20022023
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Publikationer 2002 2019

2019
105 Downloads (Pure)

Collagen density regulates the activity of tumor-infiltrating T cells

Kuczek, D. E., Larsen, A. M. H., Thorseth, M-L., Carretta, M., Kalvisa, A., Siersbæk, M. S., Simões, A. M. C., Roslind, A., Engelholm, L. H., Noessner, E., Donia, M., Svane, I. M., Straten, P. T., Grøntved, L. & Madsen, D. H., 12. mar. 2019, I : Journal for immunotherapy of cancer. 7, 1, 15 s., 68.

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Neoplasms
Cell Proliferation
Gene Expression Profiling
Autocrine Communication
CD4-CD8 Ratio
4 Downloads (Pure)

Editorial: Regulating Liver Transcriptional Networks by Endocrine, Extracellular, and Intrinsic Cues

Grøntved, L. & Goldstein, I., dec. 2019, I : Frontiers in Endocrinology. 10, 3 s., 878.

Publikation: Bidrag til tidsskriftLederForskningpeer review

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39 Downloads (Pure)

Meta-analysis of Chromatin Programming by Steroid Receptors

Paakinaho, V., Swinstead, E. E., Presman, D. M., Grøntved, L. & Hager, G. L., 24. sep. 2019, I : Cell Reports. 28, 13, s. 3523-3534 15 s.

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Steroid Receptors
Chromatin
Meta-Analysis
Transcription Factors
Forkhead Transcription Factors
2018
107 Downloads (Pure)

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver

Kalvisa, A., Siersbæk, M. S., Præstholm, S. M., Christensen, L. J. L., Nielsen, R., Stohr, O., Vettorazzi, S., Tuckermann, J., White, M., Mandrup, S. & Grøntved, L., 10. dec. 2018, I : PLOS Biology. 16, 12, s. 1-32 e2006249.

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Glucocorticoid Receptors
Gene expression
Liver
insulin
Genes

Insulin signaling in combination with reduced glucocorticoid activity attenuate post-prandial gene expression in liver

Bidragets oversatte titel: Insulin signalering i kombination med nedsat glukokortikoid aktivitet hæmmer post-prandial genudtryk i leverenSiersbæk, M., Kalvisa, A., Præstholm, S. M., Christensen, L. J. L., Nielsen, R., Stohr, O., Vettorazzi, S., Tuckermann, J., White, M., Mandrup, S. & Grøntved, L., 11. sep. 2018.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

2017
155 Downloads (Pure)

Genome-wide identification of basic helix-loop-helix and NF-1 motifs underlying GR binding sites in male rat hippocampus

Pooley, J. R., Flynn, B. P., Grøntved, L., Baek, S., Guertin, M. J., Kershaw, Y. M., Birnie, M. T., Pellatt, A., Rivers, C. A., Schiltz, R. L., Hager, G. L., Lightman, S. L. & Conway-Campbell, B. L., 2017, I : Endocrinology. 158, 5, s. 1486-1501

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Glucocorticoid Receptors
Glucocorticoids
Chromatin Immunoprecipitation
Sequence Analysis
Organizations
198 Downloads (Pure)

High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss

Siersbæk, M., Varticovski, L., Yang, S., Baek, S., Nielsen, R., Mandrup, S., Hager, G., H. Chung, J. & Grøntved, L., 10. jan. 2017, I : Scientific Reports. 7, 13 s., 40220.

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High Fat Diet
Liver
Fasting
Insulin
Transcriptome

Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

Hönes, G. S., Rakov, H., Logan, J., Liao, X. H., Werbenko, E., Pollard, A. S., Præstholm, S. M., Siersbæk, M. S., Rijntjes, E., Gassen, J., Latteyer, S., Engels, K., Strucksberg, K. H., Kleinbongard, P., Zwanziger, D., Rozman, J., Gailus-Durner, V., Fuchs, H., De Angelis, M. H., Klein-Hitpass, L. & 8 flere, Köhrle, J., Armstrong, D. L., Grøntved, L., Bassett, J. H. D., Williams, G. R., Refetoff, S., Führer, D. & Moeller, L. C., 2017, I : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, s. E11323-E11332

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Thyroid Hormone Resistance Syndrome
Thyroid Hormone Receptors
Mutation
Nucleic Acid Regulatory Sequences
DNA
130 Downloads (Pure)

Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake

Madsen, D. H., Jürgensen, H. J., Siersbæk, M. S., Kuczek, D. E., Grey Cloud, L., Liu, S., Behrendt, N., Grøntved, L., Weigert, R. & Bugge, T. H., 26. dec. 2017, I : Cell Reports. 21, 13, s. 3662-3671

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Macrophages
Tumors
Collagen
Neoplasms
Degradation
2016

HIGH FAT DIET-INDUCED CHANGES OF MOUSE HEPATIC TRANSCRIPTION AND ENHANCER ACTIVITY ARE REVERSED BY SUBSEQUENT WEIGHT LOSS.

