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    5230 Odense M

    Danmark

20132019
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Personlig profil

Forskningsområde

  • Surface and Colloid Science
  • Single (micro- nano-) Particle Science and Engineering;
  • Biological materials science;;
  • 2-phase microsystems:
    • proteins, (enzymes, antibodies); lipids; emulsions; surfactants; micelles; micro and nano crystals; micro and nano glasses;
  • Drug delivery:
    • micro- and nano-carrier engineering; liposomal drug delivery to tumors;Temperature-triggered drug release; polymer microspheres; drug formulation; endogenous theranostics.

Forskningsinformation

The Center for Single Particle Science and Engineering focuses on lipid bilayer membranes and other two-phase micro and nano systems. Of significant importance in the past five years has been the invention, fabrication, and testing, both in vitro and in vivo, (including Human Clinical trials, now in Phase III for Liver Cancer and Phase I/II for Chest Wall Recurrence of breast cancer), of a new low-temperature sensitive liposome (LTSL). This new anti-cancer drug-delivery and drug-releasing system is designed to release its drug, doxorubicin, within seconds upon being heated from a waxy state at body temperatures and below, to its main acyl chain melting transition at around 41C to 42C. This work has been carried out in close collaboration with researchers and clinicians in the DUMC Hyperthermia Program (Dewhirst PI) as well as by independent RO1 funding awarded to Professor Needham. New research with liposomes includes diagnostic applications using MRI contrast and the formulation of other drugs like cis-platin and other biological modifiers of cancer cell resistance to therapy. In other systems we are focusing on diffusion-solubility, crystallization and solidification of polymers, lipids, proteins, inorganic crystals and drugs from 2 phase Microsystems, including formulating protein nanobeads in degradable PLGA polymer microspheres. Particular applications of these materials and materials processing concepts have been expanded into 3 Small Business Research Initiation Grants from NSF and NIH that aim to develop and commercialize the dehydration technology for enzymes peptides, and antibodies. We are also interested in new formulations of more hydrophobic drugs as Bio-inspired pure-drug nano particles for metastatic tumor targeting. Here, collaborations are being established with researchers in BMB. Other collaborations include: developing an invention of a new bilayer model system (Droplet INterface Bilayers -DIBs) for studying and using single protein channel activity with collaborators at Oxford Univ., UK, and Oxford NanoPore Technologies; liposomes for fighting infectious disease, with Molecular Express, in LA.Specialist Experimental Techniques in the Laboratory:Micropipet manipulation of single and pairs of microparticles, optical/video-digital microscopy

Uddannelse (Akademiske kvalifikationer)

Physical Chemistry, PhD, University of Nottingham

1. sep. 197731. aug. 1980

Eksterne ansættelser

Honorary Professor, University of Nottingham

1. sep. 201431. aug. 2019

Professor, Duke University

1. jan. 1887 → …

Forskningsområder

  • Drug delivery fra nanopartikler
  • Lægemidler
  • Fysisk kemi

Fingeraftryk Fingeraftryk er baseret på at anvende teksten fra personernes videnskabelige dokumenter til at skabe et indeks med vægtede emneordskoncepter, som definerer de vigtigste emner for hver enkelt forsker.

  • 2 Lignende profiler
Emulsification Teknik og materialevidenskab
Surface tension Teknik og materialevidenskab
Dissolution Teknik og materialevidenskab
Water Kemiske forbindelser
Dehydration Medicin og biovidenskab
Surface-Active Agents Kemiske forbindelser
Oils Medicin og biovidenskab
Lipids Medicin og biovidenskab

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Publikationer 2013 2019

65 Downloads (Pure)
Åben adgang
Fil
Microbubbles
Oils
Lung
Capillary Action
Margarine
9 Downloads (Pure)

Oleogelating properties of ethylcellulose in oil-in-water emulsions: The impact of emulsification methods studied by 13C MAS NMR, surface tension and micropipette manipulation studies

Munk, M. B., Utoft, A., Larsen, F. H., Needham, D. & Risbo, J., apr. 2019, I : Food Hydrocolloids. 89, s. 700-706

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Emulsification
surface tension
emulsifying
Emulsions
emulsions

Particle formation from miscible binary and ternary liquid microdroplets in an immiscible environment

Madsen, A. U., Kinoshita, K., Walke, P. & Needham, D., sep. 2019, s. 303. 1 s.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

Åben adgang

Uptake of New Lipid-Coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Ollé, E. P., Walke, P., Notabi, M., El-Houri, R., Andersen, M. Ø., Needham, D. & Arnspang, E. C., 10. feb. 2019, I : Journal of Visualized Experiments. 144

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Stem cells
Mesenchymal Stromal Cells
Lipids
Nanoparticles
Cholesterol
23 Downloads (Pure)
Åben adgang
Fil
Cobalt
Neoplasms
Half-Life
Ligands
oleylamine

Projekter 2013 2019

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