• Campusvej 55

    5230 Odense M

    Danmark

1994 …2022
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Personlig profil

CV

Personal Data: Born October 22, 1963;  Married; Five children

University Address

Nucleic Acid Center
Department of Physics and Chemistry
University of Southern Denmark, Odense
Campusvej 55
DK-5230 Odense M, Denmark
Tel. +45 6550 2510
Fax. +45 6615 8780 
E-mail: jwe@sdu.dk

Private Address: Frydenlundsvej 4, 5550 Langeskov,  Denmark. Tel. +45 20846872

University Education:

Cand. scient.: Odense University (Chemistry/Biology; December 1988)
Ph.D.: Odense University (January 1992): "Synthesis of 2',3'-Dideoxynucleoside Analogues with Potential Activity against HIV" 

Research Fellow: Department of Chemistry and Biochemistry, University of Colorado, USA (October 1990 - June 1991)

Assistant Professor: In organic chemistry at Department of Chemistry, Odense University (September 1991 - March 1994)

Associate Professor: In organic chemistry at Department of Chemistry, Odense University (April 1994 - September 1996)

Professor In bioorganic chemistry at Department of Chemistry, University of Copenhagen (October 1996 - July 2000) 
In organic chemistry at Department of Chemistry, University of Southern Denmark, Odense (August 2000 -) 

Present Research: 

Bioorganic chemistry; nucleic acid biotechnology; Nanobioscience 

Editorial Board Member:

Oligonucleotides (Mary Ann Liebert). Artificial DNA: PNA & XNA (Landes BioScience)

Publications: Author or co-author of >380 research papers in peer-reviewed scientific journals. H-Index = 55; Citations > 13.000 (SCI: Wengel J*; first publication in 1989) 

Lectures and Seminars: More than 120 invited lectures and seminars have been presented during the last 10 years in Denmark and abroad

IPR and Innovation: Inventor or co-inventor on more than ten patents and patent applications. Co-inventor of the LNA (Locked Nucleic Acid) technology that forms the basis of the business activities of the companies Exiqon A/S (~60 employees) and Santaris Pharma A/S (~70 employees). Co-founder (2006) of RiboTask ApS. 

Honors and Awards:

- Elected member of the Royal Danish Academy of Sciences and Letters;
- Elected member of the Danish Academy of Natural Sciences;
- Elected member of the Danish Academy of Technical Sciences;
- Natural Science Faculty Teaching Award, Odense University, 1995;
- Bjerrum-Brøndsted-Lang Lecturer, 1997;
- Parker-Davis Lecturer, Ohio State University, 2000;
- Biochemistry Teaching Award, University of Copenhagen, 2000;
- The Bjerrum Chemistry Award, 2001;
- The Lundbeck Foundation's Research Prize for Young Researchers, 2002;
- The Danish Academy of Natural Sciences Industry Award, 2002;
- The UCB Award for Excellence in Medicinal Chemistry 2004;
- Villum Kann Rasmussen Grant for Technical Research 2005;
- OBC Lecture Award Winner 2006;
- The Danish Association of Masters and PhD Research Award 2007;
- The Ib Henriksen Foundation Research Award 2008 


Major Research Funding since 2001:

ERC Advanced Grant
- EVOLNA – Evolution of LNA-based Aptamers (2011-2016; 2.5 mio. €).

International Funds – Partner in EU projects, local PI
- Pharmaco-Gene (LSHB-CT-2007-037283) - Design of Targeted Gene Pharmaceutics Using Self-assembling Functional Entities (2007-2010; 0.43 mio. € share of funding);
- RIGHT (LSHB-CT-2004-005276) - RNA Interference Technology as Human Therapeutic Tool (2005-2008; 0.74 mio. € share of funding);
- NAC-DRUG (MEST-CT-2004-504018) - Nucleic Acid Based Drug Design Training Center (2004-2008; 1.65 mio. €);

Public Danish Funds – Center Director and PI
- The Danish National Research Foundation: “Nucleic Acid Center” (2001-2011; 9.0 mio. €)

Private Danish Funds – PI 
-The Biomolecular Nanoscale Engineering Center (2012-2022; 60 mio. DKK) – A VKR Center of Excellence funded by the Villum Foundation

- VKR Fonden: “Electronic Properties of DNA-Based Molecules - Single Molecule Nanoscience” (2007-2010; 1.06 mio. €);
- Lundbeckfonden: “NanoCan Center - Nanomedicine research center for cancer stem cell targeting therapeutics” (2009-2014; 0.70 mio. € share of funding) 



Administration

- Member of the board, Department of Chemistry, Odense University (1991-1992 and 1996)
- Member of the board, The Danish Chemical Society: Organic Chemistry Section (1997-2000); Chairman of the board (1999-2000)
- Chairman of the board, Chemical Laboratory II, Department of Chemistry, University of Copenhagen (1998-2000)
- Director of the Nucleic Acid Center funded by the Danish National Research Foundation (2001-)
- Chairman of the board, RiboTask ApS (2006-)
- Member of the Leadership Group, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark (2006-)
- Chairman of the research strategy board, Science Faculty, University of Southern Denmark (2011-)

Fingeraftryk Fingeraftryk er baseret på at anvende teksten fra personernes videnskabelige dokumenter til at skabe et indeks med vægtede emneordskoncepter, som definerer de vigtigste emner for hver enkelt forsker.