Bidragets oversatte titel: Ændringer i leverens transkriptionelle respons og enhancer aktivitet forårsaget at indtagelse af fedtholdig kost kan reverseres ved vægttab.Siersbæk, M., Varticovski, L., Yang, S., Baek, S., Nielsen, R., Mandrup, S., Hager, G., H. Chung, J. & Grøntved, L., 25. aug. 2016.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

118 Downloads (Pure)

MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3

Hallenborg, P., Siersbæk, M., Barrio-Hernandez, I., Nielsen, R., Kristiansen, K., Mandrup, S., Grøntved, L. & Blagoev, B., 1. jul. 2016, I : Cell Death & Disease. 7, 6, s. e2289

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Adipocytes
Adipogenesis
Ligases
Ubiquitin
Neoplasms

Steroid receptors reprogram FoxA1 occupancy through dynamic chromatin transitions

Swinstead, E. E., Miranda, T. B., Paakinaho, V., Baek, S., Goldstein, I., Hawkins, M., Karpova, T. S., Ball, D., Mazza, D., Lavis, L. D., Grimm, J. B., Morisaki, T., Grøntved, L., Presman, D. M. & Hager, G. L., 21. apr. 2016, I : Cell. 165, 3, s. 593-605

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Åben adgang
Steroid Receptors
Estrogen Receptors
Chromatin
Glucocorticoid Receptors
Forkhead Transcription Factors
2015

Structural Modeling of GR Interactions with the SWI/SNF Chromatin Remodeling Complex and C/EBP

Muratcioglu, S., Presman, D. M., Pooley, J. R., Grøntved, L., Hager, G. L., Nussinov, R., Keskin, O. & Gursoy, A., 15. sep. 2015, I : Biophysical Journal. 109, 6, s. 1227-39 13 s.

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Chromatin Assembly and Disassembly
Glucocorticoid Receptors
Mutation
Proteins
Leucine

Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling

Grøntved, L., Waterfall, J. J., Kim, D. W., Baek, S., Sung, M-H., Zhao, L., Park, J. W., Nielsen, R., Walker, R. L., Zhu, Y. J., Meltzer, P. S., Hager, G. L. & Cheng, S-Y., 2015, I : Nature Communications. 6, 7048.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Thyroid Hormone Receptors
chromatin
Chromatin Assembly and Disassembly
hormones
Transcriptional Activation
2014

Live cell imaging unveils multiple domain requirements for in vivo dimerization of the glucocorticoid receptor

Presman, D. M., Ogara, M. F., Stortz, M., Alvarez, L. D., Pooley, J. R., Schiltz, R. L., Grøntved, L., Johnson, T. A., Mittelstadt, P. R., Ashwell, J. D., Ganesan, S., Burton, G., Levi, V., Hager, G. L. & Pecci, A., mar. 2014, I : P L o S Biology. 12, 3, s. e1001813

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Åben adgang
dimerization
Dimerization
Glucocorticoid Receptors
image analysis
Imaging techniques
2013

C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements

Grøntved, L., John, S., Baek, S., Liu, Y., Buckley, J. R., Vinson, C., Aguilera, G. & Hager, G. L., 2013, I : E M B O Journal. 32, 11, s. 1568-83

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Glucocorticoid Receptors
Response Elements
Liver
Chromatin
Steroids

eRNAs promote transcription by establishing chromatin accessibility at defined genomic loci

Mousavi, K., Zare, H., Dell'orso, S., Grøntved, L., Gutierrez-Cruz, G., Derfoul, A., Hager, G. L. & Sartorelli, V., 2013, I : Molecular Cell. 51, 5, s. 606-17

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Nucleic Acid Regulatory Sequences
RNA
Myogenin
Chromatin Assembly and Disassembly
Muscle Development

Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation

Kieffer-Kwon, K-R., Tang, Z., Mathe, E., Qian, J., Sung, M-H., Li, G., Resch, W., Baek, S., Pruett, N., Grøntved, L., Vian, L., Nelson, S., Zare, H., Hakim, O., Reyon, D., Yamane, A., Nakahashi, H., Kovalchuk, A. L., Zou, J., Joung, J. K. & 6 flere, Sartorelli, V., Wei, C-L., Ruan, X., Hager, G. L., Ruan, Y. & Casellas, R., 2013, I : Cell. 155, 7, s. 1507-20

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Genes
Cells
myc Genes
Tissue
Cell Cycle

Reprogramming the chromatin landscape: interplay of the estrogen and glucocorticoid receptors at the genomic level

Miranda, T. B., Voss, T. C., Sung, M-H., Baek, S., John, S., Hawkins, M., Grøntved, L., Schiltz, R. L. & Hager, G. L., 2013, I : Cancer Research. 73, 16, s. 5130-9

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Glucocorticoid Receptors
Cytoplasmic and Nuclear Receptors
2012

Impact of chromatin structure on PR signaling: transition from local to global analysis

Grøntved, L. & Hager, G. L., 2012, I : Molecular and Cellular Endocrinology. 357, 1-2, s. 30-36

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Progesterone Receptors
Chromatin
Steroid Receptors
Chromatin Assembly and Disassembly
Metagenomics

Rapid genome-scale mapping of chromatin accessibility in tissue

Grøntved, L., Bandle, R., John, S., Baek, S., Chung, H-J., Liu, Y., Aguilera, G., Oberholtzer, C., Hager, G. L. & Levens, D., 2012, I : Epigenetics & Chromatin. 5, 10, 12 s.

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Chromosome Mapping
Serratia marcescens nuclease
Deoxyribonuclease I
CpG Islands
Endonucleases

The Transcription Factor Encyclopedia

Yusuf, D., Butland, S. L., Swanson, M. I., Bolotin, E., Ticoll, A., Cheung, W. A., Zhang, X. Y., Dickman, C. T., Fulton, D. L., Lim, J. S., Schnabl, J. M., Ramos, O. H., Vasseur-Cognet, M., de Leeuw, C. N., Simpson, E. M., Ryffel, G. U., Lam, E. W-F., Kist, R., Wilson, M. S., Marco-Ferreres, R. & 94 flere, Brosens, J. J., Beccari, L. L., Bovolenta, P., Benayoun, B. A., Monteiro, L. J., Schwenen, H. D., Grontved, L., Wederell, E., Mandrup, S., Veitia, R. A., Chakravarthy, H., Hoodless, P. A., Mancarelli, M., Torbett, B. E., Banham, A. H., Reddy, S. P., Cullum, R. L., Liedtke, M., Tschan, M. P., Vaz, M., Rizzino, A., Zannini, M., Frietze, S., Farnham, P. J., Eijkelenboom, A., Brown, P. J., Laperriere, D., Leprince, D., de Cristofaro, T., Prince, K. L., Putker, M., Del Peso, L., Camenisch, G., Wenger, R. H., Mikula, M., Rozendaal, M., Mader, S., Ostrowski, J., Rhodes, S. J., Van Rechem, C., Boulay, G., Olechnowicz, S. W., Breslin, M. B., Lan, M. S., Nanan, K. K., Wegner, M., Hou, J., Mullen, R. D., Colvin, S. C., Noy, P. J., Webb, C. F., Witek, M. E., Ferrell, S., Daniel, J. M., Park, J., Waldman, S. A., Peet, D. J., Taggart, M., Jayaraman, P-S., Karrich, J. J., Blom, B., Vesuna, F., O'Geen, H., Sun, Y., Gronostajski, R. M., Woodcroft, M. W., Hough, M. R., Chen, E., Europe-Finner, N., Karolczak-Bayatti, M., Bailey, J., Hankinson, O., Raman, V., Lebrun, D. P., Biswal, S., Harvey, C. J., Debruyne, J. P., Hogenesch, J. B., Hevner, R. F., Heligon, C., Luo, X. M., Blank, M. C., Millen, K. J., Sharlin, D. S., Forrest, D., Dahlman-Wright, K., Zhao, C., Mishima, Y., Sinha, S., Chakrabarti, R., Portales-Casamar, E., Sladek, F. M., Bradley, P. H. & Wasserman, W. W., 2012, I : Genome Biology (Online Edition). 13, 3, s. R24

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Encyclopedias
transcription factors
Information Storage and Retrieval
researchers
Research Personnel
2010

MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis

Grøntved, L., Madsen, M. S., Boergesen, M., Roeder, R. G. & Mandrup, S., 1. maj 2010, I : Molecular and Cellular Biology. 30, 9, s. 2155-69 15 s.

