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Publikationer 2001 2019

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Tidsskriftartikel
2019

Angiotensin-(1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4

Gómez-Mendoza, D. P., Marques, F. D., Melo-Braga, M. N., Sprenger, R. R., Sinisterra, R. D., Kjeldsen, F., Santos, R. A. & Verano-Braga, T., 30. sep. 2019, I : Journal of Proteomics. 208, 11 s., 103486.

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CXC Chemokines
Chemokine Receptors
Angiotensins
Down-Regulation
angiotensin I (1-7)

Assessment of protein extraction and digestion efficiency of well-established shotgun protocols for heart proteomics

Rodrigues-Ribeiro, L., Melo-Braga, M. N., Kjeldsen, F., Gómez-Mendoza, D. P. & Verano-Braga, T., 1. aug. 2019, I : Analytical Biochemistry. 578, s. 51-59

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Firearms
Proteolysis
Proteins
Buffers
Tissue

DirectMS1: MS/MS-free identification of 1000 proteins of cellular proteomes in 5 minutes

Ivanov, M. V., Bubis, J. A., Gorshkov, V., Tarasova, I. A., Levitsky, L. I., Lobas, A. A., Solovyeva, E. M., Pridatchenko, M. L., Kjeldsen, F. & Gorshkov, M. V., 5. sep. 2019, I : BioRxiv. 17 s.

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92 Downloads (Pure)

Protein corona formed on silver nanoparticles in blood plasma is highly selective and resistant to physicochemical changes of the solution

Gorshkov, V., Bubis, J. A., Solovyeva, E. M., Gorshkov, M. V. & Kjeldsen, F., 18. mar. 2019, I : Environmental Science: Nano. 6, 4, s. 1089-1098

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Silver
Blood
Nanoparticles
Plasmas
Hydrophobicity
82 Downloads (Pure)

Silver nanoparticle-induced expression of proteins related to oxidative stress and neurodegeneration in an in vitro human blood-brain barrier model

Khan, A. M., Korzeniowska, B., Gorshkov, V., Tahir, M., Schrøder, H., Skytte, L., Rasmussen, K. L., Khandige, S., Møller-Jensen, J. & Kjeldsen, F., 9. jan. 2019, I : Nanotoxicology. 13, 2, s. 221-239

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Oxidative stress
Silver
Nanoparticles
Proteins
Endothelial cells
2018
74 Downloads (Pure)

Co-exposure to silver nanoparticles and cadmium induce metabolic adaptation in HepG2 cells

Miranda, R. R., Gorshkov, V., Korzeniowska, B., Kempf, S. J., Neto, F. F. & Kjeldsen, F., 11. jul. 2018, I : Nanotoxicology. 12, 7, s. 781-795

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Cadmium
Silver
Nanoparticles
Proteins
Administrative data processing
103 Downloads (Pure)

Comparative proteomics as a tool for identifying specific alterations within interferon response pathways in human glioblastoma multiforme cells

Tarasova, I. A., Tereshkova, A. V., Lobas, A. A., Solovyeva, E. M., Sidorenko, A. S., Gorshkov, V., Kjeldsen, F., Bubis, J. A., Ivanov, M. V., Ilina, I. Y., Moshkovskii, S. A., Chumakov, P. M. & Gorshkov, M. V., 1. jan. 2018, I : OncoTarget. 9, 2, s. 1785-1802

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Glioblastoma
Oncolytic Virotherapy
Oncolytic Viruses
Viruses
Cell Line
140 Downloads (Pure)

SuperQuant-assisted comparative proteome analysis of glioblastoma subpopulations allows for identification of potential novel therapeutic targets and cell markers

Verano-Braga, T., Gorshkov, V., Munthe, S., Sørensen, M. D., Kristensen, B. W. & Kjeldsen, F., 6. feb. 2018, I : Oncotarget. 9, 10, s. 9400-9414

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Proteome
Glioblastoma
MicroRNAs
2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine
Activation Analysis
2017

Toxicological interactions of silver nanoparticles and non-essential metals in human hepatocarcinoma cell line

