9): 884. https://doi.org/10.3390/axioms12090884

** Convergence behavior of optimal cutpoints in receiver operating characteristics curve analysis. Mathematics 2022; 10(22): 4206. https://www.doi.org/10.3390/math10224206

** Nonparametric percentile curve estimation for a nonnegative marker with excessive zeros. MethodsX. 2022; 9: 101757. https://doi.org/10.1016/j.mex.2022.101757

** Bland-Altman Limits of Agreement from a Bayesian and frequentist perspective. Stats. 2021; 4(4): 1080-1090. https://doi.org/10.3390/stats4040062

** Reporting standards for a Bland-Altman agreement analysis: a review of methodological reviews. Diagnostics. 2020; 10(5): 334. https://doi.org/10.3390/diagnostics10050334

----- Recent clinical papers -----              

** Diagnosing Bone Metastases in Breast Cancer: A Systematic Review and Network Meta-Analysis on Diagnostic Test Accuracy Studies of 2-[18F]FDG-PET/CT, 18F-NaF-PET/CT, MRI, Contrast-Enhanced CT, and Bone Scintigraphy. Semin Nucl Med. 2025; 55(1): 137-151. https://doi.org/10.1053/j.semnuclmed.2024.10.008

** Identifying the primary tumour in patients with cancer of unknown primary (CUP) using [18F]FDG PET/CT: a systematic review and individual patient data meta-analysis. Eur J Nucl Med Mol Imaging. 2024; 52(1): 225-236. https://doi.org/10.1007/s00259-024-06860-1 

** Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock. N Engl J Med. 2024; 390(15): 1382-1393. https://doi.org/10.1056/NEJMoa2312572

CV

Current position

Biostatistician, Department of Nuclear Medicine, Odense University Hospital & Professor in Clinical Biostatistics in Diagnostic Research, Dept. of Clinical Research, University of Southern Denmark

Former positions

2011-18 Associate Professor (20%), Dept. of Business and Economics, SDU

2006 Senior Statistician, Early Clinical Development, Novartis Pharma AG, Basel

2002-06 Biometrician, Clinical Statistics Europe, Schering AG, Berlin

2001/02 Junior Specialist, Information Resources GfK GmbH, Nürnberg

Higher education & academic degrees

2024 DMSc, Faculty of Health Sciences, University of Southern Denmark

2010 Lecturer Training Programme, University of Southern Denmark

2001 PhD, Department of Statistics and Econometrics, Faculty of Economics, University of Hamburg

1998 MSc in Mathematics and Economics, University of Hamburg

Membership of scientific societies

International Biometric Society (IBS)

International Society for Clinical Biostatistics (ISCB)

Danish Society for Theoretical Statistics (DSTS)

Co-supervision of ongoing PhD projects: 4

Main / co-supervision of completed PhD projects: 1 / 22

Main supervision of completed master theses: 10

Odense, 03 Jan 2025