• Campusvej 55

    5230 Odense M

    Danmark

19952020
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Publikationer 1995 2020

2020

Binding and intracellular transport of 25-hydroxycholesterol by Niemann-Pick C2 protein

Petersen, D., Reinholdt, P., Szomek, M., Hansen, S. K., Poongavanam, V., Juhl, A. D., Heegaard, C. W., Krishnan, K., Fujiwara, H., Covey, D. F., Ory, D. S., Kongsted, J. & Wüstner, D., 1. feb. 2020, I : B B A - Biomembranes. 1862, 2, 14 s., 183063.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Cholesterol
Proteins
Sterols
Fluorescence
Fluorescence Recovery After Photobleaching
2019

Computational Characterization of a Cholesterol-Based Molecular Rotor in Lipid Membranes

Reinholdt, P., Wind, S., Wüstner, D. & Kongsted, J., 2019, I : Journal of Physical Chemistry B. 123, 34, s. 7313-7326 14 s.

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Cholesterol
cholesterol
Membrane Lipids
rotors
lipids
15 Downloads (Pure)

Computational Modeling Explains the Multi Sterol Ligand Specificity of the N-Terminal Domain of Niemann-Pick C1-Like 1 Protein

Poongavanam, V., Kongsted, J. & Wüstner, D., 2019, I : ACS Omega. 4, 25, s. 20894-20904 11 s.

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Åben adgang
Fil
Cholesterol
Sterols
Ligands
Proteins
Molecular mechanics

Direct observation of nuclear receptor dynamics by single molecule tracking and imaging of intrinsically fluorescent ligands

Wüstner, D., 2019.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

Mechanism of Cholesterol Sensing in the Niemann Pick Protein (NPC1) using Molecular Dynamics Simulations.

Dubey, V., Bozorg, B., Wüstner, D. & Khandelia, H., 2019.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

Photophysical investigation of two emissive nucleosides exhibiting gigantic stokes shifts

Stendevad, J., Hornum, M., Wüstner, D. & Kongsted, J., 17. jun. 2019, I : Photochemical and Photobiological Sciences. 18, 7, s. 1858-1865 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Deoxycytidine
nucleosides
Nucleosides
analogs
shift

Quantitative analysis of ergosterol transport across the yeast plasma membrane.

Wüstner, D., 2019.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

Rational design of novel fluorescent analogues of cholesterol: a "step-by-step" computational study

Bonvicini, A., Reinholdt, P., Tognetti, V., Joubert, L., Wüstner, D. & Kongsted, J., 24. jun. 2019, I : Physical Chemistry Chemical Physics. 21, 28, s. 15487-15503 17 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

multiphoton absorption
cholesterol
Cholesterol
analogs
membranes
61 Downloads (Pure)

Steady state analysis of influx and transbilayer distribution of ergosterol in the yeast plasma membrane

Wüstner, D., 2019, I : Theoretical Biology and Medical Modelling. 16, 26 s., 13.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Steady-state Analysis
Plasma Membrane
Cell membranes
Yeast
Cell Membrane

Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

Winkler, M. B. L., Kidmose, R. T., Szomek, M., Thaysen, K., Rawson, S., Muench, S. P., Wüstner, D. & Pedersen, B. P., 3. okt. 2019, I : Cell. 179, 2, s. 485-497.e18

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Sterols
Protein C
Membranes
Tunnels
Protons
2018
124 Downloads (Pure)

A Discontinuous Galerkin Model for Fluorescence Loss in Photobleaching

Hansen, C. V., Schroll, A. & Wüstner, D., 23. jan. 2018, I : Scientific Reports. 8, 13 s., 1387.

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Åben adgang
Fil
Fluorescence
Green Fluorescent Proteins
Microscopy
109 Downloads (Pure)

A discontinuous Galerkin model for fluorescence loss in photobleaching of intracellular polyglutamine protein aggregates

Lorenzen, C. V., Schroll, A. & Wüstner, D., 29. nov. 2018, I : B M C Biophysics. 11, 14 s., 7.

