• J.B. Winsløws Vej 21, 3.

    5000 Odense C

    Danmark

20072019
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Personlig profil

Forskningsområde

Research Area

The research conducted in the group of Henrik Dimke can be divided into two lines. Focus is directed towards:

1) Elucidating the regulatory mechanisms involved in maintaining mineral balance (Calcium, Magnesium, and Phosphate) via trans- and paracellular pathways in kidney and intestine. In particular, we aim to understand the molecular regulation of divalent cation transport proteins such as the epithelial channels TRPV5 and TRPM6, which play key roles in renal Ca2+ and Mg2+ transport as well as the paracellular pore forming claudins. In addition, focus is directed towards understanding the role of the calcium sensing receptor and its involvement in renal calcium transport and kidney stone formation.
2) Moreover, additional studies are focusing on understanding the role of the endothelium in renal physiology and various forms of kidney disease.

 

Methods and Techniques

To elucidate the regulatory mechanisms involved in maintaining mineral balance, with special focus on the transport of the divalent cations calcium and magnesium in intestine and kidney, we have set up several approaches to study these specific areas utilizing various complex targeted transgenic strategies, histological and molecular biological techniques as well as human kidney isolates. In general, all studies aim to use whole-animal models to understand the often-complex relationship between structure and function of the kidney, intestine and bone as well as signaling cascades and hormonal regulatory systems functioning between cells and organs.

 

CV

Associate Professor Henrik Dimke is a molecular biologist with a M.Sc from Aarhus University and a PhD from Radboud University Nijmegen in the Netherlands. He has worked within the field of physiology for more than 15 and been abroad for nearly 8 years at leading international research laboratories. The group of Henrik Dimke is part of the Epithelial Transport Section at the Cardiovascular and Renal Research unit, situated in the Department of Molecular Medicine at the University of Southern Denmark. In addition, Henrik Dimke is affiliated withthe Department of Nephrology, at the Odense University Hospital.

Henrik Dimke holds support from the Independent Research Fund Denmark, in the form of Research Project 1 and Sapere Aude grants. In addition, the laboratory of H. Dimke has received funding from Fabrikant Vilhelm Pedersen og Hustrus Mindelegat, the Novo Nordisk Foundation, the Carlsberg Foundation, the A.P. Møller Foundation, the Beckett Foundation and the Lundbeck Foundation.

Follow Henrik Dimke on twitter @h_dimke and connect with Henrik Dimke on linked-in  

 

 

 

 

Teaching portfolio

Experience with teaching, guidance and exams: 

-Henrik Dimke has been teaching since 2008. Focus has mainly been directed towards physiology teaching of medical and biomechanical students (lectures and class hours as well as exercises) and related exams.  

 Educational administrative tasks: 

- Course director for module B8 (since 2016)  

Classes taught at SDU since 2014: 

Medicine, Module B8: Homeostasis

- Acid Base Physiology

- Renal Clearance 

- Diuretics

- Regulatory function of the kidneys

- Responsible for physiology exercise module B8

 

Medicine, Module B7: Reproduction and Pharmacodynamics 

- Calcium and Phosphate Balance 

- Female Reproduction 

- Male Reproduction  

 

SU502 biomedicine 

- Acid Base Physiology 

 

Methods, materials and tools: 

-Lectures (PowerPoint, whiteboard), team teaching (whiteboard), responsible for group teaching (physiology-exercise).  

 

Educational development: 

-Lecturer training program at SDU (2016)  

 

Educational awards: 

-Department of Molecular Medicine Teaching Award (2017) 

 

Methods, materials and tools: 

-Lectures (PowerPoint, whiteboard)

-Classroom teaching (whiteboard)

Forskningsområder

  • Dyrefysiologi
  • Nyresygdomme
  • Blodtryk

Fingeraftryk Fingeraftryk er baseret på at anvende teksten fra personernes videnskabelige dokumenter til at skabe et indeks med vægtede emneordskoncepter, som definerer de vigtigste emner for hver enkelt forsker.

  • 6 Lignende profiler
Kidney Medicin og biovidenskab
Magnesium Medicin og biovidenskab
Nephrons Medicin og biovidenskab
Electrolytes Medicin og biovidenskab
Aldosterone Medicin og biovidenskab
Calcium-Sensing Receptors Medicin og biovidenskab
Urine Medicin og biovidenskab
Divalent Cations Medicin og biovidenskab

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Publikationer 2007 2019

121 Downloads (Pure)

A bacterial display system for effective selection of protein-biotin ligase BirA variants with novel peptide specificity

Granhøj, J., Dimke, H. & Svenningsen, P., 11. mar. 2019, I : Scientific Reports. 9, 1, 11 s., 4118.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Ligases
Biotinylation
Peptides
Proteins
Lysine

Activation of the calcium sensing receptor attenuates TRPV6-dependent intestinal calcium absorption

Lee, J. J., Liu, X., O'Neil, D., Beggs, M. R., Weissgerber, P., Flockerzi, V., Chen, X-Z., Dimke, H. & Alexander, R. T., 6. jun. 2019, I : JCI Insight. 4, 11, 14 s., e128013.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Calcium-Sensing Receptors
Secondary Hyperparathyroidism
Hypercalcemia
Intestinal Mucosa
Parathyroid Hormone

Bacterial Peptide Display for the Selection of Novel Biotinylating Enzymes

Granhøj, J., Dimke, H. & Svenningsen, P., 3. okt. 2019, I : Journal of visualized experiments : JoVE. 152, 8 s., e60266.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Peptides
Enzymes
Display devices
Proteins
Biotinylation

Forskere efterspørger små og mellemstore bevillinger

Christiansen, P. M., Dimke, H., Norn, M-T., Wohlert, J. & Zinner, N. T., 31. okt. 2019, I : Forskningspolitikk.

Publikation: Bidrag til tidsskriftTidsskriftartikelFormidling

Åben adgang

"Hvis den private sektor virkelig mangler talent, så kom og hent det på universiteterne"

Bjørk, R., Dalsgaard, P., Dimke, H., Panyella Pedersen, B., Ravnsbæk, D. B. & Sørensen, T. J., 25. feb. 2019, I : Altinget.dk. 7 s.

Publikation: Bidrag til tidsskriftBidrag til avis - Kommentar/debatFormidling

Åben adgang

Aktiviteter 2013 2017

Invited speaker at the Physiologisches Institut, Christian-Albrechts-Universität, Kiel, Germany

Henrik Dimke (Underviser)
31. jan. 2017

Aktivitet: Foredrag og mundtlige bidragForedrag og præsentationer i privat eller offentlig virksomhed

Functional characterization, molecular physiology and relevance of pendrin in lung disorders

Henrik Dimke (Eksaminator)
2017 → …

Aktivitet: Censoraktivitet og eksamineringEkstern censoraktivitet

Trimethylangelicin (TMA) interacting directly with the f508del-CFTR protein rescues the chloride secretion

Henrik Dimke (Eksaminator)
2017

Aktivitet: Censoraktivitet og eksamineringEkstern censoraktivitet

Experimental Biology

Henrik Dimke (Deltager)
2. apr. 20166. apr. 2016

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

American Journal of Physiology: Renal Physiology (Tidsskrift)

Henrik Dimke (Peer reviewer)
2016 → …

Aktivitet: Redaktionelt arbejde og fagfællebedømmelsePeer reviewer/fagfællebedømmer af manuskripterForskning