Ivan Brandslund

overlæge, dr.med.

  • Campusvej 55

    5230 Odense M

    Danmark

1982 …2019
Hvis du har foretaget ændringer i Pure, vil de snart blive vist her.

Publikationer 1982 2019

2019
46 Downloads (Pure)

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

Ahluwalia, T. S., Schulz, C-A., Waage, J., Skaaby, T., Sandholm, N., van Zuydam, N., Charmet, R., Bork-Jensen, J., Almgren, P., Thuesen, B. H., Bedin, M., Brandslund, I., Christensen, C. K., Linneberg, A., Ahlqvist, E., Groop, P-H., Hadjadj, S., Tregouet, D-A., Jørgensen, M. E., Grarup, N. & 9 flere, Pedersen, O., Simons, M., Groop, L., Orho-Melander, M., McCarthy, M. I., Melander, O., Rossing, P., Kilpeläinen, T. O. & Hansen, T., feb. 2019, I : Diabetologia. 62, 2, s. 292-305

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Exome
Albuminuria
Meta-Analysis
Kidney Diseases
Type 2 Diabetes Mellitus
1 Downloads (Pure)

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L. & 132 flere, Richardson, T. G., Yao, J., Fernandez, E. P., Ghanbari, M., Wojczynski, M. K., Lee, W-J., Argos, M., Armasu, S. M., Barve, R. A., Ryan, K. A., An, P., Baranski, T. J., Bielinski, S. J., Bowden, D. W., Broeckel, U., Christensen, K., Chu, A. Y., Corley, J., Cox, S. R., Uitterlinden, A. G., Rivadeneira, F., Cropp, C. D., Daw, E. W., van Heemst, D., de Las Fuentes, L., Gao, H., Tzoulaki, I., Ahluwalia, T. S., de Mutsert, R., Emery, L. S., Erzurumluoglu, A. M., Perry, J. A., Fu, M., Forouhi, N. G., Gu, Z., Hai, Y., Harris, S. E., Hemani, G., Hunt, S. C., Irvin, M. R., Jonsson, A. E., Justice, A. E., Kerrison, N. D., Larson, N. B., Lin, K-H., Love-Gregory, L. D., Mathias, R. A., Lee, J. H., Nauck, M., Noordam, R., Ong, K. K., Pankow, J., Patki, A., Pattie, A., Petersmann, A., Qi, Q., Ribel-Madsen, R., Rohde, R., Sandow, K., Schnurr, T. M., Sofer, T., Starr, J. M., Taylor, A. M., Teumer, A., Timpson, N. J., de Haan, H. G., Wang, Y., Weeke, P. E., Williams, C., Wu, H., Yang, W., Zeng, D., Witte, D. R., Weir, B. S., Wareham, N. J., Vestergaard, H., Turner, S. T., Torp-Pedersen, C., Stergiakouli, E., Sheu, W. H-H., Rosendaal, F. R., Ikram, M. A., Franco, O. H., Ridker, P. M., Perls, T. T., Pedersen, O., Nohr, E. A., Newman, A. B., Linneberg, A., Langenberg, C., Kilpeläinen, T. O., Kardia, S. L. R., Jørgensen, M. E., Jørgensen, T., Sørensen, T. I. A., Homuth, G., Hansen, T., Goodarzi, M. O., Deary, I. J., Christensen, C., Chen, Y-D. I., Chakravarti, A., Brandslund, I., Bonnelykke, K., Taylor, K. D., Wilson, J. G., Rodriguez, S., Davies, G., Horta, B. L., Thyagarajan, B., Rao, D. C., Grarup, N., Davila-Roman, V. G., Hudson, G., Guo, X., Arnett, D. K., Hayward, C., Vaidya, D., Mook-Kanamori, D. O., Tiwari, H. K., Levy, D., Loos, R. J. F., Dehghan, A., Elliott, P., Malik, A. N., Scott, R. A., Becker, D. M., de Andrade, M., Province, M. A., Meigs, J. B., Rotter, J. I. & North, K. E., 3. jan. 2019, I : American Journal of Human Genetics. 104, 1, s. 112-138

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Mitochondrial Genes
Body Mass Index
Insulin
Adipocytes
Type 2 Diabetes Mellitus
38 Downloads (Pure)

Cerebrospinal fluid biomarkers for predicting development of multiple sclerosis in acute optic neuritis: a population-based prospective cohort study

Olesen, M. N., Soelberg, K., Debrabant, B., Nilsson, A. C., Lillevang, S. T., Grauslund, J., Brandslund, I., Madsen, J. S., Paul, F., Smith, T. J., Jarius, S. & Asgari, N., 11. mar. 2019, I : Journal of Neuroinflammation. 16, 12 s., 59.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Optic Neuritis
Cerebrospinal Fluid
Cohort Studies
Prospective Studies
Intermediate Filaments

EGFR and EGFR ligands in serum in healthy women; reference intervals and age dependency

Kjær, I. M., Olsen, D. A., Alnor, A., Brandslund, I., Bechmann, T. & Madsen, J. S., 16. jul. 2019, I : Clinical Chemistry and Laboratory Medicine.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Ligands
Serum
Transforming Growth Factors

Home Management of Warfarin Treatment Through a Real-Time Supervised Telemedicine Solution: A Randomized Controlled Trial

Brasen, C. L., Madsen, J. S., Parkner, T. & Brandslund, I., feb. 2019, I : Telemedicine and e-Health. 25, 2, s. 109-115

