Institut for Biokemi og Molekylær Biologi

  • Campusvej 55

    5230 Odense M

Publikationer 1971 2019

2019

An IgY-based immunoassay to evaluate the biomarker potential of the Tannerella forsythia virulence factor karilysin in human saliva

Skottrup, P. D., López, R., Ksiazek, M., Højrup, P., Baelum, V., Potempa, J. & Kaczmarek, J. Z., jun. 2019, I : Journal of Immunological Methods. 769, s. 26-32

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Saliva
Immunoassay
Periodontitis
Point-of-Care Systems
Surface Plasmon Resonance
13 Downloads (Pure)

A pathogenic haplotype, common in Europeans, causes autosomal recessive albinism and uncovers missing heritability in OCA1

Grønskov, K., Jespersgaard, C., Bruun, G. H., Harris, P., Brøndum-Nielsen, K., Andresen, B. S. & Rosenberg, T., 24 jan. 2019, I : Scientific Reports. 9, 1, 7 s., 645.

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Haplotypes
Ocular Albinism
Piebaldism
Low Vision
Virulence

A sub-chronic Xysmalobium undulatum hepatotoxicity investigation in HepG2/C3A spheroid cultures compared to an in vivo model

Calitz, C., Hamman, J. H., Fey, S. J., Viljoen, A. M., Gouws, C. & Wrzesinski, K., 15 jul. 2019, I : Journal of Ethnopharmacology. 239, 8 s., 111897.

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Valproic Acid
Liver
Sprague Dawley Rats
Adenylate Kinase
Herbal Medicine

Autoantibodies as diagnostic tools

Houen, G., 1 jan. 2019, Autoantibodies: Methods and Protocols. Houen, G. (red.). Humana Press, s. 1-11 (Methods in Molecular Biology, Bind 1901).

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Automated workflow composition in mass spectrometry-based proteomics

Palmblad, M., Lamprecht, A-L., Ison, J. & Schwämmle, V., 15 feb. 2019, I : Bioinformatics (Oxford, England). 35, 4, s. 656–664

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Workflow
Computational Biology
Research Personnel
Benchmarking
Semantics

Autophagy-Mediated Cholesterol Trafficking Controls Steroid Production

Texada, M. J., Malita, A., Christensen, C. F., Dall, K. B., Faergeman, N. J., Nagy, S., Halberg, K. A. & Rewitz, K., 11 mar. 2019, I : Developmental Cell. 48, 5, s. 659-671.e4

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Steroids
Cholesterol
Steroid hormones
Nutrients
Growth and Development

Axon-Dependent Patterning and Maintenance of Somatosensory Dendritic Arbors

Ramirez-Suarez, N. J., Belalcazar, H. M., Salazar, C. J., Beyaz, B., Raja, B., Nguyen, K. C. Q., Celestrin, K., Fredens, J., Færgeman, N. J., Hall, D. H. & Bülow, H. E., 28 jan. 2019, I : Developmental Cell. 48, 2, s. 229-244.e4

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Dendrites
Maintenance
Physical vapor deposition
Neurons
Neural Cell Adhesion Molecule L1

Biochemical and structural characterization of a protein complex containing a hyaluronidase and a CRISP-like protein isolated from the venom of the spider Acanthoscurria natalensis

Barth, T., Mandacaru, S. C., Charneau, S., Souza, M. V. D., Ricart, C. A. O., Noronha, E. F., Souza, A. A., Freitas, S. M. D., Roepstorff, P., Fontes, W., Castro, M. S. & Pires Júnior, O. R., 10 feb. 2019, I : Journal of Proteomics. 192, s. 102-113

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Spider Venoms
Hyaluronoglucosaminidase
Proteins
Assays
Molecules
16 Downloads (Pure)

Chlorination and oxidation of the extracellular matrix protein laminin and basement membrane extracts by hypochlorous acid and myeloperoxidase

Nybo, T., Dieterich, S., Gamon, L. F., Chuang, C. Y., Hammer, A., Hoefler, G., Malle, E., Rogowska-Wrzesinska, A. & Davies, M. J., 1 jan. 2019, I : Redox Biology. 20, s. 496-513

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Hypochlorous Acid
Extracellular Matrix Proteins
Chlorination
Laminin
Peroxidase
15 Downloads (Pure)

CoExpresso: Assess the quantitative behavior of protein complexes in human cells

Chalabi, M. H., Tsiamis, V., Käll, L., Vandin, F. & Schwämmle, V., 9 jan. 2019, I : BMC Bioinformatics. 20, 1, s. 1-10 17.

