Forskningsinformation

LIST OF PUBLICATIONS

1. Research Articles

A. Schädlich, C. Rose, J. Kuntsche, H. Caysa, T. Mueller, A. Gӧpferich, K. Mäder. How stealthy are PEG-PLA nanoparticles? An NIR in vivo study combined with detailed size measurements. Pharm. Res., in press (doi 10.1007/s11095-011-0426-5).

J. Kuntsche, M.H.J. Koch, F. Steiniger, H. Bunjes. Influence of stabilizer systems on the properties and phase behavior of supercooled smectic nanoparticles. J. Colloid Interf. Sci. 350:229-239 (2010).

J. Kuntsche, I. Freisleben, F. Steiniger, A. Fahr. Temoporfin-loaded liposomes: Physicochemical characterization. Eur. J. Pharm. Sci. 40:305-315 (2010).

J. Kuntsche, K. Klaus, F. Steiniger. Size determinations of colloidal fat emulsions: A comparative study. J. Biomed. Nanotechnol. 5:384-395 (2009).

J. Kuntsche, M.H.J. Koch, A. Fahr, H. Bunjes. Supercooled smectic nanoparticles: Influence of the matrix composition and in vitro cytotoxicity. Eur. J. Pharm. Sci. 38:238-248 (2009).

M.M. Badran, J. Kuntsche, A. Fahr. Skin penetration enhancement by a microneedle device (Dermaroller®) in vitro: Dependency on needle size and applied formulation. Eur. J. Pharm. Sci. 36:511-523 (2009).

S. Pappinen, M. Hermansson, J. Kuntsche, P. Somerharju, P. Wertz, A. Urtti. Comparison of rat epidermal keratinocytes organotypic culture (ROC) with intact human skin: Lipid composition and thermal phase behaviour of the stratum corneum. BBA 1778:824-834 (2008).

J. Kuntsche, H. Bunjes, A. Fahr, S. Pappinen, S. Rönkkö, M. Suhonen, A. Urtti. Interaction of lipid nanoparticles with human epidermis and an organotypic cell culture model. Int. J. Pharm. 354:180-195 (2008).

J. Kuntsche, H. Bunjes. Influence of preparation conditions and heat treatment on the properties of supercooled smectic cholesteryl myristate nanoparticles. Eur. J. Pharm. Biopharm. 67:612-620 (2007).

J. Kuntsche, M.H.J. Koch, M. Drechsler, H. Bunjes. Crystallization behavior of supercooled smectic nanoparticles containing phospholipids as stabilizers. Colloid Surf. B 44:25-35 (2005).

J. Kuntsche, K. Westesen, M. Drechsler, M.H.J. Koch, H. Bunjes. Supercooled smectic nanoparticles: A potential novel carrier system for poorly water soluble drugs. Pharm. Res. 21:1834-1843 (2004).

2. Review Articles and Book Chapters

J. Kuntsche, J.C. Horst, H. Bunjes. Cryogenic transmission electron microscopy (cryo-TEM) for studying the morphology of colloidal drug delivery systems. Int. J. Pharm., in press (doi 10.1016/j.ijpharm.2011.02.001).

J. Kuntsche, K. Mäder. Solid lipid nanoparticles (SLN) for drug delivery. In: V. Torchillin, M.M. Amiji (Eds.) Handbook of Materials for Nanomedicine. Pan Stanford Publ., Singapore, 2011, pp. 383-443.

H. Bunjes, J. Kuntsche. Lipid nanoparticles based on liquid crystalline phases. In: V. Torchillin, M.M. Amiji (Eds.) Handbook of Materials for Nanomedicine. Pan Stanford Publ., Singapore, 2011, pp. 445-494.

H. Bunjes, J. Kuntsche. Supercooled Smectic Nanoparticles. In: D. Thassu, M. Deleers, Y. Pathak (Eds.) Nanoparticulate Drug Delivery Systems. Informa Health Care, New York, 2007, pp. 129-140.

A. Fahr, P. van Hoogevest, J. Kuntsche, M.L.S. Leigh. Lipophilic drug transfer between liposomal and biological membranes: What does it mean for parenteral and oral drug delivery? J. Liposome Res. 16:281-301 (2006).

3. Patent Application

H. Bunjes, G. Hammer, J. Kuntsche, K. Westesen. Nanopartikuläres Trägersystem für Wirkstoffe, insbesondere für biologisch aktive Substanzen, und Verfahren zu seiner Herstellung. German Patent Application 2003, DE 103 04 226 A1 2004.08.12.

4. Conference Contributions (Selection)

4.1. Oral Presentations

J. Kuntsche. Smectic nanoparticles: Properties and characterization. Invited contribution, Advanced characterization of particles by AF4-MALS, organized by Wyatt Technology Europe, Dernbach, Germany, September 28, 2010.

J. Kuntsche. Asymmetrical flow field-flow fractionation for the characterization of lipid-based colloidal formulations. Invited contribution, Particles 2010, Orlando, Florida/USA, May 22-25, 2010.

C. Augsten, J. Kuntsche, K. Mäder. Asymmetrical flow field-flow fractionation: Characterization of Particles and Polymers. Invited contribution, Moderne Trends bei der Charakterisierung nanostrukturierter Systeme, organized by the University of Potsdam (Department of Colloid Chemistry) and Malvern Instruments, Potsdam, Germany, April 10, 2008.