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Warfarin
Randomized Controlled Trials
International Normalized Ratio
Point-of-Care Systems
Delivery of Health Care
56 Downloads (Pure)

Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study

Bryrup, T., Thomsen, C. W., Kern, T., Allin, K. H., Brandslund, I., Jørgensen, N. R., Vestergaard, H., Hansen, T., Hansen, T. H., Pedersen, O. & Nielsen, T., jun. 2019, I : Diabetologia. 62, 6, s. 1024-1035

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Type 2 Diabetes Mellitus
Bilophila
Bacterial DNA
Microbiota
Denmark

Myalgisk encefalomyelitis eller kronisk træthedssyndrom

Brinth, L., Nielsen, H., Varming, K., Boonen, S. E., Ebsen, A. G., Fernandez-Guerra, P., Schou, A-S., Mehlsen, J., Gregersen, N., Brandslund, I. & Olsen, R. K. J., 10. jun. 2019, I : Ugeskrift for Laeger. 181, V08180570.

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Chronic Fatigue Syndrome
Research
23 Downloads (Pure)

Pharmacogenomics education in medical and pharmacy schools: conclusions of a global survey

Pharmacogenomics Education Working Group (PGxEWG), jun. 2019, I : Pharmacogenomics. 20, 9, s. 643-657

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Pharmacy Schools
Pharmacogenetics
Medical Schools
Education
Health Occupations

Polymorphisms in the NFkB, TNF-alpha, IL-1beta, and IL-18 pathways are associated with response to anti-TNF therapy in Danish patients with inflammatory bowel disease

The Danish IBD Genetics Working Group, apr. 2019, I : Alimentary Pharmacology and Therapeutics. 49, 7, s. 890-903

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Interleukin-18
Inflammatory Bowel Diseases
Ulcerative Colitis
Tumor Necrosis Factor-alpha
Crohn Disease

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

CHD Exome+ Consortium, mar. 2019, I : Nature Genetics. 51, 3, s. 452-469

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Homeostasis
Lipids
Fats
Exome
White Adipose Tissue

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (Nature Genetics, (2018), 50, 1, (26-41), 10.1038/s41588-017-0011-x)

Rabing Brix Petersen, E., Witte, D. R., CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC-InterAct Consortium, ReproGen Consortium, INTERVAL Study, T2D-GENES Consortium, the MAGIC Investigators & Understanding Society Scientific Group, jul. 2019, I : Nature Genetics. 51, 7, s. 1191-1192

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Energy Metabolism
Body Mass Index
Proteins
9 Downloads (Pure)

Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants

Sun, J., Have, C. T., Hollensted, M., Grarup, N., Linneberg, A., Pedersen, O., Nielsen, J. S., Rungby, J., Christensen, C., Brandslund, I., Kristiansen, K., Jun, W., Hansen, T. & Gjesing, A. P., 15. aug. 2019, I : PLOS ONE. 14, 8, 10 s., e0220805.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
diabetes
Glutamate Decarboxylase
Polycystic Ovary Syndrome
Third Pregnancy Trimester
Mothers
Cortisone
Fasting

Urinary nucleic acid oxidation product levels show differential associations with pharmacological treatment in patients with type 2 diabetes

Kofoed Kjær, L., Cejvanovic, V., Henriksen, T., Hansen, T., Pedersen, O., Kjeldahl Christensen, C., Torp-Pedersen, C., Alexander Gerds, T., Brandslund, I., Mandrup-Poulsen, T. & Enghusen Poulsen, H., 4. jun. 2019, I : Free Radical Research. 53, 6, s. 694-703

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Medical problems
Type 2 Diabetes Mellitus
Nucleic Acids
RNA
Oxidation
2018
58 Downloads (Pure)

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

Finnish Diabetic Nephropathy Study (FinnDiane), 1. jul. 2018, I : Diabetes. 67, 7, s. 1414-1427

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Genome-Wide Association Study
Diabetic Nephropathies
Type 2 Diabetes Mellitus
Glomerular Filtration Rate
Sample Size
81 Downloads (Pure)

Associations between functional polymorphisms and response to biological treatment in Danish patients with psoriasis

Loft, N. D., Skov, L., Iversen, L., Gniadecki, R., Dam, T. N., Brandslund, I., Hoffmann, H. J., Andersen, M. R., Dessau, R. B., Bergmann, A. C., Møller Andersen, N., Andersen, P. S., Bank, S., Vogel, U. & Andersen, V., 22. maj 2018, I : Pharmacogenomics Journal. 18, 3, s. 494–500

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Psoriasis
Single Nucleotide Polymorphism
Psoriatic Arthritis
Interleukin-13
Pharmacogenetics
105 Downloads (Pure)

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Sustarsic, E. G., Ma, T., Lynes, M. D., Larsen, M., Karavaeva, I., Havelund, J. F., Nielsen, C. H., Jedrychowski, M. P., Moreno-Torres, M., Lundh, M., Plucinska, K., Jespersen, N. Z., Grevengoed, T. J., Kramar, B., Peics, J., Hansen, J. B., Shamsi, F., Forss, I., Neess, D., Keipert, S. & 24 flere, Wang, J., Stohlmann, K., Brandslund, I., Christensen, C., Jørgensen, M. E., Linneberg, A., Pedersen, O., Kiebish, M. A., Qvortrup, K., Han, X., Pedersen, B. K., Jastroch, M., Mandrup, S., Kjær, A., Gygi, S. P., Hansen, T., Gillum, M. P., Grarup, N., Emanuelli, B., Nielsen, S., Scheele, C., Tseng, Y. H., Færgeman, N. J. & Gerhart-Hines, Z., 3. jul. 2018, I : Cell Metabolism. 28, 1, s. 159-174.e11