Miranda, R. R., Bezerra, A. G., Ribeiro, C. A. O., Randi, M. A. F., Voigt, C. L., Skytte, L., Rasmussen, K. L., Kjeldsen, F. & Neto, F. F., 2017, I : Toxicology in Vitro. 40, s. 134–143

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Silver
Assays
Metals
Cells
Nanoparticles
85 Downloads (Pure)

Uranyl Photocleavage of Phosphopeptides Yields Truncated C-Terminally Amidated Peptide Products

Elnegaard, R. L. B., Møllegaard, N. E., Zhang, Q., Kjeldsen, F. & Jørgensen, T. J. D., 2017, I : ChemBioChem. 18, 12, s. 1117-1122

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Phosphopeptides
Peptides
Ultraviolet Rays
Tandem Mass Spectrometry
Caseins
2016

High-performance hybrid Orbitrap mass spectrometers for quantitative proteome analysis: Observations and implications

Williamson, J. C., Edwards, A. V. G., Verano-Braga, T., Schwämmle, V., Kjeldsen, F., Jensen, O. N. & Larsen, M. R., mar. 2016, I : Proteomics. 16, 6, s. 907-914

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Heat-Shock Response
Mass spectrometers
Proteome
Ions
Isotope Labeling
142 Downloads (Pure)

Peptide de novo sequencing of mixture tandem mass spectra

Gorshkov, V., Hotta, S. Y. K., Braga, T. V. & Kjeldsen, F., 19. sep. 2016, I : Proteomics. 16, 18, s. 2470-2479

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Deconvolution
Peptides
Ions
Search Engine
Search engines
2015
85 Downloads (Pure)

Charge Inversion of Phospholipids by Dimetal Complexes for Positive Ion-Mode Electrospray Ionization Mass Spectrometry Analysis

Svane, S., Gorshkov, V. & Kjeldsen, F., 1. sep. 2015, I : Analytical Chemistry. 87, 17, s. 8732-8739

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Electrospray ionization
Mass spectrometry
Phospholipids
Phosphatidylinositols
Positive ions
102 Downloads (Pure)

Effect of Metals in Biomimetic Dimetal Complexes on Affinity and Gas-Phase Protection of Phosphate Esters

Svane, S., Jørgensen, T. J. D., McKenzie, C. & Kjeldsen, F., 2015, I : Analytical Chemistry. 87, 14, s. 7060–7068

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91 Downloads (Pure)

SuperQuant: a Data Processing Approach to Increase Quantitative Proteome Coverage

Gorshkov, V., Verano-Braga, T. & Kjeldsen, F., 15. maj 2015, I : Analytical Chemistry. 87, 12, s. 6319–6327

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Proteome
Peptides
Ions
Data recording
Proteins

The Selectivity of Water-based Pyrophosphate Recognition is Tuned by Metal Substitution in Dimetallic Receptors

Svane, S., Kjeldsen, F., McKee, V. & McKenzie, C., 2015, I : Dalton Transactions (Print Edition). 44, 26, s. 11877-11886

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2014

Exposure to silver nanoparticles induces size- and dose-dependent oxidative stress and cytotoxicity in human colon carcinoma cells

Miethling-Graff, R., Rumpker, R., Richter, M., Verano-Braga, T., Kjeldsen, F., Brewer, J. R., Hoyland, J., Rubahn, H-G. & Erdmann, H., 2014, I : Toxicology in Vitro. 28, 7, s. 1280–1289

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Oxidative stress
Intestinal Mucosa
Cytotoxicity
Silver
Particle Size

Insights into the Cellular Response Triggered by Silver Nanoparticles using Quantitative Proteomics

Verano-Braga, T., Miethling-Graff, R., Wojdyla, K. I., Rogowska-Wrzesinska, A., Brewer, J. R., Erdmann, H. & Kjeldsen, F., 2014, I : A C S Nano. 8, 3, s. 2161–2175

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N-terminal sequence tagging using reliably determined b2 ions: A useful approach to deconvolute tandem mass spectra of co-fragmented peptides in proteomics

Kryuchkov, F., Verano-Braga, T. & Kjeldsen, F., 2014, I : Journal of Proteomics. 103, May, s. 254–260

