20062020

Publikationer pr. år

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Personlig profil

Forskningsområde

My research focuses on how the cell’s architecture influences its metabolism and intracellular signaling and consequently its function. This has been accomplished by the use of experimental methods where the cell’s intracellular organization is maintained and by high-resolution imaging techniques as the electron microscope. Initially, my concern has been to elucidate the role and regulation of local storage of glycogen molecules (the principal storage form of glucose) in specific micro-domains within the cell. Using three different approaches, I and collaborators have shown that the link between glycogen depletion and impaired muscle function most likely originates from a connection between intramyofibrillar glycogen and SR calcium release. This was shown in mechanically skinned rat muscle fibers (Nielsen et al., 2009), isolated human SR vesicles (Ørtenblad et al.,2011), and intact mouse muscle fibers (Nielsen et al., 2014). Interestingly, we have also found that intramyofibrillar glycogen is preferentially depleted during prolonged exercise (Nielsen et al., 2011), which suggests that this could be the explanation for the glycogen-dependent component in the complexity of impaired muscle function during metabolic stress. In perspective, we have found that rodents and humans have almost the same amount of intramyofibrillar glycogen (Nielsen et al. 2014,2015), despite 4-fold differences in total glycogen, indicating a conserved role of intramyofibrillar glycogen across species. List of publications via Pubmed or Web of Science: "Nielsen J AND (Ortenblad N OR Schroder HD OR Vissing K) NOT (Nielsen JS OR Nielsen JH OR Nielsen JB OR Nielsen JL)".

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Publikationer

Inhibition of glycogenolysis prolongs action potential repriming period and impairs muscle function in rat skeletal muscle

Jensen, R., Nielsen, J. & Ørtenblad, N., feb. 2020, I : The Journal of Physiology. 598, 4, s. 789-803

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Mitochondrial Structure and Function in the Metabolic Myopathy Accompanying Patients with Critical Limb Ischemia

    Groennebaek, T., Billeskov, T. B., Schytz, C. T., Jespersen, N. R., Bøtker, H. E., Olsen, R. K. J., Eldrup, N., Nielsen, J., Farup, J., De Paoli, F. V. & Vissing, K., 28. feb. 2020, I : Cells. 9, 3, 570.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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    Utilization of biomarkers as predictors of skeletal muscle mitochondrial content after physiological intervention and in clinical settings

    Groennebaek, T., Nielsen, J., Jespersen, N. R., Botker, H. E., de Paoli, F. V., Miller, B. F. & Vissing, K., 1. jun. 2020, I : American Journal of Physiology: Endocrinology and Metabolism. 318, 6, s. E886-E889

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Myocardial subcellular glycogen distribution and sarcoplasmic reticulum Ca2+ handling: effects of ischaemia, reperfusion and ischaemic preconditioning

    Nielsen, J., Johnsen, J., Pryds, K., Ørtenblad, N. & Bøtker, H. E., 19. okt. 2019, I : Journal of Muscle Research and Cell Motility.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Skeletal muscle sarcoplasmic reticulum Ca2 uptake preferentially use glycogenolytic derived ATP

    Bidragets oversatte titel: Calcium optag i skeletmusklernes sarkoplasmatiske retikulum afhænger af glykogenolytisk afledt ATPKristiansen, M. R., Jensen, R., Nielsen, J. & Ørtenblad, N., 2019.

    Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

    Aktiviteter

    Projektstyring, VIP

    Joachim Nielsen (Deltager)

    22. sep. 2016

    Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i workshop, kursus, seminar eller lignende

    European Muscle Conference 2016

    Joachim Nielsen (Deltager)

    2. sep. 2016

    Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

    European Journal of Applied Physiology (Tidsskrift)

    Joachim Nielsen (Peer reviewer)

    2016 → …

    Aktivitet: Redaktionelt arbejde og fagfællebedømmelsePeer reviewer/fagfællebedømmer af manuskripterForskning

    Assessment and evaluation of human muscle, nervous system and tendon-aponeurosis function in sports science, clinical science and aging

    Joachim Nielsen (Oplægsholder)

    10. mar. 2015

    Aktivitet: Foredrag og mundtlige bidragGæsteforelæsning, undervisning og kursusvirksomhed ved andre universiteter

    Journal of Physiology and Biochemistry (Tidsskrift)

    Joachim Nielsen (Peer reviewer)

    2015 → …

    Aktivitet: Redaktionelt arbejde og fagfællebedømmelsePeer reviewer/fagfællebedømmer af manuskripterForskning

    Presse/medier

    Forskere: Derfor kan Delaney løbe solen sort

    Joachim Nielsen

    01/11/2016

    1 element af Mediedækning

    Presse/medie

    DR P4 Fyn: P4 morgen

    Joachim Nielsen

    01/11/2016

    1 Mediebidrag

    Presse/medie

    Priser

    Young Investigator Award - Congress of the European College of Sport Science

    Nielsen, Joachim (Modtager), 27. jun. 2009

    Pris: Priser, stipendier, udnævnelser

    Undervisning og vejledning

    Sommerskole

    Alice Kongsted, Joachim Nielsen & Henriette Bondo Andersen

    01/08/201727/09/2019

    Kursus: Undervisning