J. Kuntsche, I. Freisleben, A. Fahr. Evaluation and physicochemical characterization of different liposome formulations of temoporfin. Oral presentation, Annual Meeting of the Controlled Release Society Local Chapter, Freiburg, Germany, March 22-23, 2007.

J. Kuntsche, K. Westesen, H. Bunjes. Investigations on physicochemical properties of cholesteryl myristate nanoparticles. Annual Meeting of the German Pharmaceutical Society (DPhG), Würzburg, Germany, October 8-12, 2003.

4.2. Poster Presentations

J. Kuntsche, S. Sänger, F. Mengersen, H. Bunjes. Analysis of supercooled smectic nanoparticles by asymmetrical flow field-flow fractionation. Poster, Annual Meeting of the German Pharmaceutical Society (DPhG), Braunschweig, Germany, October 04 – 07, 2010.

C. Decker, A. Fahr; J. Kuntsche. Asymmetrical flow field-flow fractionation for the characterization of liposomes. Poster, Annual Meeting of the German Pharmaceutical Society (DPhG), Braunschweig, Germany, October 04 – 07, 2010.

A. Schädlich, C. Rose, J. Kuntsche, T. Mueller, A. Göpferich, K. Mäder. In vivo fate and tumor targeting studies of new synthesized PEG-PLA block copolymer nanoparticles using non-invasive fluorescence imaging. Poster, 7th World Meeting Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Valetta, Malta, March 08-11, 2010.

J. Kuntsche, C. Decker, A. Fahr. Characterization of temoporfin-loaded liposomes by asymmetrical flow field-flow fractionation (A4F). Poster, 7th World Meeting Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Valetta, Malta, March 08-11, 2010.

K. Klaus, C. Decker, A. Fahr, J. Kuntsche. Studies on colloidal emulsions and liposomes by asymmetrical flow field-flow fractionation. Poster, Annual Meeting of the German Pharmaceutical Society (DPhG), Jena, Germany, September 28 – October 01, 2009.

J. Kuntsche, K.S. Ahmed, A. Fahr, S.S. Funari, P. Garidel. Stratum corneum lipid organization in an epidermal cell culture model (ROC) studied by synchrotron SAXS. Poster, Annual Meeting of the German Pharmaceutical Society (DPhG), Jena, Germany, September 28 – October 01, 2009.

A. Belete, H. Metz, J. Kuntsche, K. Mäder. Development of potential MRI contrast agents using hydrophobic magnetite nanocrystals: from chemical synthesis to in vivo applications. Poster, 36th Annual Meeting of the Controlled Release Society, Copenhagen, Denmark, July 18-22, 2009.

J. Kuntsche, K.S. Ahmed, A.T. Nguyen, A. Fahr. Development of an organotypic skin model based on rat epidermal keratinocytes (REK) and de-epidermized dermis. Poster, Annual Meeting of the Controlled Release Society Local Chapter, Halle/Saale, Germany, March 19-20, 2009.

J. Kuntsche, A. Besheer, K. Mäder. Investigations of hydrophobically modified hydroxyethyl starches (HM-HES) by asymmetrical flow field-flow fractionation. Poster, 7th International Symposium on Poylmer Therapeutics: From Laboratory to Clinical Practice, Valencia, Spain, May 26-28, 2008.

J. Kuntsche, K. Mäder. Characterization of hydroxyethyl starches with different molecular weights by asymmetrical flow field-flow fractionation. Poster, Annual Meeting of the Controlled Release Society Local Chapter, Braunschweig, Germany, March 4-5, 2008.

J. Kuntsche. H. Bunjes, A. Urtti. Interaction of different kinds of lipid nanoparticles with human skin and an organotypic cell culture model. Poster, 33th Annual Meeting of the Controlled Release Society, Vienna, Austria, July 22-26, 2006.

J. Kuntsche, H. Bunjes. Investigations on the stability of supercooled smectic nanoparticles upon autoclaving and heat treatment. Poster, 33th Annual Meeting of the Controlled Release Society, Vienna, Austria, July 22-26, 2006.

J. Kuntsche, K. Westesen, M. Drechsler, H. Bunjes. Crystallization behavior of supercooled smectic nanoparticles: Particularities of phospholipid based systems. Poster, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, Germany, March 15-18, 2004.

J. Kuntsche, K. Westesen, H. Bunjes. Crystallization behavior of cholesterol ester nanoparticles in dependence on composition. Poster, 42th Biennial Meeting of the German Colloid Society/Bayreuth Polymer Symposium, Bayreuth, September 28-30, 2003.

J. Kuntsche, K. Westesen, H. Bunjes. Supercooled smectic nanoparticles – Influence of the matrix composition on the phase behavior. Poster, 30th Annual Meeting of the Controlled Release Society, Glasgow, Great Britain, July 19-23, 2003.

J. Kuntsche, K. Westesen, H. Bunjes. Supercooled smectic nanoparticles – Influence of the stabilizer system on physicochemical properties. Poster, 30th Annual Meeting of the Controlled Release Society, Glasgow, Great Britain, July 19-23, 2003.