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2013

Deconvolution of mixture spectra and increased throughput of Peptide identification by utilization of intensified complementary ions formed in tandem mass spectrometry

Kryuchkov, F., Verano-Braga, T., Hansen, T. A., Sprenger, R. R. & Kjeldsen, F., 3. jun. 2013, I : Journal of Proteome Research. 12, 7, s. 3362–3371

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Deconvolution
Tandem Mass Spectrometry
Mass spectrometry
Computer aided design
Throughput

Discovery and Characterization of Alamandine, a Novel Component of the Renin-Angiotensin System

Lautner, R. Q., Villela, D. C., Fraga-Silva, R. A., Silva, N. C., Verano-Braga, T., Costa-Fraga, F., Jankowski, J., Jankowski, V., De Sousa, F. B., Alzamora, A. C., Soares, E. R., Barbosa, C. M., Kjeldsen, F., Oliveira, A. C., Braga, J. F., Savergnini, S. Q., Etelvino, G. M., Peluso, A. A. B., Passos-Silva, D. G., Ferreira, A. J. & 12 flere, Alves, F., Martins, A. S., Raizada, M. K., Paula, R. D., Motta-Santos, D., Klempin, F., Pimenta, A. M. C., Alenina, N., Sinisterra, R. D. M., Bader, M., Campagnole-Santos, M. J. & Santos, R. A., 2013, I : Circulation Research. 112, 8, s. 1104-1111 8 s.

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Renin-Angiotensin System
Inbred SHR Rats
G-Protein-Coupled Receptors
Isoproterenol
Vasodilation

Moving pieces in a venomic puzzle: unveiling post-translationally modified toxins from Tityus serrulatus

Verano-Braga, T., Dutra, A. A. A., León, I. R., Melo-Braga, M. N., Roepstorff, P., Pimenta, A. M. C. & Kjeldsen, F., 5. jul. 2013, I : Journal of Proteome Research. 12, 7, s. 3460-70 11 s.

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Venoms
Peptides
Scorpion Venoms
Proteolysis
Molecules

The proteomic profile of Stichodactyla duerdeni secretion reveals the presence of a novel O-linked glycopeptide

Cassoli, J. S., Verano-Braga, T., Oliveira, J. S., Montandon, G. G., Cologna, C. T., Peigneur, S., Pimenta, A. M. D. C., Kjeldsen, F., Roepstorff, P., Tytgat, J. & de Lima, M. E., 2013, I : Journal of Proteomics. 87, s. 89-102

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Sea Anemones
Glycopeptides
Peptides
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Animals
2012

Automated and high confidence protein phosphorylation site localization using complementary collision-activated dissociation and electron transfer dissociation tandem mass spectrometry

Hansen, T. A., Sylvester, M., Jensen, O. N. & Kjeldsen, F., 20. nov. 2012, I : Analytical Chemistry. 84, 22, s. 9694-9699 6 s.

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Phosphorylation
Mass spectrometry
Electrons
Proteins
Phosphopeptides

Overcoming the Instability of Gaseous Peptide Phosphate Ester Groups by Dimetal Protection

Bidragets oversatte titel: Overcoming the Instability of Gaseous Peptide Phosphate Ester Groups by Dimetal ProtectionSvane, S., Kryuchkov, F., Lennartson, A., McKenzie, C. J. & Kjeldsen, F., 2012, I : Angewandte Chemie International Edition. 51, 13, s. 3216-3219

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Reduction in Database Search Space by Utilization of Amino Acid Composition Information from Electron Transfer Dissociation and Higher-Energy Collisional Dissociation Mass Spectra

Hansen, T. A., Kryuchkov, F. & Kjeldsen, F., 2012, I : Analytical Chemistry. 84, s. 6638-6645 7 s.

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Electron Transfer Dissociation Reveals Changes in the Cleavage Frequencies of Backbone Bonds Distant to Amide-to-Ester Substitutions in Polypeptides

Hansen, T. A., Jung, H. R. & Kjeldsen, F., 2011, I : Journal of the American Society for Mass Spectrometry. 22 , 11, s. 1953-1957

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2010

Undesirable charge-enhancement of isobaric tagged phosphopeptides leads to reduced identification efficiency

Thingholm, T. E., Palmisano, G., Kjeldsen, F. & Larsen, M. R., 6. aug. 2010, I : Journal of Proteome Research. 9, 8, s. 4045-52 8 s.