  • 14 Lignende profiler
Oligonucleotides Kemiske forbindelser
Nucleic Acids Kemiske forbindelser
Monomers Kemiske forbindelser
DNA Kemiske forbindelser
Nucleic acids Teknik og materialevidenskab
RNA Kemiske forbindelser
Nucleosides Kemiske forbindelser
Nucleotides Kemiske forbindelser

Netværk Nyligt eksternt samarbejde på landeniveau. Dyk ned i detaljerne ved at klikke på punkterne.

Publikationer 1994 2019

21 Downloads (Pure)

A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine

Andersen, V. L., Vinther, M., Kumar, R., Ries, A., Wengel, J., Nielsen, J. S. & Kjems, J., 2019, I : Theranostics. 9, 9, s. 2662-2677

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Nucleic Acids
Medicine
Precision Medicine
Confocal Microscopy
Hepatocytes
81 Downloads (Pure)

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

Garcia, J. P., Stein, J., Cai, Y., Riemers, F., Wexselblatt, E., Wengel, J., Tryfonidou, M., Yayon, A., Howard, K. A. & Creemers, L. B., 28 jan. 2019, I : Journal of Controlled Release. 294, s. 247-258

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Hydrogel
Hyaluronic Acid
Chondrocytes
Joints
Disintegrins

Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects

Kotkowiak, W., Wengel, J., Scotton, C. J. & Pasternak, A., 14 mar. 2019, I : Journal of Medicinal Chemistry. 62, 5, s. 2499-2507

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Nucleic Acids
Nucleotide Aptamers
RNA
Freezing
Serum
34 Downloads (Pure)

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

Moura, J., Sørensen, A., Leal, E. C., Svendsen, R., Carvalho, L., Willemoes, R. J., Jørgensen, P. T., Jenssen, H., Wengel, J., Dalgaard, L. T. & Carvalho, E., 9 apr. 2019, I : Scientific Reports. 9, 11 s., 5836.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Fibroblast Growth Factor 7
MicroRNAs
Skin
Wounds and Injuries
Diabetic Foot
35 Downloads (Pure)

Oligonucleotide binding to non-B-DNA in MYC

Umek, T., Sollander, K., Bergquist, H., Wengel, J., Lundin, K. E., Edvard Smith, C. I. & Zain, R., 12 mar. 2019, I : Molecules. 24, 5, 11 s., 1000.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
oligonucleotides
Oligonucleotides
genes
strands
Genes

Aktiviteter 2003 2019

Aarhus University - MSc exam

Jesper Wengel (Censor)
27 jun. 2019

Aktivitet: Censoraktivitet og eksamineringEkstern censoraktivitet

Research meeting at Karolinska Institute

Jesper Wengel (Deltager)
20 maj 2019

Aktivitet: Andre aktiviteterAndet

1st DelNAM Summer School - In vivo gene delivery of nanomedicines

Jesper Wengel (Deltager)
7 maj 20199 maj 2019

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

1st DelNAM Workshop on Design and Synthesis of Nucleic Acids Mimics

Jesper Wengel (Arrangør)
21 mar. 2019

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i workshop, kursus, seminar eller lignende

Fil

Novel building blocks for therapeutic oligonucleotides

Jesper Wengel (Keynote speaker)
22 nov. 2018

Aktivitet: Foredrag og mundtlige bidragKonferenceoplæg

Fil

Projekter 2007 2022

Priser

Dansk Magisterforenings forskningspris 2007

Jesper Wengel (Modtager), 27 nov. 2007

Pris: Priser, stipendier, udnævnelser

Direktør Ib Henriksens Fond Forskerprisen 2008

Jesper Wengel (Modtager), 1 dec. 2008

Pris: Priser, stipendier, udnævnelser

OBC Lecture Award Winner 2006

Jesper Wengel (Modtager), 10 sep. 2006

Pris: Priser, stipendier, udnævnelser

The UCB Award for Excellence in Medicinal Chemistry 2004

Jesper Wengel (Modtager), 15 aug. 2004

Pris: Priser, stipendier, udnævnelser

Villum Kann Rasmussen Fondens Årslegat 2005

Jesper Wengel (Modtager), 21 jan. 2005

Pris: Priser, stipendier, udnævnelser

Undervisning og vejledning