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Homeostasis
Fats
Energy Metabolism
Insulin Resistance
Adipocytes

Cerebrospinal fluid biomarkers of inflammation and neurodegeneration in acute optic neuritis

Olesen, M. N., Soelberg, K., Nilsson, A. C., Jarius, S., Madsen, J. S., Grauslund, J., Smith, T. J., Lillevang, S. T., Brandslund, I., Paul, F. & Asgari, N., 2018.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

63 Downloads (Pure)

Danish Centre for Strategic Research in Type 2 Diabetes (DD2) project cohort of newly diagnosed patients with type 2 diabetes: a cohort profile

Christensen, D. H., Nicolaisen, S. K., Berencsi, K., Beck-Nielsen, H., Rungby, J., Friborg, S., Brandslund, I., Christiansen, J. S., Vaag, A., Sørensen, H. T., Nielsen, J. S. & Thomsen, R. W., 1. apr. 2018, I : BMJ Open. 8, 4, 11 s., e017273.

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Type 2 Diabetes Mellitus
Research
Diabetes Complications
Albuminuria
Diabetic Neuropathies
37 Downloads (Pure)
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Immunoassay
Ligands
Serum
Limit of Detection
Betacellulin

False increase of glycated hemoglobin due to aspirin interference in Tosoh G8 analyzer

Gils, C., Reinholdt, B., Andreassen, B. D., Brandslund, I. & Vinholt, P. J., 25. apr. 2018, I : Clinical Chemistry and Laboratory Medicine. 56, 5, s. e118-e120

Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

29 Downloads (Pure)

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Mahajan, A., Taliun, D., Thurner, M., Robertson, N. R., Torres, J. M., Rayner, N. W., Payne, A. J., Steinthorsdottir, V., Scott, R. A., Grarup, N., Cook, J. P., Schmidt, E. M., Wuttke, M., Sarnowski, C., Mägi, R., Nano, J., Gieger, C., Trompet, S., Lecoeur, C., Preuss, M. H. & 95 flere, Prins, B. P., Guo, X., Bielak, L. F., Below, J. E., Bowden, D. W., Chambers, J. C., Kim, Y. J., Ng, M. C. Y., Petty, L. E., Sim, X., Zhang, W., Bennett, A. J., Bork-Jensen, J., Brummett, C. M., Canouil, M., Ec Kardt, K-U., Fischer, K., Kardia, S. L. R., Kronenberg, F., Läll, K., Liu, C-T., Locke, A. E., Luan, J., Ntalla, I., Nylander, V., Schönherr, S., Schurmann, C., Yengo, L., Bottinger, E. P., Brandslund, I., Christensen, C., Dedoussis, G., Florez, J. C., Ford, I., Franco, O. H., Frayling, T. M., Giedraitis, V., Hackinger, S., Hattersley, A. T., Herder, C., Ikram, M. A., Ingelsson, M., Jørgensen, M. E., Jørgensen, T., Kriebel, J., Kuusisto, J., Ligthart, S., Lindgren, C. M., Linneberg, A., Lyssenko, V., Mamakou, V., Meitinger, T., Mohlke, K. L., Morris, A. D., Nadkarni, G., Pankow, J. S., Peters, A., Sattar, N., Stančáková, A., Strauch, K., Taylor, K. D., Thorand, B., Thorleifsson, G., Thorsteinsdottir, U., Tuomilehto, J., Witte, D. R., Dupuis, J., Peyser, P. A., Zeggini, E., Loos, R. J. F., Froguel, P., Ingelsson, E., Lind, L., Groop, L., Laakso, M., Collins, F. S., Jukema, J. W., Palmer, C. N. A., Grallert, H., Metspalu, A., Dehghan, A., Köttgen, A., Abecasis, G. R., Meigs, J. B., Rotter, J. I., Marchini, J., Pedersen, O., Hansen, T., Langenberg, C., Wareham, N. J., Stefansson, K., Gloyn, A. L., Morris, A. P., Boehnke, M. & McCarthy, M. I., nov. 2018, I : Nature Genetics. 50, 11, s. 1505–1513

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Type 2 Diabetes Mellitus
Genome-Wide Association Study
Epigenomics
Equipment and Supplies
Genome-Wide Association Study
Type 2 Diabetes Mellitus
Population Control
Latent Autoimmune Diabetes in Adults
Glycolysis

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

Groop, L. C., Leslie, R. D., Grant, S. F. A. & Bone Mineral Density in Childhood Study, nov. 2018, I : Diabetes Care. 41, 11, s. 2396-2403

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Genome-Wide Association Study
Type 2 Diabetes Mellitus
Population Control
Latent Autoimmune Diabetes in Adults
Glycolysis
60 Downloads (Pure)

Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis

Sode, J., Bank, S., Vogel, U., Andersen, P. S., Sørensen, S. B., Bojesen, A. B., Andersen, M. R., Brandslund, I., Dessau, R. B., Hoffmann, H. J., Glintborg, B., Hetland, M. L., Locht, H., Heegaard, N. H. & Andersen, V., 12. sep. 2018, I : BMC Medical Genetics. 19, 16 s., 165.