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Phosphopeptides
Labeling
Cell culture
Peptides
Mass spectrometry
2008

Analytical Utility of Small Neutral Losses from Reduced Species in Electron Capture Dissociation Studied Using SwedECD Database

Kjeldsen, F., 1. nov. 2008, I : Analytical Chemistry. 80, 21, s. 8089-8094 5 s.

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Isocratic Solid Phase Extraction-Liquid Chromatography (SPE-LC) Interfaced to High-Performance Tandem Mass Spectrometry for Rapid Protein Identification

Hørning, O. B., Kjeldsen, F., Theodorsen, S., Vorm, O. & Jensen, O. N., 2008, I : Journal of Proteome Research. 7, 8, s. 3159-3167 8 s.

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Solid Phase Extraction
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography
Mass spectrometry
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography
Mass spectrometry
Negative ions
2007

A direct comparison of protein structure in the gas and solution phase: the Trp-cage

Patriksson, A., Adams, C. M., Kjeldsen, F., Zubarev, R. A. & van der Spoel, D., 22. nov. 2007, I : Journal of Physical Chemistry B. 111, 46, s. 13147-13150 3 s.

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Gases
vapor phases
proteins
Proteins
zwitterions

Analysis of histidine phosphorylation using tandem MS and ion-electron reactions

Kleinnijenhuis, A. J., Kjeldsen, F., Kallipolitis, B., Haselmann, K. F. & Jensen, O. N., 1. okt. 2007, I : Analytical Chemistry. 79, 19, s. 7450-7456 6 s.

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Backbone carbonyl group basicities are related to gas-phase fragmentation of peptides and protein folding

Savitski, M. M., Kjeldsen, F., Nielsen, M. L., Garbuzynskiy, S. O., Galzitskaya, O. V., Surin, A. K. & Zubarev, R. A., 1. jan. 2007, I : Angewandte Chemie - International Edition. 46, 9, s. 1481-1484 3 s.

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Hydrogen rearrangement to and from radical z fragments in electron capture dissociation of peptides

Savitski, M. M., Kjeldsen, F., Nielsen, M. L. & Zubarev, R. A., 1. jan. 2007, I : Journal of The American Society for Mass Spectrometry. 18, 1, s. 113-20 8 s.

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Hydrogen
Electrons
Peptides
Thermochemistry
Carbon

On studying protein phosphorylation patterns using bottom-up LC-MS/MS: the case of human alpha-casein

Kjeldsen, F., Savitski, M. M., Nielsen, M. L., Shi, L. & Zubarev, R. A., 1. aug. 2007, I : Analyst. 132, 8, s. 768-776 8 s.

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Phosphorylation
Caseins
Proteins
Casein Kinases
Peptides

Peptide sequencing and characterization of post-translational modifications by enhanced ion-charging and liquid chromatography electron-transfer dissociation tandem mass spectrometry

Kjeldsen, F., Giessing, A., Ingrell, C. R. & Jensen, O. N., 15. dec. 2007, I : Analytical Chemistry. 79, 24, s. 9243-9252 9 s.

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Liquid chromatography
Mass spectrometry
Ions
Peptides
Electrons

Relative specificities of water and ammonia losses from backbone fragments in collision-activated dissociation

Savitski, M. M., Kjeldsen, F., Nielsen, M. L. & Zubarev, R. A., 1. jul. 2007, I : Journal of Proteome Research. 6, 7, s. 2669-2673 4 s.

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Ammonia
Ions
Amino Acids
Water
Isotopes

SwedCAD, a database of annotated high-mass accuracy MS/MS spectra of tryptic peptides

Fälth, M., Savitski, M. M., Nielsen, M. L., Kjeldsen, F., Andren, P. E. & Zubarev, R. A., 1. okt. 2007, I : Journal of Proteome Research. 6, 10, s. 4063-4067 4 s.