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Cells
Proteins
Protein
Cell
Scoring
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Collagen density regulates the activity of tumor-infiltrating T cells

Kuczek, D. E., Larsen, A. M. H., Thorseth, M-L., Carretta, M., Kalvisa, A., Siersbæk, M. S., Simões, A. M. C., Roslind, A., Engelholm, L. H., Noessner, E., Donia, M., Svane, I. M., Straten, P. T., Grøntved, L. & Madsen, D. H., 12 mar. 2019, I : Journal for immunotherapy of cancer. 7, 1, 15 s., 68.

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Neoplasms
Cell Proliferation
Gene Expression Profiling
Autocrine Communication
CD4-CD8 Ratio
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Comparative analysis of sequencing technologies for single-cell transcriptomics

Natarajan, K. N., Miao, Z., Jiang, M., Huang, X., Zhou, H., Xie, J., Wang, C., Qin, S., Zhao, Z., Wu, L., Yang, N., Li, B., Hou, Y., Liu, S. & Teichmann, S. A., 2019, I : Genome Biology. 20, 8 s., 70.

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Small Cytoplasmic RNA
transcriptomics
Libraries
RNA
DNA libraries

Corrigendum to "Biochemical and structural characterization of a protein complex containing a hyaluronidase and a CRISP-like protein isolated from the venom of the spider Acanthoscurria natalensis" [J. Proteome 192. (2019) 102-113]

Barth, T., Mandacaru, S. C., Charneau, S., de Sousa, M. V., Ricart, C. A. O., Noronha, E. F., Souza, A. A., de Freitas, S. M., Roepstorff, P., Fontes, W., Castro, M. S. & Júnior, O. R. P., 15 feb. 2019, I : Journal of Proteomics.

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Delivery of proteins encapsulated in chitosan-tripolyphosphate nanoparticles to human skin melanoma cells

Stie, M. B., Thoke, H. S., Issinger, O-G., Hochscherf, J., Guerra, B. & Olsen, L. F., feb. 2019, I : Colloids and Surfaces B: Biointerfaces. 174, s. 216-223

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Chitosan
Bovine Serum Albumin
Melanoma
delivery
Skin

Determination of autoantibodies by line immunoblotting

Sternbæk, L., Friis, T. & Houen, G., 1 jan. 2019, Autoantibodies: Methods and Protocols. Houen, G. (red.). Humana Press, s. 255-262 (Methods in Molecular Biology, Bind 1901).

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Immunoblotting
Research Personnel
Membranes

Determination of rheumatoid factors by ELISA

Trier, N. H. & Houen, G., 1 jan. 2019, Autoantibodies: Methods and Protocols. Houen, G. (red.). Humana Press, s. 263-270 (Methods in Molecular Biology, Bind 1901).

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Rheumatoid Factor
Immunoassay
False Positive Reactions
Serum

Differential Ion Mobility Separations/Mass Spectrometry with High Resolution in Both Dimensions

Baird, M. A., Anderson, G. A., Shliaha, P. V., Jensen, O. N. & Shvartsburg, A. A., 2019, I : Analytical Chemistry. 91, 2, s. 1479-1485

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Pulse time modulation
Ultrahigh vacuum
Mass spectrometers
Isomers
Histones
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Draft Genome Sequence of Chromatium okenii Isolated from the Stratified Alpine Lake Cadagno

Luedin, S. M., Liechti, N., Cox, R. P., Danza, F., Frigaard, N-U., Posth, N. R., Pothier, J. F., Roman, S., Storelli, N., Wittwer, M. & Tonolla, M., 13 feb. 2019, I : Scientific Reports. 9, 1, s. 1-14 1936.

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Chromatium
Lakes
RNA
Research
Proteins
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Dynamic rating of three-core XLPE submarine cables for offshore wind farms

Nielsen, T. V. M., Jakobsen, S. & Savaghebi, M., 25 feb. 2019, I : Applied Sciences (Switzerland). 9, 4, 21 s., 800.

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submarine cables
Submarine cables
Offshore wind farms
Cable cores
ratings
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Excision of uracil from DNA by hSMUG1 includes strand incision and processing

Alexeeva, M., Moen, M. N., Grøsvik, K., Tesfahun, A. N., Xu, X. M., Muruzábal-Lecumberri, I., Olsen, K. M., Rasmussen, A., Ruoff, P., Kirpekar, F., Klungland, A. & Bjelland, S., 2019, I : Nucleic Acids Research. 47, 2, s. 779-793

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Uracil
DNA
Uracil-DNA Glycosidase
Enzymes
Deamination
30 Downloads (Pure)

First-trimester proteomic profiling identifies novel predictors of gestational diabetes mellitus

Ravnsborg, T., Svaneklink, S., Andersen, L. L. T., Larsen, M. R., Jensen, D. M. & Overgaard, M., 27 mar. 2019, I : PLOS ONE. 14, 3, 13 s., e0214457.

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gestational diabetes
Gestational Diabetes
First Pregnancy Trimester
Medical problems
proteomics

Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: an IMMEnSE study

Campa, D., Martino, A., Macauda, A., Dudziński, M., Suska, A., Druzd-Sitek, A., Raab, M-S., Moreno, V., Huhn, S., Butrym, A., Sainz, J., Szombath, G., Rymko, M., Marques, H., Lesueur, F., Vangsted, A. J., Vogel, U., Kruszewski, M., Subocz, E., Buda, G. & 27 flereIskierka-Jażdżewska, E., Ríos, R., Merz, M., Schöttker, B., Mazur, G., Perrial, E., Martinez-Lopez, J., Butterbach, K., García Sanz, R., Goldschmidt, H., Brenner, H., Jamroziak, K., Reis, R. M., Kadar, K., Dumontet, C., Wątek, M., Haastrup, E. K., Helbig, G., Jurczyszyn, A., Jerez, A., Varkonyi, J., Barington, T., Grzasko, N., Zaucha, J. M., Andersen, V., Zawirska, D. & Canzian, F., 11 jan. 2019, I : Leukemia and Lymphoma.

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Switch Genes
Genetic Polymorphisms
Genetic Association Studies
Plasma Cells
Research

Hepatic exposure of metformin in patients with non-alcoholic fatty liver disease

Sundelin, E. I. O., Gormsen, L. C., Heebøll, S., Vendelbo, M. H., Jakobsen, S., Munk, O. L., Feddersen, S., Brøsen, K., Hamilton-Dutoit, S. J., Pedersen, S. B., Grønbaek, H. & Jessen, N., 11 apr. 2019, I : British Journal of Clinical Pharmacology.

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Liver
Cations
Type 2 Diabetes Mellitus
Insulin Resistance
Western World
14 Downloads (Pure)

Increasing jojoba-like wax ester production in Saccharomyces cerevisiae by enhancing very long-chain, monounsaturated fatty acid synthesis

Wenning, L., Ejsing, C. S., David, F., Sprenger, R. R., Nielsen, J. & Siewers, V., 11 mar. 2019, I : Microbial Cell Factories. 18, 1, 49.

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Monounsaturated fatty acids
Monounsaturated Fatty Acids
Waxes
Fatty acids
Yeast

Integrated proteomics reveals apoptosis-related mechanisms associated with placental malaria

Kawahara, R., Rosa-Fernandes, L., Dos Santos, A. F., Bandeira, C. L., Dombrowski, J. G., Souza, R. M., da Fonseca, M. P., Festuccia, W. T., Labriola, L., Larsen, M. R., Marinho, C. R. F. & Palmisano, G., feb. 2019, I : Molecular and Cellular Proteomics. 18, 2, s. 182-199

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Placenta
Malaria
Apoptosis
Plasmodium falciparum
Protein folding

Interspecies interactions mediated by conductive minerals in the sediments of the iron rich meromictic Lake La Cruz, Spain

Rotaru, A-E., Posth, N., Löscher, C., Miracle, M. R., Vincence, E., Cox, R. P., Thompson, J., Poulton, S. W. & Thamdrup, B., 2019, I : Limnetica. 38, 1, s. 21-40

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meromictic lake
iron
mineral
sediment
acetate
5 Downloads (Pure)

IsoProt: A Complete and Reproducible Workflow to Analyze iTRAQ/TMT Experiments

Griss, J., Vinterhalter, G. & Schwämmle, V., 2019, I : Journal of Proteome Research. 18, 4, s. 1751-1759

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Workflow
Bioinformatics
Computational Biology
HTML
Experiments
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NADH dehydrogenase complex I is overexpressed in incipient metastatic murine colon cancer cells

Marquez, J., Kratchmarova, I., Akimov, V., Unda, F., Ibarretxe, G., Clerigué, A. S., Osinalde, N. & Badiola, I., 1 feb. 2019, I : Oncology Reports. 41, 2, s. 742-752

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NAD
Colonic Neoplasms
Oxidoreductases
Isotope Labeling
Neoplasms
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Natural compounds and derivatives as Ser/Thr protein kinase modulators and inhibitors

Guerra, B. & Issinger, O-G., 2019, I : Pharmaceuticals. 12, 21 s., 4.

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Next generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease

Dembic, M., Andersen, H. S., Bastin, J., Doktor, T. K., Corydon, T. J., Sass, J. O., Costa, A. L., Djouadi, F. & Andresen, B. S., jan. 2019, I : Molecular Genetics and Metabolism. 126, 1, s. 64-76

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Canavan Disease
RNA Sequence Analysis
RNA
Sirtuin 1
Fibroblasts

Nonhypoxic pharmacological stabilization of Hypoxia Inducible Factor 1α: Effects on dopaminergic differentiation of human neural stem cells

Hey, S. M., Jensen, P., Ryding, M., Martínez Serrano, A., Kristensen, B. W. & Meyer, M., 1 feb. 2019, I : European Journal of Neuroscience. 49, 4, s. 497-509

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Dopaminergic Neurons
Parkinson Disease
Oxygen
Neurotoxins
Tyrosine 3-Monooxygenase

Nonspecific binding in immunoassays for autoantibodies

Houen, G., 1 jan. 2019, Autoantibodies: Methods and Protocols. Houen, G. (red.). Humana Press, s. 13-17 (Methods in Molecular Biology, Bind 1901).

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

Immunoassay
Guidelines
Serum
Adipogenesis
Stem Cell Factor
Mesenchymal Stromal Cells
Osteogenesis
Chromatin Assembly and Disassembly
12 Downloads (Pure)

Phosphoproteomic and functional analyses reveal sperm-specific protein changes downstream of kappa opioid receptor in human spermatozoa

Urizar-Arenaza, I., Osinalde, N., Akimov, V., Puglia, M., Candenas, L., Pinto, F. M., Muñoa-Hoyos, I., Gianzo, M., Matorras, R., Irazusta, J., Blagoev, B., Subiran, N. & Kratchmarova, I., 8 jan. 2019, I : Molecular and Cellular Proteomics.

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kappa Opioid Receptor
G-Protein-Coupled Receptors
Phosphorylation
Proteins
(trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide

Preface

Houen, G., 1 jan. 2019, Autoantibodies: Methods and Protocols. Houen, G. (red.). Humana Press, s. V (Methods in Molecular Biology, Bind 1901).

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Protein corona formed on silver nanoparticles in blood plasma is highly selective and resistant to physicochemical changes of the solution

Gorshkov, V., Bubis, J. A., Solovyeva, E. M., Gorshkov, M. V. & Kjeldsen, F., 18 mar. 2019, I : Environmental Science: Nano. 6, 4, s. 1089-1098

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Silver
Blood
Nanoparticles
Plasmas
Hydrophobicity
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Proteomic profiling of mouse epididymosomes reveals their contributions to post-testicular sperm maturation

Nixon, B., De Iuliis, G. N., Hart, H. M., Zhou, W., Mathe, A., Bernstein, I., Anderson, A. L., Stanger, S. J., Skerrett-Byrne, D. A., Jamaluddin, M. F. B., Almazi, J. G., Bromfield, E. G., Larsen, M. R. & Dun, M. D., 15 mar. 2019, I : Molecular and Cellular Proteomics. 18, Suppl. 1, s. S91-S108

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Exosomes
Epididymis
Proteins
Genes
Zona Pellucida

Quantification of Cholesterol and Cholesteryl Ester by Direct Flow Injection High-Resolution Fourier Transform Mass Spectrometry Utilizing Species-Specific Response Factors

Höring, M., Ejsing, C. S., Hermansson, M. & Liebisch, G., 2019, I : Analytical Chemistry. 91, 5, s. 3459–3466