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Tumor Necrosis Factor-alpha
Interleukin-18
Odds Ratio
Confidence Intervals
Antirheumatic Agents
111 Downloads (Pure)

Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis

Loft, N. D., Skov, L., Rasmussen, M. K., Gniadecki, R., Dam, T. N., Brandslund, I., Hoffmann, H. J., Andersen, M. R., Dessau, R. B., Bergmann, A. C., Andersen, N. M., Abildtoft, M. K., Andersen, P. S., Hetland, M. L., Glintborg, B., Bank, S., Vogel, U. & Andersen, V., 1. feb. 2018, I : PLOS ONE. 13, 2, 12 s., e0192010.

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psoriasis
Psoriatic Arthritis
arthritis
Genetic Polymorphisms
Polymorphism
86 Downloads (Pure)

Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases: protocol for a prospective cohort study of prognostic factors and personalised medicine

Christensen, R., Heitmann, B. L., Andersen, K. W., Nielsen, O. H., Sørensen, S. B., Jawhara, M., Bygum, A., Hvid, L., Grauslund, J., Wied, J., Glerup, H., Fredberg, U., Villadsen, J. A., Kjær, S. G., Fallingborg, J., Moghadd, S. A. G. R., Knudsen, T., Brodersen, J., Frøjk, J., Dahlerup, J. F. & 21 flere, Bojesen, A. B., Sorensen, G. L., Thiel, S., Færgeman, N. J., Brandslund, I., Bennike, T. B., Stensballe, A., Schmidt, E. B., Franke, A., Ellinghaus, D., Rosenstiel, P., Raes, J., Boye, M., Werner, L., Nielsen, C. L., Munk, H. L., Nexøe, A. B., Ellingsen, T., Holmskov, U., Kjeldsen, J. & Andersen, V., 1. feb. 2018, I : B M J Open. 8, 2, 17 s., e018166.

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Precision Medicine
Cohort Studies
Prospective Studies
Tumor Necrosis Factor-alpha
Hidradenitis Suppurativa

Pathophysiology-based phenotyping in type 2 diabetes: A clinical classification tool

Stidsen, J. V., Henriksen, J. E., Olsen, M. H., Thomsen, R. W., Nielsen, J. S., Rungby, J., Ulrichsen, S. P., Berencsi, K., Kahlert, J. A., Friborg, S. G., Brandslund, I., Nielsen, A. A., Christiansen, J. S., Sørensen, H. T., Olesen, T. B. & Beck-Nielsen, H., jul. 2018, I : Diabetes - Metabolism: Research and Reviews (Print Edition). 34, 5, 11 s., e3005.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Medical problems
Type 2 Diabetes Mellitus
Insulin Resistance
Glucocorticoids
Insulin
19 Downloads (Pure)

Personalized laboratory medicine: A patient-centered future approach

Prodan Žitnik, I., Černe, D., Mancini, I., Simi, L., Pazzagli, M., Di Resta, C., Podgornik, H., Repič Lampret, B., Trebušak Podkrajšek, K., Sipeky, C., Van Schaik, R., Brandslund, I., Vermeersch, P., Schwab, M. & Marc, J., 27. nov. 2018, I : Clinical Chemistry and Laboratory Medicine. 56, 12, s. 1981–1991

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Precision Medicine
Medicine
Biostatistics
Cost effectiveness
Restoration
99 Downloads (Pure)

Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort

Gedebjerg, A., Almdal, T. P., Berencsi, K., Rungby, J., Nielsen, J. S., Witte, D. R., Friborg, S., Brandslund, I., Vaag, A., Beck-Nielsen, H., Sørensen, H. T. & Thomsen, R. W., jan. 2018, I : Journal of Diabetes and its Complications. 32, 1, s. 34-40

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Diabetes Complications
Type 2 Diabetes Mellitus
Cross-Sectional Studies
Confidence Intervals
Hypertriglyceridemia
Epidermal Growth Factor Receptor
Blood
Ligands
Biomarkers
Publications

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T. & 31 flere, Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Brandslund, I., Christensen, C., Jensen, G. B., Jørgensen, M. E., Thuesen, B. H. & CHD Exome+ Consortium, 2018, I : Nature Genetics. 50, 1, s. 26-41

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Energy Metabolism
Body Mass Index
Genome-Wide Association Study
Proteins
Adipocytes
78 Downloads (Pure)

Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

Bonàs-Guarch, S., Guindo-Martínez, M., Miguel-Escalada, I., Grarup, N., Sebastian, D., Rodriguez-Fos, E., Sánchez, F., Planas-Fèlix, M., Cortes-Sánchez, P., González, S., Timshel, P., Pers, T. H., Morgan, C. C., Moran, I., Atla, G., González, J. R., Puiggros, M., Martí, J., Andersson, E. A., Díaz, C. & 23 flere, Badia, R. M., Udler, M., Leong, A., Kaur, V., Flannick, J., Jørgensen, T., Linneberg, A., Jørgensen, M. E., Witte, D. R., Christensen, C., Brandslund, I., Appel, E. V., Scott, R. A., Luan, JA., Langenberg, C., Wareham, N. J., Pedersen, O., Zorzano, A., Florez, J. C., Hansen, T., Ferrer, J., Mercader, J. M. & Torrents, D., 30. maj 2018, I : Nature Communications. 9, 1, 2162.

Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

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Research Ethics Committees
Clinical Medicine
Medical problems
Computational Biology
Type 2 Diabetes Mellitus
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Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

Bonàs-Guarch, S., Guindo-Martínez, M., Miguel-Escalada, I., Grarup, N., Sebastian, D., Rodriguez-Fos, E., Sánchez, F., Planas-Fèlix, M., Cortes-Sánchez, P., González, S., Timshel, P., Pers, T. H., Morgan, C. C., Moran, I., Atla, G., González, J. R., Puiggros, M., Martí, J., Andersson, E. A., Díaz, C. & 23 flere, Badia, R. M., Udler, M., Leong, A., Kaur, V., Flannick, J., Jørgensen, T., Linneberg, A., Jørgensen, M. E., Witte, D. R., Christensen, C., Brandslund, I., Appel, E. V., Scott, R. A., Luan, J., Langenberg, C., Wareham, N. J., Pedersen, O., Zorzano, A., Florez, J. C., Hansen, T., Ferrer, J., Mercader, J. M. & Torrents, D., 1. dec. 2018, I : Nature Communications. 9, 1, 14 s., 321.

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Medical problems
Type 2 Diabetes Mellitus
genome
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Genome-Wide Association Study
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Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

ExomeBP Consortium, MAGIC Consortium, GIANT Consortium, Witte, D. R. & Hansen, T., 1. apr. 2018, I : Nature Genetics. 50, 4, s. 559-571

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Type 2 Diabetes Mellitus
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Testosterone levels in third trimester in polycystic ovary syndrome: Odense Child Cohort

Glintborg, D., Jensen, R. C., Bentsen, K., Schmedes, A. V., Brandslund, I., Kyhl, H. B., Bilenberg, N. & Andersen, M. S., 1. okt. 2018, I : The Journal of clinical endocrinology and metabolism. 103, 10, s. 3819–3827

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Polycystic Ovary Syndrome
Third Pregnancy Trimester
Testosterone
Sex Hormone-Binding Globulin
Pregnant Women
2017

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

Manning, A. K., Highland, H. M., Gasser, J., Sim, X., Tukiainen, T., Fontanillas, P., Grarup, N., Rivas, M. A., Mahajan, A., Locke, A. E., Cingolani, P., Pers, T. H., Viñuela, A., Brown, A., Wu, Y., Flannick, J., Fuchsberger, C., Gamazon, E. R., Gaulton, K. J., Im, H. K. & 243 flere, Teslovich, T. M., Blackwell, T. W., Bork-Jensen, J., Burtt, N. P., Chen, Y., Green, T., Hartl, C., Kang, H. M., Kumar, A., Ladenvall, C., Ma, C., Moutsianas, L., Pearson, R. D., Perry, J. R. B., Rayner, N. W., Robertson, N. R., Scott, L. J., van de Bunt, M., Eriksson, J. G., Jula, A., Koskinen, S., Lehtimäki, T., Palotie, A., Raitakari, O. T., Jacobs, S. B. R., Wessel, J., Chu, A. Y., Scott, R. A., Goodarzi, M. O., Blancher, C., Buck, G., Buck, D., Chines, P. S., Gabriel, S. B., Gjesing, A. P., Groves, C. J., Hollensted, M., Huyghe, J. R., Jackson, A. U., Jun, G., Justesen, J. M., Mangino, M., Murphy, J., Neville, M. J., Onofrio, R., Small, K. S., Stringham, H. M., Trakalo, J., Banks, E., Carey, J., Carneiro, M. O., DePristo, M., Farjoun, Y., Fennell, T., Goldstein, J. I., Grant, G., Hrabé de Angelis, M., Maguire, J., Neale, B. M., Poplin, R., Purcell, S. M., Schwarzmayr, T., Shakir, K., Smith, J. D., Strom, T. M., Wieland, T., Lindstrom, J., Brandslund, I., Christensen, C., Surdulescu, G. L., Lakka, T. A., Doney, A. S. F., Nilsson, P., Wareham, N. J., Langenberg, C., Varga, T. V., Franks, P. W., Rolandsson, O., Rosengren, A. H., Farook, V. S., Thameem, F., Puppala, S., Kumar, S., Lehman, D. M., Jenkinson, C. P., Curran, J. E., Hale, D. E., Fowler, S. P., Arya, R., DeFronzo, R. A., Abboud, H. E., Syvänen, A-C., Hicks, P. J., Palmer, N. D., Ng, M. C. Y., Bowden, D. W., Freedman, B. I., Esko, T., Mägi, R., Milani, L., Mihailov, E., Metspalu, A., Narisu, N., Kinnunen, L., Bonnycastle, L. L., Swift, A., Pasko, D., Wood, A. R., Fadista, J., Pollin, T. I., Barzilai, N., Atzmon, G., Glaser, B., Thorand, B., Strauch, K., Peters, A., Roden, M., Müller-Nurasyid, M., Liang, L., Kriebel, J., Illig, T., Grallert, H., Gieger, C., Meisinger, C., Lannfelt, L., Musani, S. K., Griswold, M., Taylor, H. A., Wilson, G., Correa, A., Oksa, H., Scott, W. R., Afzal, U., Tan, S-T., Loh, M., Chambers, J. C., Sehmi, J., Kooner, J. S., Lehne, B., Cho, Y. S., Lee, J-Y., Han, B-G., Käräjämäki, A., Qi, Q., Qi, L., Huang, J., Hu, F. B., Melander, O., Orho-Melander, M., Below, J. E., Aguilar, D., Wong, T. Y., Liu, J., Khor, C-C., Chia, K. S., Lim, W. Y., Cheng, C-Y., Chan, E., Tai, E-S., Aung, T., Linneberg, A., Isomaa, B., Meitinger, T., Tuomi, T., Hakaste, L., Kravic, J., Jørgensen, M. E., Lauritzen, T., Deloukas, P., Stirrups, K. E., Owen, K. R., Farmer, A. J., Frayling, T. M., O'Rahilly, S. P., Walker, M., Levy, J. C., Hodgkiss, D., Hattersley, A. T., Kuulasmaa, T., Stančáková, A., Barroso, I., Bharadwaj, D., Chan, J. C. N., Chandak, G. R., Daly, M. J., Donnelly, P. J., Ebrahim, S. B., Elliott, P., Fingerlin, T., Froguel, P., Hu, C., Jia, W., Ma, R. C. W., McVean, G., Park, T., Prabhakaran, D., Sandhu, M., Scott, J., Sladek, R., Tandon, N., Teo, Y. Y., Zeggini, E., Watanabe, R. M., Koistinen, H. A., Kesaniemi, Y. A., Uusitupa, M., Spector, T. D., Salomaa, V., Rauramaa, R., Palmer, C. N. A., Prokopenko, I., Morris, A. D., Bergman, R. N., Collins, F. S., Lind, L., Ingelsson, E., Tuomilehto, J., Karpe, F., Groop, L., Jørgensen, T., Hansen, T., Pedersen, O., Kuusisto, J., Abecasis, G. R., Bell, G. I., Blangero, J., Cox, N. J., Duggirala, R., Seielstad, M., Wilson, J. G., Dupuis, J., Ripatti, S., Hanis, C. L., Florez, J. C., Mohlke, K. L., Meigs, J. B., Laakso, M., Morris, A. P., Boehnke, M., Altshuler, D., McCarthy, M. I., Gloyn, A. L. & Lindgren, C. M., jul. 2017, I : Diabetes. 66, 7, s. 2019-2032

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Type 2 Diabetes Mellitus
Fasting
Insulin
Exome
Population
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A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine

Andersen, V., Holmskov, U., Sørensen, S. B., Jawhara, M., Andersen, K. W., Bygum, A., Sylvester Hvid, L., Grauslund, J., Wied, J., Glerup, H., Fredberg, U., Villadsen, J. A., Kjær, S. G., Fallingborg, J., Moghadd, S. A. G. R., Knudsen, T., Brodersen, J., Frøjk, J., Dahlerup, J. F., Nielsen, O. H. & 18 flere, Christensen, R., Bojesen, A. B., Sorensen, G. L., Thiel, S., Færgeman, N. J., Brandslund, I., Stensballe, A., Schmidt, E. B., Franke, A., Ellinghaus, D., Rosenstiel, P., Raes, J., Heitmann, B., Boye, M., Lindgaard Nielsen, C., Werner, L., Kjeldsen, J. & Ellingsen, T., 2017, I : Nutrients. 9, 5, 16 s., 499.

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Precision Medicine
tumor necrosis factors
lifestyle
medicine
inflammatory bowel disease

Cardiovascular and All-Cause Mortality Risk Associated With Urinary Excretion of 8-oxoGuo, a Biomarker for RNA Oxidation, in Patients With Type 2 Diabetes: A Prospective Cohort Study

Kjær, L. K., Cejvanovic, V., Henriksen, T., Petersen, K. M., Hansen, T., Pedersen, O., Christensen, C. K., Torp-Pedersen, C., Gerds, T. A., Brandslund, I., Mandrup-Poulsen, T. & Poulsen, H. E., 2017, I : Diabetes Care. 40, 2, s. 1771-1778

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Type 2 Diabetes Mellitus
Cohort Studies
Prospective Studies
RNA
8-hydroxyguanosine

Cell-Free DNA in Metastatic Colorectal Cancer: A Systematic Review and Meta-Analysis

Spindler, K-L. G., Boysen, A. K., Pallisgård, N., Johansen, J. S., Tabernero, J., Sørensen, M. M., Jensen, B. V., Hansen, T. F., Sefrioui, D., Andersen, R. F., Brandslund, I. & Jakobsen, A., 2017, I : Oncologist. 22, 9, s. 1049-1055

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Meta-Analysis
Colorectal Neoplasms
DNA
Magnetics
Mutation

Differential intrathecal inflammatory markers in acute optic neuritis and later conversion to multiple sclerosis

Olesen, M. N., Soelberg, K., Nilsson, A. C., Jarius, S., Madsen, J. S., Grauslund, J., Smith, T. J., Lillevang, S. T., Brandslund, I., Paul, F., Weinshenker, B. G. & Asgari, N., 2017. 1 s.

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Optic Neuritis
Cerebrospinal Fluid
Interleukin-10
Interleukin-17
Interleukin-6
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Exome-wide association study of plasma lipids in >300,000 individuals

Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Alves, A. C., Amouyel, P., Di Angelantonio, E., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., Bis, J. C. & 31 flere, Boehnke, M., Boerwinkle, E., Bork-Jensen, J., Bottinger, E. P., Brandslund, I., Brown, M., Busonero, F., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. E., Chen, Y-D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Connell, J. M., Cucca, F., Cupples, L. A., Damrauer, S. M., Davies, G., Deary, I. J., Dedoussis, G., Denny, J. C., Dominiczak, A., Dubé, M-P., Ebeling, T., Eiriksdottir, G., Hansen, T., Jensen, G. B., Jørgensen, M. E. & Charge Diabetes Working Group, 2017, I : Nature Genetics. 49, s. 1758–1766

