• J.B. Winsløws Vej 9, indgang B, 1. Sal

    5000 Odense C

    Danmark

20092020

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Forskningsområde

Ph.d.-projekt: Epidemiologiske, kliniske og immunologiske aspekter af neuromyelitis optica (NMO)

Abstract:
By neurologist, ph.d. student Nasrin Asgari, Department of Neurology, Vejle Hospital and Institute of Regional Health Services Research, Faculty of Health Sciences, University of Southern,Odense university Hospital.
Background: Neuromyelitis optica (NMO) is a severe inflammatory demyelinating CNS disorder, which predominantly affects the spinal cord and optic nerves, and later the brain. Recently, highly specific serum antibodies to aquaporin-4 (AQP4), the most abundant water channel in the CNS, have been identified. Demonstration of such autoantibodies separate NMO from multiple sclerosis (MS) and indicate that NMO is an autoimmune channelopathy disease. There is a strong relationship between AQP4-Abs titres and the clinical state as well as the clinical course of disease. 

Aim: The aims of the study are to:
1) Estimate the prevalence of NMO in the region of Southern Denmark
2) Investigate immunological serum markers and HLA-types in NMO patients and the co-morbidity with other autoimmune disorders 3) Characterise aquaporin-4 antibodies in in-vitro experiments
4) In a MS-mouse model to characterise the pathogenic effects of aquaporin-4 antibodies in CNS and perform experimental treatment. 

Status: The project has started November 2008.

Hovedvejleder: Institutleder, lektor Kirsten Ohm Kyvik, ph.d., MPM, Institut for Regional Sundhedsforskning.

Medvejledere:
Professor Trevor Owens, Ph.D., Medical Biotechnology Centre, University of Southern Denmark
Consultant Egon Stenager, Neurologisk afdeling, Vejle, Esbjerg, Sønderborg Sygehuse
Professor, dr.med. Jørgen Frøkiær, Clinical Physiology Skejby Hospital and Århus University
Consultant Søren Lillevang, Ph.D. Clinical Immunology Department, OUH (collaborator)

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Publikationer

Clinically stable disease is associated with a lower risk of both income loss and disability pension for patients with multiple sclerosis

Chalmer, T. A., Buron, M., Illes, Z., Papp, V., Theodorsdottir, A., Schäfer, J., Hansen, V., Asgari, N., Skejø, P. B., Jensen, H. B., Sørensen, P. S. & Magyari, M., jan. 2020, I : Journal of Neurology, Neurosurgery and Psychiatry. 91, 1, s. 67-74

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Efficacy and safety of rituximab in patients with refractory neuromyelitis optica spectrum disorders: A prospective observation in Iranian cases

    Ahadi, M. S., Moghadasi, A. N., Asgari, N. & Sahraian, M. A., 1. mar. 2020, I : Caspian Journal of Internal Medicine. 11, 2, s. 155-162

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Epidemiology of Neuromyelitis Optica Spectrum Disorder and Its Prevalence and Incidence Worldwide

    Guthy-Jackson Charitable Foundation International Clinical Consortium for NMOSD, 26. jun. 2020, I : Frontiers in Neurology. 11, 13 s., 501.

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

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    Highly sensitive quantification of optic neuritis intrathecal biomarker CXCL13

    Olesen, M. N., Nilsson, A. C., Pihl-Jensen, G., Soelberg, K. K., Olsen, D. A., Brandslund, I., Lillevang, S. T., Madsen, J. S., Frederiksen, J. L. & Asgari, N., sep. 2020, I : Multiple Sclerosis and Related Disorders. 44, 102281.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Inflammatory profiles relate to survival in subtypes of amyotrophic lateral sclerosis

    Olesen, M. N., Wuolikainen, A., Nilsson, A. C., Wirenfeldt, M., Forsberg, K., Madsen, J. S., Lillevang, S. T., Brandslund, I., Andersen, P. M. & Asgari, N., maj 2020, I : Neurology: Neuroimmunology & Neuroinflammation. 7, 3, 14 s., e697.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • 33 Downloads (Pure)

    Aktiviteter

    • 1 Organisering af eller deltagelse i workshop, kursus, seminar eller lignende
    • 1 Foredrag og præsentationer i privat eller offentlig virksomhed

    XIII European meeting on glial cells in health and disease

    Trevor Owens (Deltager), , Reza M. H. Khorooshi (Deltager), , Nasrin Asgari (Deltager), & Carsten Tue Berg (Deltager)

    8. jul. 2017

    Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i workshop, kursus, seminar eller lignende

    Brainstem and spinal cord abnormalities in patients with neuromyelitis optica

    Nasrin Asgari (Foredragsholder)

    26. apr. 2012

    Aktivitet: Foredrag og mundtlige bidragForedrag og præsentationer i privat eller offentlig virksomhed

    Presse/medier

    NYT JOB

    Nasrin Asgari

    04/02/2020

    1 Mediebidrag

    Presse/medie

    Ny professor

    Nasrin Asgari

    20/01/2020

    1 Mediebidrag

    Presse/medie

    Ny professor

    Nasrin Asgari

    20/01/2020

    1 Mediebidrag

    Presse/medie

    Ny professor

    Nasrin Asgari

    20/01/2020

    1 Mediebidrag

    Presse/medie