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Adipogenesis
PPAR gamma
Transcriptional Activation
TATA-Box Binding Protein
3T3-L1 Cells

The PPAR{gamma}2 A/B-domain plays a gene-specific role in transactivation and cofactor recruitment

Bugge, A. S., Grøntved, L., Aagaard, M. M., Borup, R. & Mandrup, S., 1. jun. 2009, I : Molecular Endocrinology. 23, 6, s. 794-808 14 s.

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PPAR gamma
Transcriptional Activation
CREB-Binding Protein
Cyclic AMP Response Element-Binding Protein
Chromatin Immunoprecipitation
2008

Co-factors necessary for PPAR mediated transactivation of endogenous target genes

Grøntved, L., Nielsen, R., Stunnenberg, H. & Mandrup, S., 2008.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

Transcriptional Activation
PPAR alpha
Nucleotide Motifs
Cytoplasmic and Nuclear Receptors
Lipid Metabolism

Extensive mapping of PPAR binding to genomic DNA

Nielsen, R., Pedersen, T. Å., Trindade, L., van Driel, M., Grøntved, L., Brozek, J. J., Staels, B., Hum, D., Stunnenberg, H. & Mandrup, S., 2008.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

DNA
Hepatocellular Carcinoma
Adipogenesis
Immunoglobulin Class Switching
Cell Line

MED1 independent activation of endogenous target genes by PPARα

Grøntved, L., Bugge, A. K., Roeder, R. G. & Mandrup, S., 2008.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

PPAR alpha
PPAR gamma
Transcriptional Activation
Cytoplasmic and Nuclear Receptors

PPARγ2s A/B-domæne spiller en genspecifik rolle i transaktivering og co-faktor rekruttering

Bidragets oversatte titel:   The PPARγ2 A/B-domain plays a gene specific role in transactivation and co-factor recruitmentBugge, A. S., Grøntved, L., M. Aagaard, M., Borup, R. & Mandrup, S., 2008.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

Adenoviridae
Fibroblasts
Natural Science Disciplines
Chromatin Immunoprecipitation
Transcriptional Activation

The adipogenic acetyltransferase Tip60 targets activation function 1 of peroxisome proliferator-activated receptor gamma

van Beekum, O., Brenkman, A. B., Grøntved, L., Hamers, N., van den Broek, N. J. F., Berger, R., Mandrup, S. & Kalkhoven, E., 2008, I : Endocrinology. 149, 4, s. 1840-1849 9 s.

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PPAR gamma
Adipocytes
Proteins
Adipogenesis
Chromatin Immunoprecipitation
2006

Molecular mechanisms of PPAR subtype specific transactivation of target genes as investigated by ChIP and adenoviral vectors

Nielsen, R., Grøntved, L., Bugge, A. K., Stunnenberg, H. & Mandrup, S., 2006.

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskning

Peroxisome proliferator-activated receptor subtype- and cell-type-specific activation of genomic target genes upon adenoviral transgene delivery

Nielsen, R., Grøntved, L., Stunnenberg, H. G. & Mandrup, S., 2006, I : Molecular and Cellular Biology. 26, 15, s. 5698-5714 16 s.

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PPAR gamma
PPAR alpha
Chromatin Immunoprecipitation
Transcriptional Activation
Ligands

PPAR A/B domains in ligand-dependent and independent transactivation of genomic target genes.

Bugge, A. K., Grøntved, L., Nielsen, R., Larsen, M. M. K. & Mandrup, S., 2006.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

PPAR subtype and cell type specific activation of genomic target genes upon adenoviral transgene delivery

Nielsen, R., Grøntved, L., Stunnenberg, H. & Mandrup, S., 2006.

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskning

2002

The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents.

Helledie, T., Grøntved, L., Jensen, S. S., Kiilerich, P., Rietveld, L., Albrektsen, T., Boysen, M. S., Nøhr, J., Larsen, L. K., Fleckner, J., Stunnenberg, H. G., Kristiansen, K. & Mandrup, S., 2002, I : Journal of Biological Chemistry. 277, 30, s. 26821-30

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Diazepam Binding Inhibitor
Gene encoding
PPAR gamma
Response Elements
Rodentia