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Exome
Lipids
Type 2 Diabetes Mellitus
Coronary Artery Disease
LDL Cholesterol
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High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus

Gjesing, A. P., Rui, G., Lauenborg, J., Have, C. T., Hollensted, M., Andersson, E., Grarup, N., Sun, J., Quan, S., Brandslund, I., Damm, P., Pedersen, O., Wang, J. & Hansen, T., 2017, I : Journal of the Endocrine Society. 1, 6, s. 681-690

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Gestational Diabetes
Type 2 Diabetes Mellitus
Diet
Glucose Intolerance
Introns
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New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

Kraja, A. T., Cook, J. P., Warren, H. R., Surendran, P., Liu, C., Evangelou, E., Manning, A. K., Grarup, N., Drenos, F., Sim, X., Smith, A. V., Amin, N., Blakemore, A. I. F., Bork-Jensen, J., Brandslund, I., Farmaki, A-E., Fava, C., Ferreira, T., Herzig, K-H., Giri, A. & 31 flere, Giulianini, F., Grove, M. L., Guo, X., Harris, S. E., Have, C. T., Havulinna, A. S., Zhang, H., Jørgensen, M. E., Käräjämäki, A., Kooperberg, C., Linneberg, A., Little, L., Liu, Y., Bonnycastle, L. L., Lu, Y., Mägi, R., Mahajan, A., Malerba, G., Marioni, R. E., Mei, H., Menni, C., Morrison, A. C., Padmanabhan, S., Palmas, W., Poveda, A., Rauramaa, R., Rayner, N. W., Riaz, M., Christensen, C. K., Hansen, T. & Understanding Society Scientific Group, 2017, I : Circulation: Cardiovascular Genetics. 10, 5, e001778.

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Meta-Analysis
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Rare and low-frequency coding variants alter human adult height

Marouli, E., Graff, M., Medina-Gómez, C., Lo, K. S., Wood, A. R., Kjaer, T. R., Fine, R. S., Lu, Y., Schurmann, C., Highland, H. M., Rüeger, S., Thorleifsson, G., Justice, A. E., Lamparter, D., Stirrups, K. E., Turcot, V., Young, K. L., Winkler, T. W., Esko, T., Karaderi, T. & 31 flere, Locke, A. E., Masca, N. G. D., Ng, M. C. Y., Mudgal, P., Rivas, M. A., Vedantam, S., Mahajan, A., Guo, X., Abecasis, G. R., Aben, K. K., Adair, L. S., Alam, D. S., Albrecht, E., Allin, K. H., Allison, M. A., Amouyel, P., Appel, E. V. R., Arveiler, D., Asselbergs, F. W., Auer, P. L., Balkau, B., Banas, B., Bang, L. E., Benn, M., Bergmann, S., Brandslund, I., Christensen, C., Hansen, T., Jensen, G. B., Jørgensen, M. E. & EPIC-InterAct Consortium, 9. feb. 2017, I : Nature. 542, 7640, s. 186-190

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Alleles
Insulin-Like Growth Factor Binding Protein 4
Pregnancy-Associated Plasma Protein-A
Multifactorial Inheritance
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Rhodopsin in plasma from patients with diabetic retinopathy - development and validation of digital ELISA by Single Molecule Array (Simoa) technology

Petersen, E. R. B., Olsen, D. A., Christensen, H., Hansen, S. B., Christensen, C. & Brandslund, I., 2017, I : Journal of Immunological Methods. 446, s. 60-69

