• J.B. Winsløws Vej 9, indgang B, 1. Sal

    5000 Odense C

    Danmark

20092019
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Personlig profil

Forskningsområde

Ph.d.-projekt: Epidemiologiske, kliniske og immunologiske aspekter af neuromyelitis optica (NMO)

Abstract:
By neurologist, ph.d. student Nasrin Asgari, Department of Neurology, Vejle Hospital and Institute of Regional Health Services Research, Faculty of Health Sciences, University of Southern,Odense university Hospital.
Background: Neuromyelitis optica (NMO) is a severe inflammatory demyelinating CNS disorder, which predominantly affects the spinal cord and optic nerves, and later the brain. Recently, highly specific serum antibodies to aquaporin-4 (AQP4), the most abundant water channel in the CNS, have been identified. Demonstration of such autoantibodies separate NMO from multiple sclerosis (MS) and indicate that NMO is an autoimmune channelopathy disease. There is a strong relationship between AQP4-Abs titres and the clinical state as well as the clinical course of disease. 

Aim: The aims of the study are to:
1) Estimate the prevalence of NMO in the region of Southern Denmark
2) Investigate immunological serum markers and HLA-types in NMO patients and the co-morbidity with other autoimmune disorders 3) Characterise aquaporin-4 antibodies in in-vitro experiments
4) In a MS-mouse model to characterise the pathogenic effects of aquaporin-4 antibodies in CNS and perform experimental treatment. 

Status: The project has started November 2008.

Hovedvejleder: Institutleder, lektor Kirsten Ohm Kyvik, ph.d., MPM, Institut for Regional Sundhedsforskning.

Medvejledere:
Professor Trevor Owens, Ph.D., Medical Biotechnology Centre, University of Southern Denmark
Consultant Egon Stenager, Neurologisk afdeling, Vejle, Esbjerg, Sønderborg Sygehuse
Professor, dr.med. Jørgen Frøkiær, Clinical Physiology Skejby Hospital and Århus University
Consultant Søren Lillevang, Ph.D. Clinical Immunology Department, OUH (collaborator)

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  • 6 Lignende profiler
Neuromyelitis Optica Medicin og biovidenskab
Optic Neuritis Medicin og biovidenskab
Cerebrospinal Fluid Medicin og biovidenskab
Population Medicin og biovidenskab
Central Nervous System Medicin og biovidenskab
Iran Medicin og biovidenskab
Pathology Medicin og biovidenskab
Prospective Studies Medicin og biovidenskab

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Publikationer 2009 2019

Angiotensin AT2-receptor induced interleukin-10 attenuates neuromyelitis optica spectrum disorder-like pathology

Khorooshi, R. M. H., Tofte-Hansen, E. U., Tygesen, C., Montañana Rosell, R., Limburg, H. L., Marczynska, J., Asgari, N., Steckelings, M. & Owens, T., 2019, I : Multiple Sclerosis Journal.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Angiotensin Type 2 Receptor
Neuromyelitis Optica
Interleukin-10
Pathology
Central Nervous System Diseases

Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review

Shahmohammadi, S., Doosti, R., Shahmohammadi, A., Mohammadianinejad, S. E., Sahraian, M. A., Azimi, A. R., Harirchian, M. H., Asgari, N. & Naser Moghadasi, A., jan. 2019, I : Multiple Sclerosis and Related Disorders. 27, s. 350-363

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Neuromyelitis Optica
Comorbidity
Immune System Diseases
Patient Care Management
Sjogren's Syndrome
42 Downloads (Pure)

Cerebrospinal fluid biomarkers for predicting development of multiple sclerosis in acute optic neuritis: a population-based prospective cohort study

Olesen, M. N., Soelberg, K., Debrabant, B., Nilsson, A. C., Lillevang, S. T., Grauslund, J., Brandslund, I., Madsen, J. S., Paul, F., Smith, T. J., Jarius, S. & Asgari, N., 11. mar. 2019, I : Journal of Neuroinflammation. 16, 12 s., 59.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Optic Neuritis
Cerebrospinal Fluid
Cohort Studies
Prospective Studies
Intermediate Filaments

Disability and Therapeutic Response in Paediatric Neuromyelitis Optica Spectrum Disorder: A Case Series from Iran

Baghbanian, S. M., Sahraian, M. A., Naser Moghadasi, A. & Asgari, N., 2019, I : Iranian journal of child neurology. 13, 3, s. 99-104

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Neuromyelitis Optica
Iran
Pediatrics
Registries
Pharmaceutical Preparations
21 Downloads (Pure)

Epidemiology of neuromyelitis optica spectrum disorder in Denmark (1998-2008, 2007-2014)

Asgari, N., Lillevang, S. T., Skejoe, H. P. B. & Kyvik, K. O., jul. 2019, I : Brain and Behavior. 9, 7, 8 s., e01338.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Neuromyelitis Optica
Denmark
Epidemiology
Epidemiologic Studies
Glial Fibrillary Acidic Protein

Aktiviteter 2012 2017

  • 1 Organisering af eller deltagelse i workshop, kursus, seminar eller lignende
  • 1 Foredrag og præsentationer i privat eller offentlig virksomhed

XIII European meeting on glial cells in health and disease

Trevor Owens (Deltager), Reza M. H. Khorooshi (Deltager), Nasrin Asgari (Deltager), Carsten Tue Berg (Deltager)
8. jul. 2017

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i workshop, kursus, seminar eller lignende

Brainstem and spinal cord abnormalities in patients with neuromyelitis optica

Nasrin Asgari (Foredragsholder)
26. apr. 2012

Aktivitet: Foredrag og mundtlige bidragForedrag og præsentationer i privat eller offentlig virksomhed

Presse/medie