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Personlig profil

Forskningsområde

My research evolves around computer simulations of complex biological assemblies, with special focus on biological membranes and membrane associated biological processes. The ultimate objective is to obtain fundamental scientific insight into both the assembly and evolution of complex biomolecular structures through interactions and modification of their environment; and into the functioning of isolated biomolecular machines. The goal of the investigations will also be to examine the fundamental molecular basis of diseased states resulting from a perturbation of these interactions, thus motivating biotechnological applications and the rational development of therapeutic remedies and drugs. An important feature of this research is a close interface with experiments, wherein experimental data will motivate simulations, which in turn will drive new analytical measurements. With this goal, several collaborations with leading experimental groups have been established. Representative Examples: The following are some examples of projects. All of them address fundamental scientific problems, and also have biotechnological and medical applications. My most recent work involves the discovery of multiple ion pathways in trans- membrane ion pumps, a proposal that is likely to forever change the way biology looks at ion transport (Nature, 2010, DOI: 10.1038/nature09309). In another project, we have shown for the first time, that triglyceride droplets can be stable within lipid bilayers, this has implications for lipid droplet biogenesis and the mobile lipid signal in cancer cell membranes (PLoS One, 2010, DOI: 10.1371/journal.pone.0012811). We showed how oxidized phospholipids -which are now known be in involved in the genesis of several diseases- can significantly alter the biochemical andbiophysicalpropertiesoflipidmembranes(Biophys.J.,2009,DOI: DOI:10.1016/j.bpj.2009.01.007). In recent collaborative work with the Danish Cancer Society and the University of Helsinki Medical School, we showed for the first time that lipid secondary messengers could be targeted for anticancer therapy (JACS, 2008, DOI: 10.1021/ja800516w). The seminal nature of the work attracted lot of press coverage in the scientific community. In yet another set of projects, I am investigating the effect of medicinal plant extracts on biological membranes and proteins residing therein. These representative examples illustrate the significant role of molecular simulations in the investigation of the molecular basis of diseased states, and consequent importance in realm of fundamental and health sciences research.

Uddannelse (Akademiske kvalifikationer)

Biochemical Engineering and Biotechnology, Masters in Technology, Indian Institute of Technology Delhi

Eksterne ansættelser

Visiting Professor, TATA Institute of Fundamental Research

Fingeraftryk Fingeraftryk er baseret på at anvende teksten fra personernes videnskabelige dokumenter til at skabe et indeks med vægtede emneordskoncepter, som definerer de vigtigste emner for hver enkelt forsker.

  • 1 Lignende profiler
Molecular Dynamics Simulation Medicin og biovidenskab
Membranes Kemiske forbindelser
lipids Fysik og astronomi
Lipids Kemiske forbindelser
Lipid Bilayers Medicin og biovidenskab
Lipid bilayers Kemiske forbindelser
Molecular dynamics Kemiske forbindelser
Computer simulation Kemiske forbindelser

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Publikationer 2005 2019

  • 62 Tidsskriftartikel
  • 4 Konferenceabstrakt i tidsskrift
  • 1 Konferenceabstrakt til konference
  • 1 Poster

Neurological disease mutations compromise a C-terminal ion pathway in the Na(+)/K(+)-ATPase

Poulsen, H., Khandelia, H., Morth, J. P., Bublitz, M., Mouritsen, O. G., Egebjerg, J. & Nissen, P., 2010, I : Nature. 467, 7311, s. 99-102

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Ions
Mutation
Potassium
Adenosine Triphosphatases
Protons

Lipid gymnastics: Complete acyl chain reversal in oxidized phospholipids: Evidence from Molecular simulations

Khandelia, H. & Mouritsen, O. G., 2009, I : Biophysical Journal. s. 459a 1 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskning

304 Downloads (Pure)

Triglyceride Blisters in Lipid Bilayers: Implications for Lipid Droplet Biogenesis and the Mobile Lipid Signal in Cancer Cell Membranes

Khandelia, H., Duelund, L., Pakkanen, K. I. & Ipsen, J. H., 2010, I : P L o S One. 5, 9, s. e12811

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Fil
Triolein
blisters
triolein
lipid bilayers
Lipid bilayers

Quantifying the Relationship Between Curvature and Electric Potential in Lipid Bilayers

Bruhn, D. S., Lomholt, M. A. & Khandelia, H., 2016, I : The Journal of Physical Chemistry Part B. 120, 21, s. 4812-4817

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Lipid bilayers
lipids
curvature
membranes
Membranes

A single K+-binding site in the crystal structure of the gastric proton pump

Yamamoto, K., Dubey, V., Irie, K., Nakanishi, H., Khandelia, H., Fujiyoshi, Y. & Abe, K., 22. aug. 2019, I : eLife. 8

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Proton Pumps
Adenosine Triphosphatases
Cations
Crystal structure
Binding Sites

Aktiviteter 2009 2017

Member, ESF Pool of Referees for Peer Reviewing Activities undertaken for ESF funding schemes (Ekstern organisation)

Himanshu Khandelia (Medlem)
2010 → …

Aktivitet: MedlemskabMedlemskab af forskningsnetværk eller ekspertgruppe

Nature Scientific Reports (Tidsskrift)

Himanshu Khandelia (Redaktør)
2014 → …

Aktivitet: Redaktionelt arbejde og fagfællebedømmelseRedaktør af tidsskriftForskning

International Workshop on Biomembranes: The consequences of complexity: CECAM conference, Helsinki

Himanshu Khandelia (Taler)
15. aug. 201619. aug. 2016

Aktivitet: Foredrag og mundtlige bidragForedrag og præsentationer i privat eller offentlig virksomhed

The elusive proton in ion pumps

Himanshu Khandelia (Underviser)
26. sep. 2017

Aktivitet: Foredrag og mundtlige bidragKonferenceoplæg

Breaking resistance development using molecules ‘dancing’ in Fibronacci patterns / At bremse resistensudvikling ved hjælp af molekyler der ‘danser’ i Fibonacci mønstre

S. J. Fey (Underviser), Himanshu Khandelia (Underviser), Jette E. Kristiansen (Underviser)
25. jan. 2017

Aktivitet: Foredrag og mundtlige bidragKonferenceoplæg

Projekter 2011 2022

Presse/medie

Afgrøder kan beskyttes mod radioaktivt nedfald

Himanshu Khandelia

18/03/2015

1 element af Mediedækning

Presse/medie

Punctured cell membranes lead to high blood pressure

Wojciech Kopec & Himanshu Khandelia

27/01/2014

1 element af Mediedækning

Presse/medie

HÆDER

Himanshu Khandelia

18/01/2019

1 Mediebidrag

Presse/medie