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Personlig profil

Forskningsinteresser

The impact of Noncoding RNAs (ncRNAs) such as microRNAs and, more recently, long ncRNAs (LncRNAs) onto eukaryotic gene regulation has just started to be understood. The research Group of Jan-Wilhelm Kornfeld lab would like to take part in this 'Noncoding RNA revolution' by identifying novel ncRNAs and elucidating their role in homeostatic circuits regulating energy homeostasis in health and disease. We apply state-of-the art techniques such as next-generation sequencing, the generation of transgenic mouse models and in vivo anti-ncRNA approaches to ultimately better understand the intricate biology of disease-associated ncRNAs. Our ultimatate goal is to define novel sequence-specific anti-ncRNAs therapeutics for anti-obesity intervention.

Forskningsområde

Noncoding RNAs, Energy Metabolism, Obesity, Type 2 Diabetes, Adipose tissue, Epigenetics

Forskningsområder

  • Bioinformatik
  • Transcriptomics
  • RNA function
  • Data visualization
  • Systems biology
  • Antisense og siRNA
  • RNA interference
  • Long noncoding RNAs
  • microRNAs
  • Fedme
  • Obesity
  • Insulin resistence
  • Diabetes
  • Fedtcelle-udvikling og funktion
  • Adipocyte function
  • Genetic variation
  • Chromatin regulation
  • Nutrient sensing
  • Skrumpelever
  • Hepatocyte function
  • Nutrient sensing
  • Transcriptional regulation
  • Glucose metabolism

Fingeraftryk Fingeraftryk er baseret på at anvende teksten fra personernes videnskabelige dokumenter til at skabe et indeks med vægtede emneordskoncepter, som definerer de vigtigste emner for hver enkelt forsker.

  • 5 Lignende profiler
STAT5 Transcription Factor Medicin og biovidenskab
Long Noncoding RNA Medicin og biovidenskab
Liver Medicin og biovidenskab
Glucocorticoid Receptors Medicin og biovidenskab
Somatotropin Receptors Medicin og biovidenskab
Untranslated RNA Medicin og biovidenskab
Insulin Resistance Medicin og biovidenskab
Liver Neoplasms Medicin og biovidenskab

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Publikationer 2006 2019

68 Downloads (Pure)

Rapid Generation of Long Noncoding RNA Knockout Mice Using CRISPR/Cas9 Technology

Hansmeier, N. R., Widdershooven, P. J. M., Khani, S. & Kornfeld, J-W., 23. jan. 2019, I : Non-Coding R N A. 5, 1, s. 1-12 12.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Clustered Regularly Interspaced Short Palindromic Repeats
Long Noncoding RNA
Gene Targeting
Guide RNA
Gene Knockout Techniques
52 Downloads (Pure)

s ·nr: a visual analytics framework for contextual analyses of private and public RNA-seq data

Klemm, P., Frommolt, P. & Kornfeld, J. W., 24. jan. 2019, I : BMC Genomics. 20, 12 s., 85.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Research Personnel
RNA
Transcriptome
Datasets
47 Downloads (Pure)

LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat

Schmidt, E., Dhaouadi, I., Gaziano, I., Oliverio, M., Klemm, P., Awazawa, M., Mitterer, G., Fernandez-Rebollo, E., Pradas-Juni, M., Wagner, W., Hammerschmidt, P., Loureiro, R., Kiefer, C., Hansmeier, N. R., Khani, S., Bergami, M., Heine, M., Ntini, E., Frommolt, P., Zentis, P. & 5 flere, Ørom, U. A., Heeren, J., Blüher, M., Bilban, M. & Kornfeld, J. W., 6. sep. 2018, I : Nature Communications. 9, 1, 16 s., 3622.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
obesity
adipose tissues
fats
genes
Genes

A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle

Awazawa, M., Gabel, P., Tsaousidou, E., Nolte, H., Krüger, M., Schmitz, J., Ackermann, P. J., Brandt, C., Altmüller, J., Motameny, S., Wunderlich, F. T., Kornfeld, J-W., Blüher, M. & Brüning, J. C., dec. 2017, I : Nature Medicine. 23, 12, s. 1466-1473 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Ectodysplasins
MicroRNAs
Liver
Muscle
Insulin Resistance

Decoding Lamarck-transgenerational control of metabolism by noncoding RNAs

Schmidt, E. & Kornfeld, J-W., jun. 2016, I : Pflügers Archiv - European Journal of Physiology. 468, 6, s. 959-69 11 s.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Long Noncoding RNA
Small Untranslated RNA
Untranslated RNA
Metabolism
Epigenomics

Aktiviteter 2018 2019

Conference talk 'Long noncoding RNAs in Energy Homeostasis and Metabolic Diseases'

Jan-Wilhelm Kornfeld (Foredragsholder)
12. sep. 2019

Aktivitet: Foredrag og mundtlige bidragKonferenceoplæg

Conference talk 'Plasticity of BAT signaling responses during cold exposure and metabolic disease'

Jan-Wilhelm Kornfeld (Foredragsholder)
3. jun. 2019

Aktivitet: Foredrag og mundtlige bidragForedrag og præsentationer i privat eller offentlig virksomhed

ADIPOSIGN Opening Sympoisum

Susanne Mandrup (Arrangør), Marianne Holmer (Paneldeltager), Jakob Møller-Jensen (Paneldeltager), Jan-Wilhelm Kornfeld (Paneldeltager), Zachary Gerhart-Hines (Paneldeltager), M. Madan Babu (Paneldeltager), Matthias Blüher (Paneldeltager), Ruth J F Loos (Paneldeltager), Martin Klingenspor (Paneldeltager), Christian Wolfrum (Paneldeltager)
27. maj 2019

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i workshop, kursus, seminar eller lignende

Conference talk 'Regulation of metabolism by long noncoding RNAs'

Jan-Wilhelm Kornfeld (Foredragsholder)
16. maj 2019

Aktivitet: Foredrag og mundtlige bidragKonferenceoplæg

Danish Diabetes Academy (DDA) Conference 'Non-coding RNAs in Metabolic Disease'

Jan-Wilhelm Kornfeld (Arrangør), Louise Torp Dalgaard (Deltager), Søren Nielsen (Arrangør), Haiming Cao (Deltager), Lei Sun (Deltager), Romain Barrès (Deltager), Stefanie Dimmeler (Deltager), Anna Krook (Deltager), Lena Eliasson (Deltager), Anand Harnikar (Deltager), Anders H Lund (Deltager), Ulf Andersson Vang Ørom (Deltager), Peter Arner (Deltager), Marcelo A Mori (Deltager), Mark Feinberg (Deltager), Carlos Salomon (Deltager), Manuel Mayr (Deltager)
6. maj 20198. maj 2019

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

Fil

Projekter 2016 2024