• J. B. Winsløws Vej 19, 2.

    5000 Odense C

Publikationer 1981 2020

1989

Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine

Brøsen, K. & Gram, L. F., 1. mar. 1989, I : European Journal of Clinical Pharmacology. 37, 2, s. 155-160 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Desipramine
Quinidine
Imipramine
Hydroxylation
Debrisoquin

Steady-state plasma levels of E- and Z-10-OH-nortriptyline in nortriptyline-treated patients: Significance of concurrent medication and the sparteine oxidation phenotype

Gram, L. F., Brøsen, K., Kragh-Sørensen, P. & Christensen, P., 1. jan. 1989, I : Therapeutic Drug Monitoring. 11, 5, s. 508-514 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Nortriptyline
1988

Adverse drug reactions and drug non-compliance as primary causes of admission to a cardiology department

Davidsen, F., Haghfelt, T., Gram, L. F. & Brøsen, K., 1. jan. 1988, I : European Journal of Clinical Pharmacology. 34, 1, s. 83-86 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations
Personal Health Records
Sodium Chloride Symporter Inhibitors
Patient Admission

First-pass metabolism of imipramine and desipramine: Impact of the sparteine oxidation phenotype

Brøsen, K. & Gram, L. F., 1. jan. 1988, I : Clinical Pharmacology and Therapeutics. 43, 4, s. 400-406 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Desipramine
Imipramine
Hydroxylation
Liver
Pharmaceutical Preparations

The relationship between imipramine metabolism and the sparteine oxidation polymorphism

Brosen, K., 1. jan. 1988, I : Danish Medical Bulletin. 35, 5, s. 460-468 9 s.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

1987

Extensive Metabolizers of Debrisoquine Become Poor Metabolizers during Quinidine Treatment

Brøsen, K., Gram, L. F., Haghfelt, T. & Bertilsson, L., 1. jan. 1987, I : Pharmacology & Toxicology. 60, 4, s. 312-314 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Debrisoquin
Quinidine
Hydroxylation

Pharmacokinetic considerations relevant to the pharmacodynamics of antidepressants.

Gram, L. F., Brøsen, K., Christensen, P. & Kragh-Sørensen, P., 1. jan. 1987, I : Psychopharmacology series. 3, s. 184-192 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

1986

Development of infantile hypertrophic pyloric stenosis in patients treated for oesophageal atresia. A case report

Qvist, N., Rasmussen, L., Hansen, L. P. & Pedersen, S. A., mar. 1986, I : Acta Chirurgica Scandinavica. 152, s. 237-8 2 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Esophageal Atresia
Gastroesophageal Reflux
Failure to Thrive
Alkalosis
Duodenum

Imipramine demethylation and hydroxylation: Impact of the sparteine oxidation phenotype

Brøsen, K., Victoria Otton, S. & Gram, L. F., 1. jan. 1986, I : Clinical Pharmacology and Therapeutics. 40, 5, s. 543-549 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Desipramine
Imipramine
Hydroxylation
Oxygenases
Isoenzymes

Rectal prolapse in infancy: conservative versus operative treatment

Qvist, N., Rasmussen, L., Klaaborg, K. E., Hansen, L. P. & Pedersen, S. A., okt. 1986, I : Journal of Pediatric Surgery. 21, 10, s. 887-8

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Rectal Prolapse
Mucous Membrane
Sclerosing Solutions
Defecation

Sparteine oxidation is practically abolished in quinidine‐treated patients.

Brinn, R., Brosen, K., Gram, LF., Haghfelt, T. & Otton, SV., 1. jan. 1986, I : British Journal of Clinical Pharmacology. 22, 2, s. 194-197 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Quinidine

Sparteine oxidation polymorphism: a family study.

Brosen, K., Otton, SV. & Gram, LF., 1. jan. 1986, I : British Journal of Clinical Pharmacology. 21, 6, s. 661-667 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Urine
Pharmacogenetics
Pedigree
Heterozygote
Pharmaceutical Preparations

Sparteine oxidation polymorphism in Greenlanders living in Denmark.

Brosen, K., 1. jan. 1986, I : British Journal of Clinical Pharmacology. 22, 4, s. 415-419 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Denmark
Urine Specimen Collection
Urine

Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism

Brøsen, K., Klysner, R., Gram, L. F., Otton, S. V., Bech, P. & Bertilsson, L., 1986, I : European Journal of Clinical Pharmacology. 30, 6, s. 679-84 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Debrisoquin
Imipramine
Desipramine

Steady-state levels of imipramine and its metabolites: Significance of dose-dependent kinetics

Brøsen, K., Gram, L. F., Klysner, R. & Bech, P., 1. jan. 1986, I : European Journal of Clinical Pharmacology. 30, 1, s. 43-49 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Imipramine
Desipramine
Hydroxylation
Methotrimeprazine
Perphenazine
1985

Dextropropoxyphene kinetics after single and repeated oral doses in man

Brøsen, K., Gram, L. F., Schou, J., Larsen, N. E. & Thayssen, P., 1. jan. 1985, I : European Journal of Clinical Pharmacology. 29, 1, s. 79-84 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Dextropropoxyphene
Area Under Curve
Half-Life
norpropoxyphene

Sparteine Oxidation Polymorphism in Denmark

Brøsen, K., Otton, S. V. & Gram, L. F., 1. jan. 1985, I : Acta pharmacologica et toxicologica. 57, 5, s. 357-360 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Sparteine
Denmark
Polymorphism
Oxidation
Pharmacogenetics
1984

Individuelle variationer i laegemidlers oksidative metabolisme. Betydningen af monogenetisk polymorfisme

Brøsen, K., 26. mar. 1984, I : Ugeskrift for Laeger. 146, 13, s. 955-9 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

1981

Antidepressant treatment with imipramine and nortriptyline in elderly patients

Kragh-Sørensen, P., Kristensen, C. B., Pedersen, O. L., Bjerre, M., Benjaminsen, S., Møller, M., Thayssen, P. & Gram, L. F., 1981, Clinical Pharmacology in Psychiatry: Neuroleptic and Antidepressant Research. Usdin, E., Dahl, S. G., Gram, L. F. & Lingjærde, O. (red.). Palgrave Macmillan, s. 351-357

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review