20052020

Publikationer pr. år

Hvis du har foretaget ændringer i Pure, vil de snart blive vist her.

Personlig profil

Forskningsområde

My research evolves around computer simulations of complex biological assemblies, with special focus on biological membranes and membrane associated biological processes. The ultimate objective is to obtain fundamental scientific insight into both the assembly and evolution of complex biomolecular structures through interactions and modification of their environment; and into the functioning of isolated biomolecular machines. The goal of the investigations will also be to examine the fundamental molecular basis of diseased states resulting from a perturbation of these interactions, thus motivating biotechnological applications and the rational development of therapeutic remedies and drugs. An important feature of this research is a close interface with experiments, wherein experimental data will motivate simulations, which in turn will drive new analytical measurements. With this goal, several collaborations with leading experimental groups have been established. Representative Examples: The following are some examples of projects. All of them address fundamental scientific problems, and also have biotechnological and medical applications. My most recent work involves the discovery of multiple ion pathways in trans- membrane ion pumps, a proposal that is likely to forever change the way biology looks at ion transport (Nature, 2010, DOI: 10.1038/nature09309). In another project, we have shown for the first time, that triglyceride droplets can be stable within lipid bilayers, this has implications for lipid droplet biogenesis and the mobile lipid signal in cancer cell membranes (PLoS One, 2010, DOI: 10.1371/journal.pone.0012811). We showed how oxidized phospholipids -which are now known be in involved in the genesis of several diseases- can significantly alter the biochemical andbiophysicalpropertiesoflipidmembranes(Biophys.J.,2009,DOI: DOI:10.1016/j.bpj.2009.01.007). In recent collaborative work with the Danish Cancer Society and the University of Helsinki Medical School, we showed for the first time that lipid secondary messengers could be targeted for anticancer therapy (JACS, 2008, DOI: 10.1021/ja800516w). The seminal nature of the work attracted lot of press coverage in the scientific community. In yet another set of projects, I am investigating the effect of medicinal plant extracts on biological membranes and proteins residing therein. These representative examples illustrate the significant role of molecular simulations in the investigation of the molecular basis of diseased states, and consequent importance in realm of fundamental and health sciences research.

Uddannelse (Akademiske kvalifikationer)

Biochemical Engineering and Biotechnology, Masters in Technology, Indian Institute of Technology Delhi

Eksterne ansættelser

Visiting Professor, TATA Institute of Fundamental Research

Fingeraftryk Fingeraftryk er baseret på at anvende teksten fra personernes videnskabelige dokumenter til at skabe et indeks med vægtede emneordskoncepter, som definerer de vigtigste emner for hver enkelt forsker.

  • 1 Lignende profiler

Netværk Nyligt eksternt samarbejde på landeniveau. Dyk ned i detaljerne ved at klikke på prikkerne.

Publikationer

Neurological disease mutations compromise a C-terminal ion pathway in the Na(+)/K(+)-ATPase

Poulsen, H., Khandelia, H., Morth, J. P., Bublitz, M., Mouritsen, O. G., Egebjerg, J. & Nissen, P., 2010, I : Nature. 467, 7311, s. 99-102

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Lipid gymnastics: Complete acyl chain reversal in oxidized phospholipids: Evidence from Molecular simulations

    Khandelia, H. & Mouritsen, O. G., 2009, I : Biophysical Journal. s. 459a 1 s.

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskning

    Triglyceride Blisters in Lipid Bilayers: Implications for Lipid Droplet Biogenesis and the Mobile Lipid Signal in Cancer Cell Membranes

    Khandelia, H., Duelund, L., Pakkanen, K. I. & Ipsen, J. H., 2010, I : P L o S One. 5, 9, s. e12811

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Fil
  • 415 Downloads (Pure)

    Quantifying the Relationship Between Curvature and Electric Potential in Lipid Bilayers

    Bruhn, D. S., Lomholt, M. A. & Khandelia, H., 2016, I : The Journal of Physical Chemistry Part B. 120, 21, s. 4812-4817

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Clearance of activity-evoked K+ transients and associated glia cell swelling occur independently of AQP4: A study with an isoform-selective AQP4 inhibitor

    Toft-Bertelsen, T. L., Larsen, B. R., Christensen, S. K., Khandelia, H., Waagepetersen, H. S. & MacAulay, N., 7. jun. 2020, I : Glia.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Aktiviteter

    Member, ESF Pool of Referees for Peer Reviewing Activities undertaken for ESF funding schemes (Ekstern organisation)

    Himanshu Khandelia (Medlem)

    2010 → …

    Aktivitet: MedlemskabMedlemskab af forskningsnetværk eller ekspertgruppe

    Nature Scientific Reports (Tidsskrift)

    Himanshu Khandelia (Redaktør)

    2014 → …

    Aktivitet: Redaktionelt arbejde og fagfællebedømmelseRedaktør af tidsskriftForskning

    International Workshop on Biomembranes: The consequences of complexity: CECAM conference, Helsinki

    Himanshu Khandelia (Oplægsholder)

    15. aug. 201619. aug. 2016

    Aktivitet: Foredrag og mundtlige bidragForedrag og præsentationer i privat eller offentlig virksomhed

    Invited Talk at the collaborative network SFB803

    Himanshu Khandelia (Underviser)

    18. jan. 2020

    Aktivitet: Foredrag og mundtlige bidragGæsteforelæsning, undervisning og kursusvirksomhed ved andre universiteter

    Invited Talk at the Collaborative Research Centre on the Dynamics of Membrane Systems

    Himanshu Khandelia (Underviser)

    23. nov. 2019

    Aktivitet: Foredrag og mundtlige bidragGæsteforelæsning, undervisning og kursusvirksomhed ved andre universiteter

    Projekter

    Presse/medier

    Afgrøder kan beskyttes mod radioaktivt nedfald

    Himanshu Khandelia

    18/03/2015

    1 element af Mediedækning

    Presse/medie

    Punctured cell membranes lead to high blood pressure

    Wojciech Kopec & Himanshu Khandelia

    27/01/2014

    1 element af Mediedækning

    Presse/medie

    HÆDER

    Himanshu Khandelia

    18/01/2019

    1 Mediebidrag

    Presse/medie