Drug discovery targeting G protein-coupled 7TM receptors

  • Trond Ulven (Foredragsholder)

Aktivitet: Foredrag og mundtlige bidragForedrag og præsentationer i privat eller offentlig virksomhed

Beskrivelse

Encoded by ca. 4% of human genes, the G protein-coupled 7-transmembrane receptors (GPCRs / 7TM receptors) make up the largest family of cell surface receptors, found on all cell types in the body and implicated in virtually every physiological process. Although this receptor superfamily make up 40% of all current drug targets and mediate the effects of a similar fraction of current drugs, the vast majority of the receptors considered to have drug target potential are still not exploited. Thus, discovery of selective ligands for members of this receptor class remains an important challenge, both to discover new and improved therapeutics and as tools to elucidate the physiological functions of the receptors. Approaches for targeting 7TM receptors with small molecules will be illustrated with specific examples.
Periode15. maj 2008
BegivenhedstitelThe Annual Meeting of The Danish Society of Pharmacology and Toxicology, 2008
BegivenhedstypeKonference
PlaceringCopenhagen, Danmark