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2006

Complementary sequence preferences of electron-capture dissociation and vibrational excitation in fragmentation of polypeptide polycations

Savitski, M. M., Kjeldsen, F., Nielsen, M. L. & Zubarev, R. A., 11. aug. 2006, I : Angewandte Chemie International Edition. 45, 32, s. 5301-3 3 s.

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Determination of the location of positive charges in gas-phase polypeptide polycations by tandem mass spectrometry

Kjeldsen, F., Savitski, M. M., Adams, C. M. & Zubarev, R. A., 1. jun. 2006, I : International Journal of Mass Spectrometry. 252, 3, s. 204-212 9 s.

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Mass spectrometry
Gases
Peptides
Chemical activation
Electrons

Prediction of N-Cα bond cleavage frequencies in electron capture dissociation of Trp-cage dications by force-field molecular dynamics simulations

Patriksson, A., Adams, C., Kjeldsen, F., Raber, J., Van Der Spoel, D. & Zubarev, R. A., 15. feb. 2006, I : International Journal of Mass Spectrometry. 248, 3, s. 124-135

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Molecular dynamics
Stereoisomerism
Electrons
Computer simulation
Gases

Probing solution- and gas-phase structures of Trp-cage cations by chiral substitution and spectroscopic techniques

Adams, C. M., Kjeldsen, F., Patriksson, A., van der Spoel, D., Gräslund, A., Papadopoulos, E. & Zubarev, R. A., 1. jul. 2006, I : International Journal of Mass Spectrometry. 253, 3, s. 263-273 11 s.

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Phase structure
Cations
Substitution reactions
Gases
Stereoisomerism

Zwitterionic states in gas-phase polypeptide ions revealed by 157-nm ultra-violet photodissociation

Kjeldsen, F., Silivra, O. A. & Zubarev, R. A., 16. okt. 2006, I : Chemistry: A European Journal. 12, 30, s. 7920-8 9 s.

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Cations
Gases
Ions
Peptides
Basic Amino Acids
2005

Cα-C backbone fragmentation dominates in electron detachment dissociation of gas-phase polypeptide polyanions

Kjeldsen, F., Silivra, O. A., Ivonin, I. A., Haselmann, K. F., Gorshkov, M. & Zubarev, R. A., 2005, I : Chemistry: A European Journal. 11, 6, s. 1803-1812

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Polypeptides
Electrons
Gases
Mass spectrometry
Peptides

Dissociation of peptide ions by fast atom bombardment in a quadrupole ion trap

Misharin, A. S., Silivra, O. A., Kjeldsen, F. & Zubarev, R. A., 9. aug. 2005, I : Rapid Communications in Mass Spectrometry. 19, 15, s. 2163-2171 9 s.

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Ions
Atoms
Peptides
Anions
Cations

Facile disulfide bond cleavage in gaseous peptide and protein cations by ultraviolet photodissociation at 157 nm

Fung, Y. M. E., Kjeldsen, F., Silivra, O. A., Chan, T. W. D. & Zubarev, R. A., 7. okt. 2005, I : Angewandte Chemie International Edition. 44, 39, s. 6399-403 5 s.

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Proteomics-grade de novo sequencing approach

Savitski, M. M., Nielsen, M. L., Kjeldsen, F. & Zubarev, R. A., 2005, I : Journal of Proteome Research. 4, 6, s. 2348-54 7 s.

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Peptides
Databases
Dispensers
Tandem Mass Spectrometry
Trypsin
2004

Dissociative recombination cross section and branching ratios of protonated dimethyl disulfide and N-methylacetamide

Ai-Khaiili, A., Thomas, R., Ehlerding, A., Hellberg, F., Geppert, W. D., Zhaunerchyk, V., Af Ugglas, M., Larsson, M., Uggerud, E., Vedde, J., Adlhart, C., Semaniak, J., Kamińska, M., Zubarev, R. A., Kjeldsen, F., Andersson, P. U., Österdahl, F., Bednarska, V. A. & Paál, A., 22. sep. 2004, I : Journal of Chemical Physics. 121, 12, s. 5700-5708 9 s.

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disulfides
Hydrogen
Electrons
cleavage
cross sections