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Personlig profil

Forskningsinteresser

I am a cancer researcher with a specific interest in cancer prevention and prediction. My work  focuses on cancer aetiology, through studying effects of environmental and genetics factors on 
cancer risk and progression. I use range of approaches in my work, from observational  epidemiological studies of risk factors, including case-control, population-based cohort studies,  twin studies, to meta-analysis and umbrella reviews, and multi-omics data analysis to study associations between environmental exposures, genetics, and intermediate phenotypes (biomarkers). The overarching aim of my work is to improve cancer prediction by understanding risk factors of cancer, improving cancer screening, and thus improving survival 
of cancer patient and cancer outcomes. My work is characterized by collaborative and international nature as reflected in my publication list.

Forskningsområde

  • Understanding genetics of cancer risk through multi-omic analysis.
  • Interdisciplinary Project on Adherance to Colorectal Cancer Screening. A short description of the project can be found here.
  • Meta-analysis and systematic literature review of factors associated with false-positive and false-negative FOBT results. The details of the study protocol and methods are published in PROSPERO (ID: CRD42022315767).
  • COlorectal Cancer screening Among RElatives (CoCARE): a twin-family study in Denmark.

Uddannelse (Akademiske kvalifikationer)

Epidemiology, Dr.sc.hum, Investigations into the role of Glutathione-S-transferase (GST) and Cytochrome-P450-monooxygenase (CYP) polymorphisms as risk factors for early onset lung cancer, Heidelberg University

20052009

Dimissionsdato: 19. feb. 2009

Eksterne ansættelser

Honorary Fellow, The University of Edinburgh

7. dec. 2019 → …

Statistical Geneticist , The University of Edinburgh

20132019

Postdoctoral Fellow, International Agency for Research on Cancer

20092013

Forskningsområder

  • Kræft
  • Bioinformatik
  • Genomanalyse
  • Genetik
  • RNA
  • DNA
  • Forebyggelse og screening

Fingeraftryk

Dyk ned i forskningsemnerne, hvor Maria Timofeeva er aktiv. Disse emneordskoncepter kommer fra denne persons arbejde. Sammen danner de et unikt fingerprint.
  • 1 Lignende profiler

Samarbejde og topforskningsområder i de sidste fem år

Seneste eksterne samarbejder på lande-/områdeniveau. Dyk ned i detaljerne ved at klikke på prikkerne eller
  • Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

    Thomas, M., Su, Y. R., Rosenthal, E. A., Sakoda, L. C., Schmit, S. L., Timofeeva, M. N., Chen, Z., Fernandez-Rozadilla, C., Law, P. J., Murphy, N., Carreras-Torres, R., Diez-Obrero, V., van Duijnhoven, F. J. B., Jiang, S., Shin, A., Wolk, A., Phipps, A. I., Burnett-Hartman, A., Gsur, A., Chan, A. T., & 108 flereZauber, A. G., Wu, A. H., Lindblom, A., Um, C. Y., Tangen, C. M., Gignoux, C., Newton, C., Haiman, C. A., Qu, C., Bishop, D. T., Buchanan, D. D., Crosslin, D. R., Conti, D. V., Kim, D. H., Hauser, E., Siegel, E., Schumacher, F. R., Rennert, G., Giles, G. G., Hampel, H., Brenner, H., Oze, I., Oh, J. H., Lee, J. K., Schneider, J. L., Chang-Claude, J., Kim, J., Huyghe, J. R., Zheng, J., Hampe, J., Greenson, J., Hopper, J. L., Palmer, J. R., Visvanathan, K., Matsuo, K., Matsuda, K., Jung, K. J., Li, L., Le Marchand, L., Vodickova, L., Bujanda, L., Gunter, M. J., Matejcic, M., Jenkins, M. A., Slattery, M. L., D’Amato, M., Wang, M., Hoffmeister, M., Woods, M. O., Kim, M., Song, M., Iwasaki, M., Du, M., Udaltsova, N., Sawada, N., Vodicka, P., Campbell, P. T., Newcomb, P. A., Cai, Q., Pearlman, R., Pai, R. K., Schoen, R. E., Steinfelder, R. S., Haile, R. W., Vandenputtelaar, R., Prentice, R. L., Küry, S., Castellví-Bel, S., Tsugane, S., Berndt, S. I., Lee, S. C., Brezina, S., Weinstein, S. J., Chanock, S. J., Jee, S. H., Kweon, S. S., Vadaparampil, S., Harrison, T. A., Yamaji, T., Keku, T. O., Vymetalkova, V., Arndt, V., Jia, W. H., Shu, X. O., Lin, Y., Ahn, Y. O., Stadler, Z. K., Van Guelpen, B., Ulrich, C. M., Platz, E. A., Potter, J. D., Li, C. I., Meester, R., Moreno, V., Figueiredo, J. C., Casey, G., Lansdorp Vogelaar, I., Dunlop, M. G., Gruber, S. B., Hayes, R. B., Pharoah, P. D. P., Houlston, R. S., Jarvik, G. P., Tomlinson, I. P., Zheng, W., Corley, D. A., Peters, U. & Hsu, L., 2. okt. 2023, I: Nature Communications. 14, 13 s., 6147.