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Rhodopsin
Diabetic Retinopathy
Western World
Young Adult
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Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Jason, F., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., Caulkins, L., Koesterer, R., Ma, C., Moutsianas, L., McCarthy, D. J., Rivas, M. A., Perry, J. R. B., Sim, X., Blackwell, T. W., Robertson, N. R., Rayner, N. W., Cingolani, P., Locke, A. E., Tajes, J. F. & 281 flere, Highland, H. M., Dupuis, J., Chines, P. S., Lindgren, C. M., Hartl, C., Jackson, A. U., Chen, H., Huyghe, J. R., van de Bunt, M., Pearson, R. D., Kumar, A., Müller-Nurasyid, M., Grarup, N., Stringham, H. M., Gamazon, E. R., Lee, J., Chen, Y., Scott, R. A., Below, J. E., Chen, P., Huang, J., Go, M. J., Stitzel, M. L., Pasko, D., Parker, S. C. J., Varga, T. V., Green, T., Beer, N. L., Day-Williams, A. G., Ferreira, T., Fingerlin, T., Horikoshi, M., Hu, C., Huh, I., Ikram, M. K., Kim, B-J., Kim, Y., Kim, Y. J., Kwon, M-S., Lee, J., Lee, S., Lin, K-H., Maxwell, T. J., Nagai, Y., Wang, X., Welch, R. P., Yoon, J., Zhang, W., Barzilai, N., Voight, B. F., Han, B-G., Jenkinson, C. P., Kuulasmaa, T., Kuusisto, J., Manning, A., Ng, M. C. Y., Palmer, N. D., Balkau, B., Stančáková, A., Abboud, H. E., Boeing, H., Giedraitis, V., Prabhakaran, D., Gottesman, O., Scott, J., Carey, J., Kwan, P., Grant, G., Smith, J. D., Neale, B. M., Purcell, S., Butterworth, A. S., Howson, J. M. M., Lee, H. M., Lu, Y., Kwak, S-H., Zhao, W., Danesh, J., Lam, V. K. L., Park, K. S., Saleheen, D., So, W. Y., Tam, C. H. T., Afzal, U., Aguilar, D., Arya, R., Aung, T., Chan, E., Navarro, C., Cheng, C-Y., Palli, D., Correa, A., Curran, J. E., Rybin, D., Farook, V. S., Fowler, S. P., Freedman, B. I., Griswold, M., Hale, D. E., Hicks, P. J., Khor, C-C., Kumar, S., Lehne, B., Thuillier, D., Lim, W. Y., Liu, J., Loh, M., Musani, S. K., Puppala, S., Scott, W. R., Yengo, L., Tan, S-T., Taylor, H. A., Thameem, F., Wilson, G., Wong, T. Y., Njølstad, P. R., Levy, J. C., Mangino, M., Bonnycastle, L. L., Schwarzmayr, T., Fadista, J., Surdulescu, G. L., Herder, C., Groves, C. J., Wieland, T., Bork-Jensen, J., Brandslund, I., Christensen, C., Koistinen, H. A., Doney, A. S. F., Kinnunen, L., Esko, T., Farmer, A. J., Hakaste, L., Hodgkiss, D., Kravic, J., Lyssenko, V., Hollensted, M., Jørgensen, M. E., Jørgensen, T., Ladenvall, C., Justesen, J. M., Käräjämäki, A., Kriebel, J., Rathmann, W., Lannfelt, L., Lauritzen, T., Narisu, N., Linneberg, A., Melander, O., Milani, L., Neville, M., Orho-Melander, M., Qi, L., Qi, Q., Roden, M., Rolandsson, O., Swift, A., Rosengren, A. H., Stirrups, K., Wood, A. R., Mihailov, E., Blancher, C., Carneiro, M. O., Maguire, J., Poplin, R., Shakir, K., Fennell, T., DePristo, M., de Angelis, M. H., Deloukas, P., Gjesing, A. P., Jun, G., Nilsson, P., Murphy, J., Onofrio, R., Thorand, B., Hansen, T., Meisinger, C., Hu, F. B., Isomaa, B., Karpe, F., Liang, L., Peters, A., Huth, C., O'Rahilly, S. P., Palmer, C. N. A., Pedersen, O., Rauramaa, R., Tuomilehto, J., Salomaa, V., Watanabe, R. M., Syvänen, A-C., Bergman, R. N., Bharadwaj, D., Bottinger, E. P., Cho, Y. S., Chandak, G. R., Chan, J. C., Chia, K. S., Daly, M. J., Ebrahim, S. B., Langenberg, C., Elliott, P., Jablonski, K. A., Lehman, D. M., Jia, W., Ma, R. C. W., Pollin, T. I., Sandhu, M., Tandon, N., Froguel, P., Barroso, I., Teo, Y. Y., Zeggini, E., Loos, R. J. F., Small, K. S., Ried, J. S., DeFronzo, R. A., Grallert, H., Glaser, B., Metspalu, A., Wareham, N. J., Walker, M., Banks, E., Gieger, C., Ingelsson, E., Im, H. K., Illig, T., Franks, P. W., Buck, G., Trakalo, J., Buck, D., Prokopenko, I., Mägi, R., Lind, L., Farjoun, Y., Owen, K. R., Gloyn, A. L., Strauch, K., Tuomi, T., Kooner, J. S., Lee, J-Y., Park, T., Donnelly, P., Morris, A. D., Hattersley, A. T., Bowden, D. W., Collins, F. S., Atzmon, G., Chambers, J. C., Spector, T. D., Laakso, M., Strom, T. M., Bell, G. I., Blangero, J., Duggirala, R., Tai, E. S., McVean, G., Hanis, C. L., Wilson, J. G., Seielstad, M., Frayling, T. M., Meigs, J. B., Cox, N. J., Sladek, R., Lander, E. S., Gabriel, S., Mohlke, K. L., Meitinger, T., Groop, L., Abecasis, G., Scott, L. J., Morris, A. P., Kang, H. M., Altshuler, D., Burtt, N. P., Florez, J. C., Boehnke, M. & McCarthy, M. I., 2017, I : Scientific Data. 4, 20 s., 170179.

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Diabetes
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chronic illness
statistics
Statistics

SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

CHARGE Glycemic-T2D Working Group, & CHARGE Blood Pressure Working Group, 2017, I : Journal of the American Society of Nephrology. 28, 3, s. 981-994

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Exome
Kidney
ras Guanine Nucleotide Exchange Factors
Rho Guanine Nucleotide Exchange Factors
Cytochrome P-450 CYP1A1

Stability of Biomedical Components in Blood Samples Transported by Tempus600/Sysmex GLP Robot Reception System

Bøgh Andersen, I., Mogensen, N. & Brandslund, I., jan. 2017, I : The Journal of Applied Laboratory Medicine. 2, 3, s. 376-386

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The effect of smoking on the urinary excretion of 8-oxodG and 8-oxoGuo in patients with type 2 diabetes

Sørensen, A-S., Kjær, L. K., Petersen, K. M., Henriksen, T. M., Cejvanovic, V., Pedersen, O., Hansen, T., Christensen, C. K., Brandslund, I. & Poulsen, H. E., jul. 2017, I : Scandinavian Journal of Clinical & Laboratory Investigation. 77, 4, s. 253-258

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Type 2 Diabetes Mellitus
Smoking
RNA
DNA
Population