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Personlig profil

Forskningsinteresser

Cardiovascular immunology and metabolism

Cardiovascular diseases (CVDs) are the leading cause of mortality and disability worldwide, imposing a significant burden on society. Coronary heart disease and cerebrovascular disease, the two most common forms of cardiovascular disease, are caused by acute complications of atherosclerosis. CVD kills over 17 million individuals every year, which accounts for one third of all global deaths.

Although population-wide management of traditional risk factors for CVDs (e.g. hyperlipidemia, high-blood pressure, glycaemia) has reduced the incidence of cardiovascular events in developed countries, substantial residual risk remains. Thus, translational therapeutic strategies targeting novel molecular pathways regulating atherosclerosis are needed.

Atherosclerosis is a chronic inflammatory disease initiated by retention and accumulation of lipids in the artery wall, especially low-density lipoprotein (LDL), leading to maladaptive responses of innate and adaptive immune cells. Notably, metabolism and activation are fully integrated in immune cells, and systemic or microenvironmental changes in metabolism have been shown to modulate their responses.

In pioneer work, we have identified several targets to modulate the unwanted immune responses in the artery wall, including components of LDL that can trigger innate and adaptive immune cells, and metabolites of the essential amino acid tryptophan, via the Kynurenine pathway. Our research indicates that metabolites are not just ‘fuels’ in their metabolic pathways, but that they can also act as signalling molecules in immune cells and influence atherosclerosis. By increasing the understanding of the immunometabolic reactions controlling immune responses in atherogenesis, our research will lead to the development of new drugs to treat and prevent atherosclerotic CVDs.

Eksterne ansættelser

Forskere, Karolinska Institutet

2014 → …

Forskningsområder

  • Åreforkalkning
  • Immunsystemet
  • Metabolisme

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  • 11 Lignende profiler

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Publikationer

3-Hydroxyanthralinic acid Metabolism Controls the Hepatic Srebp/Lipoprotein axis, Inhibits Inflammasome Activation in Macrophages, and Decreases Atherosclerosis in LDLR-/- Mice

Berg, M., Polyzos, K. A., Agardh, H., Baumgartner, R., Forteza, M. J., Kareinen, I., Gisterå, A., Bottcher, G., Hurt-Camejo, E., Hansson, G. K. & Ketelhuth, D. F. J., 7. okt. 2019, I : Cardiovascular Research.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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    Exhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma

    Rad Pour, S., Morikawa, H., Kiani, N. A., Yang, M., Azimi, A., Shafi, G., Shang, M., Baumgartner, R., Ketelhuth, D. F. J., Kamleh, M. A., Wheelock, C. E., Lundqvist, A., Hansson, J. & Tegnér, J., 21. aug. 2019, I : Scientific Reports. 9, 1, 11 s., 12150.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability

    Centa, M., Jin, H., Hofste, L., Hellberg, S., Busch, A., Baumgartner, R., Verzaal, N. J., Lind Enoksson, S., Perisic Matic, L., Boddul, S. V., Atzler, D., Li, D. Y., Sun, C., Hansson, G. K., Ketelhuth, D. F. J., Hedin, U., Wermeling, F., Lutgens, E., Binder, C. J., Maegdesfessel, L. & 1 flere, Malin, S. G., 21. maj 2019, I : Circulation. 139, 21, s. 2466-2482

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology

    Tuñón, J., Badimón, L., Bochaton-Piallat, ML., Cariou, B., Daemen, MJ., Egido, J., Evans, PC., Hoefer, IE., Ketelhuth, DFJ., Lutgens, E., Matter, CM., Monaco, C. & Bäck, M., 2019, I : Cardiovascular Research. 115, s. 10-19

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

    Ketelhuth, D. F. J., Lutgens, E., Bäck, M., Binder, C. J., Van den Bossche, J., Daniel, C., Dumitriu, I. E., Hoefer, I., Libby, P., O'Neill, L., Weber, C. & Evans, P. C., 15. jul. 2019, I : Cardiovascular Research. 115, 9, s. 1385-1392

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Aktiviteter

    • 21 Konferenceoplæg
    • 1 Gæsteforelæsning, undervisning og kursusvirksomhed ved andre universiteter

    Artery Club - OUH/SDU

    Daniel Ketelhuth (Oplægsholder)

    18. feb. 2020

    Aktivitet: Foredrag og mundtlige bidragGæsteforelæsning, undervisning og kursusvirksomhed ved andre universiteter

    Fokus kranskärl

    Daniel Ketelhuth (Oplægsholder)

    14. jan. 2019

    Aktivitet: Foredrag og mundtlige bidragKonferenceoplæg

    Karolinska Institute-Shandong joint symposium

    Daniel Ketelhuth (Oplægsholder)

    18. okt. 2018

    Aktivitet: Foredrag og mundtlige bidragKonferenceoplæg

    INTRICARE EU Horizon 2020 Marie Curie ITN course

    Daniel Ketelhuth (Oplægsholder)

    25. sep. 2018

    Aktivitet: Foredrag og mundtlige bidragKonferenceoplæg

    24th Annual Scientific Research Meeting KI-Mayo Clinic

    Daniel Ketelhuth (Oplægsholder)

    10. sep. 2018

    Aktivitet: Foredrag og mundtlige bidragKonferenceoplæg