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Åben adgang
Fil
Fluorescence
Proteins
Inclusion Bodies
Protein Aggregates
Cell Nucleus Active Transport

Analysis of cholesterol export from endo-lysosomes by Niemann Pick C2 protein using combined fluorescence and X-ray microscopy

Dupont, A., Lund, F. W., Jensen, M. L. V., Szomek, M., Nielsen, G. K., Heegaard, C. W., Guttmann, P., Werner, S., McNally, J., Schneider, G., Kapishnikov, S. & Wüstner, D., 6. nov. 2018, I : BioRxiv.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

111 Downloads (Pure)

Bayesian model selection with fractional Brownian motion

Krog, J. F. C., Hervig Jacobsen, L., Lund, F. W., Wüstner, D. & Lomholt, M. A., 18. sep. 2018, I : Journal of Statistical Mechanics: Theory and Experiment. 2018, 9, 23 s., 093501.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Fil
Bayesian Model Selection
Fractional Brownian Motion
trajectories
Trajectory
goodness of fit
111 Downloads (Pure)

Ergosterol is mainly located in the cytoplasmic leaflet of the yeast plasma membrane

Solanko, L. M., Sullivan, D. P., Sere, Y. Y., Szomek, M., Lunding, A., Solanko, K. A., Pizovic, A., Stanchev, L. D., Pomorski, T. G., Menon, A. K. & Wüstner, D., 2018, I : Traffic. 19, 3, s. 198-214

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Åben adgang
Fil
Ergosterol
Cell membranes
Yeast
Cell Membrane
Sterols

Live-cell imaging of new polyene sterols for improved analysis of intracellular cholesterol transport

Modzel, M., Solanko, K. A., Szomek, M., Hansen, S. K., Dupont, A., Nåbo, L. J., Kongsted, J. & Wüstner, D., 2018, I : Journal of Microscopy. 271, 1, s. 36-48

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Polyenes
Filipin
Membranes
Fluorescence Microscopy
Microscopy
134 Downloads (Pure)

Niemann-Pick C2 protein regulates sterol transport between plasma membrane and late endosomes in human fibroblasts

Berzina, Z., Solanko, L. M., Mehadi, A. S., Jensen, M. L. V., Lund, F. W., Modzel, M., Szomek, M., Solanko, K. A., Dupont, A., Nielsen, G. K., Heegaard, C. W., Ejsing, C. S. & Wüstner, D., 2018, I : Chemistry and Physics of Lipids. 213, s. 48-61

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Åben adgang
Fil
Sterols
Fibroblasts
Cell membranes
Cell Membrane
Cholesterol
134 Downloads (Pure)

Structural design of intrinsically fluorescent oxysterols

Nåbo, L. J., Modzel, M., Krishnan, K., Covey, D. F., Fujiwara, H., Ory, D. S., Szomek, M., Khandelia, H., Wüstner, D. & Kongsted, J., 2018, I : Chemistry and Physics of Lipids. 212, s. 26–34

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Åben adgang
Fil
Structural design
Photons
Membranes
Fluorescence microscopy
Electronic structure
2017

Quantitative co-localization and pattern analysis of endo-lysosomal cargo in subcellular image cytometry and validation on synthetic image sets

Lund, F. W. & Wüstner, D., 2017, Lysosomes: Methods and Protocols. Öllinger, K. & Appelqvist, H. (red.). Humana Press, s. 93-128 (Methods in Molecular Biology, Bind 1594).

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

Filipin
Exosomes
Markov Chains
Fluorescence Microscopy
Cell Communication

Synthesis and live-cell imaging of fluorescent sterols for analysis of intracellular cholesterol transport

Modzel, M., Lund, F. W. & Wüstner, D., 2017, Cholesterol Homeostasis: Methods and Protocols. C. Gelissen, I. & J. Brown, A. (red.). Humana Press, s. 111-140 (Methods in Molecular Biology, Bind 1583).

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

Photons
Caveolins
Caveolae
Homeostasis
Fluorescence
2016
154 Downloads (Pure)

A comparative study on fluorescent cholesterol analogs as versatile cellular reporters

Sezgin, E., Betul Can, F., Schneider, F., Clausen, M. P., Galiani, S., Stanly, T. A., Waithe, D., Colaco, A., Honigmann, A., Wüstner, D., Platt, F. & Eggeling, C., 2016, I : Journal of Lipid Research. 57, s. 299-309

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Cholesterol
Membranes
Assays
Cell membranes
Fluorescence

Computational analysis of sterol ligand specificity of the Niemann Pick C2 protein

Poongavanam, V., Kongsted, J. & Wüstner, D., 2016, I : Biochemistry. 55, 36, s. 5165-5179

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

153 Downloads (Pure)

Embedding beyond electrostatics: The role of wave function confinement

Nåbo, L. J., Olsen, J. M. H., Holmgaard List, N., Solanko, L. M., Wüstner, D. & Kongsted, J., 14. sep. 2016, I : The Journal of Chemical Physics. 145, 7 s., 104102.

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Åben adgang
Fil
Wave functions
embedding
Electrostatics
wave functions
electrostatics

Imaging approaches for analysis of cholesterol distribution and dynamics in the plasma membrane

Wüstner, D., Modzel, M., Lund, F. W. & Lomholt, M. A., 2016, I : Chemistry and Physics of Lipids. 199, s. 106-135

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Potential of BODIPY-cholesterol for analysis of cholesterol transport and diffusion in living cells

Wüstner, D., Lund, F. W., Röhrl, C. & Stangl, H., 2016, I : Chemistry and Physics of Lipids. 194, s. 12-28

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Cholesterol
Cells
Fluorescence
Sterols
Cell membranes
2015

Computational Modeling of Fluorescence Loss in Photobleaching

Hansen, C. V., Schroll, A. & Wüstner, D., aug. 2015, I : Computing and Visualization in Science. 17, 4, s. 151-166

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Photobleaching
Computational Modeling
Fluorescence
Microscopy
Cell

Design of new fluorescent Cholesterol and Ergosterol analogs: Insights from theory

Nåbo, L. J., List, N. H., Witzke, S., Wüstner, D., Khandelia, H. & Kongsted, J., 2015, I : BBA General Subjects. 1848, 10, part A, s. 2188–2199

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Fluorescent sterols and cholesteryl esters as probes for intracellular cholesterol transport

Solanko, K. A., Modzel, M., Solanko, L. M. & Wüstner, D., 1. jan. 2015, I : Lipid Insights. 8s1, s. 95-114 20 s.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Åben adgang
Cholesterol Esters
Sterols
Cholesterol
Polyenes
Fluorophores
283 Downloads (Pure)

How cholesterol interacts with proteins and lipids during its intracellular transport

Wüstner, D. & Solanko, K., 2015, I : B B A - Biomembranes. 1848, 9, s. 1908-26

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Åben adgang
Fil
Sterols
Cholesterol
Lipids
Proteins
Cells
2014

Atomistic Monte Carlo simulation of lipid membranes

Wüstner, D. & Sklenar, H., 24. jan. 2014, I : International Journal of Molecular Sciences. 15, 2, s. 1767-803 37 s., ijms15021767.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
lipids
membranes
Monte Carlo method
simulation
closures

Dehydroergosterol as an analogue for cholesterol: Why it mimics cholesterol so well?

Pourmosa, M., Rog, T., Mikkeli, R., Vattulaien, I., Solanko, L. M., Wüstner, D., List, N. H., Kongsted, J. & Karttunen, M., 2014, I : Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 118, s. 7345

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Photobleaching kinetics and time-integrated emission of fluorescent probes in cellular membranes.

Wüstner, D., Christensen, T., Solanko, L. M. & Sage, D., 29. jul. 2014, I : Molecules. 19, 8, s. 11096-11130 35 s., molecules190811096.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Photobleaching
Bleaching
Fluorescent Dyes
Membranes
Kinetics

SpatTrack: an imaging toolbox for analysis of vesicle motility and distribution in living cells.

Lund, F. W., Jensen, M. L., Christensen, T., Nielsen, G. K., Heegaard, C. W. & Wüstner, D., 16. okt. 2014, I : Traffic. 15, 12, s. 1406-29 25 s., tra.12228.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Cells
Imaging techniques
Spatial Analysis
Fluorescence microscopy
Complex networks

The second-order polarization propagator approximation (SOPPA) method coupled to the polaizable continuum model

Eriksen, J. J., Solanko, L. M., Nåbo, L. J., Wüstner, D., Sauer, S. P. A. & Kongsted, J., 2014, I : Computational and Theoretical Chemistry. 1040-1041, s. 54

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

2013

A comparison of single particle tracking and temporal image correlation spectroscopy for quantitative analysis of endosome motility

Lund, F. W. & Wustner, D., 2013, I : Journal of Microscopy. 252, 2, s. 169-188

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Noise
Signal-To-Noise Ratio
Lighting
Fibroblasts
Fluorescence

Membrane orientation and lateral diffusion of BODIPY-cholesterol as a function of probe structure

Solanko, L. M., Wüstner, D., Lund, F. W., Brewer, J. R., Midtiby, H., Bittman, R., Eggeling, C., Honigmann, A. & Dekaris, V., 5. nov. 2013, I : Biophysical Journal. 105, 9, s. 2082-2092 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Cholesterol
Membranes
Cell membranes
Fluorophores
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
2012

Analysis of Cholesterol Trafficking with Fluorescent Probes

Bidragets oversatte titel: Analysis of Cholesterol Trafficking with Fluorescent ProbesMaxfield, F. R. & Wustner, D., 2012, LIPIDS, VOL 108. DiPaolo, G. & Wenk, MR. (red.). Bind 108. s. 367-393 27 s. (Methods in Cell Biology, Bind 108).

