Forskningsområde

Arbejder med translationel forskning indenfor behandlingen af hjernetumorer

Forskningsinformation

Hjernetumorer, translationel forskning, klinisk forskning

CV

CURRICULUM VITAE PHD, MD Bo Halle PROFILE -Junior Consultant Neurosurgery, Associate Professor, MD, PhD -Board member, Danish Neurosurgical Society (2014-2019) -Member of the Danish Brain Cancer Society Expert Panel (2017-) -Research focus: Brain tumor models, Brain cancer, Skull base tumors, Drug-delivery, Convection-enhanced delivery -18 publications EDUCATION 2018 Specialist in Neurosurgery 2014 PhD, Univ. of Southern Denmark 2006 Medical Doctor (MD), Univ. of Southern Denmark SCIENTIFIC ACTIVITIES SCIENTIFIC POSITIONS 2018, Associate Professor, Clinical Institute, Univ. of Southern Denmark 2011-2014, PhD student, Faculty of Health Sciences, Univ. of Southern Denmark SUPERVISION OF STUDENTS (Co supervisor) -One-year pre-graduate medical research stud: 3 INTERNATIONAL COLLABORATIONS -E Marcusson, PhD, Regulus Therapeutics, Inc. 3545 John Hopkins Ct., Suite 210, San Diego, CA 92121-1121, USA -N Barua, MD, PhD, Consultant Neurosurgeon / Research Fellow, Neuro-oncology and Functional Neurosurgery Southmead Hospital/University of Bristol, UK -Renishaw Plc., Gloucester, United Kingdom AWARDS 2016, Alavi-Mandell Award 2015, First prize, Annual oral presentation competition, Spring meeting Danish Neurosurgical Society 2014, Second prize, Annual oral presentation competition, Spring meeting Danish Neurosurgical Society 2006, Prize from the Danish Arthritis Foundation Research Council TEACHING ACTIVITIES 1995-2004, Teaching soldiers in the Danish Armed Forces. From 1997-2004 as an officer. 1999-2006, Teaching Med. Students in traumatology and acute medicine. Approx. 300 hours. 2006-, Teaching Med. Students in the everyday clinic, in neurosurgical topics as both Problem Based Learning sessions as well as formal lectures. OTHER ACTIVITIES 2014, Chairman, Kongres for Medicinsk Studenterforskning Several invited talks on neurosurgery in student associations, patient associations and scientific societies GRANTS 2017, 200,000 Dkr from The Danish Cancer Society 2017, 600,000 Dkr from the Region of Southern Denmark 2016, 12,000 Dkr from Overlægerådets Forskningsfond 2012, 35,000 Dkr from AJ Andersen og Hustrus Fond 2012, 25,000 Dkr from Grosserer M Brogaard og Hustrus Mindefond 2012, 175,000 Dkr from Dansk Kræftforskningsfond 2011, 60,000 Dkr from AJ Andersen og Hustrus Fond 2011, 25,000 Dkr from Direktør Kurt Bønnelycke og hustru fru Grethr Bønnelyckes Fond 2011, 12,000 Dkr from Lægernes Forsikringsforening af 1891 PATENTS Auger electron therapy for glioblastoma (EP14173218.0) Publications Total number of publications: 18 Total number of Senior author publications: 1 Total number of 1. author publications: 6 Total number of shared 1. author publications: 1 H-index 7

PUBLICATION LIST

Winkler Møller, M., Skovsager Andersen, M., Glintborg, D., Pedersen, C. B., & Halle, B. (2019). Hypofyseadenom. Ugeskrift for Laeger, 181(10), PMID: 31124446

Andersen, M. C. S., Pedersen, C. B., Mathiesen, T. I., Poulsgaard, L., Kristensen, B. W., Halle, B., & Rom Poulsen, F. (2019). Intrakraniale meningeomer. Ugeskrift for Laeger, 181(10), PMID: 30722833

Halle B, Mongelard K, Poulsen FR. Convection-enhanced Drug Delivery for Glioblastoma: A Systematic Review Focused on Methodological Differences in the Use of the Convection-enhanced Delivery Method. Asian J Neurosurg 2019 Jan-Mar;14(1):5-14, PMID: 30937002

Aaberg-Jessen C, Fogh L, Sørensen MD, Halle B, Brünner N, Kristensen BW. Overexpression of TIMP-1 and Sensitivity to Topoisomerase Inhibitors in Glioblastoma Cell Lines. Pathol Oncol Res. 2017 Sep 30. PMID: 28962609

