Maria Bibi Lyng

cand.scient., ph.d.

  • J.B. Winsløws Vej 25, 3.

    5000 Odense C

    Danmark

20072018
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Personlig profil

Forskningsområde

Hormone-receptor positive breast cancer, with special focus on responsiveness to treatment modalities.

 

CV

Born 1978

Education2004 M.Sc. degree in Biomedicine from University of Southern Denmark (SDU), Denmark

Research experience 2004 – 2005: Research assistant: Dept. of Pathology, Odense University Hospital (OUH), Denmark 2005 – 2009: Ph.D. student at Institute for Molecular Medicine, SDU, Denmark. The project was conducted in collaboration with Dept. of Pathology, OUH, Denmark. Title: Identification of which estrogen receptor positive breast cancer patients that will respond to endocrine treatment using focused gene profiling.

2009 – present : post.doc at Institute for Molecular Medicine, SDU, Denmark.

Teaching • Instructor for medical students. Subject: Module 2 - Enzyme kinetics. Scope: 60 hr pr year, excl preparation. March 2007 to January 2009. November 2010 – present. • Co-supervisor for master student (biomedicine). August 2008 – June 2009. • Co-supervisor for master student (biomedicine). September 2011 – august 2012.

Forskningsinformation

Breast cancer is a clinically heterogeneous disease with varying natural history and response to treatment. The estrogen receptor status is an important factor for determining the therapeutic approach. However, it is known that approximately 30 % of patients with an estrogen receptor positive primary tumor will have relapse of their disease at some point. We examine the gene expression to further understand and possibly aid in better prediction of response to therapy, employing primarily a quantitative real-time Reverse Transcriptase PCR-based (qRT-PCR-based) technique termed TaqMan® Low Density Array.

Fingeraftryk Fingeraftryk er baseret på at anvende teksten fra personernes videnskabelige dokumenter til at skabe et indeks med vægtede emneordskoncepter, som definerer de vigtigste emner for hver enkelt forsker.

  • 44 Lignende profiler
MicroRNAs Medicin og biovidenskab
Neoplasms Medicin og biovidenskab
Up-Regulation Medicin og biovidenskab
Hepatocyte Growth Factor Medicin og biovidenskab
Hormones Medicin og biovidenskab
Tamoxifen Kemiske forbindelser
Estrogen Receptors Kemiske forbindelser
Biomarkers Kemiske forbindelser

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Publikationer 2007 2018

100 Downloads (Pure)

Coexisting genomic aberrations associated with lymph node metastasis in breast cancer

Bao, L., Qian, Z., Lyng, M. B., Wang, L., Yu, Y., Wang, T., Zhang, X., Yang, H., Brünner, N., Wang, J. & Ditzel, H. J., 1. jun. 2018, I : Journal of Clinical Investigation. 128, 6, s. 2310-2324

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Lymph Nodes
Neoplasms
Exome
Mutation
Point Mutation
70 Downloads (Pure)
Åben adgang
Fil
Up-Regulation
Small Interfering RNA
Cell Movement
Gene Knockdown Techniques
fulvestrant

Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence

Goh, J. Y., Feng, M., Wang, W., Oguz, G., Yatim, S. M. J. M., Lee, P. L., Bao, Y., Lim, T. H., Wang, P., Tam, W. L., Kodahl, A. R., Lyng, M. B., Sarma, S., Lin, S. Y., Lezhava, A., Yap, Y. S., Lim, A. S. T., Hoon, D. S. B., Ditzel, H. J., Lee, S. C. & 2 flere, Tan, E. Y. & Yu, Q., 2017, I : Nature Medicine. 23, 11, s. 1319–1330

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Biomarkers
Chromosomes
Amplification
Tumors
Interleukin-1 Receptor-Associated Kinases

CDK6 as a predictive marker of response to fulvestrant treatment and a potential indicator of benefit from CDK4/6 inhibitor therapy in estrogen receptor-positive metastatic breast cancer

Alves, C. M. L., Elias, D., Lyng, M. B., Bak, M., Lykkesfeldt, A. E. & Ditzel, H., 9. jul. 2016.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

High CDK6 protects cells from fulvestrant-mediated apoptosis and is a predictor of resistance to fulvestrant in estrogen receptor-positive metastatic breast cancer

Alves, C. M. L., Elias, D., Lyng, M. B., Bak, M., Kirkegaard, T., Lykkesfeldt, A. E. & Ditzel, H. J., 2016, I : Clinical Cancer Research. 22, 22, s. 5514-5526

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Apoptosis
letrozole
Disease-Free Survival
fulvestrant
Gene Knockdown Techniques

Aktiviteter 2011 2011

  • 2 Organisering af eller deltagelse i workshop, kursus, seminar eller lignende
  • 2 Foredrag og præsentationer i privat eller offentlig virksomhed
  • 1 Organisering af eller deltagelse i konference
  • 1 Medlemskab af udvalg, kommission, råd, nævn, forening, organisation eller lignende

Molekylære profiler for ER+ brystkræftpatienter

Maria Bibi Lyng (Foredragsholder)
30. nov. 2011

Aktivitet: Foredrag og mundtlige bidragForedrag og præsentationer i privat eller offentlig virksomhed

karriereudviklingsprogram for yngre kvindelige forskere

Maria Bibi Lyng (Deltager)
23. aug. 201125. jan. 2012

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i workshop, kursus, seminar eller lignende

Kommunikation

Maria Bibi Lyng (Deltager)
20. jun. 201122. jun. 2011

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i workshop, kursus, seminar eller lignende

Ukendt (Ekstern organisation)

Maria Bibi Lyng (Deltager)
26. maj 2011

Aktivitet: MedlemskabMedlemskab af udvalg, kommission, råd, nævn, forening, organisation eller lignende

Keystone Symposia

Maria Bibi Lyng (Deltager)
6. mar. 201111. mar. 2011

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference