• J. B. Winsløws Vej 19, 2.

    5000 Odense C

Publikationer 1981 2019

1992

Lack of effect of mianserin on the symptoms of diabetic neuropathy

Sindrup, S. Ø. H., Tuxen, C., Gram, L. F., Grodum, E., Skjold, T., Brøsen, K. & Beck-Nielsen, H., 1. sep. 1992, I : European Journal of Clinical Pharmacology. 43, 3, s. 251-255 5 s.

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Mianserin
Diabetic Neuropathies
Imipramine
Mephenytoin
Placebos

Pharmacogenetics in psychopharmacology: basic principles and clinical implications.

Gram, L. F., Brøsen, K., Sindrup, S., Skjelbo, E. & Nielsen, K. K., 1. jan. 1992, I : Clinical Neuropharmacology. 15 Suppl 1 Pt A

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Pharmacogenetics of tricyclic and novel antidepressants: recent developments.

Brøsen, K., Gram, L. F., Sindrup, S., Skjelbo, E. & Nielsen, K. K., 1. jan. 1992, I : Clinical Neuropharmacology. 15 Suppl 1 Pt A

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Pharmacokinetics of the selective serotonin reuptake inhibitor paroxetine: Nonlinearity and relation to the sparteine oxidation polymorphism

Sindrup, S. H., Brøsen, K. & Gram, L. F., 1. jan. 1992, I : Clinical Pharmacology & Therapeutics. 51, 3, s. 288-295 8 s.

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Paroxetine
Serotonin Uptake Inhibitors
Pharmacokinetics
Cytochrome P-450 CYP2D6
Diabetic Neuropathies

Reference intervals for trace elements in blood: Significance of risk factors

Grandjean, P., Nielsen, G. D., Jørgensen, P. J. & Hørder, M., 1. jan. 1992, I : Scandinavian Journal of Clinical and Laboratory Investigation. 52, 4, s. 321-337 17 s.

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Selenium
Mercury
Menopause
Nickel
Zinc

Steady-state plasma levels of clomipramine and its metabolites: Impact of the sparteine/debrisoquine oxidation polymorphism

Kramer Nielsen, K., Brøsen, K. & Gram, L. F., 1. okt. 1992, I : European Journal of Clinical Pharmacology. 43, 4, s. 405-411 7 s.

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Debrisoquin
Clomipramine
Cytochrome P-450 CYP2D6
Placebos
Hydroxylation

The effect of quinidine on the analgesic effect of codeine

Sindrup, S. H., Arendt-Nielsen, L., Brøsen, K., Bjerring, P., Angelo, H. R., Eriksen, B. & Gram, L. F., 1. jun. 1992, I : European Journal of Clinical Pharmacology. 42, 6, s. 587-591 5 s.

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Quinidine
Placebos
Pain Threshold
Morphine
Cytochrome P-450 CYP2D6

The mechanism of action of antidepressants in pain treatment: controlled cross-over studies in diabetic neuropathy.

Sindrup, S. H., Brøsen, K. & Gram, L. F., 1. jan. 1992, I : Clinical Neuropharmacology. 15 Suppl 1 Pt A

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The relationship between paroxetine and the sparteine oxidation polymorphism

Sindrup, S. H., Brøsen, K., Gram, L. F., Hallas, J., Skjelbo, E., Allen, A., Allen, G. D., Cooper, S. M., Mellows, G., Tasker, T. C. G. & Zussman, B. D., 1. jan. 1992, I : Clinical Pharmacology & Therapeutics. 51, 3, s. 278-287 10 s.

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Paroxetine
Cytochrome P-450 CYP2D6
Oxygenases
Clinical Pharmacology
Serotonin Uptake Inhibitors

The selective serotonin reuptake inhibitor citalopram relieves the symptoms of diabetic neuropathy

Sindrup, S. H., Bjerre, U., Dejgaard, A., Brøsen, K., Aaes‐Jørgensen, T. & Gram, L. F., 1. jan. 1992, I : Clinical Pharmacology & Therapeutics. 52, 5, s. 547-552 6 s.

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Citalopram
Diabetic Neuropathies
Serotonin Uptake Inhibitors
Placebos
Clinical Pharmacology
1991

Cytokrom P450 gen-superfamiliens betydning for laegemidlers kliniske farmakokinetik.

Brøsen, K., 4. feb. 1991, I : Ugeskrift for Laeger. 153, 6, s. 417-422 6 s.

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Cytochrome P-450 Enzyme System
Isoenzymes
Mephenytoin
Pharmacokinetics
Pharmaceutical Preparations

Drug related events and drug utilization in patients admitted to a geriatric hospital department

Hallas, J., Worm, J., Beck-Nielsen, J., Gram, L. F., Grodum, E., Damsbo, N. & Brosen, K., 1. jan. 1991, I : Danish Medical Bulletin. 38, 5, s. 417-420 4 s.

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Drugs and femoral neck fracture: a case‐control study

JENSEN, J., NIELSEN, L. H., LYHNE, N., HALLAS, J., BRØSEN, K. & GRAM, L. F., 1. jan. 1991, I : Journal of Internal Medicine. 229, 1, s. 29-33 5 s.

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Femoral Neck Fractures
Internship and Residency
Nursing Homes
Pharmaceutical Preparations
Psychotropic Drugs

Fluoxetine and norfluoxetine are potent inhibitors of P450IID6‐the source of the sparteine/debrisoquine oxidation polymorphism [letter]

Brosen, K. & Skjelbo, E., 1. jan. 1991, I : British Journal of Clinical Pharmacology. 32, 1, s. 136-137 2 s.

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Jerndepoter, jernmangel og jernberigelse.

Wiggers, P., Dalhøj, J., Nielsen, G. D., Grandjean, P. A. & Hørder, M., 1. jan. 1991, I : Ugeskrift for Laeger. 153, 9, s. 646-648 3 s.

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Iron
Serum
Population
Zea mays
Age Groups

Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine

Brøsen, K., Zeugin, T. & Meyer, U. A., 1. jan. 1991, I : Clinical Pharmacology and Therapeutics. 49, 6, s. 609-617 9 s.

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Debrisoquin
Imipramine
Hydroxylation
COS Cells
Methotrimeprazine

Sparteine and mephenytoin oxidation: Genetic polymorphisms in East and West Greenland

Clasen, K., Madsen, L., Brøsen, K., Albøge, K., Misfeldt, S. & Gram, L. F., 1. jan. 1991, I : Clinical Pharmacology and Therapeutics. 49, 6, s. 624-631 8 s.

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Mephenytoin
Greenland
Genetic Polymorphisms
Urine
Population

Svaer nortriptylinforgiftning hos dårlig omdanner af sparteintypen.

Petersen, P. & Brøsen, K., 4. feb. 1991, I : Ugeskrift for Laeger. 153, 6, s. 443-444 2 s.

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Nortriptyline
Poisoning
Poisons
Isoenzymes
Medicine

Terapistyring af perfenazinbehandling ved paranoide tilstande. 1. Organisatoriske aspekter.

Rask, P. H., Krarup, G., Kragh-Sørensen, P., Andersen, E., Brøsen, K., Gerholt, F., Glue, P., Hørder, M., Kjeldsen, C. S. & Klitgaard, N. A., 19. aug. 1991, I : Ugeskrift for Laeger. 153, 34, s. 2336-2339 4 s.

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Perphenazine
Serum
Physicians
Therapeutic Uses

Terapistyring af perfenazinbehandling ved paranoide tilstande. 2. Kliniske aspekter.

Kjeldsen, C. S., Larsen, N. E., Kragh-Sørensen, P., Andersen, E., Brøsen, K., Gerholt, F., Glue, P., Hørder, M., Klitgaard, N. A. & Krarup, G., 19. aug. 1991, I : Ugeskrift for Laeger. 153, 34, s. 2339-2343 5 s.

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Perphenazine
Therapeutic Uses
Serum
Decanoates
Physicians

The activation of the biguanide antimalarial proguanil co‐segregates with the mephenytoin oxidation polymorphism‐a panel study.

Ward, SA., Helsby, NA., Skjelbo, E., Brosen, K., Gram, LF. & Breckenridge, AM., 1. jan. 1991, I : British Journal of Clinical Pharmacology. 31, 6, s. 689-692 4 s.

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Mephenytoin
Proguanil
Urine

The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine

Skjelbo, E., Brøsen, K., Hallas, J. & Gram, L. F., 1. jan. 1991, I : Clinical Pharmacology and Therapeutics. 49, 1, s. 18-23 6 s.

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Mephenytoin
Imipramine
Oxygenases
Desipramine
Hydroxylation
1990

A dose‐effect study of the in vivo inhibitory effect of quinidine on sparteine oxidation in man.

Nielsen, MD., Brosen, K. & Gram, LF., 1. jan. 1990, I : British Journal of Clinical Pharmacology. 29, 3, s. 299-304 6 s.

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Quinidine

Clomipramine vs desipramine vs placebo in the treatment of diabetic neuropathy symptoms. A double‐blind cross‐over study.

Sindrup, SH., Gram, LF., Skjold, T., Grodum, E., Brosen, K. & Beck‐Nielsen, H., 1. jan. 1990, I : British Journal of Clinical Pharmacology. 30, 5, s. 683-691 9 s.

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Clomipramine
Desipramine
Diabetic Neuropathies
Cross-Over Studies
Placebos

Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine

Sindrup, S. H., Brøsen, K., Bjerring, P., Arendt-Nielsen, L., Larsen, U., Angelo, H. R. & Gram, L. F., 1. jan. 1990, I : Clinical Pharmacology and Therapeutics. 48, 6, s. 686-693 8 s.

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Pain Threshold
Gas Lasers
Morphine
Placebos
Pharmaceutical Preparations

Determination of imipramine and seven of its metabolites in human liver microsomes by a high-performance liquid chromatographic method

Zeugin, T. B., Brosen, K. & Meyer, U. A., 15. aug. 1990, I : Analytical Biochemistry. 189, 1, s. 99-102 4 s.

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Imipramine
Liver Microsomes
Metabolites
Liver
Liquids

Drug related hospital admissions: the role of definitions and intensity of data collection, and the possibility of prevention

HALLAS, J., HARVALD, B., GRAM, L. F., GRODUM, E., BRØSEN, K., HAGHFELT, T. & DAMSBO, N., 1. jan. 1990, I : Journal of Internal Medicine. 228, 2, s. 83-90 8 s.

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Pharmaceutical Preparations
Health Services
Drug Monitoring
Primary Care Physicians
Drug-Related Side Effects and Adverse Reactions

Nonlinear kinetics of imipramine in low and medium plasma level ranges

Sindrup, S. H., Brøsen, K. & Gram, L. F., 1. jan. 1990, I : Therapeutic Drug Monitoring. 12, 5, s. 445-449 5 s.

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Imipramine
Desipramine
Diabetic Neuropathies
Pharmaceutical Preparations

Paroxetine: A selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study

Danish University Antidepressant Group, 1. jan. 1990, I : Journal of Affective Disorders. 18, 4, s. 289-299 11 s.

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Clomipramine
Paroxetine
Serotonin Uptake Inhibitors
Multicenter Studies
Citalopram

Quinidine kinetics after a single oral dose in relation to the sparteine oxidation polymorphism in man.

Brosen, K., Davidsen, F. & Gram, LF., 1. jan. 1990, I : British Journal of Clinical Pharmacology. 29, 2, s. 248-253 6 s.

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Quinidine
Isoenzymes
Cytochrome P-450 Enzyme System
Half-Life

Recent Developments in Hepatic Drug Oxidation Implications for Clinical Pharmacokinetics

Brosen, K., 1. jan. 1990, I : Clinical Pharmacokinetics. 18, 3, s. 220-239 20 s.

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Pharmacokinetics
Liver
Pharmaceutical Preparations
Debrisoquin
Propafenone

The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms

Sindrup, S. H., Gram, L. F., Brøsen, K., Eshøj, O. & Mogensen, E. F., 1. jan. 1990, I : Pain. 42, 2, s. 135-144 10 s.

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Paroxetine
Diabetic Neuropathies
Imipramine
Serotonin Uptake Inhibitors
Social Adjustment
1989

Art og omfang af laegemiddelinformation til alment praktiserende laeger. En spørgeskemaundersøgelse.

Rotwitt, L. B., Rosholm, J. U., Brøsen, K. & Gram, L. F., 6. mar. 1989, I : Ugeskrift for Laeger. 151, 10, s. 647-650 4 s.

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Clinical significance of the sparteine/debrisoquine oxidation polymorphism

Brøsen, K. & Gram, L. F., 1. nov. 1989, I : European Journal of Clinical Pharmacology. 36, 6, s. 537-547 11 s.

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Debrisoquin
Pharmaceutical Preparations
Perphenazine
Propafenone
Flecainide

Imipramine treatment in diabetic neuropathy: relief of subjective symptoms without changes in peripheral and autonomic nerve function

Sindrup, S. H., Ejlertsen, B., Frøland, A., Sindrup, E. H., Brøsen, K. & Gram, L. F., 1. mar. 1989, I : European Journal of Clinical Pharmacology. 37, 2, s. 151-153 3 s.

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Diabetic Neuropathies
Imipramine
Peripheral Nerves
Placebos
Desipramine

Inhibitors of the microsomal oxidation of psychotropic drugs: selectivity and clinical significance.

Gram, L. F. & Brøsen, K., 1. dec. 1989, I : Psychopharmacology series. 7, s. 172-180 9 s.

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Mephenytoin and sparteine oxidation: genetic polymorphisms in Denmark

Kjeldsen, A. D., Bathum, L., Brøsen, K. & Gram, L. F., 1989, I : British Journal of Clinical Pharmacology. 27, 5, s. 620-5 6 s.

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Mephenytoin
Genetic Polymorphisms
Denmark
Pedigree
Gas Chromatography

Pharmacokinetic and clinical significance of genetic variability in psychotropic drug metabolism.

Brøsen, K. & Gram, L. F., 1. dec. 1989, I : Psychopharmacology series. 7, s. 192-200 9 s.

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Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine

Brøsen, K. & Gram, L. F., 1. mar. 1989, I : European Journal of Clinical Pharmacology. 37, 2, s. 155-160 6 s.

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Desipramine
Quinidine
Imipramine
Hydroxylation
Debrisoquin

Steady-state plasma levels of E- and Z-10-OH-nortriptyline in nortriptyline-treated patients: Significance of concurrent medication and the sparteine oxidation phenotype

Gram, L. F., Brøsen, K., Kragh-Sørensen, P. & Christensen, P., 1. jan. 1989, I : Therapeutic Drug Monitoring. 11, 5, s. 508-514 7 s.

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Nortriptyline
1988

Adverse drug reactions and drug non-compliance as primary causes of admission to a cardiology department

Davidsen, F., Haghfelt, T., Gram, L. F. & Brøsen, K., 1. jan. 1988, I : European Journal of Clinical Pharmacology. 34, 1, s. 83-86 4 s.

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Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations
Personal Health Records
Sodium Chloride Symporter Inhibitors
Patient Admission

First-pass metabolism of imipramine and desipramine: Impact of the sparteine oxidation phenotype

Brøsen, K. & Gram, L. F., 1. jan. 1988, I : Clinical Pharmacology and Therapeutics. 43, 4, s. 400-406 7 s.

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Desipramine
Imipramine
Hydroxylation
Liver
Pharmaceutical Preparations

The relationship between imipramine metabolism and the sparteine oxidation polymorphism

Brosen, K., 1. jan. 1988, I : Danish Medical Bulletin. 35, 5, s. 460-468 9 s.

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1987

Extensive Metabolizers of Debrisoquine Become Poor Metabolizers during Quinidine Treatment

Brøsen, K., Gram, L. F., Haghfelt, T. & Bertilsson, L., 1. jan. 1987, I : Pharmacology & Toxicology. 60, 4, s. 312-314 3 s.

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Debrisoquin
Quinidine
Hydroxylation

Pharmacokinetic considerations relevant to the pharmacodynamics of antidepressants.

Gram, L. F., Brøsen, K., Christensen, P. & Kragh-Sørensen, P., 1. jan. 1987, I : Psychopharmacology series. 3, s. 184-192 9 s.

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1986

Development of infantile hypertrophic pyloric stenosis in patients treated for oesophageal atresia. A case report

Qvist, N., Rasmussen, L., Hansen, L. P. & Pedersen, S. A., mar. 1986, I : Acta Chirurgica Scandinavica. 152, s. 237-8 2 s.

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Esophageal Atresia
Gastroesophageal Reflux
Failure to Thrive
Alkalosis
Duodenum

Imipramine demethylation and hydroxylation: Impact of the sparteine oxidation phenotype

Brøsen, K., Victoria Otton, S. & Gram, L. F., 1. jan. 1986, I : Clinical Pharmacology and Therapeutics. 40, 5, s. 543-549 7 s.

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Desipramine
Imipramine
Hydroxylation
Oxygenases
Isoenzymes

Rectal prolapse in infancy: conservative versus operative treatment

Qvist, N., Rasmussen, L., Klaaborg, K. E., Hansen, L. P. & Pedersen, S. A., okt. 1986, I : Journal of Pediatric Surgery. 21, 10, s. 887-8

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Rectal Prolapse
Mucous Membrane
Sclerosing Solutions
Defecation

Sparteine oxidation is practically abolished in quinidine‐treated patients.

Brinn, R., Brosen, K., Gram, LF., Haghfelt, T. & Otton, SV., 1. jan. 1986, I : British Journal of Clinical Pharmacology. 22, 2, s. 194-197 4 s.

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Quinidine

Sparteine oxidation polymorphism: a family study.

Brosen, K., Otton, SV. & Gram, LF., 1. jan. 1986, I : British Journal of Clinical Pharmacology. 21, 6, s. 661-667 7 s.

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Urine
Pharmacogenetics
Pedigree
Heterozygote
Pharmaceutical Preparations