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  • Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

    Fernandez-Rozadilla, C., Timofeeva, M., Chen, Z., Law, P., Thomas, M., Schmit, S., Díez-Obrero, V., Hsu, L., Fernandez-Tajes, J., Palles, C., Sherwood, K., Briggs, S., Svinti, V., Donnelly, K., Farrington, S., Blackmur, J., Vaughan-Shaw, P., Shu, X. O., Long, J., Cai, Q., & 190 flereGuo, X., Lu, Y., Broderick, P., Studd, J., Huyghe, J., Harrison, T., Conti, D., Dampier, C., Devall, M., Schumacher, F., Melas, M., Rennert, G., Obón-Santacana, M., Martín-Sánchez, V., Moratalla-Navarro, F., Oh, J. H., Kim, J., Jee, S. H., Jung, K. J., Kweon, S. S., Shin, M. H., Shin, A., Ahn, Y. O., Kim, D. H., Oze, I., Wen, W., Matsuo, K., Matsuda, K., Tanikawa, C., Ren, Z., Gao, Y. T., Jia, W. H., Hopper, J., Jenkins, M., Win, A. K., Pai, R., Figueiredo, J., Haile, R., Gallinger, S., Woods, M., Newcomb, P., Duggan, D., Cheadle, J., Kaplan, R., Maughan, T., Kerr, R., Kerr, D., Kirac, I., Böhm, J., Mecklin, L. P., Jousilahti, P., Knekt, P., Aaltonen, L., Rissanen, H., Pukkala, E., Eriksson, J., Cajuso, T., Hänninen, U., Kondelin, J., Palin, K., Tanskanen, T., Renkonen-Sinisalo, L., Zanke, B., Männistö, S., Albanes, D., Weinstein, S., Ruiz-Narvaez, E., Palmer, J., Buchanan, D., Platz, E., Visvanathan, K., Ulrich, C., Siegel, E., Brezina, S., Gsur, A., Campbell, P., Chang-Claude, J., Hoffmeister, M., Brenner, H., Slattery, M., Potter, J., Tsilidis, K., Schulze, M., Gunter, M., Murphy, N., Castells, A., Castellví-Bel, S., Moreira, L., Arndt, V., Shcherbina, A., Stern, M., Pardamean, B., Bishop, T., Giles, G., Southey, M., Idos, G., McDonnell, K., Abu-Ful, Z., Greenson, J., Shulman, K., Lejbkowicz, F., Offit, K., Su, Y. R., Steinfelder, R., Keku, T., van Guelpen, B., Hudson, T., Hampel, H., Pearlman, R., Berndt, S., Hayes, R., Martinez, M. E., Thomas, S., Corley, D., Pharoah, P., Larsson, S., Yen, Y., Lenz, H. J., White, E., Li, L., Doheny, K., Pugh, E., Shelford, T., Chan, A., Cruz-Correa, M., Lindblom, A., Hunter, D., Joshi, A., Schafmayer, C., Scacheri, P., Kundaje, A., Nickerson, D., Schoen, R., Hampe, J., Stadler, Z., Vodicka, P., Vodickova, L., Vymetalkova, V., Papadopoulos, N., Edlund, C., Gauderman, W., Thomas, D., Shibata, D., Toland, A., Markowitz, S., Kim, A., Chanock, S., van Duijnhoven, F., Feskens, E., Sakoda, L., Gago-Dominguez, M., Wolk, A., Naccarati, A., Pardini, B., FitzGerald, L., Lee, S. C., Ogino, S., Bien, S., Kooperberg, C., Li, C., Lin, Y., Prentice, R., Qu, C., Bézieau, S., Tangen, C., Mardis, E., Yamaji, T., Sawada, N., Iwasaki, M., Haiman, C., Le Marchand, L., Wu, A., Qu, C., McNeil, C., Coetzee, G., Hayward, C., Deary, I., Harris, S., Theodoratou, E., Reid, S., Walker, M., Ooi, L. Y., Moreno, V., Casey, G., Gruber, S., Tomlinson, I., Zheng, W., Dunlop, M., Houlston, R. & Peters, U., jan. 2023, I: Nature Genetics. 55, s. 89-99

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  • Development and Validation of Risk Prediction Models for Colorectal Cancer in Patients with Symptoms

    Xu, W., Mesa-Eguiagaray, I., Kirkpatrick, T., Devlin, J., Brogan, S., Turner, P., Macdonald, C., Thornton, M., Zhang, X., He, Y., Li, X., Timofeeva, M., Farrington, S., Din, F., Dunlop, M. & Theodoratou, E., jul. 2023, I: Journal of Personalized Medicine. 13, 7, 16 s., 1065.

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  • Dissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk

    Zhou, X., Xiao, Q., Jiang, F., Sun, J., Wang, L., Yu, L., Zhou, Y., Zhao, J., Zhang, H., Yuan, S., Timofeeva, M., Spiliopoulou, A., Mesa-Eguiagaray, I., Farrington, S. M., Law, P. J., Houlston, R. S., Ding, K., Dunlop, M. G., Theodoratou, E. & Li, X., okt. 2023, I: British Journal of Cancer. 129, 8, s. 1306-1313

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  • Exploring the cross-cancer effect of smoking and its fingerprints in blood DNA methylation on multiple cancers: A Mendelian randomization study

    Zhou, Y., Zhou, X., Sun, J., Wang, L., Zhao, J., Chen, J., Yuan, S., He, Y., Timofeeva, M., Spiliopoulou, A., Mesa-Eguiagaray, I., Farrington, S. M., Ding, K., Dunlop, M. G., Qian, X., Theodoratou, E. & Li, X., 15. okt. 2023, I: International Journal of Cancer. 153, 8, s. 1477-1486

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