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

Cholesterol trafficking and distribution between cellular membranes

Wüstner, D., Solanko, L. M. & Lund, F. W., 2012, Cholesterol Regulation of Ion Channels and Receptors . Levitan, I. & Barrantes, F. (red.). John Wiley & Sons Ltd, s. 3-25

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

Following Intracellular Cholesterol Transport by Linear and Non-Linear Optical Microscopy of Intrinsically Fluorescent Sterols

Bidragets oversatte titel: Following Intracellular Cholesterol Transport by Linear and Non-Linear Optical Microscopy of Intrinsically Fluorescent SterolsWustner, D., 2012, I : Current Pharmaceutical Biotechnology. 13, 2, s. 303-318 16 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Quantitative fluorescence loss in photobleaching for analysis of protein transport and aggregation

Wüstner, D., Solanko, L. M., Lund, F. W., Sage, D., Schroll, A. & Lomholt, M. A., 2012, I : B M C Bioinformatics. 13, s. 296

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Quantitative fluorescence studies of intracellular sterol transport and distribution

Wüstner, D., Lund, F. W. & Solanko, L. M., 2012, Fluorescent Methods to Study Biological Membranes. Mély, Y. & Duportail, G. (red.). Bind 13. s. 185-213 (Springer Series on Fluorescence).

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

Two-photon time-lapse microscopy of BODIPY-cholesterol reveals anomalous sterol diffusion in chinese hamster ovary cells

Lund, F. W., Lomholt, M. A., Solanko, L. M., Bittman, R. & Wustner, D., 2012, I : B M C Biophysics. 5, s. 20

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

2011

Multicolor bleach-rate imaging enlightens in vivo sterol transport

Wüstner, D. & Sage, D., 2011, I : Communicative & Integrative Biology. 3, 4, s. 370-373 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

sterols
image analysis
bleaching
endosomes
Caenorhabditis elegans

Potential of ultraviolet widefield imaging and multiphoton microscopy for analysis of dehydroergosterol in cellular membranes

Wüstner, D., Brewer, J. R., Bagatolli, L. & Sage, D., jan. 2011, I : Microscopy Research and Technique. 74, 1, s. 92-108 17 s.

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Microscopy
Microscopic examination
membranes
microscopy
Membranes

Quantitative assessment of sterol traffic in living cells by dual labeling with dehydroergosterol and BODIPY-cholesterol

Wustner, D., Solanko, L., Sokol, O., Garvik, O., Li, Z. G., Bittman, R., Korte, T. & Herrmann, A., 2011, I : Chemistry and Physics of Lipids. 164, 3, s. 221-235 15 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The role of ABC proteins Aus1p and Pdr11p in the uptake of external sterols in yeast: dehydroergosterol fluorescence study.

Kohut, P., Wüstner, D., Hronska, L., Kuchler, K., Hapala, I. & Valachovic, M., 2011, I : Biochemical and Biophysical Research Communications. 404, 1, s. 233-238 6 s.

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Sterols
Yeast
Adenosine Triphosphate
Fluorescence
Ergosterol
2010

Selective visualization of fluorescent sterols in Caenorhabditis elegans by bleach-rate-based image segmentation

Wüstner, D., Landt Larsen, A., Færgeman, N. J., Brewer, J. R. & Sage, D., 1. apr. 2010, I : Traffic. 11, 4, s. 440-54 15 s.

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Caenorhabditis elegans
Sterols
Image segmentation
Visualization
Bleaching
2009

Intracellular Cholesterol Transport

Wüstner, D., 2009, Cellular Lipid Metabolism. Ehnholm, C. (red.). Heidelberg: Springer, s. 157-190 34 s.

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskning

Live cell linear dichroism imaging reveals extensive membrane ruffling within the docking structure of natural killer cell immune synapses

Benninger, R. K. P., Vanherberghen, B., Young, S., Taner, S. B., Culley, F. J., Schnyder, T., Neil, M. A. A., Wüstner, D., French, P. M. W., Davis, D. M. & Onfelt, B., 1. jan. 2009, I : Biophysical Journal. 96, 2, s. L13-5

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Membranes
Cell Membrane
Optical Imaging
Photons

The fluorescent cholesterol analog dehydroergosterol induces liquid-ordered domains in model membranes

Garvik, O., Benediktson, P., Simonsen, A. C., Ipsen, J. H. & Wüstner, D., 2009, I : Chemistry and Physics of Lipids. 159, 2, s. 114–118 5 s.

Publikation: Bidrag til tidsskriftLetterForskningpeer review