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Cholesterol Esters
Mass spectrometry
Fourier transforms
Electrospray ionization
Lipids
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Rapid Generation of Long Noncoding RNA Knockout Mice Using CRISPR/Cas9 Technology

Hansmeier, N. R., Widdershooven, P. J. M., Khani, S. & Kornfeld, J-W., 23 jan. 2019, I : Non-Coding R N A. 5, 1, s. 1-12

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Clustered Regularly Interspaced Short Palindromic Repeats
Long Noncoding RNA
Gene Targeting
Guide RNA
Gene Knockout Techniques
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s ·nr: a visual analytics framework for contextual analyses of private and public RNA-seq data

Klemm, P., Frommolt, P. & Kornfeld, J. W., 24 jan. 2019, I : BMC Genomics. 20, 1, 1 s., 85.

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Research Personnel
RNA
Transcriptome
Datasets
sponge
phytoplankton
bacterium
biomass
bacteria

Silver nanoparticle-induced expression of proteins related to oxidative stress and neurodegeneration in an in vitro human blood-brain barrier model

Khan, A. M., Korzeniowska, B., Gorshkov, V., Tahir, M., Schrøder, H., Skytte, L., Rasmussen, K. L., Khandige, S., Møller-Jensen, J. & Kjeldsen, F., mar. 2019, I : Nanotoxicology. 13, 2, s. 221-239

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Oxidative stress
Silver
Nanoparticles
Proteins
Endothelial cells

Site-Directed Mutagenesis for In Vitro and In Vivo Experiments Exemplified with RNA Interactions in Escherichia Coli

Andreassen, P. R., Pettersen, J. S. & Jørgensen, M., 5 feb. 2019, I : Journal of visualized experiments : JoVE. 144, e58996.

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Mutagenesis
Site-Directed Mutagenesis
RNA
Escherichia coli
Polymerase Chain Reaction

Super-resolution microscopy and empirically validated autocorrelation image analysis discriminates microstructures of dairy derived gels

Glover, Z. J., Ersch, C., Andersen, U., Holmes, M. J., Povey, M. J., Brewer, J. R. & Simonsen, A. C., 1 maj 2019, I : Food Hydrocolloids. 90, s. 62-71

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Dairies
autocorrelation
Autocorrelation
Image analysis
microstructure

The association between activated protein C ratio and Factor V Leiden are gender-dependent

Hansen, R. S. & Nybo, M., 23 mar. 2019, I : Clinical Chemistry and Laboratory Medicine.

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Protein C
Association reactions
factor V Leiden
Activated Protein C Resistance
Thrombophilia

The LhrC sRNAs control expression of T cell-stimulating antigen TcsA in Listeria monocytogenes by decreasing tcsA mRNA stability

Ross, J. A., Thorsing, M., Lillebæk, E. M. S., Dos Santos, P. T. & Kallipolitis, B. H., 2019, I : R N A Biology. 16, 3, s. 270-281

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Listeria monocytogenes
Messenger RNA
Base Pairing
Half-Life
Virulence

The nanoscopic molecular pathway through human skin

Iachina, I., Antonescu, I. E., Dreier, J., Sørensen, J. A. & Brewer, J. R., 1 jul. 2019, I : Biochimica et Biophysica Acta - General Subjects. 1863, 7, s. 1226-1233

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Skin
Lipid Bilayers
Lipid bilayers
Molecules
Skin Absorption
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The temporal profile of activity-dependent presynaptic phospho-signalling reveals long-lasting patterns of poststimulus regulation

Engholm-Keller, K., Waardenberg, A. J., Müller, J. A., Wark, J. R., Fernando, R. N., Arthur, J. W., Robinson, P. J., Dietrich, D., Schoch, S. & Graham, M. E., mar. 2019, I : PLOS Biology. 17, 3, e3000170.

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Phosphorylation
protein kinases
Protein Kinases
phosphorylation
Phosphopeptides
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Total Fatty Acid Analysis of Human Blood Samples in One Minute by High-Resolution Mass Spectrometry

Gallego, S. F., Hermansson, M., Liebisch, G., Hodson, L. & Ejsing, C. S., 1 jan. 2019, I : Biomolecules. 9, 1, s. 1-16 7.

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Gas chromatography
Mass spectrometry
Blood
Fatty Acids
Mass spectrometers