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Personlig profil

Forskningsområde

My research focuses on how the cell’s architecture influences its metabolism and intracellular signaling and consequently its function. This has been accomplished by the use of experimental methods where the cell’s intracellular organization is maintained and by high-resolution imaging techniques as the electron microscope. Initially, my concern has been to elucidate the role and regulation of local storage of glycogen molecules (the principal storage form of glucose) in specific micro-domains within the cell. Using three different approaches, I and collaborators have shown that the link between glycogen depletion and impaired muscle function most likely originates from a connection between intramyofibrillar glycogen and SR calcium release. This was shown in mechanically skinned rat muscle fibers (Nielsen et al., 2009), isolated human SR vesicles (Ørtenblad et al.,2011), and intact mouse muscle fibers (Nielsen et al., 2014). Interestingly, we have also found that intramyofibrillar glycogen is preferentially depleted during prolonged exercise (Nielsen et al., 2011), which suggests that this could be the explanation for the glycogen-dependent component in the complexity of impaired muscle function during metabolic stress. In perspective, we have found that rodents and humans have almost the same amount of intramyofibrillar glycogen (Nielsen et al. 2014,2015), despite 4-fold differences in total glycogen, indicating a conserved role of intramyofibrillar glycogen across species. List of publications via Pubmed or Web of Science: "Nielsen J AND (Ortenblad N OR Schroder HD OR Vissing K) NOT (Nielsen JS OR Nielsen JH OR Nielsen JB OR Nielsen JL)".

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  • 28 Lignende profiler
Skeletal Muscle Medicin og biovidenskab
Muscles Medicin og biovidenskab
Sarcoplasmic Reticulum Medicin og biovidenskab
Soccer Medicin og biovidenskab
Muscle Kemiske forbindelser
Glycogen Kemiske forbindelser
Leg Medicin og biovidenskab
Exercise Medicin og biovidenskab

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Publikationer 2006 2019

Myocardial subcellular glycogen distribution and sarcoplasmic reticulum Ca2+ handling: effects of ischaemia, reperfusion and ischaemic preconditioning

Nielsen, J., Johnsen, J., Pryds, K., Ørtenblad, N. & Bøtker, H. E., 19. okt. 2019, I : Journal of Muscle Research and Cell Motility.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Sarcoplasmic Reticulum
Glycogen
Rats
Myocardial Reperfusion Injury
Saponins

Skeletal muscle sarcoplasmic reticulum Ca2 uptake preferentially use glycogenolytic derived ATP

Bidragets oversatte titel: Calcium optag i skeletmusklernes sarkoplasmatiske retikulum afhænger af glykogenolytisk afledt ATPKristiansen, M. R., Jensen, R., Nielsen, J. & Ørtenblad, N., 2019.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

Subcellular localization- and fibre type-dependent utilization of muscle glycogen during heavy resistance training in elite weight lifters

Hokken, R., Laugesen, S., Aagaard, P., Suetta, C., Frandsen, U., Ørtenblad, N. & Nielsen, J., 2019, (Accepteret/In press) I : Acta Physiologica (Print).

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

The inhibitory effects of two distinct inhibitors on glycogen phoshorylase activity and contractile function in chemically skinned skinned single fibers

Bidragets oversatte titel: Effekten af to forskellige hæmmere på glykogen phosphorylase aktivitet og kontraktilitet i kemisk skinnede enkeltfibreJensen, R., Kristiansen, M. R., Nielsen, J. & Ørtenblad, N., 2019.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

The inhibitory effects of two distinct inhibitors on glycogen phoshorylase activity and contractile function in chemically skinned skinned single fibers

Bidragets oversatte titel: Effekten af to forskellige hæmmere på glykogen phosphorylase aktivitet og kontraktilitet i kemisk skinnede enkeltfibreJensen, R., Kristiansen, M. R., Nielsen, J. & Ørtenblad, N., 2019.

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskning

Aktiviteter 2008 2016

Projektstyring, VIP

Joachim Nielsen (Deltager)
22. sep. 2016

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i workshop, kursus, seminar eller lignende

European Muscle Conference 2016

Joachim Nielsen (Deltager)
2. sep. 2016

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

European Journal of Applied Physiology (Tidsskrift)

Joachim Nielsen (Peer reviewer)
2016 → …

Aktivitet: Redaktionelt arbejde og fagfællebedømmelsePeer reviewer/fagfællebedømmer af manuskripterForskning

Assessment and evaluation of human muscle, nervous system and tendon-aponeurosis function in sports science, clinical science and aging

Joachim Nielsen (Taler)
10. mar. 2015

Aktivitet: Foredrag og mundtlige bidragGæsteforelæsning, undervisning og kursusvirksomhed ved andre universiteter

Journal of Physiology and Biochemistry (Tidsskrift)

Joachim Nielsen (Peer reviewer)
2015 → …

Aktivitet: Redaktionelt arbejde og fagfællebedømmelsePeer reviewer/fagfællebedømmer af manuskripterForskning

Presse/medie

Forskere: Derfor kan Delaney løbe solen sort

Joachim Nielsen

01/11/2016

1 element af Mediedækning

Presse/medie

DR P4 Fyn: P4 morgen

Joachim Nielsen

01/11/2016

1 Mediebidrag

Presse/medie

Priser

Young Investigator Award - Congress of the European College of Sport Science

Joachim Nielsen (Modtager), 27. jun. 2009

Pris: Priser, stipendier, udnævnelser