Jensen SS, Petterson SA, Halle B, Aaberg-Jessen C, Kristensen BW. Effects of the lysosomal destabilizing drug siramesine on glioblastoma in vitro and in vivo. BMC Cancer. 2017 Mar 7;17(1):178. PMID: 28270132

Munthe S, Halle B, Boldt HB, Christiansen H, Schmidt S, Kaimal V, et al. Shift of microRNA profile upon glioma cell migration using patient-derived spheroids and serum-free conditions. J Neurooncol. 2017 Mar;(132(1):45-54. PMID: 28091986

Gaist D, Garcia Rodriguez LA, Hellfritzsch M, Poulsen FR, Halle B, Hallas J, Pottegård A. Association of Antithrombotic Drug Use With Subdural Hematoma Risk. JAMA 2017 Feb 28;317(8):836-846. PMID: 28245322

Aaberg-Jessen C, Halle B, Jensen SS, Muller S, Romer UM, Pedersen CB, et al. Comparative studies of TIMP-1 immunohistochemistry, TIMP-1 FISH analysis and plasma TIMP-1 in glioblastoma patients. J Neurooncol. 2016 Dec;130(3):439-48. PMID: 27619981

Poulsen FR, Halle B, Pottegård A, García Rodríguez LA, Hallas J, Gaist D. Subdural hematoma cases identified through a Danish patient register: diagnosis validity, clinical characteristics, and preadmission antithrombotic drug use. Pharmacoepidemiol Drug Saf. 2016 Nov;25(11):1253-1262. PMID: 27384945

Thisgaard H*, Halle B*, Aaberg-Jessen C, Olsen BB, Therkelsen ASN, Dam JH, et al. Highly Effective Auger-Electron Therapy in an Orthotopic Glioblastoma Xenograft Model using Convection-Enhanced Delivery. Theranostics. 2016;6(12):2278-91. (*Shared first authorship). PMID: 27924163

Halle B, Thomassen M, Venkatesan R, Kaimal V, Marcusson EG, Munthe S, et al. Shift of microRNA profile upon orthotopic xenografting of glioblastoma spheroid cultures. J Neurooncol. 2016 Jul;128(3):395-404. PMID: 27063952

Jensen SS, Meyer M, Petterson SA, Halle B, Rosager AM, Aaberg-Jessen C, Thomassen M, Burton M, Kruse TA, Kristensen BW. Establishment and Characterization of a Tumor Stem Cell-Based Glioblastoma Invasion Model. PLoS One. 2016 Jul 25;11(7). PMID: 27454178

Petterson SA, Jakobsen IP, Jensen SS, Aaberg-Jessen C, Halle B, Nielsen M, Halle DM, Johansen J, Kristensen BW. Short-term effects of radiation in glioblastoma spheroids. Int J Clin Exp Pathol 2016;9(2):576-588.

Halle B, Marcusson EG, Aaberg-Jessen C, Jensen SS, Meyer M, Schulz MK, et al. Convection-enhanced delivery of an anti-miR is well-tolerated, preserves anti-miR stability and causes efficient target de-repression: a proof of concept. J Neurooncol. 2016 Jan;126(1):47-55. PMID: 26428358

Halle B, Thisgaard H, Hvidsten S, Dam JH, Aaberg-Jessen C, Thykjaer AS, et al. Estimation of Tumor Volumes by C-11-MeAIB and F-18-FDG PET in an Orthotopic Glioblastoma Rat Model. Journal of Nuclear Medicine. 2015 Oct;56(10):1562-8. PMID: 26229144 Poulsen FR, Munthe S, Soe M,

Halle B. Perindopril and residual chronic subdural hematoma volumes six weeks after burr hole surgery: A randomized trial. Clin Neurol Neurosurg. 2014 Aug;123:4-8. PMID: 25012003

Halle B, Andersen C, Schulz MK, Kristensen BW. New glioma therapy using specific microRNAs. Ugeskr Laeger. 2012 Mar 5;174(10):630-3. PMID: 22395010

Halle B, Halle DM, Torfing T, Overgaard S. The role of acetabulum geometry and femoral head-neck ratio in the development of osteoarthritis in young men. Hip Int. 2007 Jul-Sep;17(3):131-6. PMID: 19197857