Post mortem computertomografi til påvisning af kulmonoxid relaterede læsioner i globus pallidus

Kathrine K. Hansen (Underviser), Joakim B. Kunkel (Underviser), Leth, P. M. (Underviser)

Aktivitet: Foredrag og mundtlige bidragKonferenceoplæg

Beskrivelse

Objectives: Is acute and lethal exposure to carbon monoxide associated with subsequent changes in globus pallidus, as can be visualized and measured with post mortem computed tomography? The literature describes varying prevalences in vivo of globus pallidus specific radiological changes associated with carbon monoxide exposure, but this has never been investigated in a forensic setting. Materials & methods: In this retrospective, cross-sectional study, we obtained medical forensics reports and imaging for 10 exposed individuals whom had died following acute carbon monoxide poisoning. Data for an unexposed group of deceased individuals were gathered for comparison. We attempted to rule out obvious confounding factors during selection. A board certified radiologist performed 2D measurements of globus pallidus attenuation parameters, randomized and blinded to all details except for sex and age. Group measurements were compared using two-sample t-test and the Mann-Whitney U test. Results: In the group of exposed individuals, we found a significantly lower maximum attenuation, right-sided (t-test: Δ-5,2, CI = -8,995;-1,405, p=0,01, two-tailed). The Mann-Whitney U test indicated significance as well. Left sided maximum and bilateral average attenuation was consistently lower, but did not reach statistical significance. Conclusion: The significant difference on a single parameter is notable, however a bilateral response was to be expected. We reason that components of bias such as time alive after the exposure, together with the design and power of the current study, add to the conclusion that further studies, including one with another modality such as magnetic resonance imaging (MRI), may be proposed.
Periode1. nov. 2019
BegivenhedstitelDansk Selskab for Retsmedicins Årsmøde 2019
BegivenhedstypeKonference
PlaceringOdense, Danmark

Emneord

  • Forensic Imaging
  • Forensic Medicine
  • Forensic Radiology
  • carbon monoxide poisoning
  • toxicology