Morten Gjerstorff

cand.scient., Ph.D.

  • J.B. Winsløws Vej 25, 3.

    5000 Odense C

    Danmark

20042019
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Personlig profil

Forskningsinformation

I flere nye cancervacciner bruges cancer-testis antigener som mål for kræftbehandlingen, men man kender meget lidt til disse proteiners funktion i normale og maligne celler. Vores forskning viser at de spiller en vigtig rolle i celledifferentiering og tumordannelse

Forskningsområde

Research interests

The role of cancer-germline antigens in tumorigenesis


Cancer-germline (CG) antigens are among the most promising tumor targets. They are widely expressed in different cancer types and are essentially tumor-specific, since their expression in normal tissues is largely restricted to immune-privileged sites. Natural cellular and humoral immune responses against CG antigens can frequently be observed in cancer patients, indicating that they are immunogenic. These characteristics make them widely applicable as targets for cancer immunotherapy with little risk of harmful side effects and CG antigen vaccines are being evaluated in a large number of clinical trials worldwide.
Despite the great optimism about the future of CG antigen targeting therapies, two important questions remain to be answered before the full therapeutic potential of these proteins can be realized: 1) Are CG antigens directly involved in tumorigenesis? 2) Which of the more than 100 CG antigens are the best therapeutic targets? The overall aim of our research is to clarify these matters by functional characterization of CG antigens, using both functional screens to identify CG antigens involved in key pathways of tumor development and in-dept investigation of the cellular roles of specific CG antigens. We expect that our results will increase the overall understanding of tumorgenesis and can be directly translated into the clinic to improve cancer immunotherapeutic strategies.

Fingeraftryk Fingeraftryk er baseret på at anvende teksten fra personernes videnskabelige dokumenter til at skabe et indeks med vægtede emneordskoncepter, som definerer de vigtigste emner for hver enkelt forsker.

  • 9 Lignende profiler
Neoplasms Medicin og biovidenskab
Proteins Medicin og biovidenskab
Germ Cells Medicin og biovidenskab
Epigenomics Medicin og biovidenskab
MicroRNAs Medicin og biovidenskab
Antigens Kemiske forbindelser
irinotecan Medicin og biovidenskab
Gene Expression Profiling Medicin og biovidenskab

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Publikationer 2004 2019

A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence

Brückmann, N. H., Bennedsen, S. N., Duijf, P. H. G., Terp, M. G., Thomassen, M., Larsen, M., Pedersen, C. B., Kruse, T., Alcaraz, N., Ditzel, H. J. & Gjerstorff, M. F., 6. nov. 2019, I : Cell Death & Disease. 10, 11, 12 s., 841.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Åben adgang
Fil
Neoplasms
Epirubicin
Proteins
Cell Aging
Nevus

Chimeric antigen receptor T cells targeting CD79b show efficacy in lymphoma with or without co-targeting CD19

Ormhøj, M., Scarfò, I., Cabral, M. L., Bailey, S. R., Lorrey, S. J., Bouffard, A. A., Castano, A. P., Larson, R. C., Riley, L. S., Schmidts, A., Choi, B. D., Andersen, R. S., Cédile, O., Nyvold, C. G., Haaber, J., Gjerstorff, M. F., Ditzel, H. J., Weinstock, D. M., Barington, T., Frigault, M. J. & 1 flere, Maus, M. V., 22. aug. 2019, I : Clinical Cancer Research.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Antigen Receptors
B-Cell Lymphoma
T-Cell Antigen Receptor
Lymphoma
CD19 Antigens

Corrigendum to "MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis" [Free Radic. Biol. Med. 139 (2019) 1-15]

Shirjang, S., Mansoori, B., Asghari, S., Duijf, P. H., Mohammadi, A., Gjerstorff, M. & Baradaran, B., 20. jun. 2019, I : Free Radical Biology & Medicine.

Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

HMGA2 and Bach-1 cooperate to promote breast cancer cell malignancy

Mansoori, B., Mohammadi, A., Asadzadeh, Z., Shirjang, S., Minouei, M., Abedi Gaballu, F., Shajari, N., Kazemi, T., Gjerstrorff, M. F., Duijf, P. H. G. & Baradaran, B., okt. 2019, I : Journal of Cellular Physiology. 234, 10, s. 17714-17726

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

varespladib methyl
Neoplasms
Cell Death
Proteins
Caspase 9

MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis

Shirjang, S., Mansoori, B., Asghari, S., Duijf, P. H. G., Mohammadi, A., Gjerstorff, M. & Baradaran, B., 1. aug. 2019, I : Free Radical Biology & Medicine. 139, s. 1-15 15 s.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Cell death
MicroRNAs
Cell Death
Apoptosis
Neoplasms

Aktiviteter 2014 2017

  • 2 Organisering af eller deltagelse i konference
  • 1 Foredrag og præsentationer i privat eller offentlig virksomhed

Chromatin and epigenetics: from mechanism to function

Nadine Brückmann (Deltager), Morten Gjerstorff (Deltager)
4. apr. 20177. apr. 2017

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

Oncogenic functions of cancer/testis antigen SSX2 highlights its therapeutic potential

Morten Gjerstorff (Foredragsholder)
10. feb. 2015

Aktivitet: Foredrag og mundtlige bidragForedrag og præsentationer i privat eller offentlig virksomhed

2014 Annual Paris Melanoma Conference

Morten Gjerstorff (Deltager)
4. jul. 20146. jul. 2014

Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference